In view of the pressure time of emergency rescue against the infectious diseases,a mathematical model to optimize the location of emergency rescue centers is proposed.The model takes full account of the spread functio...In view of the pressure time of emergency rescue against the infectious diseases,a mathematical model to optimize the location of emergency rescue centers is proposed.The model takes full account of the spread function of infectious diseases,the cycle of pulse vaccination,the distance between the demand area and the emergency rescue centers,as well as the building and maintenance cost for the emergency rescue center,and so on.At the same time,the model integrates the traditional location selection models which are the biggest cover model,the p-center model and the p-median model,and it embodies the principles of fairness and efficiency for the emergency center location.Finally,a computation of an example arising from practice provides satisfactory results.展开更多
The DPSIR assessment method, which implies the relationships among driving force (D), pressure (P), status (S), impact (I), and response (R), is widely applied by scholars. This paper aims to establish a com...The DPSIR assessment method, which implies the relationships among driving force (D), pressure (P), status (S), impact (I), and response (R), is widely applied by scholars. This paper aims to establish a comprehensive assessment system for regional energy security in eastern coastal China based on the above model using different indicators. Factor analysis and the SPSS statistical analysis software were used to carry out scientific and quantitative assessments. The results indicated that con- tradictions of energy supply and demand as well as environmental pollution are the critical factors that present great challenges to regional energy security in this area. The authors argued that a sustainable, stable, and safe supply energy supply is crucial in solving the aforesaid dilemma, and improving the energy use efficiency is one of the best choices. Some countermeasures and suggestions regarding regional energy supply stability and utilization security were pointed out.展开更多
At the time of writing,coronavirus disease 2019(COVID-19)is seriously threatening human lives and health throughout the world.Many epidemic models have been developed to provide references for decision-making by gover...At the time of writing,coronavirus disease 2019(COVID-19)is seriously threatening human lives and health throughout the world.Many epidemic models have been developed to provide references for decision-making by governments and the World Health Organization.To capture and understand the characteristics of the epidemic trend,parameter optimization algorithms are needed to obtain model parameters.In this study,the authors propose using the Levenberg–Marquardt algorithm(LMA)to identify epidemic models.This algorithm combines the advantage of the Gauss–Newton method and gradient descent method and has improved the stability of parameters.The authors selected four countries with relatively high numbers of confirmed cases to verify the advantages of the Levenberg–Marquardt algorithm over the traditional epidemiological model method.The results show that the Statistical-SIR(Statistical-Susceptible–Infected–Recovered)model using LMA can fit the actual curve of the epidemic well,while the epidemic simulation of the traditional model evolves too fast and the peak value is too high to reflect the real situation.展开更多
The classical Kermack-McKendrick homogeneous SIR (susceptible, infected and removed) model is well known, Its general solution is a function of the unique parameter (the reproduction number) that is equal to a mea...The classical Kermack-McKendrick homogeneous SIR (susceptible, infected and removed) model is well known, Its general solution is a function of the unique parameter (the reproduction number) that is equal to a mean number of secondary cases produced by a typical infected individual in a completely susceptible population. If the reproduction number is more than one (the threshold value) its value describes an epidemic scope: larger values correspond to more severe epidemics. In the more complex compartment SIR models the population is divided into several non-overlapping groups. It allows us to partly remove assumptions of the classical model. It is well known that for this kind of models, just as for the classical model there is the threshold parameter R0. Usually it is called by the same name--the reproduction number--though the physical meaning of this parameter has changed. The main purpose of the paper is to show that this new parameter is a not unique measure of an epidemic severity for any compartment SIR model. In particular it means that for such models comparison of the severity of two epidemics by simple comparing values of their reproduction numbers is incorrect. For compartment models these statements were proved with the help of the corresponding ODEs analysis. Very popular now individual-based models (IBMs) are more complex in comparison with the compartment ones since they use overlapping groups (school children are members of families also, for example). In such a case Diekmann's calculation method for the reproduction number used in many papers is inapplicable as well as a presentation the simulation results obtained as functions of this parameter.展开更多
