Smoke is the main cause of fire death. In order to minimize the potential danger of smoke hazard, a rational VR based fire training simulator should fully consider all aspects of smoke hazard. In the simulator, the vi...Smoke is the main cause of fire death. In order to minimize the potential danger of smoke hazard, a rational VR based fire training simulator should fully consider all aspects of smoke hazard. In the simulator, the visualization of data based on FDS (Fire Dynamics Simulator) and FED fire dynamic data and volume rendering is further optimized, which can be effectively and quickly applied to virtual fire protection. In addition, a comprehensive smoke hazard assessment model based on FED and FED is established to assess the IHD value of different paths, which represents the safety of different paths, and can be used for evacuation or rescue in virtual training. Taking the case of campus fire drill as an experiment, the research shows the accuracy and effectiveness of smoke assessment based on FDS and FED model. The road force with the highest safety can be selected through the comprehensive model. So the assessment model is proved to be valuable.展开更多
Objective To establish a smoke-induced chronic bronchitis rat model and evaluate the patho-logical change semi-quantitatively, and study the characteristics of the inflammatory cells in the bronchoalveolar lav-age flu...Objective To establish a smoke-induced chronic bronchitis rat model and evaluate the patho-logical change semi-quantitatively, and study the characteristics of the inflammatory cells in the bronchoalveolar lav-age fluid (BALF) in various stages. Methods Chronic bronchitis sequential rat model was established by passively inhaling smoke mixture. Experiments were performed in 30 young male Sprague-Dawley rats, which comprised 5 groups in random, i.e.,4 chronic bronchitis model groups and 1 control group. After stained with hematoxylin and eosin, the specimens were studied by semi-quantitative method to evaluate the morphologic changes in various stages. Meanwhile, the inflammatory cells of the BALF and the activity of myeloperoxidase (MPO) of lung tissue were analysed. Results During the process of the chronic bronchitis, the pathologic score was increasing as time went on, and the typical morphologic changes of chronic bronchitis emerged in the group 7 weeks. The total number of inflammatory cells in BALF was increasing as time went on, correlated with the pathologic scores (P <0.01). And the percentage of lymphocyte increased as well as positively correlated with pathologic scores (P < 0. 05) , whereas that of macrophage decreased and negatively correlated with pathologic scores (P <0. 05). The MPO lever of lung tissue was correlated with the pathologic scores (P < 0. 01). But the percentage of the neutrophil in the BALF was just in a high level during the first week, then it maintained relatively lower. Conclusion Smoke-induced chronic bronchitis is a slowly progressive inflammation process. The model we established is convenient and simple for the longitudinal study on the inflammatory process of chronic bronchitis and the therapy in the early stage. The semi-quantitative evaluation for the pathological change is with much more value. During the inflammatory sequential process of early stage of chronic bronchitis, the cellular characteristics are similar to that of the common chronic inflammation.展开更多
Chronic obstructive pulmonary disease(COPD) is a chronic inflammatory disorder characterized by airflow obstruction and progressive damage of lung tissues. As currently more than 3 billion people use biomass fuel for ...Chronic obstructive pulmonary disease(COPD) is a chronic inflammatory disorder characterized by airflow obstruction and progressive damage of lung tissues. As currently more than 3 billion people use biomass fuel for cooking and heating worldwide, exposure to biomass smoke(BS) is recognized as a significant risk factor for COPD. Recent clinical data have shown that BS-COPD patients have a Th2-type inflammatory profile significantly different from that in COPD induced by cigarette smoke. As COPD is essentially proinflammatory,however, the mechanism underlying this Th2-type anti-inflammatory profile remains elusive.In this work, a network model is applied to study BS-induced inflammatory dynamics. The network model involves several positive feedback loops, activations of which are responsible for different mechanisms by which clinical phenotypes of COPD are produced. Our modeling study in this work has identified a subset of BS-COPD patients with a mixed M1-and Th2-type inflammatory profile. The model’s prediction is in good agreement with clinical experiments and our in silico knockout simulations have demonstrated several important network components that play an important role in the disease. Our modeling study provides novel insight into BS-COPD progression, offering a rationale for targeted therapy and personalized medicine for treatment of the disease in future.展开更多
