Objective To determine the effect of needling at Sanyinjiao(SP6)on random blood glucose(RBG)levels and cardiovascular function in patients with type 2 diabetes mellitus(T2DM).Methods In this randomized placebo-control...Objective To determine the effect of needling at Sanyinjiao(SP6)on random blood glucose(RBG)levels and cardiovascular function in patients with type 2 diabetes mellitus(T2DM).Methods In this randomized placebo-controlled study,T2DM patients(aged 35-65 years)were recruited from the Government Yoga and Naturopathy Medical College and Hospital,Chennai,India,between January 5,2022 and March 15,2023.Participants were randomly as-signed to either acupuncture group or sham acupuncture group.The acupuncture group re-ceived bilateral needling at Sanyinjiao(SP6)while sham acupuncture group received needling at a non-acupuncture point[1.5 cun lateral to Sanyinjiao(SP6)]for 30 min.Primary outcome was RBG,and secondary outcomes included systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse rate(PR),pulse pressure(PP),mean arterial pressure(MAP),rate pressure product(RPP),and double product(Do-P).All parameters were assessed imme-diately before and after intervention.Results A total of 100 patients with T2DM were enrolled in the study,and blinded to acupuncture group(n=50)and sham acupuncture group(n=50).Intergroup analysis showed that significant reductions in RBG(P<0.001),SBP(P=0.035),DBP(P=0.008),and MAP(P=0.009)were found in acupuncture group compared with sham acupuncture group.Within-group analysis showed significant reductions in RBG(P<0.001),SBP(P<0.001),DBP(P=0.008),PP(P=0.023),MAP(P<0.001),RPP(P<0.001),and Do-P(P=0.002)in acupunc-ture group,whereas sham acupuncture group showed a significant decrease in PR(P=0.023)only in the post-test assessment compared with pre-test assessment.Conclusion A period of 30 min of needling at the Sanyinjiao(SP6)acupuncture point re-duces RBG and promotes cardiovascular function in patients with T2DM as compared with needling at non-acupuncture points.Sanyinjiao(SP6)acupuncture may offer an immediate,non-pharmacological intervention to strengthen glycemic control management and cardio-vascular health in T2DM patients.展开更多
To study the central mechanism of acupuncture stimulation of Sanyinjiao （三阴交 SP 6） in relieving dysmenorrhea. Methods： A total of 6 dysmenorrhea volunteer patients were subjected into this study. On the first po...To study the central mechanism of acupuncture stimulation of Sanyinjiao （三阴交 SP 6） in relieving dysmenorrhea. Methods： A total of 6 dysmenorrhea volunteer patients were subjected into this study. On the first positron emission tomography （PET） scan examination, they were assigned to pseudoacupuncture group by using the acupuncture needle just to prick the skin of Sanyinjiao （SP 6） ; while on the second PET scans, they were assigned to acupuncture group by inserting the needle into the same acupoint. 18F fluorodeoxyglucose （;SF-FDG） PET of the whole brain was performed during pseudo-acupuncture and real acupuncture of Sanyinjiao （SP 6）. The acquired PET data were analyzed by using statistical parametric mapping （SPM） software to determine changes of glucose metabolism in different cerebral regions. The patient＇s pain intensity was rated by using 0-10 numerical pain intensity scale. Results： After pseudo-acupuncture stimulation of Sanyinjiao （SP 6）, no significant changes were found in the pain intensity （ P 〉0.05）, while after real-acupuncture stimulation, the pain intensity declined significantly （ P〈0.01 ）. Following acupuncture of the right Sanyinjiao （SP 6）, multiple cerebral regions involving pain were activated （increase of glucose metabolism）, including ipsilateral lenticular nucleus （globus palliclus, putamen）, ipsilateral cerebellum and insular lobe, bilateral dorsal thalamus, ipsilateral paracentral Iobule, bilateral amygdaloid bodies, contralateral substantia nigra of the midbrain, bilateral second somatosensory （S Ⅱ ） areas, ispsilateral hippocampal gyms, frontal part of the ipsilateral cingulated gyrus, and bilateral mammary bodies of the hypothalamus. In addition, fewer regions of the cerebral cortex responded with decrease of the glucose metabolism after real acupuncture.展开更多
Objective: To explore the analgesic effects and uterine hemodynamics of perpendicular needling(PN)and transverse needling(TN) at SP 6 in patients with primary dysmenorrhea(PD).Methods: In this randomized controlled tr...Objective: To explore the analgesic effects and uterine hemodynamics of perpendicular needling(PN)and transverse needling(TN) at SP 6 in patients with primary dysmenorrhea(PD).Methods: In this randomized controlled trial, patients with PD diagnosed with cold-dampness congealing pattern were randomly assigned in a ratio of 1:1 to receive PN or TN at bilateral SP 6 for 10 min.Acupuncture was performed when the menstrual pain score was over 40 mm on the first day of menstruation, as measured using the visual analog scale for pain(VAS-P). The primary outcome was average menstrual pain(VAS-P). Secondary outcomes included the pulsatility index(PI), resistance index(RI), and systolic-diastolic peaks ratio(S/D) in uterine arteries as measured using color Doppler ultrasonography;anxiety as assessed using the Hamilton Anxiety Rating Scale(HAMA), blood pressure(BP),and heart rate(HR).Results: Forty-eight patients completed the study. The TN group exhibited a significant reduction in VAS-P scores(-5.71 mm, 95% confidence interval(CI): -8.78, -2.63, P =.001), RI values(-0.05, 95% CI:-0.09, -0.01, P=.015), and HAMA values(-2.50, 95% CI: -4.78, -0.22, P=.032) when compared with the PN group. No significant differences in PI, S/D, BP, or HR values were observed between the two groups(P >.05).Conclusion: TN at SP 6 was superior to PN in alleviating menstrual pain and anxiety in patients with PD.This analgesic effect of TN may be due to its better ability to improve uterine arterial blood flow via decreases in RI values.展开更多
