The present study attempted to test a novel hypothesis that Ca^2+ sparks play an important role in arterial relaxation induced by tacrolimus. Recorded with confocal laser scanning microscopy, tacrolimus(10 μmol/L)...The present study attempted to test a novel hypothesis that Ca^2+ sparks play an important role in arterial relaxation induced by tacrolimus. Recorded with confocal laser scanning microscopy, tacrolimus(10 μmol/L) increased the frequency of Ca^2+ sparks, which could be reversed by ryanodine(10 μmol/L). Electrophysiological experiments revealed that tacrolimus(10 μmol/L) increased the large-conductance Ca^2+-activated K+ currents(BKCa) in rat aortic vascular smooth muscle cells(AVSMCs), which could be blocked by ryanodine(10 μmol/L). Furthermore, tacrolimus(10 and 50 μmol/L) reduced the contractile force induced by norepinephrine(NE) or KCl in aortic vascular smooth muscle in a concentration-dependent manner, which could be also significantly attenuated by iberiotoxin(100 nmol/L) and ryanodine(10 μmol/L) respectively. In conclusion, tacrolimus could indirectly activate BKCa currents by increasing Ca^2+ sparks released from ryanodine receptors, which inhibited the NE- or KCl-induced contraction in rat aorta.展开更多
正At 19 o'clock, October 11th, Beijing time, the Swedish Academy awarded the 2012 Nobel Prize for Literature to the Chinese writer Mo Yan. Within several hours, Mo Yan's works were struck by the "Nobel ef...正At 19 o'clock, October 11th, Beijing time, the Swedish Academy awarded the 2012 Nobel Prize for Literature to the Chinese writer Mo Yan. Within several hours, Mo Yan's works were struck by the "Nobel effect", sales shooting up in both bookstores and online marts. Some websites also jumped on the bandwagon and put up a reservation service for the new editions.展开更多
Hinterland rural towns are the last sanctuaries of old traditions, best honored at the Chinese New Year.YUXIAN in northwestern Hebei Province is a three-hour drive from Beijing.
A controversial annual dog meat festival is celebrated on summer solstice, falling on June 21 or 22, in Yulin, a city in south China's Guangxi Zhuang Autonomous Region. However, the festival has drawn widespread crit...A controversial annual dog meat festival is celebrated on summer solstice, falling on June 21 or 22, in Yulin, a city in south China's Guangxi Zhuang Autonomous Region. However, the festival has drawn widespread criticism in recent years.展开更多
An experimental device was designed for studying methane explosion ignited by sparks of cable bolt breakage. With the methane concentration being in explosion range, a series of experiments were conducted to study the...An experimental device was designed for studying methane explosion ignited by sparks of cable bolt breakage. With the methane concentration being in explosion range, a series of experiments were conducted to study the law of spark generation during cable bolt breakage and the probability of methane explosion caused by the spark. The results show that the probability of generating sparks during cable bolt breakage is 50%. The spark generated by the breakage of steel cable bolt strand can't ignite a methane explosion. A detection was carried out using infrared-ray imaging apparatus (IRIA) to measure temperature of the spark generated by cable bolt breakage. It is indicated that the maximum temperature of the spark generated by cable bolt breakage is far less than the required ignition temperature for a methane explosion.展开更多
In this paper, two types of underwater discharges, spark discharge and corona discharge, are investigated by optical diagnosis using a high speed framing camera (HSFC) with the framing time within nanoseconds under ...In this paper, two types of underwater discharges, spark discharge and corona discharge, are investigated by optical diagnosis using a high speed framing camera (HSFC) with the framing time within nanoseconds under the same experimental conditions. In order to capture the photographs of streamer propagation, the influence of the randomicity of the prebreakdown duration is taken into consideration. By increasing the conductivity of water, the randomicity reduces effectively. Experimental results show that, for a spark discharge, the process can be separated into three stages: the generation and propagation of a streamer, the generation and expansion of the discharge channel, and the development and annihilation of the plasma. The streamers do not directly move to the opposite electrode, but form a bush-like figure. With the increase of the number of branches, the velocity of streamer propagation slows down. The trajectory of the initial channel between electrodes is not straight. However, with the channel expanding, its shape transforms into a straight column. For a corona discharge, there are two stages: the generation and propagation of a streamer, and the stagnation and annihilation of the streamer. The initial streamer in a corona discharge is generated later than in a spark discharge. The forms of streamers for both kinds of discharge are similar; however, streamers generated by a corona discharge propagate with a slower velocity and the number of branches is less compared with a spark discharge. When the energy injection stops, the luminescence of plasma inside the discharge channel (spark discharge) or streamers (corona discharge) becomes weaker and weaker, and finally disappears.展开更多
