The active mechanism of the Sheng Yang San Huo decoction on diabetic peripheral neuropathy on network pharmacology

Objectives:To discuss the mechanism of Sheng Yang San Huo decoction on diabetic peripheral neuropathy using the network pharmacology method.Methods:The BATMAN-TCM database,TCM-ID database,Chinese Natural Product Chemical Composition Database,and TCMIP database were employed to screen the chemical active ingredients of each herb in Sheng Yang San Huo decoction based on the“Libinsky Drug Rules”.SwissTargetPrediction was used to screen effective action targets for each herb in the prescription.Additionally,Cytoscape 3.7.0 was utilized to construct a“drug-target”network.GeneCards,OMIM,and MaLaCards databases were utilized to gather targets related to diabetic peripheral neuropathy.VENNY 2.1 online platform was employed to match drug and disease targets,draw a Venn diagram,and construct a“drug-active compounds-common target”network using Cytoscape 3.7.0.gene ontology biological process analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for the targets were conducted using the DAVID 6.8 database.Enrichment analysis results were visualized using the OmicShareTool online platform.Molecular docking was performed using CB-Dock2.Results:Following screening,a total of 217 active compounds and 132 potential targets were identified in Sheng Yang San Huo decoction.The effects are primarily enriched in pathways such as Lipid and Atherosclerosis,AGE-RAGE signaling pathway in diabetic complications,and the IL-17 signaling pathway.The binding energy of the key active ingredients to the core protein targets of DPN was favorable.Conclusion:The study reveals the characteristics of multiple targets and pathways of Sheng Yang San Huo decoction,providing new insights for the clinical application of this prescription.

The 3,300-ton rare earth oxide project of Shenghe Resources to be completed and put into production by the end of 2023

Shenghe Resources recently said in an investor survey that the company has a recycling plant in Jiangxi province,capable of processing NdFeB and phosphor slags.The 3,300-ton rare earth oxide project currently under construction is also a recycling plant,and is expected to be completed and put into operation by the end of 2023.

Translator Stylistics:A Corpus Analysis of Two English Translations of Traditional Chinese Medicine Classic Da Sheng Bian

Da Sheng Bian,a significant work on obstetrics and gynecology that emerged in the early Qing Dynasty,was initially published as“A Treatise on Midwifery”in 1842 by William Lockhart,a British missionary to China.In 1894,John G.Kerr,an American missionary,translated the text as“The Tat Shang Pin”.This paper conducts a comparative study of the two English translations using a self-constructed English-Chinese parallel corpus of Da Sheng Bian.The study explores the translation styles of the two translators by examining the token-types ratio and frequency at the lexical level,mean sentence length at the syntactic level,and the use of conjunctions at the discourse level.The observed differences in translation styles between the two translations are analyzed in relation to the translators’backgrounds and translation strategies.

Effect of Sheng-jiang powder on multiple-organ inflammatory injury in acute pancreatitis in rats fed a high-fat diet

BACKGROUND Obesity worsens inflammatory organ injury in acute pancreatitis(AP), but there is no effective preventive strategy. Sheng-jiang powder(SJP) has been shown to alleviate multiple-organ inflammatory injury in rats with high-fat diet-induced obesity. Hence, SJP is supposed to have an effect on multiple-organ inflammatory injury in AP in rats fed a high-fat diet.AIM To explore how obesity may contribute to aggravating inflammatory organ injury in AP in rats and observe the effect of SJP on multiple-organ inflammatory injury in AP in rats fed a high-fat diet.METHODS Rats were randomly assigned to a control group(CG), an obese group(OG), and an SJP treatment group(SG), with eight rats per group. The rats in the OG and SG were fed a high-fat diet. From the third week, the rats in the SG were given oral doses of SJP(5 g/kg of body weight). After 12 wk, AP was induced in the three groups. Serum amylase level, body weight, Lee's index, serum biochemistry parameters, and serum inflammatory cytokine and tissue cytokine levels were assessed, and the tissue histopathological scores were evaluated and compared.RESULTS Compared with the CG, serum triglyceride, total cholesterol, interleukin-6, and interleukin-10 levels were significantly higher in the OG, and serum high-density lipoprotein cholesterol level was significantly lower in the OG. Moreover,enhanced oxidative damage was observed in the pancreas, heart, spleen, lung,intestine, liver, and kidney. Evidence of an imbalanced antioxidant defense system, especially in the pancreas, spleen, and intestine, was observed in the obese AP rats. Compared with the OG, serum high-density lipoprotein cholesterol, interleukin-10, and superoxide dismutase expression levels in the pancreas, spleen, and intestine were increased in the SG. Additionally, SJP intervention led to a decrease in the following parameters: body weight; Lee's index; serum triglyceride levels; serum total cholesterol levels; malondialdehyde expression levels in the pancreas, heart, spleen, lung, and liver; myeloperoxidase expression levels in the lung; and pathological scores in the liver.CONCLUSION Obesity may aggravate the inflammatory reaction and pathological multipleorgan injury in AP rats, and SJP may alleviate multiple-organ inflammatory injury in AP in rats fed a high-fat diet.

