To explore the mechanism of Yigong San anti-gastric cancer and immune regulation

BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 years.However,the mechanism of its anti-gastric cancer and regulate immunity are still remains unclear.AIM To explore the mechanism of YGS anti-gastric cancer and immune regulation.METHODS Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric cancer.Secondly,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub genes.Then the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were analyzed.Finally,molecular docking was used to verify the binding ability of YGS active ingredient and hub genes.RESULTS Firstly,obtained 55 common targets of gastric cancer and YGS.The Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub genes.The 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer progression.Finally,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic targets.CONCLUSION YGS has the effect of anti-gastric cancer and immune regulation.

Therapeutic effect of San Bi Tang combined with glucosamine sulfate capsules in cold-dampness-type knee osteoarthritis

BACKGROUND Cold-dampness-type knee osteoarthritis is a common middle-aged and elderly disease,but its pathogenesis is not fully understood,and its clinical treatment has limitations.Glucosamine sulfate capsules are commonly used for treating arthritis,and San Bi Tang is a classic formula of traditional Chinese medicine(TCM)that has the effects of warming yang,dispelling dampness,relaxing muscles,and activating collaterals.This research hypothesized that the combination of modified San Bi Tang and glucosamine sulfate capsules could enhance the clinical efficacy of treating cold-dampness-type knee osteoarthritis through complementary effects.AIM To analyze the clinical efficacy of San Bi Tang combined with glucosamine sulfate capsules when treating cold-dampness-type knee osteoarthritis.METHODS A total of 110 patients with cold-dampness-type knee osteoarthritis were selected as research subjects and randomly divided into a control group and an experimental group of 55 cases each.The control group received only treatment with glucosamine sulfate capsules,while the experimental group received additional treatment with modified San Bi Tang for a duration of 5 wk.The patients’knee joint functions,liver and kidney function indicators,adverse reactions,and vital signs were evaluated and analyzed using SPSS 26.0 software.RESULTS Before treatment,the two groups’genders,ages,and scores were not significantly different,indicating comparability.Both groups’scores improved after treatment,which could indicate pain and knee joint function improvement,but the test group had better scores.The TCM-specific symptoms and the clinical efficacy of the treatment in the test group were higher.Before and after treatment,there were no abnormalities in the patients’liver and kidney function indicators.CONCLUSION The combination of modified San Bi Tang and glucosamine sulfate capsules is superior to treatment with sulfated glucosamine alone and has high safety.

Bioactive constituents and action mechanism of Xiaoyao San for treatment of non-alcoholic fatty liver disease

Xiaoyao San(XYS)is a classic Chinese medicine prescription.It is traditionally used to relieve syndrome of“liver stagnation and spleen deficiency”,a common syndrome type in traditional Chinese medicine,through soothing liver,tonifying spleen,and nourishing blood.Correspondingly,XYS has long application in the treatment of depression,dyspepsia and liver diseases.Given the rising of cutting-edge researches on XYS,there’s a significant need to diligently uncover the bioactive constituents and action mechanisms of XYS for treating non-alcoholic fatty liver disease accordingly.

Suppression of hepatic steatosis in non-alcoholic steatohepatitis model by modified Xiaoyao San formula:Evidence,mechanisms and perspective

In this letter,we comment on a recent publication by Mei et al,in the World Journal of Hepatology,investigating the hepatoprotective effects of the modified Xiaoyao San(MXS)formula in a male rat model of non-alcoholic steatohepatitis(NASH).The authors found that MXS treatment mitigated hepatic steatosis and inflam-mation in the NASH model,as evidenced by the reduction in lipid droplets(LDs),fibrosis markers and lipogenic factors.Interestingly,these hepatoprotective effects were associated with androgen upregulation(based on metabolomics analysis of male steroid hormone metabolites),adenosine 5’-monophosphate-activated protein kinase(AMPK)activation,and restoration of phosphatase and tensin homolog(PTEN)expression.However,the authors did not clearly discuss the relationships between MXS-induced hepatic steatosis reduction in the NASH model,and androgen upregulation,AMPK activation,and restoration of PTEN expression.This editorial emphasizes the reported mechanisms and explains how they act or interact with each other to reduce hepatic steatosis and inflammation in the NASH model.As a perspective,we propose additional mechanisms(such as autophagy/lipophagy activation in hepatocytes)for the clearance of LDs and suppression of hepatic steatosis by MXS in the NASH model.A proper understanding of the mechanisms of MXS-induced reduction of hepatic steatosis might help in the treatment of NASH and related diseases.