This paper discusses the application of a pulse vaccination strategy to prevent and control some infectious diseases, which is described by age-structured SIR model in which susceptible and recovered individuals are s...This paper discusses the application of a pulse vaccination strategy to prevent and control some infectious diseases, which is described by age-structured SIR model in which susceptible and recovered individuals are structured by chronological age, while infected individuals are structured by infection age (duration since infection). The time dependent disease-free equilibrium is determined, for which an explicit expression exists. The analytical results show that there exists a globally stable infectiomfree situation if the impulsive period T and proportion p satisfy Ro(p,T) 〈 1. Optimal problem is discussed: Pulse vaccination strategy with minimal costs at given R0(p, T) 〈 1.展开更多
This paper is mainly concerned with the existence and nonexistence of traveling wave solutions of a nonlocal dispersal SIRS model with nonlocal delayed transmissions. We find that the existence and nonexistence of tra...This paper is mainly concerned with the existence and nonexistence of traveling wave solutions of a nonlocal dispersal SIRS model with nonlocal delayed transmissions. We find that the existence and nonexistence of traveling wave solutions are determined by the critical wave speed c^*. More specifically, we establish the existence of traveling wave solutions for every wave speed c〉c^* and R0 〉 1 by means of upper-lower solutions and Schauder's fixed point theorem. Nonexistence of traveling wave solutions is obtained by Laplace transform for any wave speed c ∈ (0, c^*) and R0 〉 1.展开更多
In this paper, we study a delayed SIRS model with nonlocal diffusion. The well posedness of the model is investigated. Furthermore, we concern with the problem of traveling wave solutions. By using the partial quasi-m...In this paper, we study a delayed SIRS model with nonlocal diffusion. The well posedness of the model is investigated. Furthermore, we concern with the problem of traveling wave solutions. By using the partial quasi-monotone condition, cross-iteration scheme and fixed-point theorem, sufficient conditions are derived for the existence of traveling waves connecting the two equilibria which depends on the existence of a pair of upper solution and lower solution. We in fact construct a pair of upper solution and lower solution concretely to guarantee the existence of traveling waves.展开更多
In this paper, we present a differential infectivity SIR epidemic model with modified saturation incidences and stochastic perturbations. We show that the stochastic epidemic model has a unique global positive solutio...In this paper, we present a differential infectivity SIR epidemic model with modified saturation incidences and stochastic perturbations. We show that the stochastic epidemic model has a unique global positive solution, and we utilize stochastic Lyapunov functions to show the asymptotic behavior of the solution.展开更多
In this paper, we consider the backward Euler discretization derived from a continuous SIRS epidemic model, which contains a remaining problem that our discrete model has two solutions for infected population; one is ...In this paper, we consider the backward Euler discretization derived from a continuous SIRS epidemic model, which contains a remaining problem that our discrete model has two solutions for infected population; one is positive and the other is negative. Under an additional positiveness condition on infected population, we show that the backward Euler discretization is one of simple discrete-time analogue which preserves the global asymptotic stability of equilibria of the corresponding continuous model.展开更多
In this paper, to study rumor spreading, we propose a novel susceptible-infected-removed (SIR) model by introducing the trust mechanism. We derive mean-field equations that describe the dynamics of the SIR model on ...In this paper, to study rumor spreading, we propose a novel susceptible-infected-removed (SIR) model by introducing the trust mechanism. We derive mean-field equations that describe the dynamics of the SIR model on homogeneous networks and inhomogeneous networks. Then a steady-state analysis is conducted to investigate the critical threshold and the finaJ size of the rumor spreading. We show that the introduction of trust mechanism reduces the final rumor size and the velocity of rumor spreading, but increases the critical thresholds on both networks. Moreover, the trust mechanism not only greatly reduces the maximum rumor influence, but also postpones the rumor terminal time, which provides us with more time to take measures to control the rumor spreading. The theoretical results are confirmed by sufficient numerical simulations.展开更多
