Objective: To investigate the clinical performance of implants with chemically modified surfaces in irradiated bone in a period of five-years. Patients & Methods: 15 (6 females, 9 males, 50.2 years with a range of...Objective: To investigate the clinical performance of implants with chemically modified surfaces in irradiated bone in a period of five-years. Patients & Methods: 15 (6 females, 9 males, 50.2 years with a range of 38 - 60 years) patients who had been operated for oral tumors and had undergone radiotherapy were enrolled and 40 SLActive surface implants were placed (24 in the maxilla, 16 in the mandible). Implants were allowed to integrate for a period of 90 days and the stability of the implants was measured with Resonance Frequency Analyzer/Osstell? Mentor (Integration Diagnostics, Savedalen, Sweden) at implant placement, 30 days later and at the end of the 90th day. Patients follow up periods after the implant placement varied from 20 months to 60 months (mean: 45 months). Results: Two implants were lost in maxilla in healing period as a result of osseointegration failure. The survival rate was 95%. During the observation period, totally 4 implants were lost. The overall success rate was 90%. 3 of the lost implants were in maxilla and one was in mandible. The initial ISQ values of the implants differed from 20 - 71;the second values were between 24 - 71 and the last values were between 30 - 89. The implants which were lost could not show a value greater than 35. Conclusion: There was no any complication on the SLActive surface implant placed bones due to irradiation. Within the limitations of this study, it may be concluded that osseointegrated implants can be placed in irradiated bones, unless a careful patient selection and treatment planning is performed.展开更多
Regardless of the substantial progress in designing titanium-based dental implants and aseptic techniques,infection remains as the most common complication after implantation surgeries.Although,having a weakened immun...Regardless of the substantial progress in designing titanium-based dental implants and aseptic techniques,infection remains as the most common complication after implantation surgeries.Although,having a weakened immune system or systematic diseases is not seen as contraindicated for dental implants anymore,controlling the immune system is required to avoid surgical site infections after implantation.These patients have to control the surgical site infections by taking a high daily dose of oral antibiotics after dental implantation.The antibiotics oral administration has many side effects such as gastrointestinal symptoms,skin rashes and thrush.Coating antibiotics on the biomaterials surface could be a promising solution to reduce these disadvantages through locally releasing antibiotics in a controlled manner.The aim of this study was to investigate the effects of doxycycline coating layer on titanium-zirconium alloy surfaces in vitro and in vivo.In our previous studies,we demonstrated the chemical presence of doxycycline layer in vitro.In this study,we examined its physical presence using field emission scanning electron microscope and confocal microscope.We also analyzed its controlled released manner using Nano-Drop UV Vis spectrometer.After in vitro characterization of the coating layer,we evaluated its effects on the implant osseointegration in dogs and rabbits.The histological and histomorphometrical results exhibited no significant difference between doxycycline coated and uncoated groups regarding the implants osseointegration and biocompatibility for dental applications.Therefore,coating a doxycycline layer on TiZr implants could be favorable for reducing or removing the antibiotics oral administration after the implantation surgery.展开更多
文摘Objective: To investigate the clinical performance of implants with chemically modified surfaces in irradiated bone in a period of five-years. Patients & Methods: 15 (6 females, 9 males, 50.2 years with a range of 38 - 60 years) patients who had been operated for oral tumors and had undergone radiotherapy were enrolled and 40 SLActive surface implants were placed (24 in the maxilla, 16 in the mandible). Implants were allowed to integrate for a period of 90 days and the stability of the implants was measured with Resonance Frequency Analyzer/Osstell? Mentor (Integration Diagnostics, Savedalen, Sweden) at implant placement, 30 days later and at the end of the 90th day. Patients follow up periods after the implant placement varied from 20 months to 60 months (mean: 45 months). Results: Two implants were lost in maxilla in healing period as a result of osseointegration failure. The survival rate was 95%. During the observation period, totally 4 implants were lost. The overall success rate was 90%. 3 of the lost implants were in maxilla and one was in mandible. The initial ISQ values of the implants differed from 20 - 71;the second values were between 24 - 71 and the last values were between 30 - 89. The implants which were lost could not show a value greater than 35. Conclusion: There was no any complication on the SLActive surface implant placed bones due to irradiation. Within the limitations of this study, it may be concluded that osseointegrated implants can be placed in irradiated bones, unless a careful patient selection and treatment planning is performed.
基金supported by a project“Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants,MgSafe”funded by European Training Network within the framework of Horizon 2020 Marie Skłodowska-Curie Action(MSCA)grant number No 811226(www.mgsafe.eu)Research Council of Norway grant no.231530.
文摘Regardless of the substantial progress in designing titanium-based dental implants and aseptic techniques,infection remains as the most common complication after implantation surgeries.Although,having a weakened immune system or systematic diseases is not seen as contraindicated for dental implants anymore,controlling the immune system is required to avoid surgical site infections after implantation.These patients have to control the surgical site infections by taking a high daily dose of oral antibiotics after dental implantation.The antibiotics oral administration has many side effects such as gastrointestinal symptoms,skin rashes and thrush.Coating antibiotics on the biomaterials surface could be a promising solution to reduce these disadvantages through locally releasing antibiotics in a controlled manner.The aim of this study was to investigate the effects of doxycycline coating layer on titanium-zirconium alloy surfaces in vitro and in vivo.In our previous studies,we demonstrated the chemical presence of doxycycline layer in vitro.In this study,we examined its physical presence using field emission scanning electron microscope and confocal microscope.We also analyzed its controlled released manner using Nano-Drop UV Vis spectrometer.After in vitro characterization of the coating layer,we evaluated its effects on the implant osseointegration in dogs and rabbits.The histological and histomorphometrical results exhibited no significant difference between doxycycline coated and uncoated groups regarding the implants osseointegration and biocompatibility for dental applications.Therefore,coating a doxycycline layer on TiZr implants could be favorable for reducing or removing the antibiotics oral administration after the implantation surgery.
