对于影音消赞者,通过 SENSYS D 系列,不仅可以获得轻松的影音之娱,还可从中体验天朗的风格与魅力,更有同轴与宽频两大技术的切实感受。而天朗将产品不断延伸,惠及大众的行为无疑也是有长远眼光、值得赞赏的。影音的变革与时代的发展在 S...对于影音消赞者,通过 SENSYS D 系列,不仅可以获得轻松的影音之娱,还可从中体验天朗的风格与魅力,更有同轴与宽频两大技术的切实感受。而天朗将产品不断延伸,惠及大众的行为无疑也是有长远眼光、值得赞赏的。影音的变革与时代的发展在 SENSYS D 系列中留下了鲜明的印迹。展开更多
AIM: To investigate the microbiological characteristics and drug resistance in liver cirrhosis patients with spontaneous peritonitis.METHODS: We analyzed the data of patients with liver cirrhosis and abdominal infecti...AIM: To investigate the microbiological characteristics and drug resistance in liver cirrhosis patients with spontaneous peritonitis.METHODS: We analyzed the data of patients with liver cirrhosis and abdominal infection at the First Affiliated Hospital of Zhejiang University between January 2011 and December 2013. Pathogens present in the ascites were identified,and their sensitivity to various antibiotics was determined. RESULTS: We isolated 306 pathogenic bacteria from 288 cases: In 178 cases,the infection was caused by gram-negative strains(58.2%); in 85 cases,grampositive strains(27.8%); in 9 cases,fungi(2.9%); and in 16 cases,more than one pathogen. The main pathogens were Escherichia coli(E. coli)(24.2%),Klebsiella pneumoniae(18.9%),Enterococcus spp.(11.1%),and Staphylococcus aureus(7.5%). Of the 306 isolated pathogens,99 caused nosocomial infections and 207 caused community-acquired andother infections. The E. coli and K. pneumoniae strains produced more extended-spectrum β-lactamases in cases of nosocomial infections than non-nosocomial infections(62.5% vs 38%,P < 0.013; 36.8% vs 12.8%,P < 0.034,respectively). The sensitivity to individual antibiotics differed between nosocomial and non-nosocomial infections: Piperacillin/tazobactam was significantly more effective against non-nosocomial E. coli infections(4% vs 20.8%,P < 0.021). Nitrofurantoin had stronger antibacterial activity against Enterococcus species causing non-nosocomial infections(36.4% vs 86.3%,P < 0.009).CONCLUSION: The majority of pathogens that cause abdominal infection in patients with liver cirrhosis are gram-negative,and drug resistance is significantly higher in nosocomial infections than in non-nosocomial infections.展开更多
OBJECTIVE:To observe the effect of Pingan Fang(PG)on behavioral sensitization and conditioned place preference(CPP)induced by ethanol in mice,and to determine the intervention mechanism of PG on alcohol addiction.METH...OBJECTIVE:To observe the effect of Pingan Fang(PG)on behavioral sensitization and conditioned place preference(CPP)induced by ethanol in mice,and to determine the intervention mechanism of PG on alcohol addiction.METHODS:A behavioral sensitization mouse model induced by ethanol was established to observe the effect of PG on the development and expression of behavioral sensitization induced by ethanol by recording the spontaneous activity of mice.The resident time of mice in a white box was measured to evaluate the effect of PG on developing CPP induced by ethanol.Concentrations of dopamine(DA),Glutamate(Glu),and?-aminobutyric acid(GABA)in the corresponding mesolimbic region of mice were determined by enzyme-linked immunosorbent assay.RESULTS:Although PG did not alter spontaneous activity in mice,it reduced the growth of spontaneous activity stimulated by ethanol.The residence time in the white box after-ethanol-training of mice in CPP experiments was decreased.CONCLUSION:Our data suggested that PG blocked the development and expression of behavioral sensitization induced by ethanol and the development of CPP in mice.The mechanism might be related to the decreased content of DA and Glu and increased content of GABA in the mesolimbic dopamine system.This suggests that PG might be useful for the prevention and treatment of alcohol addiction.展开更多
Schistosomiasis is a parasitic disease from the family of Schistosomatidae and genus Schistosoma,which is caused by blood flukes.The disease is endemic in many countries and still a serious threat to global public hea...Schistosomiasis is a parasitic disease from the family of Schistosomatidae and genus Schistosoma,which is caused by blood flukes.The disease is endemic in many countries and still a serious threat to global public health and development.In this paper,a new deterministic model is designed and analyzed qualitatively to explore the dynamics of schistosomiasis transmission in human,cattle and snail populations.Results from our mathematical analysis show that the model has a disease-free equilibrium(DFE)which is locally asymptotically stable(LAS)whenever a particular epidemiological threshold quantity,also known as basic reproduction number(R0)is less than unity.Further analysis shows that the model has a unique endemic equilibrium(EE)which is globally asymptotically stable whenever R0>1 and unstable when R0<1.Furthermore,we adopt partial rank correlation coefficient for sensitivity analysis to reveal the most important parameters for effective control and mitigation of schistosomiasis disease in a community.Finally,we obtain some numerical results by simulating the entire dynamics of the model,which show that the infections in the compartments of each population decrease with respect to time.This further indicates that avoiding contact with infected human,cattle or infested water is vital to prevent the spread of schistosomiasis disease infection.展开更多