In this manuscript,we consider a stochastic smoking epidemic model from behavioural sciences.Also,we develop a structure preserving numerical method to describe the dynamics of stochastic smoking epidemic model in a h...In this manuscript,we consider a stochastic smoking epidemic model from behavioural sciences.Also,we develop a structure preserving numerical method to describe the dynamics of stochastic smoking epidemic model in a human population.The structural properties of a physical system include positivity,boundedness and dynamical consistency.These properties play a vital role in non-linear dynamics.The solution for nonlinear stochastic models necessitates the conservation of these properties.Unfortunately,the aforementioned properties of the model have not been restored in the existing stochastic methods.Therefore,it is essential to construct a structure preserving numerical method for a reliable analysis of stochastic smoking model.The usual explicit stochastic numerical methods are time-dependent and violate most of the structural properties.In this work,we have developed the implicitly driven explicit method for the solution of stochastic smoking model.It is also proved that the newly developed method sustains all the aforementioned properties of the system.Finally,the convergence analysis of the newly developed method and graphical illustrations are presented.展开更多
A new model of rats with Xueyu Syndrome which was characterized by erythrocyte injury was presented. Observation of morphology and functions of erythrocytes showed that this model could not only be used as a model i...A new model of rats with Xueyu Syndrome which was characterized by erythrocyte injury was presented. Observation of morphology and functions of erythrocytes showed that this model could not only be used as a model in Xueyu Syndrome and Huoxuequyu treatment study, but also be used for screening of drugs with the effect of preventing and treating damage of red blood cells.展开更多
The adverse effects of maternal smoking during pregnancy on both the offspring and women are well known. The main objective of this research article is to provide health professional causal modelling approach to make ...The adverse effects of maternal smoking during pregnancy on both the offspring and women are well known. The main objective of this research article is to provide health professional causal modelling approach to make a more comprehensive assessment of major determinants of smoking behaviour during and after pregnancy and consequently the outcomes of pregnant women smoking which are adversely affecting both the offspring and pregnant women. The causal model based on theory and evidence was modified and applied to material smoking cessation intervention to control the adverse effects of smoking on offspring obesity and neurodevelopment. In this approach a generic model links behavioural determinants, causally through behaviour, to physiological and biochemical variables, and health outcomes. It is tailored to context, target population, behaviours and health outcomes. The model provides a rational guide to appropriate measures, intervention points and intervention techniques, and can be tested quantitatively. The causal modelling approach showed promising results which can be used to help maternal smoking women to understand the risk of smoking and help them to quit smoking. The regression analysis of maternal smoking women BMI (n = 1000) on offspring BMI was statistically significant, p 0.05). This supported the hypothesis that maternal smoking women BMI during pregnancy is an important determinant of offspring obesity and consequently the risk factors of cardiovascular development. The causal modelling approach is unique as it provides an incentive to health professional to use these models to target any important and modifiable determinants of the maternal smoking behaviour and decrease the risk of adverse pregnancy outcomes for the offspring and the mother.展开更多
In this paper, the global stability of free smoking equilibrium point was evaluated and presented graphically. The linear stability of a developed mathematical model illustrates the effect on the population of chain, ...In this paper, the global stability of free smoking equilibrium point was evaluated and presented graphically. The linear stability of a developed mathematical model illustrates the effect on the population of chain, mild and passive smokers. MATLAB programming was used to simulate the solutions, the reproduction number R0 and the nature of the equilibria.展开更多