Since the spreading of harmful rumors can deeply endanger a society, it is valuable to investigate strategies that can efficiently prevent hazardous rumor propagation. To conduct this investigation, the authors modify...Since the spreading of harmful rumors can deeply endanger a society, it is valuable to investigate strategies that can efficiently prevent hazardous rumor propagation. To conduct this investigation, the authors modify the SIR model to describe rumor propagation on networks, and apply two major immunization strategies, namely, the random immunization and the targeted immunization to the rumor model on a small-world network. The authors find that when the average degree of the network is small, both two strategies are effective and when the average degree is large, neither strategy is efficient in preventing rumor propagation. In the latter case, the authors propose a new strategy by decreasing the credibility of the rumor and applying either the random or the targeted immunization at the same time. Numerical simulations indicate that this strategy is effective in preventing rumor spreading on the small-world network with large average degree.展开更多
Studying different theoretical properties of epidemiological models has been widely addressed, while numerical studies and especially the calibration of models, which are often complicated and loaded with a high numbe...Studying different theoretical properties of epidemiological models has been widely addressed, while numerical studies and especially the calibration of models, which are often complicated and loaded with a high number of unknown parameters, against mea- sured data have received less attention. In this paper, we describe how a combination of simulated data and Markov Chain Monte Carlo (MCMC) methods can be used to study the identifiability of model parameters with different type of measurements. Three known models are used as case studies to illustrate the importance of parameter identi- fiability: a basic SIR model, an influenza model with vaccination and treatment and a HIV-Malaria co-infection model. The analysis reveals that calibration of complex models commonly studied in mathematical epidemiology, such as the HIV Malaria co-dynamics model, can be difficult or impossible, even if the system would be fully observed. The pre- sented approach provides a tool for design and optimization of real-life field campaigns of collecting data, as well as for model selection.展开更多
基金The National Natural Science Foundation of China(No.70671021)the National Key Technology R&D Program of China during the 11th Five-Year Plan Period(No.2006BAH02A06)
文摘In view of the pressure time of emergency rescue against the infectious diseases,a mathematical model to optimize the location of emergency rescue centers is proposed.The model takes full account of the spread function of infectious diseases,the cycle of pulse vaccination,the distance between the demand area and the emergency rescue centers,as well as the building and maintenance cost for the emergency rescue center,and so on.At the same time,the model integrates the traditional location selection models which are the biggest cover model,the p-center model and the p-median model,and it embodies the principles of fairness and efficiency for the emergency center location.Finally,a computation of an example arising from practice provides satisfactory results.
基金Supported by the State Nature Science Foundation (40771085) the National Science & Technology Support Program (2006BZC 18B01-05)
文摘The DPSIR assessment method, which implies the relationships among driving force (D), pressure (P), status (S), impact (I), and response (R), is widely applied by scholars. This paper aims to establish a comprehensive assessment system for regional energy security in eastern coastal China based on the above model using different indicators. Factor analysis and the SPSS statistical analysis software were used to carry out scientific and quantitative assessments. The results indicated that con- tradictions of energy supply and demand as well as environmental pollution are the critical factors that present great challenges to regional energy security in this area. The authors argued that a sustainable, stable, and safe supply energy supply is crucial in solving the aforesaid dilemma, and improving the energy use efficiency is one of the best choices. Some countermeasures and suggestions regarding regional energy supply stability and utilization security were pointed out.
基金This work was jointly supported by the National Natural Science Foundation of China[grant number 41521004]the Gansu Provincial Special Fund Project for Guiding Scientific and Technological Innovation and Development[grant number 2019ZX-06].
