Lipoic acid (LA) has received great attention in the area of gold surface functionalization. In this study, LA was employed as a linker for the attachment of antibody to the gold surface of surface plasmon resonance (...Lipoic acid (LA) has received great attention in the area of gold surface functionalization. In this study, LA was employed as a linker for the attachment of antibody to the gold surface of surface plasmon resonance (SPR) chip. By using this chip in a homemade SPR immunosensor, low molecular weight compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) can be detected at a low level of 0.01 ng/mL. There is a good linear relationship(R2 =0.943 1) between the results of SPR biosensor and enzyme-linked immunosorbent assay(ELISA).展开更多
A photonic crystal fiber based surface plasmon resonance(PCF-SPR)sensor is simulated by finite element method and experimentally realized.The calculations show that there is an obvious loss peak in the vicinity of 1.2...A photonic crystal fiber based surface plasmon resonance(PCF-SPR)sensor is simulated by finite element method and experimentally realized.The calculations show that there is an obvious loss peak in the vicinity of 1.2μm while the PCF of LMA-8 is used as a sensor.The suspension of silver nanoparticle mixed with hexadecyl trimethyl ammonium bromide (CTAB)is inhaled into the PCF to form a metal film which can be stimulated to generate plasmon in the experiment.A spectrometer is utilized to detect the continuous broadband transmission spectrum from the PCF.The experimental results verify the loss peak.Compared with the theoretical calculations,the offset of loss peak about 40 nm can be acceptable, because the uniformity of the metal coating is difficult to guarantee and the film thickness is difficult to control.展开更多
Recently, many programs have been developed for simulation or analysis of the different parameters of light propagation in optical fibers, either for sensing or for communication purposes. In this paper, it is shown t...Recently, many programs have been developed for simulation or analysis of the different parameters of light propagation in optical fibers, either for sensing or for communication purposes. In this paper, it is shown the COMSOL Multiphysics as a fairly robust and simple program, due to the existence of a graphical environment, to perform simulations with good accuracy. Results are compared with other simulation analysis, focusing on the surface plasmon resonance （SPR） phenomena for refractive index sensing in a D-type optical fiber, where the characteristics of the material layers, in terms of the type and thickness, and the residual fiber cladding thickness are optimized.展开更多
The temperature characteristics of near infrared surface plasmon resonance （SPR） sensors with Kretschmann configuration are studied theoretically and experimentally. The experimental results match with the numerical...The temperature characteristics of near infrared surface plasmon resonance （SPR） sensors with Kretschmann configuration are studied theoretically and experimentally. The experimental results match with the numerical simulations in the temperature range from 10 ℃ to 40.℃. With the increase of temperature, the resonance angle for gas increases slightly, but that for aqueous solution decreases obviously. No matter the dielectric layer is gas or aqueous solution, the resonance peaks are both broadened.展开更多
An overview of recent researches of surface plasmon resonance （SPR） sensing technology in Laboratory of Science and Technology of Micro-Nano Optics （LMNO）, University of Science and Technology of China, is present...An overview of recent researches of surface plasmon resonance （SPR） sensing technology in Laboratory of Science and Technology of Micro-Nano Optics （LMNO）, University of Science and Technology of China, is presented. Some novel SPR sensors, such as sensors based on metallic grating, metal-insulator-metal （MIM） nanoring and optical fiber, are designed or fabricated and tested. The sensor based on localized surface plasmon resonance （LSPR） of metallic nanoparticles is also be summarized. Because of the coupling of propagating surface plasmons and localized surface plasmons, the localized electromagnetic field is extremely enhanced, which is applied to surface-enhanced Raman scattering （SERS） and fluorenscence enhancement. Future prospects of SPR and/or LSPR sensing developments and applications are atso discussed.展开更多
Optical fiber based SPR sensors have attracted more and more attention due to their unique advantages over the prism-based SPR sensors. A novel fiber-optic SPR sensor with multi-alternating metal layers for biochemica...Optical fiber based SPR sensors have attracted more and more attention due to their unique advantages over the prism-based SPR sensors. A novel fiber-optic SPR sensor with multi-alternating metal layers for biochemical analysis is presented in this paper. Based on the fundamental SPR theory of the fiber optic sensing technology, we theoretically investigated the effects of the existence of alternating layers deposited on sensing region SPR wavelength changes. The emphasis was placed on the numerical simulation of the fiber-optic SPR sensor＇s sensitivity which could be affected by its technical parameters such as the metal thickness, number of alternating layers. Results showed that, compared to the normal SPR sensor with the single metal layer, the proposed sensor had a wider detecting range of the refractive index and higher sensitivity, which can find applications in biological analysis.展开更多
基金Supported by the National Natural Science Foundation of Tianjin (No. 09JCZDJC25700, 12JCZDJC29600 and KJXH2011-11)
文摘Lipoic acid (LA) has received great attention in the area of gold surface functionalization. In this study, LA was employed as a linker for the attachment of antibody to the gold surface of surface plasmon resonance (SPR) chip. By using this chip in a homemade SPR immunosensor, low molecular weight compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) can be detected at a low level of 0.01 ng/mL. There is a good linear relationship(R2 =0.943 1) between the results of SPR biosensor and enzyme-linked immunosorbent assay(ELISA).