This is the twinned paper of the increased mass paper, “Gravity is acting at superluminous infinite speed, thus collapsing special theory of relativity of Einstein, an explanation for almost everything (according to ...This is the twinned paper of the increased mass paper, “Gravity is acting at superluminous infinite speed, thus collapsing special theory of relativity of Einstein, an explanation for almost everything (according to the authors’ rigorous mathematical proof and overwhelming experimental evidence)"?[1]. In the present paper, we describe the repeated spark or repeat current in terms of the hidden, Non-Relativistic Longitudinal Cardinal Ampere Force which is not found yet infallible for every case. The impressive finding is the fact that these repeated sparks as we shall see, have no back-emf, but forward-emf and forward-Ampere-motive-force. The only consumption is the resistive load with the very high currents needed. This means its total energy consumption is less than the released energy-output work plus heat, plus the energy recharging the batteries. All these are in excess of the consumed input energy. This means the Repeated sparking is “over-unity” efficiency and that, using super-conductive materials, we shall have constructed the first “perpetual mobile” plus producing extra electrical energy. Several previous journals that we did not mention here their names did not dare to publish our disliked papers of very important and revolutionary results but were not able to counter argue our arguments. They preferred the silence and have not answered us at all for many years now. Even some of them were involved previously with the repeated sparking which is the same topic of our present paper.展开更多
“One World,One Family”is a theme that conjures up images of harmony and the desire to bridge cultural divides,so it was a fitting backdrop for the 18th“Chinese Bridge”—Chinese Proficiency Competition for Foreign ...“One World,One Family”is a theme that conjures up images of harmony and the desire to bridge cultural divides,so it was a fitting backdrop for the 18th“Chinese Bridge”—Chinese Proficiency Competition for Foreign College Students held in Changsha,Hunan Province this year.展开更多
Spark is a widely studied plasma source for active species production;however,it ex-periences unstable transitions(e.g.to a thermal arc)at high frequencies or long pulse durations.In this study,the sparks generated in...Spark is a widely studied plasma source for active species production;however,it ex-periences unstable transitions(e.g.to a thermal arc)at high frequencies or long pulse durations.In this study,the sparks generated in a pulse train were studied and modulated based on a physics‐corrected deep learning method.Our results show that a highly repeatable and stable spark plasma source can be achieved by automatically adjusting the voltage amplitude according to the discharge frequency in a high‐frequency pulse train within the time scale of the fluid response.The influences of the electron number density increasing mode and modulated driven voltage profiles on the energy efficiencies were also studied.展开更多
医学影像学是临床医学中一门实践性极强辅助学科,同时也是发展迅猛,日新月异的学科,在现代医疗中扮演着越来越重要的角色。文章通过对影像医学教学的基本要求、教学目标和目的进行说明,采用影像存储和传输系统(picture archiving and co...医学影像学是临床医学中一门实践性极强辅助学科,同时也是发展迅猛,日新月异的学科,在现代医疗中扮演着越来越重要的角色。文章通过对影像医学教学的基本要求、教学目标和目的进行说明,采用影像存储和传输系统(picture archiving and communication system,PACS)结合以问题为基础的教学法(problem-based learning,PBL)及以案例为基础的教学法(case-based learning,CBL)教学法进行实践。针对非影像专业学员学习时间短、学习任务重,学员影像基础和需求迥异,部分非影像专业学员自身对医学影像学的重视不足以及放射基地重视不足等问题。文章阐述了PACS与PBL、CBL教学法、钉钉、微信及SPARK学习平台等学习沟通平台相结合,并增加专职人员对基地管理、带教老师一对一指导,以及不断加强科室建设、安排名师上课来提高科室影响力等多种混合教学模式的解决对策,来唤起学员学习影像相关知识的内驱力,达到提高学员轮转学习效果的目的。展开更多
针对大数据环境下并行深度森林算法中存在不相关及冗余特征过多、多粒度扫描不平衡、分类性能不足以及并行化效率低等问题,提出了基于互信息和融合加权的并行深度森林算法(parallel deep forest algorithm based on mutual information ...针对大数据环境下并行深度森林算法中存在不相关及冗余特征过多、多粒度扫描不平衡、分类性能不足以及并行化效率低等问题,提出了基于互信息和融合加权的并行深度森林算法(parallel deep forest algorithm based on mutual information and mixed weighting,PDF-MIMW)。首先,在特征降维阶段提出了基于互信息的特征提取策略(feature extraction strategy based on mutual information,FE-MI),结合特征重要性、交互性和冗余性度量过滤原始特征,剔除过多的不相关和冗余特征;接着,在多粒度扫描阶段提出了基于填充的改进多粒度扫描策略(improved multi-granularity scanning strategy based on padding,IMGS-P),对精简后的特征进行填充并对窗口扫描后的子序列进行随机采样,保证多粒度扫描的平衡;其次,在级联森林构建阶段提出了并行子森林构建策略(sub-forest construction strategy based on mixed weighting,SFC-MW),结合Spark框架并行构建加权子森林,提升模型的分类性能;最后,在类向量合并阶段提出基于混合粒子群算法的负载均衡策略(load balancing strategy based on hybrid particle swarm optimization algorithm,LB-HPSO),优化Spark框架中任务节点的负载分配,降低类向量合并时的等待时长,提高模型的并行化效率。实验表明,PDF-MIMW算法的分类效果更佳,同时在大数据环境下的训练效率更高。展开更多