Decadal Forecasts of Large Earthquakes along the Northern San Andreas Fault System, California: Increased Activity on Regional Creeping Faults Prior to Major and Great Events

The three largest earthquakes in northern California since 1849 were preceded by increased decadal activity for moderate-size shocks along surrounding nearby faults. Increased seismicity, double-difference precise locations of earthquakes since 1968, geodetic data and fault offsets for the 1906 great shock are used to re-examine the timing and locations of possible future large earthquakes. The physical mechanisms of regional faults like the Calaveras, Hayward and Sargent, which exhibit creep, differ from those of the northern San Andreas, which is currently locked and is not creeping. Much decadal forerunning activity occurred on creeping faults. Moderate-size earthquakes along those faults became more frequent as stresses in the region increased in the latter part of the cycle of stress restoration for major and great earthquakes along the San Andreas. They may be useful for decadal forecasts. Yearly to decadal forecasts, however, are based on only a few major to great events. Activity along closer faults like that in the two years prior to the 1989 Loma Prieta shock needs to be examined for possible yearly forerunning changes to large plate boundary earthquakes. Geodetic observations are needed to focus on identifying creeping faults close to the San Andreas. The distribution of moderate-size earthquakes increased significantly since 1990 along the Hayward fault but not adjacent to the San Andreas fault to the south of San Francisco compared to what took place in the decades prior to the three major historic earthquakes in the region. It is now clear from a re-examination of the 1989 mainshock that the increased level of moderate-size shocks in the one to two preceding decades occurred on nearby East Bay faults. Double-difference locations of small earthquakes provide structural information about faults in the region, especially their depths. The northern San Andreas fault is divided into several strongly coupled segments based on differences in seismicity.

融合多尺度通道注意力的开放词汇语义分割模型SAN

随着视觉语言模型的发展,开放词汇方法在识别带注释的标签空间之外的类别方面具有广泛应用。相比于弱监督和零样本方法,开放词汇方法被证明更加通用和有效。文章研究的目标是改进面向开放词汇分割的轻量化模型SAN,即引入基于多尺度通道注意力的特征融合机制AFF来改进该模型,并改进原始SAN结构中的双分支特征融合方法。然后在多个语义分割基准上评估了该改进算法,结果显示在几乎不改变参数量的情况下,模型表现有所提升。这一改进方案有助于简化未来开放词汇语义分割的研究。

SAN单元设备布置探讨

设备布置是化工工程设计的核心,也是开始详细工程设计的重要前提。设备布置既要做到安全、经济合理,也需满足工艺设计及操作、检维修和施工的要求。本文针对ABS装置中SAN单元部分展开设备布置讨论。

SANS在RPV辐照钢纳米结构相的研究进展

辐照通常会引起RPV钢纳米尺度团簇或沉淀相的形成演变,小角中子散射(SANS)技术是研究该类纳米结构的重要工具之一。该技术在材料研究中具有诸多优点:如研究尺度适中,具有较强的穿透性,对磁性结构敏感,能够区分近邻元素等。应用该技术可以研究RPV钢中子辐照诱发的纳米结构体尺寸、成分、体积分数等重要参数,深入理解宏观力学性能。本文介绍了几个典型的应用研究案例,具体包括磁场环境下的纳米结构观测;长周期辐照条件下的辐照缺陷特征研究;材料成分和辐照剂量率对析出团簇尺寸和体积分数的影响;原位退火过程的纳米析出物结构演化情况;以及氢元素对纳米团簇的影响等等。

应用于非编网的SAN共享管理软件分析与评述

主要从非编网的共享存储网络结构、SANergy软件及其特点、ImageSAN软件及其特点、StorNext软件及其特点等方面,就应用于非编网的SAN共享管理软件的诸多问题进行一些分析与评述。

Combination of Shengmai San and Radix puerariae ameliorates depression-like symptoms in diabetic rats at the nexus of PI3K/BDNF/SYN protein expression

