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Quality of life and psychological distress in end-stage renal disease patients undergoing hemodialysis and transplantation
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作者 Emad A Shdaifat Firas T Abu-Sneineh Abdallah M Ibrahim 《World Journal of Nephrology》 2024年第3期34-40,共7页
BACKGROUND Among diverse profound impacts on patients’quality of life(QoL),end-stage renal disease(ESRD)frequently results in increased levels of depression,anxiety,and stress.Renal replacement therapies such as hemo... BACKGROUND Among diverse profound impacts on patients’quality of life(QoL),end-stage renal disease(ESRD)frequently results in increased levels of depression,anxiety,and stress.Renal replacement therapies such as hemodialysis(HD)and transplantation(TX)are intended to enhance QoL,although their ability to alleviate psychological distress remains uncertain.This research posits the existence of a significant correlation between negative emotional states and QoL among ESRD patients,with varying effects observed in HD and TX patients.AIM To examine the relationship between QoL and negative emotional states(depression,anxiety,and stress)and predicted QoL in various end-stage renal replacement therapy patients with ESRD.METHODS This cross-sectional study included HD or TX patients in the Eastern Region of Saudi Arabia.The 36-item Short Form Survey and Depression Anxiety Stress Scale(DASS)was used for data collection,and correlation and regression analyses were performed.RESULTS The HD and TX transplantation groups showed statistically significant inverse relationships between QoL and DASS scores.HD patients with high anxiety levels and less education scored low on the physical component summary(PCS).In addition,the results of the mental component summary(MCS)were associated with reduced depression.Compared with older transplant patients,TX patients’PCS scores were lower,and depression,stress,and negative working conditions were highly correlated with MCS scores.CONCLUSION The findings of this study revealed notable connections between well-being and mental turmoil experienced by individuals undergoing HD and TX.The PCS of HD patients is affected by heightened levels of anxiety and lower educational attainment,while the MCS of transplant patients is influenced by advancing age and elevated stress levels.These insights will contribute to a more comprehensive understanding of patient support. 展开更多
关键词 ANXIETY DEPRESSION End-stage renal disease HEMODIALYSIS Patient Reported Outcome Measures psychological distress Quality of life Renal replacement therapy outcomes Saudi Arabia stress
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Relationship between preoperative psychological stress and shortterm prognosis in elderly patients with femoral neck fracture
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作者 Wen-Hui Fu Zhi-Long Hu +6 位作者 Yuan-Jun Liao Ri-Jiang Chen Jian-Bin Qiu Wu-Tang Que Wan-Tao Wang Wei-Hua Li Wei-Bin Lan 《World Journal of Psychiatry》 SCIE 2024年第6期838-847,共10页
BACKGROUND Older adults are at high risk of femoral neck fractures(FNFs).Elderly patients face and adapt to significant psychological burdens,resulting in different degrees of psychological stress response.Total hip r... BACKGROUND Older adults are at high risk of femoral neck fractures(FNFs).Elderly patients face and adapt to significant psychological burdens,resulting in different degrees of psychological stress response.Total hip replacement is the preferred treatment for FNF in elderly patients;however,some patients have poor postoperative prognoses,and the underlying mechanism is unknown.We speculated that the postoperative prognosis of elderly patients with FNF may be related to preoperative psychological stress.AIM To explore the relationship between preoperative psychological stress and the short-term prognosis of elderly patients with FNF.METHODS In this retrospective analysis,the baseline data,preoperative 90-item Symptom Checklist score,and Harris score within 6 months of surgery of 120 elderly patients with FNF who underwent total hip arthroplasty were collected.We analyzed the indicators of poor short-term postoperative prognosis and the ability of the indicators to predict poor prognosis and compared the correlation between the indicators and the Harris score.RESULTS Anxiety,depression,garden classification of FNF,cause of fracture,FNF reduction quality,and length of hospital stay were independent influencing factors for poor short-term postoperative prognoses in elderly patients with FNF(P<0.05).The areas under the curve for anxiety,depression,and length of hospital stay were 0.742,0.854,and 0.749,respectively.The sensitivities of anxiety,depression,garden classification of FNF,and prediction of the cause of fracture were 0.857,0.786,0.821,and 0.821,respectively.The specificities of depression,FNF quality reduction,and length of hospital stay were the highest at 0.880,0.783,and 0.761,respectively.Anxiety,depression,and somatization scores correlated moderately with Harris scores(r=-0.523,-0.625,and-0.554;all P<0.001).CONCLUSION Preoperative anxiety,depression,and somatization are correlated with poor short-term prognosis in elderly patients with FNF and warrant consideration. 展开更多