基金supported by the National Natural Science Foundation of China(No.81102439)
文摘The present study attempted to test a novel hypothesis that Ca^2+ sparks play an important role in arterial relaxation induced by tacrolimus. Recorded with confocal laser scanning microscopy, tacrolimus(10 μmol/L) increased the frequency of Ca^2+ sparks, which could be reversed by ryanodine(10 μmol/L). Electrophysiological experiments revealed that tacrolimus(10 μmol/L) increased the large-conductance Ca^2+-activated K+ currents(BKCa) in rat aortic vascular smooth muscle cells(AVSMCs), which could be blocked by ryanodine(10 μmol/L). Furthermore, tacrolimus(10 and 50 μmol/L) reduced the contractile force induced by norepinephrine(NE) or KCl in aortic vascular smooth muscle in a concentration-dependent manner, which could be also significantly attenuated by iberiotoxin(100 nmol/L) and ryanodine(10 μmol/L) respectively. In conclusion, tacrolimus could indirectly activate BKCa currents by increasing Ca^2+ sparks released from ryanodine receptors, which inhibited the NE- or KCl-induced contraction in rat aorta.
文摘正At 19 o'clock, October 11th, Beijing time, the Swedish Academy awarded the 2012 Nobel Prize for Literature to the Chinese writer Mo Yan. Within several hours, Mo Yan's works were struck by the "Nobel effect", sales shooting up in both bookstores and online marts. Some websites also jumped on the bandwagon and put up a reservation service for the new editions.
文摘Hinterland rural towns are the last sanctuaries of old traditions, best honored at the Chinese New Year.YUXIAN in northwestern Hebei Province is a three-hour drive from Beijing.
文摘A controversial annual dog meat festival is celebrated on summer solstice, falling on June 21 or 22, in Yulin, a city in south China's Guangxi Zhuang Autonomous Region. However, the festival has drawn widespread criticism in recent years.
文摘An experimental device was designed for studying methane explosion ignited by sparks of cable bolt breakage. With the methane concentration being in explosion range, a series of experiments were conducted to study the law of spark generation during cable bolt breakage and the probability of methane explosion caused by the spark. The results show that the probability of generating sparks during cable bolt breakage is 50%. The spark generated by the breakage of steel cable bolt strand can't ignite a methane explosion. A detection was carried out using infrared-ray imaging apparatus (IRIA) to measure temperature of the spark generated by cable bolt breakage. It is indicated that the maximum temperature of the spark generated by cable bolt breakage is far less than the required ignition temperature for a methane explosion.
文摘In this paper, two types of underwater discharges, spark discharge and corona discharge, are investigated by optical diagnosis using a high speed framing camera (HSFC) with the framing time within nanoseconds under the same experimental conditions. In order to capture the photographs of streamer propagation, the influence of the randomicity of the prebreakdown duration is taken into consideration. By increasing the conductivity of water, the randomicity reduces effectively. Experimental results show that, for a spark discharge, the process can be separated into three stages: the generation and propagation of a streamer, the generation and expansion of the discharge channel, and the development and annihilation of the plasma. The streamers do not directly move to the opposite electrode, but form a bush-like figure. With the increase of the number of branches, the velocity of streamer propagation slows down. The trajectory of the initial channel between electrodes is not straight. However, with the channel expanding, its shape transforms into a straight column. For a corona discharge, there are two stages: the generation and propagation of a streamer, and the stagnation and annihilation of the streamer. The initial streamer in a corona discharge is generated later than in a spark discharge. The forms of streamers for both kinds of discharge are similar; however, streamers generated by a corona discharge propagate with a slower velocity and the number of branches is less compared with a spark discharge. When the energy injection stops, the luminescence of plasma inside the discharge channel (spark discharge) or streamers (corona discharge) becomes weaker and weaker, and finally disappears.
