目的:采用系统评价和Meta分析的方法,探讨DNA甲基转移酶1(DNMT1)表达水平与系统性红斑狼疮(SLE)疾病活动指数的相关性。方法:计算机检索PubMed、Web of Science、Embase、Cochrane Library、知网、万方及维普数据库中关于DNMT1表达水平...目的:采用系统评价和Meta分析的方法,探讨DNA甲基转移酶1(DNMT1)表达水平与系统性红斑狼疮(SLE)疾病活动指数的相关性。方法:计算机检索PubMed、Web of Science、Embase、Cochrane Library、知网、万方及维普数据库中关于DNMT1表达水平与SLE疾病活动指数相关性的研究,研究类型不限。检索时限为数据库建立至2020年4月3日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Comprehensive Meta Analysis V2软件、Engauge软件、SPSS 20.0软件与Excel进行数据的判断、提取、转化和计算,最后使用Stata 15.0软件进行meta分析。结果:共纳入8项病例对照研究,包括304例患者,NOS量表评价>5颗星。Meta分析结果显示:DNMT1表达水平与SLE疾病活动指数呈低度相关性,相关系数有统计学意义[r=-0.23,95%CI(-0.42,-0.03),P=0.008]。结论:现有证据表明DNAMT1表达水平与SLE疾病活动指数之间有低相关性,但还需要更多同质的研究来进行佐证。展开更多
Background. Lupus band test still has no clearly defined position within either diagnostic or disease activity measuring tools for systemic lupus erythematosus (SLE). Objectives. We tested the hypothesis that positive...Background. Lupus band test still has no clearly defined position within either diagnostic or disease activity measuring tools for systemic lupus erythematosus (SLE). Objectives. We tested the hypothesis that positive LBT correlates with global activity of SLE measured by the SLE Disease Activity Index (SLEDAI) score. Methods. In total, 90 SLE patients who underwent biopsy of sunprotected non lesional (SPNL) skin were studied prospectively. The skin specimen was processed for standard direct immunofluorescence. The patients were classified into groups as negative and positive LBT, and the latter were further subdivided on the basis of the type and morphology of the deposits. Every patient was thoroughly examined and assigned a SLEDAI score. The relationship between LBT findings and SLEDAI score was analysed. Results. The disease was significantly more active in patients with positive LBT and in those with a higher number of deposited immunoreactants. Almost all patients with renal involvement had a positive LBT. Conclusions. LBT on SPNL skin may be a good marker of severe disease at presentation, particularly when three immunoglobulins are found at the dermoepidermal junction.展开更多
文摘目的:采用系统评价和Meta分析的方法,探讨DNA甲基转移酶1(DNMT1)表达水平与系统性红斑狼疮(SLE)疾病活动指数的相关性。方法:计算机检索PubMed、Web of Science、Embase、Cochrane Library、知网、万方及维普数据库中关于DNMT1表达水平与SLE疾病活动指数相关性的研究,研究类型不限。检索时限为数据库建立至2020年4月3日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Comprehensive Meta Analysis V2软件、Engauge软件、SPSS 20.0软件与Excel进行数据的判断、提取、转化和计算,最后使用Stata 15.0软件进行meta分析。结果:共纳入8项病例对照研究,包括304例患者,NOS量表评价>5颗星。Meta分析结果显示:DNMT1表达水平与SLE疾病活动指数呈低度相关性,相关系数有统计学意义[r=-0.23,95%CI(-0.42,-0.03),P=0.008]。结论:现有证据表明DNAMT1表达水平与SLE疾病活动指数之间有低相关性,但还需要更多同质的研究来进行佐证。
文摘Background. Lupus band test still has no clearly defined position within either diagnostic or disease activity measuring tools for systemic lupus erythematosus (SLE). Objectives. We tested the hypothesis that positive LBT correlates with global activity of SLE measured by the SLE Disease Activity Index (SLEDAI) score. Methods. In total, 90 SLE patients who underwent biopsy of sunprotected non lesional (SPNL) skin were studied prospectively. The skin specimen was processed for standard direct immunofluorescence. The patients were classified into groups as negative and positive LBT, and the latter were further subdivided on the basis of the type and morphology of the deposits. Every patient was thoroughly examined and assigned a SLEDAI score. The relationship between LBT findings and SLEDAI score was analysed. Results. The disease was significantly more active in patients with positive LBT and in those with a higher number of deposited immunoreactants. Almost all patients with renal involvement had a positive LBT. Conclusions. LBT on SPNL skin may be a good marker of severe disease at presentation, particularly when three immunoglobulins are found at the dermoepidermal junction.
