Introduction: The diagnostic criteria for glaucomatous acquired pit of the optic nerve head (APON) were established by Javitt et al. The SLO findings of this particular lesion have not been described. APON is a predic...Introduction: The diagnostic criteria for glaucomatous acquired pit of the optic nerve head (APON) were established by Javitt et al. The SLO findings of this particular lesion have not been described. APON is a predictive factor for progressive glaucomatous damage. Purpose: To determine the SLO morphologic find-展开更多
Background:This study compared SLO microperimetry scotoma size measurements with the sizes of lesions assessed with OCT in the areas of scotoma.Methods:SLO microperimetry was performed on eight patients to assess the ...Background:This study compared SLO microperimetry scotoma size measurements with the sizes of lesions assessed with OCT in the areas of scotoma.Methods:SLO microperimetry was performed on eight patients to assess the location and extent of scotoma areas.An SLO microperimetry master image was used to localize the scotoma areas in the real time OCT fundus image and to center OCT cross scans on the areas of scotoma.The sizes of the morphological changes measured by OCT were compared with the scotoma size measurements.Results:In each patient,OCT revealed a morphological change located in the area of scotoma.Scotoma sizes ranged from 465 to 3180 μ m horizontally and from 570 to 2550 μ m vertically.The corresponding lesion sizes ranged from 461 to 2660 μ m horizontally and from 523 to 2282 μ m vertically.The average difference between SLO and OCT measurements was 2.4% horizontally and 4.9% vertically.There were significant correlations between horizontal and vertical SLO and OCT measurements(Horizontal:Rsq=0.955,P < 0.0001;Vertical:Rsq=0.898,P=0.0003).Conclusion:SLO microperimetry scotoma size measurements and OCT lesion size measurements are similar to each other.Combining retinal functional testing with morphological testing provides information about the underlying causes of scotoma.展开更多
Recently, we reported that the novel mitochondrial RNA editing factor SLO2 is essential for mitochondrialelectron transport, and vital for plant growth through regulation of carbon and energy metabolism. Here, we show...Recently, we reported that the novel mitochondrial RNA editing factor SLO2 is essential for mitochondrialelectron transport, and vital for plant growth through regulation of carbon and energy metabolism. Here, we show thatmutation in SL02 causes hypersensitivity to ABA and insensitivity to ethylene, suggesting a link with stress responses.Indeed, slo2 mutants are hypersensitive to salt and osmotic stress during the germination stage, while adult plantsshow increased drought and salt tolerance. Moreover, slo2 mutants are more susceptible to Botrytis cinerea infection.An increased expression of nuclear-encoded stress-responsive genes, as well as mitochondrial-encoded NAD genes ofcomplex I and genes of the alternative respiratory pathway, was observed in slo2 mutants, further enhanced by ABAtreatment. In addition, H202 accumulation and altered amino acid levels were recorded in slo2 mutants. We conclude thatSLO2 is required for plant sensitivity to ABA, ethylene, biotic, and abiotic stress. Although two stress-related RNA editingfactors were reported very recently, this study demonstrates a unique role of SLO2, and further supports a link betweenmitochondrial RNA editing events and stress response.展开更多
With the increasing scale of information technology(IT)service system,traditional thresholdbased static service level management(SLM)solution appears to be inadequate to meet current increasingly management requiremen...With the increasing scale of information technology(IT)service system,traditional thresholdbased static service level management(SLM)solution appears to be inadequate to meet current increasingly management requirement of SLM.Due to the stochastic service request rate,the random inherent failure and load surge of IT devices during service operating stage of large scaled IT system,service level objective(SLO)maintenance issue has become a realistic and important issue in dynamic SLM.This paper proposes a closed-loop feedback control mechanism to adaptively maintain SLO that service provider(SP)guaranteed at service operation stage.The mechanism can automatically tune the capacity of IT infrastructure according to service performance dispersion and reduce SLO violations.Considering that the tuning operations also affect service performance,fuzzy control is applied to alleviate the negative effect caused by tuning operations.In the dynamic SLM system that is applied with this mechanism compared with the traditional threshold-based solution,it is proved that the amount of SLO violations obviously decreases,the reliability of the service system increases relatively,and the resource utilization of IT infrastructure is optimized.展开更多
