The study was dedicated to explore the clinical efficacy and tolerability of photodynamic/electroion therapy of skin cancer and precancerous lesions.Firstly,a total of 60 patients with skin cancer and precancerous les...The study was dedicated to explore the clinical efficacy and tolerability of photodynamic/electroion therapy of skin cancer and precancerous lesions.Firstly,a total of 60 patients with skin cancer and precancerous lesions,who were admitted to the Dermatology Department of the Fifth Affiliated Hospital of Zhengzhou University from November 2013 to November 2016,were selected and divided into observation group and control group according to the random number table,with 30 patients in each group.Observation group adopted the photodynamic/electroion therapy,and control group adopted photodynamic therapy(PDT).Two groups of patients were last follow-up to December 2018,and loss of follow-up and death were taken as the end point events of follow-up.The frequency of treatment,clinical efficacy and severity of adverse reactions of the two groups were calculated,and Kaplan-Meier curves were plotted to compare the progression free survival(PFS)of the two groups.The results showed that the number of treatment times per capita in the observation group was 3.6±1.1 times,which was lower than that of in the control group(4.1±1.1 times),but the difference was not statistically significant(t=1.760,P=0.083).The total effective rate in the observation group(100.00%)was higher than that of in the control group(80.00%),and the difference was significant(P<0.05).In addition,during the treatment,both groups had adverse reactions such as burning,pain,redness,swelling and exudation of different degrees,but there was no significant difference in the severity score of adverse reactions(P>0.05).There was no statistically significant difference in the follow-up time and PFS between the two groups(P>0.05),but the recurrence rate of the observation group was significantly lower than that of the control group(P<0.05).Therefore,the clinical efficacy of photodynamic/electroion treatment in patients with skin cancer and precancerous lesions was superior to that of PDT alone,which increased the risk of tolerance.So,it is worthy of clinical promotion.展开更多
目的观察梅花针联合凉血消疕汤加减治疗银屑病的临床疗效及对患者血清Th1/Th2细胞因子水平和皮肤屏障功能的影响。方法选取银屑病患者72例,根据治疗方法分为联合组(36例)和对照组(36例)。对照组采用常规西药治疗,联合组予梅花针联合凉...目的观察梅花针联合凉血消疕汤加减治疗银屑病的临床疗效及对患者血清Th1/Th2细胞因子水平和皮肤屏障功能的影响。方法选取银屑病患者72例,根据治疗方法分为联合组(36例)和对照组(36例)。对照组采用常规西药治疗,联合组予梅花针联合凉血消疕汤加减治疗。比较两组治疗前后的银屑病面积与严重程度指数(psoriasis area and severity index,PASI)评分、血清Th1/Th2细胞因子[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、干扰素-γ(interferon-γ,IFN-γ)、白介素-10(interleukin-10,IL-10)和白介素-4(interleukin-4,IL-4)]水平以及皮肤屏障功能指标(角质层水含量、皮脂含量和经表皮水分丢失),比较两组临床疗效和不良反应发生情况。结果治疗后,两组PASI评分均降低(P<0.05),且联合组低于对照组(P<0.05);两组血清TNF-α和IFN-γ水平均降低(P<0.05),且联合组低于对照组(P<0.05);两组血清IL-10和IL-4水平均升高(P<0.05),且联合组高于对照组(P<0.05);两组角质层水含量和皮脂含量均升高(P<0.05),且联合组均高于对照组(P<0.05);经表皮水分丢失量均降低(P<0.05),且联合组低于对照组(P<0.05)。联合组总有效率高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论梅花针联合凉血消疕汤加减治疗银屑病能改善患者的临床症状,调节血清Th1/Th2细胞因子水平,修复皮肤屏障功能,提高临床疗效。展开更多