Sheng-jiang powder ameliorates obesity-induced pancreatic inflammatory injury via stimulating activation of the AMPK signalling pathway in rats

AIM To investigate the mechanisms by which Sheng-jiang powder(SJP) ameliorates obesity-induced pancreatic inflammatory injury.METHODS Sprague-Dawley rats were randomized into three groups: normal group(NG), obese group(HLG), or SJP treatment group(HSG). Obesity was induced by feeding a high-fat diet in the HLG and HSG, while the NG received standard chow. Rats were euthanized after 12 wk, and blood and pancreatic tissues were collected for histopathological analyses. Nuclear factor kappa-light-chain-enhancer of activated B cells(NF-κB) and transforming growth factor beta(TGF-β) expression, serum triglyceride and adiponectin levels, and apoptosis in pancreatic acinar cells were assessed. A high-fat AR42 J acinar cell injury model was established using very low-density lipoprotein(VLDL). AR42 J acinar cell culture supernatant, treated with different interventions, was applied to seven groups of pancreatic stellate cells(PSCs). The proliferation of PSCs and the expression of fibronectin and type I collagenase were assessed.RESULTS Compared with the NG, we found higher pathological scores for pancreatic tissues, lower serum adiponectin levels, higher expression levels of NF-κB in pancreatic tissues and TGF-β in pancreatic inflammatory cells, and increased apoptosis among pancreatic acinar cells for the HLG(P < 0.05). Compared with the HLG, we found reduced body weight, Lee's index scores, serum triglyceride levels, and pathological scores for pancreatic tissues; higher serum adiponectin levels; and lower expression levels of NF-κB, in pancreatic tissue and TGF-β in pancreatic inflammatory cells for the HSG(P < 0.05). The in vitro studies showed enhanced PSC activation and increased expression levels of fibronectin and type I collagenase after SJP treatment. An adenosine 5‘-monophosphate-activated protein kinase(AMPK) inhibitor inhibited PSC activation.CONCLUSION SJP may ameliorate obesity-induced pancreatic inflammatory injury in rats by regulating key molecules of the adiponectin-AMPK signalling pathway.

Regulatory Effect of Shenge Yifei Capsule on TGF-β1/Smad Signaling Pathway in Rats with Chronic Obstructive Pulmonary Disease

[Objectives]This study aimed to study the effects of Shenge Yifei capsule on the TGF-β1/Smad signaling pathway in rats with chronic obstructive pulmonary disease(COPD).[Methods]Ten rats were randomly selected as the control group,and the other 40 rats were selected for modeling by fumigation combined with Klebsiella pneumoniae infection.A total of 38 rats were successfully modeled.They were randomly divided into model group(8 rats),low-dose Shenge Yifei capsule group(10 rats),high-dose Shenge Yifei capsule group(10 rats)and theophylline group(10 rats)in accordance with the principle of half male and half female.The rats in the model and control groups were given with distilled water by gavage,and the rats in the drug administration groups were given with corresponding drugs.The TGF-β1 level in the serum,and the expression levels of TGF-β1,Smad2,Smad3 and Smad7 and TGF-β1,Smad3 and Smad7 in airway tissues were detected.[Results]After 12 weeks,the serum TGF-β1 levels of the theophylline group and high-dose Shenge Yifei capsule group were lower than that of the low-dose Shenge Yifei capsule group(P<0.05).The expression levels of TGF-β1 and Smad3 in the theophylline group and high-dose Shenge Yifei capsule group were lower than that in the low-dose Shenge Yifei capsule group(P<0.05).The expression levels of TGF-β1 and Smad3 in the high-dose Shenge Yifei capsule group were lower than those in the low-dose Shenge Yifei capsule group and theophylline group(P<0.05).The expression levels of Smad7 and the proteins in the model group were lower than those in the other groups(P<0.05).The expression levels of Smad7 in the theophylline group and high-dose Shenge Yifei capsule group were higher than that in the low-dose Shenge Yifei capsule group(P<0.05).After 18 weeks,no significant difference was found in serum TGF-β1 level among the theophylline group and low and high-dose Shenge Yifei capsule groups(P>0.05).The expression levels of Smad7 and the proteins in the model group were lower than those in the other groups.The expression level of Smad7 in the high-dose Shenge Yifei capsule group was lower than that in the theophylline group(P<0.05).[Conclusions]Shenge Yifei capsule can regulate the TGF-β1/Smads signaling pathway.They can down-regulate the expression of TGF-β1,Smad2 and Smad3 and up-regulate the expression of Smad7,reducing the degree of airway modeling,delaying the development of COPD disease.Conventional high-dose Shenge Yifei capsule is more effective in inhibiting the expression of Smad2.