文摘Objective To determine the effect of needling at Sanyinjiao(SP6)on random blood glucose(RBG)levels and cardiovascular function in patients with type 2 diabetes mellitus(T2DM).Methods In this randomized placebo-controlled study,T2DM patients(aged 35-65 years)were recruited from the Government Yoga and Naturopathy Medical College and Hospital,Chennai,India,between January 5,2022 and March 15,2023.Participants were randomly as-signed to either acupuncture group or sham acupuncture group.The acupuncture group re-ceived bilateral needling at Sanyinjiao(SP6)while sham acupuncture group received needling at a non-acupuncture point[1.5 cun lateral to Sanyinjiao(SP6)]for 30 min.Primary outcome was RBG,and secondary outcomes included systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse rate(PR),pulse pressure(PP),mean arterial pressure(MAP),rate pressure product(RPP),and double product(Do-P).All parameters were assessed imme-diately before and after intervention.Results A total of 100 patients with T2DM were enrolled in the study,and blinded to acupuncture group(n=50)and sham acupuncture group(n=50).Intergroup analysis showed that significant reductions in RBG(P<0.001),SBP(P=0.035),DBP(P=0.008),and MAP(P=0.009)were found in acupuncture group compared with sham acupuncture group.Within-group analysis showed significant reductions in RBG(P<0.001),SBP(P<0.001),DBP(P=0.008),PP(P=0.023),MAP(P<0.001),RPP(P<0.001),and Do-P(P=0.002)in acupunc-ture group,whereas sham acupuncture group showed a significant decrease in PR(P=0.023)only in the post-test assessment compared with pre-test assessment.Conclusion A period of 30 min of needling at the Sanyinjiao(SP6)acupuncture point re-duces RBG and promotes cardiovascular function in patients with T2DM as compared with needling at non-acupuncture points.Sanyinjiao(SP6)acupuncture may offer an immediate,non-pharmacological intervention to strengthen glycemic control management and cardio-vascular health in T2DM patients.
文摘To study the central mechanism of acupuncture stimulation of Sanyinjiao （三阴交 SP 6） in relieving dysmenorrhea. Methods： A total of 6 dysmenorrhea volunteer patients were subjected into this study. On the first positron emission tomography （PET） scan examination, they were assigned to pseudoacupuncture group by using the acupuncture needle just to prick the skin of Sanyinjiao （SP 6） ; while on the second PET scans, they were assigned to acupuncture group by inserting the needle into the same acupoint. 18F fluorodeoxyglucose （;SF-FDG） PET of the whole brain was performed during pseudo-acupuncture and real acupuncture of Sanyinjiao （SP 6）. The acquired PET data were analyzed by using statistical parametric mapping （SPM） software to determine changes of glucose metabolism in different cerebral regions. The patient＇s pain intensity was rated by using 0-10 numerical pain intensity scale. Results： After pseudo-acupuncture stimulation of Sanyinjiao （SP 6）, no significant changes were found in the pain intensity （ P 〉0.05）, while after real-acupuncture stimulation, the pain intensity declined significantly （ P〈0.01 ）. Following acupuncture of the right Sanyinjiao （SP 6）, multiple cerebral regions involving pain were activated （increase of glucose metabolism）, including ipsilateral lenticular nucleus （globus palliclus, putamen）, ipsilateral cerebellum and insular lobe, bilateral dorsal thalamus, ipsilateral paracentral Iobule, bilateral amygdaloid bodies, contralateral substantia nigra of the midbrain, bilateral second somatosensory （S Ⅱ ） areas, ispsilateral hippocampal gyms, frontal part of the ipsilateral cingulated gyrus, and bilateral mammary bodies of the hypothalamus. In addition, fewer regions of the cerebral cortex responded with decrease of the glucose metabolism after real acupuncture.
基金funded by the Longitudinal Research Project of BUCM (2018-ZXFZJJ-010)。
文摘Objective: To explore the analgesic effects and uterine hemodynamics of perpendicular needling(PN)and transverse needling(TN) at SP 6 in patients with primary dysmenorrhea(PD).Methods: In this randomized controlled trial, patients with PD diagnosed with cold-dampness congealing pattern were randomly assigned in a ratio of 1:1 to receive PN or TN at bilateral SP 6 for 10 min.Acupuncture was performed when the menstrual pain score was over 40 mm on the first day of menstruation, as measured using the visual analog scale for pain(VAS-P). The primary outcome was average menstrual pain(VAS-P). Secondary outcomes included the pulsatility index(PI), resistance index(RI), and systolic-diastolic peaks ratio(S/D) in uterine arteries as measured using color Doppler ultrasonography;anxiety as assessed using the Hamilton Anxiety Rating Scale(HAMA), blood pressure(BP),and heart rate(HR).Results: Forty-eight patients completed the study. The TN group exhibited a significant reduction in VAS-P scores(-5.71 mm, 95% confidence interval(CI): -8.78, -2.63, P =.001), RI values(-0.05, 95% CI:-0.09, -0.01, P=.015), and HAMA values(-2.50, 95% CI: -4.78, -0.22, P=.032) when compared with the PN group. No significant differences in PI, S/D, BP, or HR values were observed between the two groups(P >.05).Conclusion: TN at SP 6 was superior to PN in alleviating menstrual pain and anxiety in patients with PD.This analgesic effect of TN may be due to its better ability to improve uterine arterial blood flow via decreases in RI values.