Background:Hyperglycemia is a characteristic feature of diabetes that often results in neuropsychological complications such as depression.Diabetic individuals are more vulnerable to experience depression compared to the normal population.Thus,novel treatment approaches are required to reduce depressive symptoms among diabetic individuals.Traditional Chinese medicines(TCMs)such as Shengmai San(SMS)and Radix puerariae(R)are usually widely used to treat ailments such as neurological com-plications since ancient time.Methods:In this study,SMS was combined with R to prepare an R-SMS formulation and screened for their antidepressant activity in diabetic rats.The antidepressant po-tential of the prepared combination was evaluated behaviorally using open field test,novelty-induced hypophagia,and forced swim test in diabetic rats with biochemical and protein expression(PI3K,BDNF[brain-derived neurotrophic factor],and SYN[pr-esynaptic vesicle protein])analysis.Results:Diabetic rats(streptozotocin,45 mg/kg)showed elevated fasting blood glu-cose(FBG)>12 mM with depressive symptoms throughout the study.Treatment with R-SMS(0.5,1.5,and 4.5 g/kg)significantly reverted depressive symptoms in diabetic rats as evinced by significantly(p<0.05)reduced immobility time with an increased tendency to eat food in a novel environment.Treatment with R-SMS also significantly increased the protein expression of PI3K,BDNF,and SYN protein,which play a crucial role in depression.Conclusion:This study showed that R-SMS formulation antagonized depressive symptoms in diabetic rats;thus,this formulation might be studied further to develop as an antidepressant.

SAN反应系统中单体竞聚率的测定及应用的研究

通过对SAN反应釜中苯乙烯、丙烯腈瞬时组成与聚合物中粒子的组分之间的关系进行研究,实验测定SAN反应釜在固定转化率下不同单体组成形成共聚物组分,通过计算确定各单体在现有反应条件下的竞聚率,根据研究结果,修正反应釜内单体组成与聚合物组分函数曲线,并分析不同反应条件对所得曲线造成的影响,以达到新牌号SAN开发时反应釜进料组成制定及优化的目的。

基于IP-SAN的电视节目非线性制作网络的设计与建设

本文介绍了扬州广播电视总台基于IP-SAN的电视节目非线性制作网络的设计与建设。重点介绍了网络组建方案对比与选型。提出了系统安全性方面的一些设计方案。对以后其他单位采用IP-SAN网络搭建中等规模的非线性制作网有一定的借鉴作用。

Metabolomics characterization of Qingwei San on oral ulcer in db/db mice with stomach heat pattern

Objective:To characterize the effects of Qingwei San(QWS)on diabetic oral ulcer(OU)mice with stomach heat pattern through metabolomic analysis.Methods:A stomach heat pattern mouse model was established by treating C57BLKS/J Leprdb/db(db/db)mice with dried Zingiber officinale Rosc.rhizome(Z.officinale,Gan Jiang)decoction by gavage.All model mice had blood glucose levels of≥11.1 m M.Subsequently,OU was induced by Na OH cauterization.After 1 week of administration of QWS,non-targeted metabolomic analysis of serum was conducted using ultra high performance liquid chromatography coupled with mass spectrometry(UHPLC-MS/MS).Results:The non-targeted metabolomics results indicated that tryptophan metabolism,2-oxocarboxylic acid metabolism,serotonergic synapses,amino sugar and nucleotide sugar metabolism,and amino acid biosynthesis were involved in the therapeutic effects of QWS,with tryptophan metabolism playing a predominant role.Conclusion:QWS treatment can significantly improve the pathological status of diabetic OU mice with stomach heat pattern.QWS may regulate the release of inflammatory factors through the tryptophan metabolism pathway.

IP-SAN的研究与设计

FC-SAN存在着传播距离有限、成本高、管理困难等不足,IP-SAN的出现解决了FC-SAN的不足.通过对IP-SAN的体系结构和性能的研究,发现沿用FC-SAN体系结构的IP-SAN存在共享冲突、系统和数据不安全等问题.由于IP-SAN中的用户网与存域网在逻辑上属于不同的网络,但在物理上是同一网络.采用三方传送协议实现IP-SAN可以解决这些问题,实验表明这种方法是可行的.

