We investigate the exact solutions of one-dimensional (1D) time-independent Gross-Pitaevskii equation(GPE),which governs a Bose-Einstein condensate (BEC) in the magnetic waveguide with a square-Sech potential.Boththe ...We investigate the exact solutions of one-dimensional (1D) time-independent Gross-Pitaevskii equation(GPE),which governs a Bose-Einstein condensate (BEC) in the magnetic waveguide with a square-Sech potential.Boththe bound state and transmission state are found and the corresponding spatial configurations and transport propertiesof BEC are analyzed.It is shown that the well-known absolute transmission of the linear system can occur in theconsidered nonlinear system.展开更多
Many seminal advances have been made in human immunodeficiency virus(HIV)/AIDS research over the past four decades.Treatment strategies,such as gene therapy and immunotherapy,are yielding promising results to effectiv...Many seminal advances have been made in human immunodeficiency virus(HIV)/AIDS research over the past four decades.Treatment strategies,such as gene therapy and immunotherapy,are yielding promising results to effectively control HIV infection.Despite this,a cure for HIV/AIDS is not envisioned in the near future.A recently published academic study has raised awareness regarding a promising alternative therapeutic option for HIV/AIDS,referred to as“selective elimination of host cells capable of producing HIV”(SECH).Similar to the“shock and kill strategy,”the SECH approach requires the simultaneous administration of drugs targeting key mechanisms in specific cells to efficiently eliminate HIV replication-competent cellular reservoirs.Herein,we comprehensively review the specific mechanisms targeted by the SECH strategy.Briefly,the suggested cocktail of drugs should contain(i)latency reversal agents to promote the latency reversal process in replication-competent reservoir cells,(ii)pro-apoptotic and anti-autophagy drugs to induce death of infected cells through various pathways,and finally(iii)drugs that eliminate new cycles of infection by prevention of HIV attachment to host cells,and by HIV integrase inhibitor drugs.Finally,we discuss three major challenges that are likely to restrict the application of the SECH strategy in HIV/AIDS patients.展开更多
The bounded and smooth solitary wave solutions of 10 nonlinear evolution equations with a positive fractional power term of dependent variable are successfully obtained by homogeneous balance principle and with the ai...The bounded and smooth solitary wave solutions of 10 nonlinear evolution equations with a positive fractional power term of dependent variable are successfully obtained by homogeneous balance principle and with the aid of sub-ODEs that admits a solution of sech-power or tanh-power type.In the special cases that the fractional power equals to 1 and 2,the solitary wave solutions of more than 10 important model equations arisen from mathematical physics are easily rediscovered.展开更多
基金National Natural Science Foundation of China under Grant No.10575034the Laboratory of Magnetic Resonance and Atomic and Molecular Physics of China under Grant No.T152504
文摘We investigate the exact solutions of one-dimensional (1D) time-independent Gross-Pitaevskii equation(GPE),which governs a Bose-Einstein condensate (BEC) in the magnetic waveguide with a square-Sech potential.Boththe bound state and transmission state are found and the corresponding spatial configurations and transport propertiesof BEC are analyzed.It is shown that the well-known absolute transmission of the linear system can occur in theconsidered nonlinear system.
基金the Medical Research Project of Chongqing Municipal Science and Technology Bureau and Health Commission(No.2020GDRC004)the Key Medical Research Project of Chongqing Municipal Science and Technology Bureau and Health Commission(No.2019ZDXM012).
文摘Many seminal advances have been made in human immunodeficiency virus(HIV)/AIDS research over the past four decades.Treatment strategies,such as gene therapy and immunotherapy,are yielding promising results to effectively control HIV infection.Despite this,a cure for HIV/AIDS is not envisioned in the near future.A recently published academic study has raised awareness regarding a promising alternative therapeutic option for HIV/AIDS,referred to as“selective elimination of host cells capable of producing HIV”(SECH).Similar to the“shock and kill strategy,”the SECH approach requires the simultaneous administration of drugs targeting key mechanisms in specific cells to efficiently eliminate HIV replication-competent cellular reservoirs.Herein,we comprehensively review the specific mechanisms targeted by the SECH strategy.Briefly,the suggested cocktail of drugs should contain(i)latency reversal agents to promote the latency reversal process in replication-competent reservoir cells,(ii)pro-apoptotic and anti-autophagy drugs to induce death of infected cells through various pathways,and finally(iii)drugs that eliminate new cycles of infection by prevention of HIV attachment to host cells,and by HIV integrase inhibitor drugs.Finally,we discuss three major challenges that are likely to restrict the application of the SECH strategy in HIV/AIDS patients.
基金Supported by the Natural Science Foundation of Education Department of Henan Province of China under Grant No.2011B110013
文摘The bounded and smooth solitary wave solutions of 10 nonlinear evolution equations with a positive fractional power term of dependent variable are successfully obtained by homogeneous balance principle and with the aid of sub-ODEs that admits a solution of sech-power or tanh-power type.In the special cases that the fractional power equals to 1 and 2,the solitary wave solutions of more than 10 important model equations arisen from mathematical physics are easily rediscovered.