Introduction: Among young teens, about one in five smokes worldwide. Adolescents spend a considerable amount of their time in school, and the school environment is therefore important for child health practices and ou...Introduction: Among young teens, about one in five smokes worldwide. Adolescents spend a considerable amount of their time in school, and the school environment is therefore important for child health practices and outcomes. Objectives: We aimed to investigate the impact on smoking behavior of the school environment and the personal characteristics of male teenage students attending schools in Pakistan, taking into account the survey sampling structure. Methods: A two-stage cluster sampling with stratification was employed, and we interviewed 772 male secondary school students. We adopted random effect and generalizing estimating equation models. Results: Peer pressure in particular had a strong influence on adolescents smoking;those whose friends smoked were up to 6 times more likely to smoke. Family smoking was also significantly associated with adolescents smoking, but those students whose mother was educated were 50% less likely to smoke. The fitted random effect model indicated that the between school variability was significant (p-value < 0.01), indicating differences in smoking habits between schools. A random coefficient model showed that variability among schools was not significantly different for public and private schools. Conclusion: Public health campaigns for smoking cessation should target not only the individual but also the families of adolescents attending schools.展开更多
The fact that adolescents are starting to smoke at a younger age is an issue in Japan, but no studies have identified the causal relationship between factors affecting this early smoking initiation. The aim of this st...The fact that adolescents are starting to smoke at a younger age is an issue in Japan, but no studies have identified the causal relationship between factors affecting this early smoking initiation. The aim of this study was to produce a causal model of factors related to smoking initiation by adolescents and early smoking initiation. A specially prepared questionnaire containing 72 items extracted from previous studies as constituting factors in smoking by minors was administered to 215 students aged ≥ 20 years. All items were rated on a 5-point Likert scale according to how closely they were connected to smoking initiation. Exploratory factor analysis of factors related to smoking initiation by adolescents was performed, after which the data were analyzed by structural equation modeling. The following five factors were found to affect early smoking initiation: self-disgust, growing up in an inappropriate home environment, reduction of norms consciousness for adolescents’ smoking, perception of smoking as stress relief, and inadequate knowledge of the dangers of smoking. The findings suggest that antismoking education for adolescents should provide more information on smoking, and that assessing the home environment and mediating in the parent-child relationship, increasing self- control of stress, emotions, and the capacity for self-regulation, and incorporating parents into antismoking education may also be important.展开更多
Tbe experimental simulation has been performed to investigate the smoke flowing properties within the 1/5 reduced-scale model of a sleeping carriage. The velocity field of the running train on fire is simulated in a w...Tbe experimental simulation has been performed to investigate the smoke flowing properties within the 1/5 reduced-scale model of a sleeping carriage. The velocity field of the running train on fire is simulated in a wind tunnel of the State Key Lab of Fire Science, USTC (University of Science & Technology of China). In this paper, the fire-smoking properties and the variation of the temperature field in the sleeping carriage are analyzed. This paper introduces the simulation method of reducedscale experiment about the running train and the analysis or the experimental data. It provides the basis of experiment for the running train’s fire-safety and full-scale experiment in the future study.展开更多
文摘Smoke is the main cause of fire death. In order to minimize the potential danger of smoke hazard, a rational VR based fire training simulator should fully consider all aspects of smoke hazard. In the simulator, the visualization of data based on FDS (Fire Dynamics Simulator) and FED fire dynamic data and volume rendering is further optimized, which can be effectively and quickly applied to virtual fire protection. In addition, a comprehensive smoke hazard assessment model based on FED and FED is established to assess the IHD value of different paths, which represents the safety of different paths, and can be used for evacuation or rescue in virtual training. Taking the case of campus fire drill as an experiment, the research shows the accuracy and effectiveness of smoke assessment based on FDS and FED model. The road force with the highest safety can be selected through the comprehensive model. So the assessment model is proved to be valuable.