The active mechanism of the Sheng Yang San Huo decoction on diabetic peripheral neuropathy on network pharmacology

Objectives:To discuss the mechanism of Sheng Yang San Huo decoction on diabetic peripheral neuropathy using the network pharmacology method.Methods:The BATMAN-TCM database,TCM-ID database,Chinese Natural Product Chemical Composition Database,and TCMIP database were employed to screen the chemical active ingredients of each herb in Sheng Yang San Huo decoction based on the“Libinsky Drug Rules”.SwissTargetPrediction was used to screen effective action targets for each herb in the prescription.Additionally,Cytoscape 3.7.0 was utilized to construct a“drug-target”network.GeneCards,OMIM,and MaLaCards databases were utilized to gather targets related to diabetic peripheral neuropathy.VENNY 2.1 online platform was employed to match drug and disease targets,draw a Venn diagram,and construct a“drug-active compounds-common target”network using Cytoscape 3.7.0.gene ontology biological process analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for the targets were conducted using the DAVID 6.8 database.Enrichment analysis results were visualized using the OmicShareTool online platform.Molecular docking was performed using CB-Dock2.Results:Following screening,a total of 217 active compounds and 132 potential targets were identified in Sheng Yang San Huo decoction.The effects are primarily enriched in pathways such as Lipid and Atherosclerosis,AGE-RAGE signaling pathway in diabetic complications,and the IL-17 signaling pathway.The binding energy of the key active ingredients to the core protein targets of DPN was favorable.Conclusion:The study reveals the characteristics of multiple targets and pathways of Sheng Yang San Huo decoction,providing new insights for the clinical application of this prescription.

SAN技术的探讨分析

存储区域网络(SAN)的被广泛接受,改变了原有的存储格局。本文对两种不同架构的SAN进行了介绍,分析了RAID这一存储的关键技术,研究了在实际应用中对不同RAID等级的选择原则,最后提出了制约发展的局限性,并介绍了业界最新的发展。

PB-g-SAN弹性体的合成及其对SAN树脂的增韧

采用种子乳液聚合技术在聚丁二烯(PB)乳胶粒子上接枝共聚苯乙烯(St)和丙烯腈(AN)合成了一系列PB质量分数为40%的PB g SAN弹性体·研究了共聚单体中叔 十二烷基硫醇(TDDM)质量分数对SAN共聚物接枝行为、弹性体粒子结构及其动态力学性能的影响·结果发现,随着单体中TDDM质量分数的增加,SAN在PB上的接枝率和接枝效率降低,弹性体粒子中SAN包容结构的尺寸增大,在低温区的动态剪切模量下降·将其与SAN树脂共混后发现在共聚单体中引入TDDM后提高了弹性体粒子的增韧效率·

SKALAR San++连续流动分析仪测定水中总氮的方法研究

利用SKALAR San++连续流动分析仪测定了水中的总氮含量,结果表明:此方法具有自动化程度高、分析速度快、试剂用量少等优点。该方法的线性范围为0~5.00 mg/L,线性相关系数达到0.99994,检出限为0.04 mg/L,加标回收率为90%~107%。对比传统行业标准分析法,连续流动分析法可实现全过程自动化处理、大大节省人力,并提高了检测效率,且两种方法的测定结果无显著性差异,而连续流动分析法更适合于大批量样品和复杂样品的批量检测与分析。

精致与摩登——法国轻奢品牌SANDRO眼镜赏析

品牌故事SANDRO品牌由Evelyne Chetrite和Didier Chetrite夫妇于1984年在法国创立,并在法国巴黎圣殿老街开设了第一家精品店。迄今为止,SANDRO在39个国家拥有超过646个销售点,以典雅别致的法式风格著称,以中高价为定位掀起了追捧“Accessible Luxury”(轻奢)的热潮,不仅受到了都市年轻女性的钟爱,在不少明星街拍中也经常能见到身着SANDRO服饰或配饰的身影。

网络存储新技术IP-SAN在数字图书馆中的应用

FC-SAN存在着传播距离有限、成本高、管理困难等不足,IP-SAN的出现解决了FC-SAN的不足。本文介绍了基于iSCSI协议的SAN架构,讨论了FC-SAN和IP-SAN的区别,分析了IP-SAN在图书馆存储建设中的优势。