基金Supported by Grants from the National Basic Research Program of China,973 Program,No.2013CB531401
文摘AIM: To investigate the microbiological characteristics and drug resistance in liver cirrhosis patients with spontaneous peritonitis.METHODS: We analyzed the data of patients with liver cirrhosis and abdominal infection at the First Affiliated Hospital of Zhejiang University between January 2011 and December 2013. Pathogens present in the ascites were identified,and their sensitivity to various antibiotics was determined. RESULTS: We isolated 306 pathogenic bacteria from 288 cases: In 178 cases,the infection was caused by gram-negative strains(58.2%); in 85 cases,grampositive strains(27.8%); in 9 cases,fungi(2.9%); and in 16 cases,more than one pathogen. The main pathogens were Escherichia coli(E. coli)(24.2%),Klebsiella pneumoniae(18.9%),Enterococcus spp.(11.1%),and Staphylococcus aureus(7.5%). Of the 306 isolated pathogens,99 caused nosocomial infections and 207 caused community-acquired andother infections. The E. coli and K. pneumoniae strains produced more extended-spectrum β-lactamases in cases of nosocomial infections than non-nosocomial infections(62.5% vs 38%,P < 0.013; 36.8% vs 12.8%,P < 0.034,respectively). The sensitivity to individual antibiotics differed between nosocomial and non-nosocomial infections: Piperacillin/tazobactam was significantly more effective against non-nosocomial E. coli infections(4% vs 20.8%,P < 0.021). Nitrofurantoin had stronger antibacterial activity against Enterococcus species causing non-nosocomial infections(36.4% vs 86.3%,P < 0.009).CONCLUSION: The majority of pathogens that cause abdominal infection in patients with liver cirrhosis are gram-negative,and drug resistance is significantly higher in nosocomial infections than in non-nosocomial infections.
基金Supported by Grants from The Administration of Traditional Chinese Medicine Sichuan Province(Exploration of Molecular Mechanisms of Fuyangfang Which Based on the TCM Theory of Yang Deficiency Qi Qie about Alcohol Addiction about Alcohol Addiction Memory and Eliminate,No.2014-E-069)
文摘OBJECTIVE:To observe the effect of Pingan Fang(PG)on behavioral sensitization and conditioned place preference(CPP)induced by ethanol in mice,and to determine the intervention mechanism of PG on alcohol addiction.METHODS:A behavioral sensitization mouse model induced by ethanol was established to observe the effect of PG on the development and expression of behavioral sensitization induced by ethanol by recording the spontaneous activity of mice.The resident time of mice in a white box was measured to evaluate the effect of PG on developing CPP induced by ethanol.Concentrations of dopamine(DA),Glutamate(Glu),and?-aminobutyric acid(GABA)in the corresponding mesolimbic region of mice were determined by enzyme-linked immunosorbent assay.RESULTS:Although PG did not alter spontaneous activity in mice,it reduced the growth of spontaneous activity stimulated by ethanol.The residence time in the white box after-ethanol-training of mice in CPP experiments was decreased.CONCLUSION:Our data suggested that PG blocked the development and expression of behavioral sensitization induced by ethanol and the development of CPP in mice.The mechanism might be related to the decreased content of DA and Glu and increased content of GABA in the mesolimbic dopamine system.This suggests that PG might be useful for the prevention and treatment of alcohol addiction.
文摘Schistosomiasis is a parasitic disease from the family of Schistosomatidae and genus Schistosoma,which is caused by blood flukes.The disease is endemic in many countries and still a serious threat to global public health and development.In this paper,a new deterministic model is designed and analyzed qualitatively to explore the dynamics of schistosomiasis transmission in human,cattle and snail populations.Results from our mathematical analysis show that the model has a disease-free equilibrium(DFE)which is locally asymptotically stable(LAS)whenever a particular epidemiological threshold quantity,also known as basic reproduction number(R0)is less than unity.Further analysis shows that the model has a unique endemic equilibrium(EE)which is globally asymptotically stable whenever R0>1 and unstable when R0<1.Furthermore,we adopt partial rank correlation coefficient for sensitivity analysis to reveal the most important parameters for effective control and mitigation of schistosomiasis disease in a community.Finally,we obtain some numerical results by simulating the entire dynamics of the model,which show that the infections in the compartments of each population decrease with respect to time.This further indicates that avoiding contact with infected human,cattle or infested water is vital to prevent the spread of schistosomiasis disease infection.