关键词 psychological stress Old age Femoral neck fracture Hip replacement Short-term prognosis CORRELATION
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Exploring the Interplay between Job Stress,Work Performance,and Attitudes toward Professional Psychological Help among Employees
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作者 Cong Minh Le Son Van Huynh +3 位作者 Ky Luu Quynh-Nhi Ngoc Ho Van Thi Le Nguyen Vinh-Long Tran-Chi 《International Journal of Mental Health Promotion》 2024年第7期531-545,共15页
Objective:This study explores the interplay between job stress,job-related factors,work performance,and attitudes toward seeking professional psychological help among Vietnamese employees.Methods:A total of 374 employ... Objective:This study explores the interplay between job stress,job-related factors,work performance,and attitudes toward seeking professional psychological help among Vietnamese employees.Methods:A total of 374 employees in Vietnam were surveyed using random sampling and an online questionnaire from November 07 to November 28,2023.Demographic data and self-reported from three scales:The New Job Stress Scale(NJSS),Work Performance(WP),and Attitudes Toward Seeking Professional Psychological Help(ATSPPH_SF)were collected.Results:Significant variations were found across several variables,including forms of work,operating hours,education levels,monthly income,numbers of daily working hours,and the presence of a psychological counseling department within the company.Our analysis has highlighted direct relationships between key latent variables.Employees who were more open to seeking professional help tended to report higher levels of job stress.The negative relationship was found between job stress and attitudes toward seeking professional help.Additionally,work effort was positively associated with work quality.Moderation analyses revealed the influence of co-worker support on role expectation conflict and work effort,role expectation conflict and work-life balance,as well as interactions between role expectation conflict and attitudes needed toward seeking professional help.Mediation analyses showed that work effort mediated relationships between openness to seeking professional help,co-worker support,work-life balance,role expectation conflict,and work quality.Attitudes toward seeking professional help also mediated relationships between work-life balance,job stress,and work quality.Conclusion:The study highlights the complex dynamics surrounding job stress,job-related factors,work performance,and attitudes toward seeking professional psychological help among Vietnamese employees.It highlights the importance of addressing help-seeking barriers,promoting work engagement,and fostering healthy work-life balance for employee well-being and productivity.Further research across diverse contexts and interventions is needed. 展开更多
关键词 stress co-worker support work-life balance role expectation conflict professional psychological help-seeking
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Unlocking the power of physical activity in easing psychological distress
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作者 Xin-Qiao Liu Xin Wang 《World Journal of Psychiatry》 SCIE 2024年第1期1-7,共7页
The severity of the current global mental health situation and the importance of maintaining psychological well-being call for more powerful,convenient,and efficient solutions for addressing psychological issues and r... The severity of the current global mental health situation and the importance of maintaining psychological well-being call for more powerful,convenient,and efficient solutions for addressing psychological issues and relieving mental stress.Physical activity not only effectively improves physical fitness and reduces negative emotions such as anxiety and depression but also increases the improvement of psychological health and sense of well-being.At the same time,physical activity interventions for mental health have unique advantages,including reducing the side effects of psychological interventions and increasing necessity,convenience,and cost-effectiveness,as well as flexible adaptability across multiple methods,groups,and age ranges,providing stronger support for relieving psychological stress and addressing psychological issues.Although physical activity is an important intervention measure in relieving psychological stress,its value and role in mental health care seem to have not yet received sufficient attention,and its potential remains to be further revealed.Given the significant advantages and effectiveness of physical activity in mental health intervention practices,it is necessary to stimulate its potential in relieving psychological stress through various means in future studies to better safeguard the public’s physical and mental health.Developing guidelines for physical activity for improved mental health,enhancing organic integration with other intervention measures,and providing necessary respect,encouragement,and support are important directions to consider. 展开更多