目的在肛周封闭治疗基础上,观察耳穴贴压联合穴位埋线治疗慢性肛周湿疹的临床疗效和安全性。方法将80例慢性肛周湿疹患者按随机数字表法分为观察组(40例,脱落1例)和对照组(40例,脱落2例)。两组患者均采用亚甲蓝混合液肛周封闭治疗,观察...目的在肛周封闭治疗基础上,观察耳穴贴压联合穴位埋线治疗慢性肛周湿疹的临床疗效和安全性。方法将80例慢性肛周湿疹患者按随机数字表法分为观察组(40例,脱落1例)和对照组(40例,脱落2例)。两组患者均采用亚甲蓝混合液肛周封闭治疗,观察组另予耳穴贴压联合穴位埋线治疗,对照组另予单纯耳穴贴压治疗。观察两组治疗前后肛周瘙痒程度评分、肛周潮湿程度评分、肛周皮损面积评分、肛周皮损形态评分、皮肤病生活质量指数(dermatology life quality index,DLQI)评分的变化,比较两组临床疗效、不良反应发生情况及复发情况。结果治疗后,两组肛周瘙痒程度评分、肛周潮湿程度评分、肛周皮损面积评分、肛周皮损形态评分、DLQI评分均较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。观察组总有效率高于对照组(P<0.05)。观察组复发率低于对照组(P<0.05)。治疗过程中两组均未发生严重不良反应。结论在肛周封闭治疗基础上,耳穴贴压联合穴位埋线治疗慢性肛周湿疹可有效缓解肛周瘙痒和潮湿的症状,改善肛周局部皮损形态,提高患者生活质量,临床疗效优于单一耳穴贴压,且复发率较低。展开更多
目的探索中医药（traditional Chinese medicine，TCM）对艾滋病（AIDS）抗病毒治疗（cART）患者皮肤损害发生率的影响因素。方法以“艾滋病综合防治数据信息系统”和“中医药治疗艾滋病数据库”为信息来源，采用回顾性队列研究，以中...目的探索中医药（traditional Chinese medicine，TCM）对艾滋病（AIDS）抗病毒治疗（cART）患者皮肤损害发生率的影响因素。方法以“艾滋病综合防治数据信息系统”和“中医药治疗艾滋病数据库”为信息来源，采用回顾性队列研究，以中医项目地区服用抗病毒治疗的AIDS患者为研究对象，收集2009和2012年皮肤损害发生情况，以是否参与中医项目为分组，采用Logistic回归分析中医药对AIDS患者皮肤损害发生的影响。结果共有1081例AIDS患者纳入分析，TCM＋cART组252例，cART组829例。Logistic回归分析结果显示，cART组在2012年发生皮肤损害的风险是TCM＋cART组的1．74倍（OR=1．74，95％CI 1．26～2．41）；2009年发生皮肤损害的患者更客易在2012年发生皮肤损害，风险是2009年未发生者的4．44倍（OR=4．44，95％CI 3．37～5．85）。结论中医药治疗可降低皮肤损害的发生率。展开更多
文摘The study was dedicated to explore the clinical efficacy and tolerability of photodynamic/electroion therapy of skin cancer and precancerous lesions.Firstly,a total of 60 patients with skin cancer and precancerous lesions,who were admitted to the Dermatology Department of the Fifth Affiliated Hospital of Zhengzhou University from November 2013 to November 2016,were selected and divided into observation group and control group according to the random number table,with 30 patients in each group.Observation group adopted the photodynamic/electroion therapy,and control group adopted photodynamic therapy(PDT).Two groups of patients were last follow-up to December 2018,and loss of follow-up and death were taken as the end point events of follow-up.The frequency of treatment,clinical efficacy and severity of adverse reactions of the two groups were calculated,and Kaplan-Meier curves were plotted to compare the progression free survival(PFS)of the two groups.The results showed that the number of treatment times per capita in the observation group was 3.6±1.1 times,which was lower than that of in the control group(4.1±1.1 times),but the difference was not statistically significant(t=1.760,P=0.083).The total effective rate in the observation group(100.00%)was higher than that of in the control group(80.00%),and the difference was significant(P<0.05).In addition,during the treatment,both groups had adverse reactions such as burning,pain,redness,swelling and exudation of different degrees,but there was no significant difference in the severity score of adverse reactions(P>0.05).There was no statistically significant difference in the follow-up time and PFS between the two groups(P>0.05),but the recurrence rate of the observation group was significantly lower than that of the control group(P<0.05).Therefore,the clinical efficacy of photodynamic/electroion treatment in patients with skin cancer and precancerous lesions was superior to that of PDT alone,which increased the risk of tolerance.So,it is worthy of clinical promotion.