文摘This is the twinned paper of the increased mass paper, “Gravity is acting at superluminous infinite speed, thus collapsing special theory of relativity of Einstein, an explanation for almost everything (according to the authors’ rigorous mathematical proof and overwhelming experimental evidence)"?[1]. In the present paper, we describe the repeated spark or repeat current in terms of the hidden, Non-Relativistic Longitudinal Cardinal Ampere Force which is not found yet infallible for every case. The impressive finding is the fact that these repeated sparks as we shall see, have no back-emf, but forward-emf and forward-Ampere-motive-force. The only consumption is the resistive load with the very high currents needed. This means its total energy consumption is less than the released energy-output work plus heat, plus the energy recharging the batteries. All these are in excess of the consumed input energy. This means the Repeated sparking is “over-unity” efficiency and that, using super-conductive materials, we shall have constructed the first “perpetual mobile” plus producing extra electrical energy. Several previous journals that we did not mention here their names did not dare to publish our disliked papers of very important and revolutionary results but were not able to counter argue our arguments. They preferred the silence and have not answered us at all for many years now. Even some of them were involved previously with the repeated sparking which is the same topic of our present paper.
文摘“One World,One Family”is a theme that conjures up images of harmony and the desire to bridge cultural divides,so it was a fitting backdrop for the 18th“Chinese Bridge”—Chinese Proficiency Competition for Foreign College Students held in Changsha,Hunan Province this year.
基金supported by the National Natural Science Foundation of China(51907204)Natural Science Foundation of Shaanxi Province(2021JQ‐358).
文摘Spark is a widely studied plasma source for active species production;however,it ex-periences unstable transitions(e.g.to a thermal arc)at high frequencies or long pulse durations.In this study,the sparks generated in a pulse train were studied and modulated based on a physics‐corrected deep learning method.Our results show that a highly repeatable and stable spark plasma source can be achieved by automatically adjusting the voltage amplitude according to the discharge frequency in a high‐frequency pulse train within the time scale of the fluid response.The influences of the electron number density increasing mode and modulated driven voltage profiles on the energy efficiencies were also studied.
文摘医学影像学是临床医学中一门实践性极强辅助学科,同时也是发展迅猛,日新月异的学科,在现代医疗中扮演着越来越重要的角色。文章通过对影像医学教学的基本要求、教学目标和目的进行说明,采用影像存储和传输系统(picture archiving and communication system,PACS)结合以问题为基础的教学法(problem-based learning,PBL)及以案例为基础的教学法(case-based learning,CBL)教学法进行实践。针对非影像专业学员学习时间短、学习任务重,学员影像基础和需求迥异,部分非影像专业学员自身对医学影像学的重视不足以及放射基地重视不足等问题。文章阐述了PACS与PBL、CBL教学法、钉钉、微信及SPARK学习平台等学习沟通平台相结合,并增加专职人员对基地管理、带教老师一对一指导,以及不断加强科室建设、安排名师上课来提高科室影响力等多种混合教学模式的解决对策,来唤起学员学习影像相关知识的内驱力,达到提高学员轮转学习效果的目的。
文摘针对大数据环境下并行深度森林算法中存在不相关及冗余特征过多、多粒度扫描不平衡、分类性能不足以及并行化效率低等问题,提出了基于互信息和融合加权的并行深度森林算法(parallel deep forest algorithm based on mutual information and mixed weighting,PDF-MIMW)。首先,在特征降维阶段提出了基于互信息的特征提取策略(feature extraction strategy based on mutual information,FE-MI),结合特征重要性、交互性和冗余性度量过滤原始特征,剔除过多的不相关和冗余特征;接着,在多粒度扫描阶段提出了基于填充的改进多粒度扫描策略(improved multi-granularity scanning strategy based on padding,IMGS-P),对精简后的特征进行填充并对窗口扫描后的子序列进行随机采样,保证多粒度扫描的平衡;其次,在级联森林构建阶段提出了并行子森林构建策略(sub-forest construction strategy based on mixed weighting,SFC-MW),结合Spark框架并行构建加权子森林,提升模型的分类性能;最后,在类向量合并阶段提出基于混合粒子群算法的负载均衡策略(load balancing strategy based on hybrid particle swarm optimization algorithm,LB-HPSO),优化Spark框架中任务节点的负载分配,降低类向量合并时的等待时长,提高模型的并行化效率。实验表明,PDF-MIMW算法的分类效果更佳,同时在大数据环境下的训练效率更高。