关键词 Physical activity psychological distress Mental health Artificial intelligence GUIDANCE
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Tendency to Avoid Physical Activity and Sport:Associations with Weight Stigma,and Psychological Distress in a Two-Wave Longitudinal Study
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作者 Saffari Mohsen Yi-Ching Lin +7 位作者 Po-Ching Huang Yu-Ting Huang Ru-Yi Huang Chi Hsien Huang Jung-Sheng Chen Wai Chuen Poon Mark D.Griffiths Chung-Ying Lin 《International Journal of Mental Health Promotion》 2024年第8期633-641,共9页
Background:Physical inactivity is a major public health problem worldwide that results in physical and mental health problems.One major issue for physical inactivity is weight stigma(WS),especially perceived WS,which ... Background:Physical inactivity is a major public health problem worldwide that results in physical and mental health problems.One major issue for physical inactivity is weight stigma(WS),especially perceived WS,which could lead to a tendency to avoid physical activity(PA).To better understand the association between perceived WS and PA,knowledge of the likely mediators in this association such as weight bias internalization(WBI)and psychological distress were investigated in the present study.Methods:Using a two-wave longitudinal study and convenient sampling,388 Taiwan residents participants(55%females;mean age=29.7 years[SD±6.3])completed two surveys six months apart.Body mass index(BMI),Perceived Weight Stigma Scale(PWSS),Weight Bias Internalization Scale(WBIS),Depression,Anxiety,Stress Scale(DASS-21),and Tendency to Avoid Physical Activity and Sport Scale(TAPAS)were assessed.Results:A mediation model controlling for age,gender,and BMI with 5000 bootstrapping resamples was performed.Perceived WS exerted significant direct effects on WBI(β=0.25;p<0.001),psychological distress(β=0.15;p=0.003),and tendency to avoid PA(β=0.10;p=0.027);WBI exerted a significant direct effect on tendency to avoid PA(β=0.47;p<0.001).Standardized indirect effects of WBI and psychological distress on the association between perceived WS and tendency to avoid PA were 0.12 and 0.01,respectively.Conclusion:Given the direct association of perceived WS on the tendency to avoid PA and the mediating role of WBI in this association,interventions addressing perceived WS and WBI may contribute to promoting PA.Therefore,health interventionists(both when planning and executing PA programs)need to consider weight stigmawhen encouraging physical activity. 展开更多
关键词 Mediation model physical activity psychological distress weight stigma young adults
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Advances in the Study of Psychological Stress and Eating Behavior in Children and Adolescents
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作者 Ting He Le Wang +3 位作者 Sha Wang Nannan Ma Li Mei Mengdan Zheng 《Journal of Clinical and Nursing Research》 2024年第7期191-195,共5页
With the rapid development and change in society,children and adolescents are facing more and more psychological pressure,which comes not only from academic performance and interpersonal relationships but also from fa... With the rapid development and change in society,children and adolescents are facing more and more psychological pressure,which comes not only from academic performance and interpersonal relationships but also from family environment,social expectations and other aspects.Psychological stress not only affects the mental health of children and adolescents but is also closely related to their eating behavior.Therefore,exploring the relationship between psychological stress and eating behaviors is of great significance in promoting the physical and mental health development of children and adolescents.Based on this,the study reviewed the research progress on the relationship between psychological stress and eating behavior of children and adolescents in recent years.The relationships between psychological stress and general eating behaviors,abnormal eating behaviors and eating disorders were successively reviewed,and the related physiological mechanisms were explored with a view to providing a scientific basis for mental health education and eating behavior intervention for children and adolescents. 展开更多
关键词 CHILDREN Adolescents psychological stress Eating behavior Research progress
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Linking Perceived Risk of Public Health Emergency to Psychological Distress among Chinese College Students: The Chain Mediation Role of Balanced Time Perspective and Negative Coping Styles
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作者 Biru Chang Shengqiang Zhu +1 位作者 Qian Xie Yanghui Dai 《International Journal of Mental Health Promotion》 2024年第8期599-610,共12页
