KáLIDA SANT PAU中心是一个为癌症患者及其家人、朋友提供情感交流和社交的场所。作为对传统医疗的补充,它如同一个家,向人们敞开着怀抱。在这里,患者可以得到专业医疗人士的帮助。该疗养中心位于西班牙巴塞罗那,坐落在一个新建医...KáLIDA SANT PAU中心是一个为癌症患者及其家人、朋友提供情感交流和社交的场所。作为对传统医疗的补充,它如同一个家,向人们敞开着怀抱。在这里,患者可以得到专业医疗人士的帮助。该疗养中心位于西班牙巴塞罗那,坐落在一个新建医院和原有的新艺术风格建筑群之间,项目内包括一栋400 m^2的小型建筑和宽敞的室外花园,主要立面与区域内新规划的道路平行。建筑师的基本理念是想打造一处种植有五彩斑斓花朵的花园,因此疗养中心被设计为一个带有花园凉棚的场所,模糊了内外空间的界限。疗养中心为使用者提供了光线充足、温馨惬意、保护患者私密的庇护之地。展开更多
As a core part of the electronic warfare(EW) system,de-interleaving is used to separate interleaved radar signals. As interleaved radar pulses become more complex and denser, intelligent classification of radar signal...As a core part of the electronic warfare(EW) system,de-interleaving is used to separate interleaved radar signals. As interleaved radar pulses become more complex and denser, intelligent classification of radar signals has become very important. The self-organizing feature map(SOFM) is an excellent artificial neural network, which has huge advantages in intelligent classification of complex data. However, the de-interleaving process based on SOFM is faced with the problems that the initialization of the map size relies on prior information and the network topology cannot be adaptively adjusted. In this paper, an SOFM with self-adaptive network topology(SANT-SOFM) algorithm is proposed to solve the above problems. The SANT-SOFM algorithm first proposes an adaptive proliferation algorithm to adjust the map size, so that the initialization of the map size is no longer dependent on prior information but is gradually adjusted with the input data. Then,structural optimization algorithms are proposed to gradually optimize the topology of the SOFM network in the iterative process,constructing an optimal SANT. Finally, the optimized SOFM network is used for de-interleaving radar signals. Simulation results show that SANT-SOFM could get excellent performance in complex EW environments and the probability of getting the optimal map size is over 95% in the absence of priori information.展开更多
法国新的卫生评估机构Haute Autorite de Sante(HAS)即将于1月1日正式运作。HAS将负责评估药物产品用于补偿目的的医学利益。它也宣布已指定曾任国家卫生评估局ANAES总主任的Alain Conlomb为其主任。这一机构是HAS的一部分，与委员会一...法国新的卫生评估机构Haute Autorite de Sante(HAS)即将于1月1日正式运作。HAS将负责评估药物产品用于补偿目的的医学利益。它也宣布已指定曾任国家卫生评估局ANAES总主任的Alain Conlomb为其主任。这一机构是HAS的一部分，与委员会一起进行医学利益评估。展开更多
In eukaryotes,histone acetylation is a major modification on histone N-terminal tails that is tightly connected to transcriptional activation.HDA6 is a histone deacetylase involved in the transcriptional regulation of...In eukaryotes,histone acetylation is a major modification on histone N-terminal tails that is tightly connected to transcriptional activation.HDA6 is a histone deacetylase involved in the transcriptional regulation of genes and transposable elements(TEs)in Arabidopsis thaliana.HDA6 has been shown to participate in several complexes in plants,including a conserved SIN3 complex.Here,we uncover a novel protein complex containing HDA6,several Harbinger transposon-derived proteins(HHP1,SANT1,SANT2,SANT3,and SANT4),and MBD domain-containing proteins(MBD1,MBD2,and MBD4).We show that mutations of all four SANT genes in the sant-null mutant cause increased expression of the flowering repressors FLC,MAF4,and MAF5,resulting in a late flowering phenotype.Transcriptome deep sequencing reveals that while the SANT proteins and HDA6 regulate the expression of largely overlapping sets of genes,TE silencing is unaffected in sant-null mutants.Our global histone H3 acetylation profiling shows that SANT proteins and HDA6 modulate gene expression through deacetylation.Collectively,our findings suggest that Harbinger transposon-derived SANT domain-containing proteins are required for histone deacetylation and flowering time control in plants.展开更多
文摘KáLIDA SANT PAU中心是一个为癌症患者及其家人、朋友提供情感交流和社交的场所。作为对传统医疗的补充,它如同一个家,向人们敞开着怀抱。在这里,患者可以得到专业医疗人士的帮助。该疗养中心位于西班牙巴塞罗那,坐落在一个新建医院和原有的新艺术风格建筑群之间,项目内包括一栋400 m^2的小型建筑和宽敞的室外花园,主要立面与区域内新规划的道路平行。建筑师的基本理念是想打造一处种植有五彩斑斓花朵的花园,因此疗养中心被设计为一个带有花园凉棚的场所,模糊了内外空间的界限。疗养中心为使用者提供了光线充足、温馨惬意、保护患者私密的庇护之地。
