As an internationally peer-reviewed academic periodical,Shanghai Journal of Stomatology is issued both at home and abroad,presenting the latest advances and new experiences in stomatology for intermediate and senior d...As an internationally peer-reviewed academic periodical,Shanghai Journal of Stomatology is issued both at home and abroad,presenting the latest advances and new experiences in stomatology for intermediate and senior doctors,teachers and scientific researchers in the field.This journal has been included in CA and MEDLINE and is published as a bimonthly periodical.展开更多
As an internationally peer-reviewed academic periodical, Shanghai Journal of Stomatology is issued both at home and abroad, presenting the latest advances and new experiences in stomatology for intermediate and senior...As an internationally peer-reviewed academic periodical, Shanghai Journal of Stomatology is issued both at home and abroad, presenting the latest advances and new experiences in stomatology for intermediate and senior doctors, teachers and scientific researchers in the field. This journal has been included in CA and MEDLINE and is published as a bimonthly periodical, 6 issues a year. To ensure the quality of articles and standardization of editing, please read these instructions carefully and abide by them strictly before writing and submitting manuscripts. All manuscripts that do not adhere to the requirements detailed in these instructions will be returned to the corresponding author(s) for revision. The instructions can be downloaded from : http://www.omschina.org.cn/sjs/baseinfo.asp?ClassID=newsroomcontribute2.展开更多
<span style="font-family:Verdana;">Enzalutamide is a hormonal therapy that blocks the action of androgens, such as testosterone in the treatment of metastatic castration-resistant prostate cancer. <...<span style="font-family:Verdana;">Enzalutamide is a hormonal therapy that blocks the action of androgens, such as testosterone in the treatment of metastatic castration-resistant prostate cancer. </span><span style="font-family:Verdana;">Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) overlap and are part of an adverse drug reaction continuum of disease, in which there is a 10% - 30% involvement of the skin surface with mucositis, blisters, skin slough, and a macular rash. A 66-year-old male was treated with enzalutamide for metastatic prostate cancer and developed SJS/TEN overlap with 25% total body surface area skin involvement. The patient received a </span><span style="font-family:Verdana;">seven-day course of cyclosporine to which he responded by re-epithelialization </span><span style="font-family:Verdana;">but succumbed to multi-organ failure. While SJS/TEN has been reported with apalutamide, to our knowledge, this is the first case of SJS/TEN overlap with enzalutamide.</span>展开更多
文摘As an internationally peer-reviewed academic periodical,Shanghai Journal of Stomatology is issued both at home and abroad,presenting the latest advances and new experiences in stomatology for intermediate and senior doctors,teachers and scientific researchers in the field.This journal has been included in CA and MEDLINE and is published as a bimonthly periodical.
文摘As an internationally peer-reviewed academic periodical, Shanghai Journal of Stomatology is issued both at home and abroad, presenting the latest advances and new experiences in stomatology for intermediate and senior doctors, teachers and scientific researchers in the field. This journal has been included in CA and MEDLINE and is published as a bimonthly periodical, 6 issues a year. To ensure the quality of articles and standardization of editing, please read these instructions carefully and abide by them strictly before writing and submitting manuscripts. All manuscripts that do not adhere to the requirements detailed in these instructions will be returned to the corresponding author(s) for revision. The instructions can be downloaded from : http://www.omschina.org.cn/sjs/baseinfo.asp?ClassID=newsroomcontribute2.
文摘<span style="font-family:Verdana;">Enzalutamide is a hormonal therapy that blocks the action of androgens, such as testosterone in the treatment of metastatic castration-resistant prostate cancer. </span><span style="font-family:Verdana;">Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) overlap and are part of an adverse drug reaction continuum of disease, in which there is a 10% - 30% involvement of the skin surface with mucositis, blisters, skin slough, and a macular rash. A 66-year-old male was treated with enzalutamide for metastatic prostate cancer and developed SJS/TEN overlap with 25% total body surface area skin involvement. The patient received a </span><span style="font-family:Verdana;">seven-day course of cyclosporine to which he responded by re-epithelialization </span><span style="font-family:Verdana;">but succumbed to multi-organ failure. While SJS/TEN has been reported with apalutamide, to our knowledge, this is the first case of SJS/TEN overlap with enzalutamide.</span>