文摘目的观察梅花针联合凉血消疕汤加减治疗银屑病的临床疗效及对患者血清Th1/Th2细胞因子水平和皮肤屏障功能的影响。方法选取银屑病患者72例,根据治疗方法分为联合组(36例)和对照组(36例)。对照组采用常规西药治疗,联合组予梅花针联合凉血消疕汤加减治疗。比较两组治疗前后的银屑病面积与严重程度指数(psoriasis area and severity index,PASI)评分、血清Th1/Th2细胞因子[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、干扰素-γ(interferon-γ,IFN-γ)、白介素-10(interleukin-10,IL-10)和白介素-4(interleukin-4,IL-4)]水平以及皮肤屏障功能指标(角质层水含量、皮脂含量和经表皮水分丢失),比较两组临床疗效和不良反应发生情况。结果治疗后,两组PASI评分均降低(P<0.05),且联合组低于对照组(P<0.05);两组血清TNF-α和IFN-γ水平均降低(P<0.05),且联合组低于对照组(P<0.05);两组血清IL-10和IL-4水平均升高(P<0.05),且联合组高于对照组(P<0.05);两组角质层水含量和皮脂含量均升高(P<0.05),且联合组均高于对照组(P<0.05);经表皮水分丢失量均降低(P<0.05),且联合组低于对照组(P<0.05)。联合组总有效率高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论梅花针联合凉血消疕汤加减治疗银屑病能改善患者的临床症状,调节血清Th1/Th2细胞因子水平,修复皮肤屏障功能,提高临床疗效。
文摘目的在肛周封闭治疗基础上,观察耳穴贴压联合穴位埋线治疗慢性肛周湿疹的临床疗效和安全性。方法将80例慢性肛周湿疹患者按随机数字表法分为观察组(40例,脱落1例)和对照组(40例,脱落2例)。两组患者均采用亚甲蓝混合液肛周封闭治疗,观察组另予耳穴贴压联合穴位埋线治疗,对照组另予单纯耳穴贴压治疗。观察两组治疗前后肛周瘙痒程度评分、肛周潮湿程度评分、肛周皮损面积评分、肛周皮损形态评分、皮肤病生活质量指数(dermatology life quality index,DLQI)评分的变化,比较两组临床疗效、不良反应发生情况及复发情况。结果治疗后,两组肛周瘙痒程度评分、肛周潮湿程度评分、肛周皮损面积评分、肛周皮损形态评分、DLQI评分均较治疗前降低(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。观察组总有效率高于对照组(P<0.05)。观察组复发率低于对照组(P<0.05)。治疗过程中两组均未发生严重不良反应。结论在肛周封闭治疗基础上,耳穴贴压联合穴位埋线治疗慢性肛周湿疹可有效缓解肛周瘙痒和潮湿的症状,改善肛周局部皮损形态,提高患者生活质量,临床疗效优于单一耳穴贴压,且复发率较低。
文摘目的探索中医药（traditional Chinese medicine，TCM）对艾滋病（AIDS）抗病毒治疗（cART）患者皮肤损害发生率的影响因素。方法以“艾滋病综合防治数据信息系统”和“中医药治疗艾滋病数据库”为信息来源，采用回顾性队列研究，以中医项目地区服用抗病毒治疗的AIDS患者为研究对象，收集2009和2012年皮肤损害发生情况，以是否参与中医项目为分组，采用Logistic回归分析中医药对AIDS患者皮肤损害发生的影响。结果共有1081例AIDS患者纳入分析，TCM＋cART组252例，cART组829例。Logistic回归分析结果显示，cART组在2012年发生皮肤损害的风险是TCM＋cART组的1．74倍（OR=1．74，95％CI 1．26～2．41）；2009年发生皮肤损害的患者更客易在2012年发生皮肤损害，风险是2009年未发生者的4．44倍（OR=4．44，95％CI 3．37～5．85）。结论中医药治疗可降低皮肤损害的发生率。