文摘【目的】从澳洲坚果(Macadamia integrifolia)叶片中克隆MYB1转录因子基因(MiMYB1)并进行生物信息学分析,为揭示R2R3-MYB家族转录因子成员在澳洲坚果中的抗逆作用机制提供参考依据。【方法】利用PCR从澳洲坚果品种桂热一号叶片中克隆MiMYB1基因,采用ProtParam、TMHMM Server v.2.0和SMART:Main page等在线分析软件对MiMYB1蛋白进行生物信息学分析,运用DNAMAN 7.0进行蛋白氨基酸多序列比对分析,并从NCBI中选取126个拟南芥R2R3-MYB家族成员,以Geneious Pro v4.8.4中的邻接法(Neighbor-joining,NJ)构建系统发育进化树。【结果】从澳洲坚果品种桂热一号叶片中克隆获得的MiMYB1基因序列全长1205 bp,包含1062 bp的开放阅读框(ORF),共编码353个氨基酸,GenBank登录号为MN254975。MiMYB1蛋白具有2个SANT保守结构域,属于R2R3-MYB家族,是无跨膜结构、无信号肽且定位于细胞核的不稳定亲水性蛋白。MiMYB1氨基酸序列(MN254975)与荷花NnMYB39氨基酸序列(XP010277911.1)的亲缘关系最近,相似性为71.81%;与哥伦比亚锦葵HuMYB102-like(XP021293847.1)、榴莲DzMYB102-like(XP022777375.1)、木薯MeMYB102-like(XP021596793.1)和高山栎QsMYB102-like(XP023877052.1)的MYB氨基酸序列相似性分别为67.47%、68.63%、64.44%和67.28%。MiMYB1蛋白与126个拟南芥R2R3-MYB家族成员的系统发育进化分析结果显示,MiMYB1与AtMYB41的亲缘关系最近,与AtMYB41、AtMYB74和AtMYB102同属于S11亚族,具有相似的生物学功能,即与植物抗逆性功能相关。【结论】MiMYB1是典型的植物R2R3-MYB转录因子,在澳洲坚果的抗逆反应中发挥作用。
基金supported by the National Natural Science Foundation of China(61571043)the 111 Project of China(B14010)。
文摘As a core part of the electronic warfare(EW) system,de-interleaving is used to separate interleaved radar signals. As interleaved radar pulses become more complex and denser, intelligent classification of radar signals has become very important. The self-organizing feature map(SOFM) is an excellent artificial neural network, which has huge advantages in intelligent classification of complex data. However, the de-interleaving process based on SOFM is faced with the problems that the initialization of the map size relies on prior information and the network topology cannot be adaptively adjusted. In this paper, an SOFM with self-adaptive network topology(SANT-SOFM) algorithm is proposed to solve the above problems. The SANT-SOFM algorithm first proposes an adaptive proliferation algorithm to adjust the map size, so that the initialization of the map size is no longer dependent on prior information but is gradually adjusted with the input data. Then,structural optimization algorithms are proposed to gradually optimize the topology of the SOFM network in the iterative process,constructing an optimal SANT. Finally, the optimized SOFM network is used for de-interleaving radar signals. Simulation results show that SANT-SOFM could get excellent performance in complex EW environments and the probability of getting the optimal map size is over 95% in the absence of priori information.
基金This work was supported by grants from the National Key Research and Development Program of China(2020YFE0202300)the Central Public-interest Scientific Institution Basal Research Fund,the BBSRC under the Grant Reference BB/P008569/1 to J.G.C.N.V.and E.dL.,and an Erasmus plus training award to L.G.
文摘In eukaryotes,histone acetylation is a major modification on histone N-terminal tails that is tightly connected to transcriptional activation.HDA6 is a histone deacetylase involved in the transcriptional regulation of genes and transposable elements(TEs)in Arabidopsis thaliana.HDA6 has been shown to participate in several complexes in plants,including a conserved SIN3 complex.Here,we uncover a novel protein complex containing HDA6,several Harbinger transposon-derived proteins(HHP1,SANT1,SANT2,SANT3,and SANT4),and MBD domain-containing proteins(MBD1,MBD2,and MBD4).We show that mutations of all four SANT genes in the sant-null mutant cause increased expression of the flowering repressors FLC,MAF4,and MAF5,resulting in a late flowering phenotype.Transcriptome deep sequencing reveals that while the SANT proteins and HDA6 regulate the expression of largely overlapping sets of genes,TE silencing is unaffected in sant-null mutants.Our global histone H3 acetylation profiling shows that SANT proteins and HDA6 modulate gene expression through deacetylation.Collectively,our findings suggest that Harbinger transposon-derived SANT domain-containing proteins are required for histone deacetylation and flowering time control in plants.
