Alzheimer’s disease(AD)is the most common form of agerelated neurodegenerative disease.Importantly,the prevalence of AD is expected to increase as the population ages,and it will place a huge burden on health care in...Alzheimer’s disease(AD)is the most common form of agerelated neurodegenerative disease.Importantly,the prevalence of AD is expected to increase as the population ages,and it will place a huge burden on health care in the future.AD is clinically characterized by confusion,disorientation,and progressive memory and language decline.Diagnosis is confirmed histologically by the accumulation of extracellular b-amyloid(Ab)plaques,intracellular tangles of abnormally phosphorylated tau protein,and progressive neuronal loss in the brain.1 Current treatment focuses on symptom alleviation since there is not yet a cure for AD,despite the wealth of research on the mechanisms underlying the disease and its pathophysiology.展开更多
基金supported by the Fundamental Research Funds for the Central Universities(40500-20104-222290).
文摘Alzheimer’s disease(AD)is the most common form of agerelated neurodegenerative disease.Importantly,the prevalence of AD is expected to increase as the population ages,and it will place a huge burden on health care in the future.AD is clinically characterized by confusion,disorientation,and progressive memory and language decline.Diagnosis is confirmed histologically by the accumulation of extracellular b-amyloid(Ab)plaques,intracellular tangles of abnormally phosphorylated tau protein,and progressive neuronal loss in the brain.1 Current treatment focuses on symptom alleviation since there is not yet a cure for AD,despite the wealth of research on the mechanisms underlying the disease and its pathophysiology.
