The phenotype, DNA-binding activities of NF-κB, cytokine production, endocytosis and stimulatory capacity of spleen OX-62-positive dendritc calls （SDCs） from Fischer rats were compared with those from Lewis rats. R...The phenotype, DNA-binding activities of NF-κB, cytokine production, endocytosis and stimulatory capacity of spleen OX-62-positive dendritc calls （SDCs） from Fischer rats were compared with those from Lewis rats. Results showed that the expressions of CDllb, MHC-II, CD8, CD45RA, CD54 and CD86 on SDCs were significantly higher in Fischer than those in Lewis rats. The levels of IL-2, IL-4, IL-10 and IFN-T in SDCs from Fischer rats were distinctly higher than those from Lewis. Both stimulatory capacity and DNA-binding activities of NF-κB in SDCs were all lower in Fischer than those in Lewis rats. These differences may partly contribute to rat strainspecificity in susceptibility to chronic inflammatory stimuli.展开更多
文摘The phenotype, DNA-binding activities of NF-κB, cytokine production, endocytosis and stimulatory capacity of spleen OX-62-positive dendritc calls （SDCs） from Fischer rats were compared with those from Lewis rats. Results showed that the expressions of CDllb, MHC-II, CD8, CD45RA, CD54 and CD86 on SDCs were significantly higher in Fischer than those in Lewis rats. The levels of IL-2, IL-4, IL-10 and IFN-T in SDCs from Fischer rats were distinctly higher than those from Lewis. Both stimulatory capacity and DNA-binding activities of NF-κB in SDCs were all lower in Fischer than those in Lewis rats. These differences may partly contribute to rat strainspecificity in susceptibility to chronic inflammatory stimuli.