基金Supported by the fund from Shanghai Science and Technology Committee (004119060)
文摘Objective To establish a smoke-induced chronic bronchitis rat model and evaluate the patho-logical change semi-quantitatively, and study the characteristics of the inflammatory cells in the bronchoalveolar lav-age fluid (BALF) in various stages. Methods Chronic bronchitis sequential rat model was established by passively inhaling smoke mixture. Experiments were performed in 30 young male Sprague-Dawley rats, which comprised 5 groups in random, i.e.,4 chronic bronchitis model groups and 1 control group. After stained with hematoxylin and eosin, the specimens were studied by semi-quantitative method to evaluate the morphologic changes in various stages. Meanwhile, the inflammatory cells of the BALF and the activity of myeloperoxidase (MPO) of lung tissue were analysed. Results During the process of the chronic bronchitis, the pathologic score was increasing as time went on, and the typical morphologic changes of chronic bronchitis emerged in the group 7 weeks. The total number of inflammatory cells in BALF was increasing as time went on, correlated with the pathologic scores (P <0.01). And the percentage of lymphocyte increased as well as positively correlated with pathologic scores (P < 0. 05) , whereas that of macrophage decreased and negatively correlated with pathologic scores (P <0. 05). The MPO lever of lung tissue was correlated with the pathologic scores (P < 0. 01). But the percentage of the neutrophil in the BALF was just in a high level during the first week, then it maintained relatively lower. Conclusion Smoke-induced chronic bronchitis is a slowly progressive inflammation process. The model we established is convenient and simple for the longitudinal study on the inflammatory process of chronic bronchitis and the therapy in the early stage. The semi-quantitative evaluation for the pathological change is with much more value. During the inflammatory sequential process of early stage of chronic bronchitis, the cellular characteristics are similar to that of the common chronic inflammation.
基金This work was supported by the National Natural Science Foundation of China(No.21273209).
文摘Chronic obstructive pulmonary disease(COPD) is a chronic inflammatory disorder characterized by airflow obstruction and progressive damage of lung tissues. As currently more than 3 billion people use biomass fuel for cooking and heating worldwide, exposure to biomass smoke(BS) is recognized as a significant risk factor for COPD. Recent clinical data have shown that BS-COPD patients have a Th2-type inflammatory profile significantly different from that in COPD induced by cigarette smoke. As COPD is essentially proinflammatory,however, the mechanism underlying this Th2-type anti-inflammatory profile remains elusive.In this work, a network model is applied to study BS-induced inflammatory dynamics. The network model involves several positive feedback loops, activations of which are responsible for different mechanisms by which clinical phenotypes of COPD are produced. Our modeling study in this work has identified a subset of BS-COPD patients with a mixed M1-and Th2-type inflammatory profile. The model’s prediction is in good agreement with clinical experiments and our in silico knockout simulations have demonstrated several important network components that play an important role in the disease. Our modeling study provides novel insight into BS-COPD progression, offering a rationale for targeted therapy and personalized medicine for treatment of the disease in future.
文摘In this manuscript,we consider a stochastic smoking epidemic model from behavioural sciences.Also,we develop a structure preserving numerical method to describe the dynamics of stochastic smoking epidemic model in a human population.The structural properties of a physical system include positivity,boundedness and dynamical consistency.These properties play a vital role in non-linear dynamics.The solution for nonlinear stochastic models necessitates the conservation of these properties.Unfortunately,the aforementioned properties of the model have not been restored in the existing stochastic methods.Therefore,it is essential to construct a structure preserving numerical method for a reliable analysis of stochastic smoking model.The usual explicit stochastic numerical methods are time-dependent and violate most of the structural properties.In this work,we have developed the implicitly driven explicit method for the solution of stochastic smoking model.It is also proved that the newly developed method sustains all the aforementioned properties of the system.Finally,the convergence analysis of the newly developed method and graphical illustrations are presented.
基金This project was supported by the National Natural ScienceFoundation of China (No. 39270826).
文摘A new model of rats with Xueyu Syndrome which was characterized by erythrocyte injury was presented. Observation of morphology and functions of erythrocytes showed that this model could not only be used as a model in Xueyu Syndrome and Huoxuequyu treatment study, but also be used for screening of drugs with the effect of preventing and treating damage of red blood cells.