Prof.Sheng Canruo's Experience in Acupuncture Treatment of Throat Diseases with Yan Si Xue

Yan Si Xue(咽四穴)refer to four points in the throat summarized by Prof.Sheng Canruo in his long-year clinical experience based on the combination of TCM theory and the knowledge of modernmedical anatomy.By taking “Yan Si Xue” as main points,and other differential adjunct points,Prof.Sheng has obtained satisfactory therapeutic results in treating various throat diseases such ashoarseness,paralysis of vocal cord,dysphonia after radiotherapy on throat tumor,vocal nodules,disorder of the glossopharyngeal nerve,hysteric aphasia,and acute or chronic laryngopharyngitis.

A Comparative Study on the Translation of Ou Yang Xiu's Qiu Sheng Fu——in terms of communicative and semantic translation

Qiu Sheng Fu,is considered as one of the finest works in Chinese literature, famous for its daring imagery. The translation of this masterpiece exposes a most difficult task for translators. The author picks out two well-accepted translated versions:one is Ruo Jingguo's Ode To The Sound Of Autumn and L. Cranmer-Byng's Autumn, as the author sees it, they are the typical example of semantic translation and communicative translation of the source text respectively. From this perspective, the writer aims to make a comparative study and demonstrate the differences between the two.

Sheng Jiang San, traditional multi-herb formulation, exerts anti-influenza effects in vitro and in vivo via neuraminidaseinhibition and immune regulation

OBJECTIVE Sheng Jiang San(SJS),a multi-herb formulation,is used in treating high fever,thirsty and anxiety in ancient China and it is sometimes used to treat seasonal influenza in modern.However,there is no evidencebased investigation and mechanism research to support SJS′s anti-influenza efficacy.This study aims to investigate the anti-influenza effect of SJS and its possible mechanisms.METHODS In this study,we examined the inhibitory effect of SJS against different influenza viruses on Madin-Darby canine kidney cells.Influenza virus infected BALB/c mice were employed as in vivo model to evaluate the efficacy.Mice challenged with A/PR/8/34(H1N1)were orally administrated SJS 1 g·kg^-1 daily for seven days and monitored for 14 d.The survival rate,body mass changes,lung index,lung viral load,histopathologic changes and immune-regulation of the mice were measured.The underlying anti-influenza virus mechanisms were studied by a series of biological assays in vitro to determine if hemagglutinin,ribonucleoprotein complex or nerauminidase were targets of SJS.RESULTS SJS exerted a broad spectrum of inhibitory effects on multiple influenza strains in a dose-dependent manner.And IC50 of SJS against A/WSN/33(H1N1)was lower than 35 mg·L^-1.SJS also protected 50%of mice from influenza virus PR8 infection.The lung index and the lung viral load of SJS treated mice were signifi⁃cantly decrease compared with untreated mice.SJS 2 g·L^-1 inhibited 80%of neuraminidase enzymatic activity.SJS also up-regulated TNF-αand IFN-αand down-regulated IL-2 of influenza virus induced mice.CONCLUSION SJS is a useful formulation for treating influenza virus infection.

A CLINICAL OBSERVATION OF HUANG LIAN SHENG MAI YIN IN TREATMENT OF 86 PATIENTS WITH PREMATURE BEAT

Clinically,premature beat is a commonly en-countered arrhythmia.We have adopted HuangLian Sheng Mai Yin to treat 86 cases of variouspremature beat for three years.The effectivenesswas satisfactory.CLINICAL DATAOf the 86 cases,52 were male,and 34 female;

MEDICAL AND HEALTH CARE QIGONG(Qu Bing Yang Sheng Gong)(Continued)

Qigong is one of the Chinese traditionalexercises for medical and health care.Qigong exercisers achieve self-regulationand self-control through mental inductionand respiratory adjustment.Since 1958,wehave focused our study on the effect ofQigong on prevention and treatment ofcardiovascular diseases and anti-aging.Sub-stantial data suggest that Qigong can regu-late the body function in various ways,andis an effective measure for keeping a goodhealth.