Background:With public health emergencies(PHE)worldwide increasing,the perceived risk of PHE has been one of the critical factors influencing college students’psychological distress.However,the mechanisms by which th... Background:With public health emergencies(PHE)worldwide increasing,the perceived risk of PHE has been one of the critical factors influencing college students’psychological distress.However,the mechanisms by which the perceived risk of PHE affects college students’psychological distress are not clear.The study’s purpose was to investigate the mediation roles of deviation from a balanced time perspective(DBTP)and negative coping styles between the perceived risk of PHE and psychological distress.Methods:A convenience sampling method was used to survey 1054 Chinese college students with self-reporting.Data was collected using the Public Risk Perception Scale(PRPS),the Zimbardo Time Perspective Inventory(ZTPI),the Simplified Coping Style Questionnaire(SCSQ),the PHE Anxiety Scale,and the Chinese version of the Patient Health Questionnaire(PHQ).The associations between the perceived risk of PHE,DBTP,negative coping styles,and psychological distress were clarified using the correlation analysis.Additionally,the mediating roles of DBTP and negative coping styles between the perceived risk of PHE and psychological distress were investigated using a structural equation model.Results:The findings revealed low to moderate correlations between the variables studied.Students’perceived risk of PHE was a positive predictor of their psychological distress(b=0.219,p<0.01).DBTP and negative coping styles played chain mediation roles between them with the effect being 0.009 and a 95%Boot CI of[0.003,0.023].This chain mediation model had an excellent fit index(χ^(2)/df=4.732,CFI=0.973,TLI=0.930,RMSEA=0.048,SRMR=0.047).Conclusion:These findings showed how the perceived risk of PHE affected college students’psychological distress.Specifically,these results suggested that improving students’mental ability to switch effectively among different time perspectives depending on task features and situational considerations and reducing their negative coping styles might be effective ways to promote their mental health. 展开更多
关键词 Perceived risk of public health emergency balanced time perspective negative coping styles psychological distress college students China
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Analysis of the Degree of Psychological Distress of Elderly Patients with Recurrent Trigeminal Neuralgia and Its Influencing Factors
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作者 Jiqiang Duan 《Journal of Clinical and Nursing Research》 2024年第6期184-188,共5页
Objective:To analyze the degree of psychological distress among elderly patients with recurrent trigeminal neuralgia and its influencing factors.Methods:A single-center cross-sectional study was conducted on 126 elder... Objective:To analyze the degree of psychological distress among elderly patients with recurrent trigeminal neuralgia and its influencing factors.Methods:A single-center cross-sectional study was conducted on 126 elderly patients with recurrent trigeminal neuralgia who visited the Pain Department of our hospital from March 2022 to April 2024.Logistic regression analysis was employed to evaluate the factors influencing psychological distress,based on general patient data,the Distress Thermometer(DT),the Perceived Social Support from Family Scale(PSS-Fa),and the Pitsburgh Sleep Quality Index(PSQI).Results:Among the 126 elderly patients with recurrent trigeminal neuralgia,those with a DT score≥4(72 patients,57.14%)were more prevalent than those with a DT score<4(54 patients,42.86%).The average DT score for all patients was 4.35±1.72.Patients in the DT score≥4 group were older than those in the DT score<4 group(t=4.207,P=0.000),had lower PSS-Fa scores(t=5.925,P=0.000),and had higher PSQI scores(t=17.858,P=0.000).There were no statistically significant differences in gender,marital status,residence area,education level,disease type,or pain location(all P>0.05).Older age and poor sleep quality were identified as independent risk factors for psychological distress in elderly patients with recurrent trigeminal neuralgia(OR=1.258,OR=1.713,both P<0.05),while higher levels of family support were identified as a protective factor(OR=0.581,P=0.025).Conclusion:Elderly patients with recurrent trigeminal neuralgia experience psychological distress,and the degree of severity depends on age,quality of sleep,and level of family support. 展开更多
关键词 Elderly patients Recurrent trigeminal neuralgia psychological distress Influencing factors Family support
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Psychological stress impact neurotrophic factor levels in patients with androgenetic alopecia and correlated with disease progression
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作者 Yi Cheng Li-Jing Lv +3 位作者 Yu Cui Xiao-Mei Han Yan Zhang Cai-Xia Hu 《World Journal of Psychiatry》 SCIE 2024年第10期1437-1447,共11页