文摘The adverse effects of maternal smoking during pregnancy on both the offspring and women are well known. The main objective of this research article is to provide health professional causal modelling approach to make a more comprehensive assessment of major determinants of smoking behaviour during and after pregnancy and consequently the outcomes of pregnant women smoking which are adversely affecting both the offspring and pregnant women. The causal model based on theory and evidence was modified and applied to material smoking cessation intervention to control the adverse effects of smoking on offspring obesity and neurodevelopment. In this approach a generic model links behavioural determinants, causally through behaviour, to physiological and biochemical variables, and health outcomes. It is tailored to context, target population, behaviours and health outcomes. The model provides a rational guide to appropriate measures, intervention points and intervention techniques, and can be tested quantitatively. The causal modelling approach showed promising results which can be used to help maternal smoking women to understand the risk of smoking and help them to quit smoking. The regression analysis of maternal smoking women BMI (n = 1000) on offspring BMI was statistically significant, p 0.05). This supported the hypothesis that maternal smoking women BMI during pregnancy is an important determinant of offspring obesity and consequently the risk factors of cardiovascular development. The causal modelling approach is unique as it provides an incentive to health professional to use these models to target any important and modifiable determinants of the maternal smoking behaviour and decrease the risk of adverse pregnancy outcomes for the offspring and the mother.
文摘In this paper, the global stability of free smoking equilibrium point was evaluated and presented graphically. The linear stability of a developed mathematical model illustrates the effect on the population of chain, mild and passive smokers. MATLAB programming was used to simulate the solutions, the reproduction number R0 and the nature of the equilibria.
文摘Introduction: Among young teens, about one in five smokes worldwide. Adolescents spend a considerable amount of their time in school, and the school environment is therefore important for child health practices and outcomes. Objectives: We aimed to investigate the impact on smoking behavior of the school environment and the personal characteristics of male teenage students attending schools in Pakistan, taking into account the survey sampling structure. Methods: A two-stage cluster sampling with stratification was employed, and we interviewed 772 male secondary school students. We adopted random effect and generalizing estimating equation models. Results: Peer pressure in particular had a strong influence on adolescents smoking;those whose friends smoked were up to 6 times more likely to smoke. Family smoking was also significantly associated with adolescents smoking, but those students whose mother was educated were 50% less likely to smoke. The fitted random effect model indicated that the between school variability was significant (p-value < 0.01), indicating differences in smoking habits between schools. A random coefficient model showed that variability among schools was not significantly different for public and private schools. Conclusion: Public health campaigns for smoking cessation should target not only the individual but also the families of adolescents attending schools.
文摘The fact that adolescents are starting to smoke at a younger age is an issue in Japan, but no studies have identified the causal relationship between factors affecting this early smoking initiation. The aim of this study was to produce a causal model of factors related to smoking initiation by adolescents and early smoking initiation. A specially prepared questionnaire containing 72 items extracted from previous studies as constituting factors in smoking by minors was administered to 215 students aged ≥ 20 years. All items were rated on a 5-point Likert scale according to how closely they were connected to smoking initiation. Exploratory factor analysis of factors related to smoking initiation by adolescents was performed, after which the data were analyzed by structural equation modeling. The following five factors were found to affect early smoking initiation: self-disgust, growing up in an inappropriate home environment, reduction of norms consciousness for adolescents’ smoking, perception of smoking as stress relief, and inadequate knowledge of the dangers of smoking. The findings suggest that antismoking education for adolescents should provide more information on smoking, and that assessing the home environment and mediating in the parent-child relationship, increasing self- control of stress, emotions, and the capacity for self-regulation, and incorporating parents into antismoking education may also be important.
文摘Tbe experimental simulation has been performed to investigate the smoke flowing properties within the 1/5 reduced-scale model of a sleeping carriage. The velocity field of the running train on fire is simulated in a wind tunnel of the State Key Lab of Fire Science, USTC (University of Science & Technology of China). In this paper, the fire-smoking properties and the variation of the temperature field in the sleeping carriage are analyzed. This paper introduces the simulation method of reducedscale experiment about the running train and the analysis or the experimental data. It provides the basis of experiment for the running train’s fire-safety and full-scale experiment in the future study.
基金financial support by the National Natural Science Foundation of China(No.52206180)the Fundamental Research Funds for the Central Universities,China(No.WK2320000050)。
