The importance of Daniel Silva’s past,close to a Portuguese cultural environment,will be relevant to understand the psychological profile of his popular protagonist and central character,Gabriel Allon,a melancholic m...The importance of Daniel Silva’s past,close to a Portuguese cultural environment,will be relevant to understand the psychological profile of his popular protagonist and central character,Gabriel Allon,a melancholic man haunted by his past,but also someone who is a gifted art restorer,very sensitive to the values of loyalty and fidelity,which the author assumed to have inherited from his Portuguese family.Being a spy and an art expert,Allon seems to conciliate two contradictory sides of the human personality.The connection between Portuguese and American culture,in this writer’s background,could have been responsible for the creation of a character who can be,at the same time,very sensitive and very violent;an assassin who is an Israeli secret agent and the world’s finest restorer of the Old Masters’paintings.A perfect double who does justice to his creator’s double origin,which contributed to the success of The Kill Artist(2000),where terror is practiced as one of the fine arts by a hero very loyal and faithful to his complex cultural origins,living in a diaspora as the eternal wandering Jew.展开更多
文摘目的:探讨SPY1(Speedy A1)和p27^(kip1)(cyclin-dependent kinase inhibitor 1B,p27)在子宫内膜癌中的表达情况及其临床意义。方法:采用生物医学信息数据库分析子宫内膜癌中SPY1、p27^(kip1) mRNA表达水平;采用免疫组织化学染色法及蛋白质印迹法检测子宫内膜癌及正常子宫内膜组织中SPY1、p27^(kip1)蛋白的表达水平,并分析其表达与患者临床病理参数、激素受体、癌症基因组图谱分子分型的关系,以及两者之间的相关性。通过Kaplan-Meier法绘制生存曲线,应用Cox比例风险模型分析影响子宫内膜癌患者的预后因素。结果:SPY1在子宫内膜癌组织中的蛋白质表达水平显著高于不典型增生的子宫内膜及正常子宫内膜组织(P=0.009),p27kip1在子宫内膜癌组织中的蛋白质表达水平显著低于不典型增生的子宫内膜及正常子宫内膜组织(P=0.001);SPY1蛋白表达与肿瘤病理分级(P=0.023)、国际妇产科协会(The International Federation of Gynecology and Obstetrics,FIGO)癌分期(P=0.003),肌层浸润深度(P=0.010)及淋巴结转移(P<0.001)有关,p27kip1蛋白表达与肿瘤病理分级(P=0.001)、FIGO癌分期(P=0.001)及淋巴结转移(P<0.001)有关;SPY1与p27kip1表达呈负相关(r=−0.563,P<0.001);Kaplan-Meier预后分析表明SPY1高表达患者生存率低于低表达患者(P<0.05),p27kip1高表达患者的生存率高于低表达患者(P<0.05)。Cox单因素及多因素分析表明FIGO癌分期(P=0.023)、病理分级(P<0.001)、淋巴结转移(P<0.001)及p27kip1表达(P<0.001)可作为子宫内膜癌患者的独立预后指标。结论:子宫内膜癌组织中SPY1蛋白呈高表达,p27kip1蛋白呈低表达,且两者之间呈负相关,可用于评估子宫内膜癌的发生和发展。
文摘The importance of Daniel Silva’s past,close to a Portuguese cultural environment,will be relevant to understand the psychological profile of his popular protagonist and central character,Gabriel Allon,a melancholic man haunted by his past,but also someone who is a gifted art restorer,very sensitive to the values of loyalty and fidelity,which the author assumed to have inherited from his Portuguese family.Being a spy and an art expert,Allon seems to conciliate two contradictory sides of the human personality.The connection between Portuguese and American culture,in this writer’s background,could have been responsible for the creation of a character who can be,at the same time,very sensitive and very violent;an assassin who is an Israeli secret agent and the world’s finest restorer of the Old Masters’paintings.A perfect double who does justice to his creator’s double origin,which contributed to the success of The Kill Artist(2000),where terror is practiced as one of the fine arts by a hero very loyal and faithful to his complex cultural origins,living in a diaspora as the eternal wandering Jew.