文摘Introduction: The diagnostic criteria for glaucomatous acquired pit of the optic nerve head (APON) were established by Javitt et al. The SLO findings of this particular lesion have not been described. APON is a predictive factor for progressive glaucomatous damage. Purpose: To determine the SLO morphologic find-
文摘Background:This study compared SLO microperimetry scotoma size measurements with the sizes of lesions assessed with OCT in the areas of scotoma.Methods:SLO microperimetry was performed on eight patients to assess the location and extent of scotoma areas.An SLO microperimetry master image was used to localize the scotoma areas in the real time OCT fundus image and to center OCT cross scans on the areas of scotoma.The sizes of the morphological changes measured by OCT were compared with the scotoma size measurements.Results:In each patient,OCT revealed a morphological change located in the area of scotoma.Scotoma sizes ranged from 465 to 3180 μ m horizontally and from 570 to 2550 μ m vertically.The corresponding lesion sizes ranged from 461 to 2660 μ m horizontally and from 523 to 2282 μ m vertically.The average difference between SLO and OCT measurements was 2.4% horizontally and 4.9% vertically.There were significant correlations between horizontal and vertical SLO and OCT measurements(Horizontal:Rsq=0.955,P < 0.0001;Vertical:Rsq=0.898,P=0.0003).Conclusion:SLO microperimetry scotoma size measurements and OCT lesion size measurements are similar to each other.Combining retinal functional testing with morphological testing provides information about the underlying causes of scotoma.
文摘Recently, we reported that the novel mitochondrial RNA editing factor SLO2 is essential for mitochondrialelectron transport, and vital for plant growth through regulation of carbon and energy metabolism. Here, we show thatmutation in SL02 causes hypersensitivity to ABA and insensitivity to ethylene, suggesting a link with stress responses.Indeed, slo2 mutants are hypersensitive to salt and osmotic stress during the germination stage, while adult plantsshow increased drought and salt tolerance. Moreover, slo2 mutants are more susceptible to Botrytis cinerea infection.An increased expression of nuclear-encoded stress-responsive genes, as well as mitochondrial-encoded NAD genes ofcomplex I and genes of the alternative respiratory pathway, was observed in slo2 mutants, further enhanced by ABAtreatment. In addition, H202 accumulation and altered amino acid levels were recorded in slo2 mutants. We conclude thatSLO2 is required for plant sensitivity to ABA, ethylene, biotic, and abiotic stress. Although two stress-related RNA editingfactors were reported very recently, this study demonstrates a unique role of SLO2, and further supports a link betweenmitochondrial RNA editing events and stress response.
基金Acknowledgements This work was partly supported by the State Key Development Program for Basic Research of China(No.2007CB310703)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(Grant No.60821001)the National High Technology Research and Development Program of China(No.2008AA01Z201).
文摘With the increasing scale of information technology(IT)service system,traditional thresholdbased static service level management(SLM)solution appears to be inadequate to meet current increasingly management requirement of SLM.Due to the stochastic service request rate,the random inherent failure and load surge of IT devices during service operating stage of large scaled IT system,service level objective(SLO)maintenance issue has become a realistic and important issue in dynamic SLM.This paper proposes a closed-loop feedback control mechanism to adaptively maintain SLO that service provider(SP)guaranteed at service operation stage.The mechanism can automatically tune the capacity of IT infrastructure according to service performance dispersion and reduce SLO violations.Considering that the tuning operations also affect service performance,fuzzy control is applied to alleviate the negative effect caused by tuning operations.In the dynamic SLM system that is applied with this mechanism compared with the traditional threshold-based solution,it is proved that the amount of SLO violations obviously decreases,the reliability of the service system increases relatively,and the resource utilization of IT infrastructure is optimized.