BACKGROUND Androgenetic alopecia(AGA)is a common form of hair loss that can be influenced by psychological factors.AIM To investigate the impact of mental stress on neurotrophic factors in patients with AGA and correl... BACKGROUND Androgenetic alopecia(AGA)is a common form of hair loss that can be influenced by psychological factors.AIM To investigate the impact of mental stress on neurotrophic factors in patients with AGA and correlate the findings with the progression of AGA.METHODS A total of 120 patients with AGA were analyzed in this study,which were divided into a non-stress group(n=30)and a stress group(n=90)on the basis of the presence or absence of psychological stress confirmed by Depression Anxiety Stress Scale-21 scale.The baseline demographic characteristics,serum cortisol levels,hair growth parameters,neurotrophic factors,and AGA progression scores between the non-stress and stress groups were compared.Correlation analyses were conducted to assess the relationships among stress,neurotrophic factors,hair loss progression,and AGA progression.RESULTS This study revealed significantly higher cortisol levels throughout the day in the stress group than in the non-stress group.The stress group exhibited lower levels of nerve growth factor,brain-derived neurotrophic factor,and glial cell linederived neurotrophic factor and higher expression levels of neurotrophin(NT)-3 and NT-4 than the non-stress group.Hair parameters indicated lower hair diameter,decreased hair density,and more severe AGA grading in the stress group,whereas follicle count and terminal/vellus hair ratio showed no significant differences between the two groups.After 1 year of treatment with 5%minoxidil,efficacy was observed to be lower but AGA progression was notably more pronounced in the stress group than in the non-stress group.Disease progression was positively correlated with high stress and NT-4 levels.CONCLUSION This study provides compelling evidence of the influence of mental stress on neurotrophic factors and its correlation with the progression of AGA.The findings underscore the need for a comprehensive approach to the management of AGA that considers the physiological and psychosocial aspects.Further research is warranted to validate the findings and explore targeted therapeutic interventions for individuals with stress-related AGA. 展开更多
关键词 Mental stress Neurotrophic factors Androgenetic alopecia PROGRESSION
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Reciprocal Association between Psychological Distress and PTSD and Their Relationship with Pre-Displacement Stressors among Displaced Women
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作者 Erhabor S.Idemudia Babatola D.Olawa +1 位作者 Gail E.Wyatt Norweeta G.Milburn 《International Journal of Mental Health Promotion》 2023年第5期699-710,共12页
It is established in the psychological literature that pre-displacement stressors,PTSD symptoms,and psycholo-gical distress are associated among internally displaced persons.However,existing studies have not demonstra... It is established in the psychological literature that pre-displacement stressors,PTSD symptoms,and psycholo-gical distress are associated among internally displaced persons.However,existing studies have not demonstrated the mechanism underlying these associations.This study compared two explanatory models;one with PTSD symptoms severity explaining the indirect association between pre-displacement stressors and psychological dis-tress,and the other with psychological distress explaining the indirect relationship between pre-displacement stressors and PTSD symptoms severity.In a cross-sectional design,631 women(Mean age=31.18±8.59)were conveniently and purposely selected from the displaced women harboured in two camps in Borno State,Nigeria,due to the Boko-Haram insurgency.Data were collected utilizing structured questionnaires and subjected to path analyses.Results demonstrated that PTSD symptoms severity and psychological distress indirectly explained their respective and independent association with pre-displacement stressors.However,PTSD symptoms had a statis-tically larger standardized indirect effect size,greater indirect effect percentage,and bigger kappa-squared(k2)effect size than psychological distress.PTSD symptoms and psychological distress may have a reciprocal influence on each other from pre-displacement stressors.However,PTSD symptoms can better explain the association between pre-displacement stressors and psychological distress than the other way around.These outcomes have important implications for the psychological treatment of displaced persons. 展开更多
关键词 PTSD symptoms psychological distress traumatic stress internally displaced persons
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Anti-infective therapy durations predict psychological stress and laparoscopic surgery quality in pelvic abscess patients 被引量:3
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作者 Rui-Rui Zhang Lei Zhang Rui-Heng Zhao 《World Journal of Psychiatry》 SCIE 2023年第11期903-911,共9页