The Effect of Sheng Bai Solution on Irradiated Mice Bone Marrow Cell Division Index and DNA Content

Before and after general irradiation with 60Co-γ, mice were orally given Sheng Bai Solution (SBS) for one week. SBS alleviated the irradiation-induced reduction of bone marrow cell chromosome division index. The irradiation-induced decrease of marrow DNA amount, thymic and splenic fractions, and total leukocyte number were restored to some extent. SBS also helped to ameliorate general condition of patients.

Obituary for Dang Sheng Su

We are saddened to the death of Dr.Dang Sheng Su at the age of 57 on June 22,2019.Dang Sheng was one of the world's most distinguished carbocatalysis scientists and microscopist.He made many important contributions to the field of sustainable chemistry,advanced microscopical science,and carbon materials for catalysis applications.

INVESTIGATION OF BEHAVIOR OF AMMONIUM SULFATE ON SURFACE OF IRON OXIDE Rong Sheng LI~*, Jing Feng CHEN, Hun YANG, Wu Yang ZHANG Dept. of Chemistry, Jilin University, Changchun 130023,

hhen ammonium sulfate-iron oxide is treated below 573 K, ammonium sulfate can spontaneously desperse on the surface of iron oxide. Simultaneously ammonium sulfate decomposes to some extent. During or after the dispersion, sulfate ion can interact with Fe atom on the surface of iron oxide to form a sort of surface sulfato complex of Fe and thus is transformed from the isolated into the bidentately bound form. Above 573 K the sulfato complex of Fe will gradually decompose with a further increase in temperature.

Wang Sheng duo:A Dauntless Pioneer in Study of Malthusianism

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Thirty-six Cases of Respiratory Dysfunction Treated with the Modified Sheng Xian Tang

The patients with respiratory dysfunction usually suffer from dyspnea similar toasthma with oppressed feeling in the chest, and they need a deep inspiration before expiration. The author has in recent years used the modified Sheng Xian Tang (升陷汤Decoction for Elevating the Sunken Qi) for treatment of the disorder with good therapeutic results. A report follows. ……

Guan Sheng Yuan (Group) Co. Ltd.

Guan Sheng Yuan was founded in 1918. As a famous, time-honoured brand enterprise of China’s national industry, it has a history of about 80 years. Since 1993 when it was re-estab-lished in accordance with the demand for the modern enterprise system, the Guan Sheng Yuan (Group) Co. Ltd.

CHINA'S TIME-HONORED BRAND SHENGXIFU HAT

公元1924年至1934年间,盛锡福获得国民政府各类奖状15种。一些社会名流不仅成为盛锡福的座上客,还多有题字馈赠,其中宋哲元题"名驰中外",秦得纯题"冠冕群伦",曹锟题"国货之光"。由吴佩孚手书的牌匾,一直挂到现在。From 1924 to 1934,Sheng Xifu won15 rewards of all kinds from the Kuomintang Government.Some luminaries often Sheng Xifu and left calligraphies as presents,of which included"High Reputation At Home and Abroad"by Song Zheyuan,"Worn by Talents"by Qin Dechun,"Outstanding in National Commodities"by Cao Kun.The tablet by Wu Peifu has been on till now.

Breeding of a New Fruit Radish Variety"Sheng Qing Yi Hao"

"Sheng Qing Yi Hao",a new fruit radish F1 hybrid,which was bred from HSR54 A,a self-bred sterile line,and HS1356,an excellent male parent.The flesh of the roots is emerald green,delicate,sweet and crisp.The skin of the roots is little spicy.It takes about 70 d from sowing to maturity.The fleshy roots have a length of 22-27 cm,a diameter of 6-8 cm,and a root weight of 0.8-1.1 kg.The F1 hybrid has stronger resistance to soft rot disease in the field the control group‘Chengyangqing’.It is suitable for cultivation in greenhouse in spring and open field in autumn in north China.

CHINA'S TIME-HONORED BRAND SHENGXIFU HAT

公元1924年至1934年间,盛锡福获得国民政府各类奖状15种。一些社会名流不仅成为盛锡福的座上客,还多有题字馈赠,其中宋哲元题"名驰中外",秦得纯题"冠冕群伦",曹锟题"国货之光"。由吴佩孚手书的牌匾,一直挂到现在。