文摘At the time of writing,coronavirus disease 2019(COVID-19)is seriously threatening human lives and health throughout the world.Many epidemic models have been developed to provide references for decision-making by governments and the World Health Organization.To capture and understand the characteristics of the epidemic trend,parameter optimization algorithms are needed to obtain model parameters.In this study,the authors propose using the Levenberg–Marquardt algorithm(LMA)to identify epidemic models.This algorithm combines the advantage of the Gauss–Newton method and gradient descent method and has improved the stability of parameters.The authors selected four countries with relatively high numbers of confirmed cases to verify the advantages of the Levenberg–Marquardt algorithm over the traditional epidemiological model method.The results show that the Statistical-SIR(Statistical-Susceptible–Infected–Recovered)model using LMA can fit the actual curve of the epidemic well,while the epidemic simulation of the traditional model evolves too fast and the peak value is too high to reflect the real situation.
基金Acknowledgements This work was assisted through participation in "Optimal Control and Optimization for Individual- based and Agent-based Models" Investigative Workshop at the National Institute for Mathematical and Biological Synthesis, sponsored by the National Science Foundation, the U.S. Department of Homeland Security, and the U.S. Department of Agriculture through NSF Award #EF-0832858, with additional support from The University of Tennessee, Knoxville.
文摘The classical Kermack-McKendrick homogeneous SIR (susceptible, infected and removed) model is well known, Its general solution is a function of the unique parameter (the reproduction number) that is equal to a mean number of secondary cases produced by a typical infected individual in a completely susceptible population. If the reproduction number is more than one (the threshold value) its value describes an epidemic scope: larger values correspond to more severe epidemics. In the more complex compartment SIR models the population is divided into several non-overlapping groups. It allows us to partly remove assumptions of the classical model. It is well known that for this kind of models, just as for the classical model there is the threshold parameter R0. Usually it is called by the same name--the reproduction number--though the physical meaning of this parameter has changed. The main purpose of the paper is to show that this new parameter is a not unique measure of an epidemic severity for any compartment SIR model. In particular it means that for such models comparison of the severity of two epidemics by simple comparing values of their reproduction numbers is incorrect. For compartment models these statements were proved with the help of the corresponding ODEs analysis. Very popular now individual-based models (IBMs) are more complex in comparison with the compartment ones since they use overlapping groups (school children are members of families also, for example). In such a case Diekmann's calculation method for the reproduction number used in many papers is inapplicable as well as a presentation the simulation results obtained as functions of this parameter.
基金supported by Natural Science Foundation of Henan Province under Grant No.092300410206Science and Technology Program of Educational Department of Henan Province under Grant No. 2009A110015
文摘This paper discusses the application of a pulse vaccination strategy to prevent and control some infectious diseases, which is described by age-structured SIR model in which susceptible and recovered individuals are structured by chronological age, while infected individuals are structured by infection age (duration since infection). The time dependent disease-free equilibrium is determined, for which an explicit expression exists. The analytical results show that there exists a globally stable infectiomfree situation if the impulsive period T and proportion p satisfy Ro(p,T) 〈 1. Optimal problem is discussed: Pulse vaccination strategy with minimal costs at given R0(p, T) 〈 1.
基金AcknowledgmentsWe are very grateful to the invaluable suggestions made by anonymous referees. This work is supported by the National Natural Science Foundation of China, RFDP and the Fundamental Research Funds for the Central University.
文摘This paper is mainly concerned with the existence and nonexistence of traveling wave solutions of a nonlocal dispersal SIRS model with nonlocal delayed transmissions. We find that the existence and nonexistence of traveling wave solutions are determined by the critical wave speed c^*. More specifically, we establish the existence of traveling wave solutions for every wave speed c〉c^* and R0 〉 1 by means of upper-lower solutions and Schauder's fixed point theorem. Nonexistence of traveling wave solutions is obtained by Laplace transform for any wave speed c ∈ (0, c^*) and R0 〉 1.
文摘In this paper, we study a delayed SIRS model with nonlocal diffusion. The well posedness of the model is investigated. Furthermore, we concern with the problem of traveling wave solutions. By using the partial quasi-monotone condition, cross-iteration scheme and fixed-point theorem, sufficient conditions are derived for the existence of traveling waves connecting the two equilibria which depends on the existence of a pair of upper solution and lower solution. We in fact construct a pair of upper solution and lower solution concretely to guarantee the existence of traveling waves.