BACKGROUND The degree of psychological stress and the difficulty and efficacy of laparoscopic surgery differ in patients with pelvic abscesses after different durations of antiinfection treatment.AIM To compare and an... BACKGROUND The degree of psychological stress and the difficulty and efficacy of laparoscopic surgery differ in patients with pelvic abscesses after different durations of antiinfection treatment.AIM To compare and analyse the effects of different durations of anti-infective therapy on patients’preoperative psychological stress level and the clinical efficacy of laparoscopic surgery in patients with pelvic abscesses to offer a reference for the selection of therapy plans.METHODS A total of 100 patients with pelvic abscesses who were admitted to the Department of Gynecology of Suzhou Ninth Hospital affiliated to Soochow University(Suzhou Ninth People's Hospital)from January 2018 to December 2022 were retrospectively enrolled.According to the different durations of antiinfective therapy,they were divided into Group S(50 patients,received antiinfective therapy for 24-48 h)and Group L(50 patients,received anti-infective therapy for 48-96 h).Baseline data,state-trait anxiety score at admission and before surgery,self-rating anxiety scale(SAS)+self-rating depression scale(SDS)score,surgery time,adhesion grading score,intraoperative blood loss,presence or absence of intraoperative intestinal injury,ureteral injury or bladder injury,postoperative body temperature,length of hospital stay,and presence or absence of recurrence within 3 mo after surgery,chronic pelvic pain,incision infection,dysmenorrhea,menstrual disorder or intestinal obstruction were compared between the S group and the L group.RESULTS There was no significant difference in the background data between the S group and the L group(P<0.05).There was no significant difference in the state-trait anxiety score or SAS+SDS score between the S group and the L group on admission(P<0.05).The state-trait anxiety score and SAS+SDS score of the S group were lower than those of Group L after receiving different durations of anti-infective therapy(P<0.05).There was no significant difference in the incidence of intestinal,ureteral or bladder injury between the S group and the L group(P<0.05).The surgery time of Group S was shorter than that of Group L,and the adhesion score and intraoperative blood loss volume were lower than those of Group L(P<0.05).There was no significant difference in the incidence of incision infection,dysmenorrhea,menstrual disorder or intestinal obstruction between the S group and the L group(P<0.05).The postoperative body temperature of Group S was lower than that of Group L(P<0.05),and the hospital stay was shorter than that of Group L(P<0.05).The incidences of recurrence and chronic pelvic pain within 3 mo after surgery were lower than that of Group L(P<0.05).CONCLUSION Twenty-four to forty-eight hours of anti-infective therapy is better than 48-96 h of anti-infective therapy for patients with pelvic abscesses because the degree of psychological stress is lower,which is more conducive to achieving better outcomes after laparoscopic surgery. 展开更多
关键词 Anti-infective therapy Pelvic abscesses psychological stress Laparoscopic surgery EFFICACY
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Fang-Xia-Dihuang decoction inhibits breast cancer progression induced by psychological stress via down-regulation of PI3K/AKT and JAK2/STAT3 pathways:An in vivo and a network pharmacology assessment 被引量:1
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作者 LINGYAN LV JING ZHAO +5 位作者 XUAN WANG LIUYAN XU YINGYI FAN CHUNHUI WANG HONGQIAO FAN XIAOHUA PEI 《BIOCELL》 SCIE 2023年第9期1977-1994,共18页
Background:The development and prognosis of breast cancer are intricately linked to psychological stress.In addition,depression is the most common psychological comorbidity among breast cancer survivors,and reportedly... Background:The development and prognosis of breast cancer are intricately linked to psychological stress.In addition,depression is the most common psychological comorbidity among breast cancer survivors,and reportedly,Fang-Xia-Dihuang decoction(FXDH)can effectively manage depression in such patients.However,its pharmacological and molecular mechanisms remain obscure.Methods:Public databases were used for obtaining active components and related targets.Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry(UPLC-HRMS).Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways.Molecule docking was used to understand the interactions between main compounds and hub targets.In addition,an animal model of breast cancer combined with depression was established to evaluate the intervention effect of FXDH and verify the pathways screened by network pharmacology.Results:174 active components of FXDH and 163 intersection targets of FXDH,breast cancer,and depression were identified.Quercetin,methyl ferulate,luteolin,ferulaldehyde,wogonin,and diincarvilone were identified as the principal active components of FXDH.Protein–protein interaction and KEGG enrichment analyses revealed that the phosphoinositide-3-kinase–protein kinase B(PI3K/AKT)and Janus kinase/signal transducer and activator of transcription(JAK2/STAT3)signaling pathways played a crucial role in mediating the efficacy of FXDH for inhibiting breast cancer progression induced by depression.In addition,in vivo experiments revealed that FXDH ameliorated depression-like behavior in mice and inhibited excessive tumor growth in mice with breast cancer and depression.FXDH treatment downregulated the expression of epinephrine,PI3K,AKT,STAT3,and JAK2 compared with the control treatment(p<0.05).Molecular docking verified the relationship between the six primary components of FXDH and the three most important targets,including phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha(PIK3CA),AKT,and STAT3.Conclusion:This study provides a scientific basis to support the clinical application of FXDH for improving depression-like behavior and inhibiting breast cancer progression promoted by chronic stress.The therapeutic effects FXDH may be closely related to the PI3K/AKT and JAK2/STAT3 pathways.This finding helps better understand the regulatory mechanisms underlying the efficacy of FXDH. 展开更多