基金supported by the Major State Basic Research Development Program of China(No.2010CB327801)the Science and Technology Project of Shandong College(No.J11LG74)the Science and Technology Project of Zaozhuang in Shandong Province(No.201127)
文摘A photonic crystal fiber based surface plasmon resonance(PCF-SPR)sensor is simulated by finite element method and experimentally realized.The calculations show that there is an obvious loss peak in the vicinity of 1.2μm while the PCF of LMA-8 is used as a sensor.The suspension of silver nanoparticle mixed with hexadecyl trimethyl ammonium bromide (CTAB)is inhaled into the PCF to form a metal film which can be stimulated to generate plasmon in the experiment.A spectrometer is utilized to detect the continuous broadband transmission spectrum from the PCF.The experimental results verify the loss peak.Compared with the theoretical calculations,the offset of loss peak about 40 nm can be acceptable, because the uniformity of the metal coating is difficult to guarantee and the film thickness is difficult to control.
文摘Recently, many programs have been developed for simulation or analysis of the different parameters of light propagation in optical fibers, either for sensing or for communication purposes. In this paper, it is shown the COMSOL Multiphysics as a fairly robust and simple program, due to the existence of a graphical environment, to perform simulations with good accuracy. Results are compared with other simulation analysis, focusing on the surface plasmon resonance （SPR） phenomena for refractive index sensing in a D-type optical fiber, where the characteristics of the material layers, in terms of the type and thickness, and the residual fiber cladding thickness are optimized.
基金supported by the National Natural Science Foundation of China(No.61177076)the Fundamental Research Funds for the Central Universities(Nos.2013-Ia-038,2013-Ia-006 and 2013-ZY-121)
文摘The temperature characteristics of near infrared surface plasmon resonance （SPR） sensors with Kretschmann configuration are studied theoretically and experimentally. The experimental results match with the numerical simulations in the temperature range from 10 ℃ to 40.℃. With the increase of temperature, the resonance angle for gas increases slightly, but that for aqueous solution decreases obviously. No matter the dielectric layer is gas or aqueous solution, the resonance peaks are both broadened.
基金This work is supported by the National Key Basic Research Program of China （No. 2011cb301802）, and Key Program of National Natural Science Foundation of China （No. 60736037）. The authors gratefully acknowledge Prof. Y. H. Lu, D. G. Zhang, and P. Wang for many helpful discussions.
文摘An overview of recent researches of surface plasmon resonance （SPR） sensing technology in Laboratory of Science and Technology of Micro-Nano Optics （LMNO）, University of Science and Technology of China, is presented. Some novel SPR sensors, such as sensors based on metallic grating, metal-insulator-metal （MIM） nanoring and optical fiber, are designed or fabricated and tested. The sensor based on localized surface plasmon resonance （LSPR） of metallic nanoparticles is also be summarized. Because of the coupling of propagating surface plasmons and localized surface plasmons, the localized electromagnetic field is extremely enhanced, which is applied to surface-enhanced Raman scattering （SERS） and fluorenscence enhancement. Future prospects of SPR and/or LSPR sensing developments and applications are atso discussed.
基金The authors would like to thank the financial supports from the National Nature Science Foundation of China （Grant Nos. 61137005 and 60977055） and the Ministry of Education of China （Grant Nos.NCET-09-0255 and SRFDP 20120041110040）.
文摘Optical fiber based SPR sensors have attracted more and more attention due to their unique advantages over the prism-based SPR sensors. A novel fiber-optic SPR sensor with multi-alternating metal layers for biochemical analysis is presented in this paper. Based on the fundamental SPR theory of the fiber optic sensing technology, we theoretically investigated the effects of the existence of alternating layers deposited on sensing region SPR wavelength changes. The emphasis was placed on the numerical simulation of the fiber-optic SPR sensor＇s sensitivity which could be affected by its technical parameters such as the metal thickness, number of alternating layers. Results showed that, compared to the normal SPR sensor with the single metal layer, the proposed sensor had a wider detecting range of the refractive index and higher sensitivity, which can find applications in biological analysis.