基金Acknowledgments The authors would like to thank the anonymous referees and the editor for their very helpful comments and suggestions. J. Wang and G. Li are supported by the Science and Technology Research Project of Department of Education of Heilongjiang Province (No. 12531495). J. Wang is supported by Natural Science Foundation of China (TianYuan, No. 11226255).
文摘In this paper, we present a differential infectivity SIR epidemic model with modified saturation incidences and stochastic perturbations. We show that the stochastic epidemic model has a unique global positive solution, and we utilize stochastic Lyapunov functions to show the asymptotic behavior of the solution.
文摘In this paper, we consider the backward Euler discretization derived from a continuous SIRS epidemic model, which contains a remaining problem that our discrete model has two solutions for infected population; one is positive and the other is negative. Under an additional positiveness condition on infected population, we show that the backward Euler discretization is one of simple discrete-time analogue which preserves the global asymptotic stability of equilibria of the corresponding continuous model.
基金Supported by the National Natural Science Foundation of China under Grant Nos.61103231,61103230the Innovation Program of Graduate Scientific Research in Institution of Higher Education of Jiangsu Province of China under Grant No.CXZZ110401+1 种基金the Basic Research Foundation of Engineering University of the Chinese People's Armed Police Force under Grant No.WJY201218 the Natural Science Basic Research Plan in Shaanxi Province of China under Grant No.2011JM8012
文摘In this paper, to study rumor spreading, we propose a novel susceptible-infected-removed (SIR) model by introducing the trust mechanism. We derive mean-field equations that describe the dynamics of the SIR model on homogeneous networks and inhomogeneous networks. Then a steady-state analysis is conducted to investigate the critical threshold and the finaJ size of the rumor spreading. We show that the introduction of trust mechanism reduces the final rumor size and the velocity of rumor spreading, but increases the critical thresholds on both networks. Moreover, the trust mechanism not only greatly reduces the maximum rumor influence, but also postpones the rumor terminal time, which provides us with more time to take measures to control the rumor spreading. The theoretical results are confirmed by sufficient numerical simulations.
基金supported by the Natural Science Foundation of China under Grant No.61070069Zhejiang Provincial Natural Science Foundation of China under Grant No.Y1100290
文摘Since the spreading of harmful rumors can deeply endanger a society, it is valuable to investigate strategies that can efficiently prevent hazardous rumor propagation. To conduct this investigation, the authors modify the SIR model to describe rumor propagation on networks, and apply two major immunization strategies, namely, the random immunization and the targeted immunization to the rumor model on a small-world network. The authors find that when the average degree of the network is small, both two strategies are effective and when the average degree is large, neither strategy is efficient in preventing rumor propagation. In the latter case, the authors propose a new strategy by decreasing the credibility of the rumor and applying either the random or the targeted immunization at the same time. Numerical simulations indicate that this strategy is effective in preventing rumor spreading on the small-world network with large average degree.
文摘Studying different theoretical properties of epidemiological models has been widely addressed, while numerical studies and especially the calibration of models, which are often complicated and loaded with a high number of unknown parameters, against mea- sured data have received less attention. In this paper, we describe how a combination of simulated data and Markov Chain Monte Carlo (MCMC) methods can be used to study the identifiability of model parameters with different type of measurements. Three known models are used as case studies to illustrate the importance of parameter identi- fiability: a basic SIR model, an influenza model with vaccination and treatment and a HIV-Malaria co-infection model. The analysis reveals that calibration of complex models commonly studied in mathematical epidemiology, such as the HIV Malaria co-dynamics model, can be difficult or impossible, even if the system would be fully observed. The pre- sented approach provides a tool for design and optimization of real-life field campaigns of collecting data, as well as for model selection.