关键词 Fang-Xia-Dihuang decoction Breast cancer psychological stress Depression Network pharmacology PI3K/AKT JAK2/STAT3
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Psychological trauma,posttraumatic stress disorder and traumarelated depression:A mini-review 被引量:1
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作者 Shi-Kai Wang Min Feng +7 位作者 Yu Fang Liang Lv Gui-Lan Sun Sheng-Liang Yang Ping Guo Shan-Fei Cheng Min-Cai Qian Huan-Xin Chen 《World Journal of Psychiatry》 SCIE 2023年第6期331-339,共9页
There are various types of traumatic stimuli,such as catastrophic events like wars,natural calamities like earthquakes,and personal trauma from physical and psychological neglect or abuse and sexual abuse.Traumatic ev... There are various types of traumatic stimuli,such as catastrophic events like wars,natural calamities like earthquakes,and personal trauma from physical and psychological neglect or abuse and sexual abuse.Traumatic events can be divided into type I and type II trauma,and their impacts on individuals depend not only on the severity and duration of the traumas but also on individuals’self-evaluation of the traumatic events.Individual stress reactions to trauma include posttraumatic stress disorder(PTSD),complex PTSD and trauma-related depression.Trauma-related depression is a reactive depression with unclear pathology,and depression occurring due to trauma in the childhood has gained increasing attention,because it has persisted for a long time and does not respond to conventional antidepressants but shows good or partial response to psychotherapy,which is similar to the pattern observed for PTSD.Because trauma-related depression is associated with high risk of suicide and is chronic with a propensity to relapse,it is necessary to explore its pathogenesis and therapeutic strategy. 展开更多
关键词 psychological trauma Trauma-related depression Reactive depression Posttraumatic stress disorder ANTIDEPRESSANT PSYCHOTHERAPY
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Mediating role of physical activity in the relationship between psychological distress and intimate relationships among stroke patients 被引量:1
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作者 Chang-Yue Luo Peng Jiao +2 位作者 Shu-Min Tu Lin Shen Yong-Mei Sun 《World Journal of Psychiatry》 SCIE 2023年第12期1096-1105,共10页
BACKGROUND Stroke patients often experience psychological distress,which can impact their intimate relationships with spouses,subsequently influencing their treatment and recovery.Physical activity is considered a key... BACKGROUND Stroke patients often experience psychological distress,which can impact their intimate relationships with spouses,subsequently influencing their treatment and recovery.Physical activity is considered a key rehabilitation method for stroke patients.This paper aims to analyze whether psychological distress affects intimate relationship between spouses through physical activity.AIM To explore the mediating effect of physical activity between psychological distress and intimate relationship in stroke patients.METHODS A total of 256 stroke patients who underwent treatment at the First People’s Hospital of Shangqiu between July 2021 and July 2022 were enrolled in this study.The participants completed questionnaires,including the Kessler Psychological Distress Scale(K10),the Quality of Relationship Index(QRI),International Physical Activity Questionnaire,and a general information questionnaire.Data analysis were performed using SPSS 23.0.The Harman test was employed to detect common method deviations,and Spearman correlation was used for correlation analysis.The mediating effect was assessed using Process 3.4.1,with significance testing of the regression coefficients conducted using the bias-corrected percentile Bootstrap method(5000 iterations,95%confidence interval).Statistical significance was set at P<0.05.RESULTS The results showed that patients scored an average of 21.61±6.44 points on the K10,32.40±6.19 points on the QRI;the median physical activity level according to the International Physical Activity Questionnaire was 1861(566,2846)MET·min/w.The level of physical activity(the physical activity intensity of the patients reflected by the Interna-tional Physical Activity Questionnaire-Long Form scale)negatively correlated with psychological distress and intimacy(P<0.05),and positively correlated with each other(P<0.05),with