One specific example reflecting the completity ofcardiovascular responses induced by serotonin ( 5-hydroxytryptamine; 5-HT) and the progress achieved inthe pharmacological characterization of the receptorsinvolved can...One specific example reflecting the completity ofcardiovascular responses induced by serotonin ( 5-hydroxytryptamine; 5-HT) and the progress achieved inthe pharmacological characterization of the receptorsinvolved can be illustrated by the effects of 5-HT on thecanine external carotid artery bed. Within thisframework, it has been shown that the external carotidvasoconstrictor response to 5-HT in the dog is mediatedby '5-HT_1-like' receptors, which being blocked by the5-HT_(1B/1D) receptor antagonist GR127935, resemble 5-HT_(1B/1D)(previously called 5-HT_(1B/1D) ) receptors.展开更多
基金Project supported by Consejo Nacional de Ciencia y Tecnologia (Mexico City)
文摘One specific example reflecting the completity ofcardiovascular responses induced by serotonin ( 5-hydroxytryptamine; 5-HT) and the progress achieved inthe pharmacological characterization of the receptorsinvolved can be illustrated by the effects of 5-HT on thecanine external carotid artery bed. Within thisframework, it has been shown that the external carotidvasoconstrictor response to 5-HT in the dog is mediatedby '5-HT_1-like' receptors, which being blocked by the5-HT_(1B/1D) receptor antagonist GR127935, resemble 5-HT_(1B/1D)(previously called 5-HT_(1B/1D) ) receptors.