the correlation stronger at lower physical activity levels compared to higher ones.The mediating effect of physical activity between psychological distress and intimate relationship was calculated to be 40.23%.Bootstrap analysis further validated the results.The mediating effect of psychological distress on intimate relationships through physical activity level was-0.284,with a confidence interval of-0.409 to-0.163,excluding 0,confirming a significant mediating effect of psychological distress on intimate relationships.CONCLUSION Physical activity significantly affects relationship between psychological distress and intimate relationships among stroke patients.Addressing the role of physical activity may have implications for improving patient outcomes and rehabilitation strategies. 展开更多
关键词 STROKE Cross-sectional study psychological distress Intimate relationship Mediating effect Physical activity level
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Who Is More Vulnerable?The Age-Period-Cohort Effect of Psychological Distress among Urban Residents in China
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作者 Wenbin Wang Yang Cao 《International Journal of Mental Health Promotion》 2023年第10期1127-1136,共10页
How does psychological distress evolve over time?This study utilizes cross-sectional data from the China General Social Survey from 2010 to 2017 to explore the differences in psychological distress among Chinese resid... How does psychological distress evolve over time?This study utilizes cross-sectional data from the China General Social Survey from 2010 to 2017 to explore the differences in psychological distress among Chinese residents at various ages,periods,and cohorts.The dummy variable method and random effects hierarchical age-period-cohort model were employed to isolate the age,period,and cohort effects that impacted the psychological distress of Chinese urban residents.First,in terms of the age effect,the psychological distress experienced by residents tends to increase initially and then decrease with age.Middle-aged individuals,around 40 years old,often face a particularly severe form of psychological distress known as the“midlife crisis.”Additionally,middle-aged people who have larger families may experience more significant psychological distress due to increased family burdens.Second,in terms of the period effect,the psychological distress experienced by residents has been on the rise due to the continued development of society.Those who are at a disadvantage in market competition and work longer hours may be particularly vulnerable to increased psychological distress.Thirdly,the cohort effect refers to the different social behaviors and attitudes exhibited by individuals of different generations.In terms of this effect,psychological distress initially decreased and then increased among those born between 1945 and 1990.Individuals born in the 1980s and 1990s experienced higher levels of psychological distress,with internet use having a greater negative impact.Additionally,the positive effect of income on their psychological distress was reduced.The psychological distress of Chinese urban residents is affected by a variety of time-related factors,which are closely related to Chinese clan culture,market competition and social changes.The heavy family burden imposed by traditional clan culture,the different working conditions created by market competition,and the emergence of new lifestyles,such as internet use during social changes,have led to diverse psychological distress experiences among residents across different ages,time periods,and cohorts.In the future,longitudinal studies are needed to strengthen the robustness of the conclusions and consider the long-term impact of the COVID-19 pandemic.Mental health support should pay specific attention to the psychological distress of middle-aged individuals,long-time workers,and internet users. 展开更多
关键词 psychological distress age effect period effect cohort effect
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Identify Psychological Distress among Cancer Patients: A Study at Kilimanjaro Christian Medical Center (KCMC) in Moshi Municipality, Kilimanjaro Tanzania
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作者 Godfrey Livingstone Mbowe Simion Ambakisye Dorothy Lubawa 《Open Journal of Medical Psychology》 2023年第4期173-191,共19页
Introduction: The major objective of this study was to identify the Psychological Distress among Cancer Patients at KCMC in Moshi Municipality, Kilimanjaro Tanzania. The specific objectives were to identify the psycho... Introduction: The major objective of this study was to identify the Psychological Distress among Cancer Patients at KCMC in Moshi Municipality, Kilimanjaro Tanzania. The specific objectives were to identify the psychological distress among cancer patients at KCMC, and to explore relationship between demographic characteristics of cancer patients and psychological distress. Methodology: The study used a sample of 175 respondents. The study was cross-sectional design, a quantitative approach. The data gathered for the study were analyzed using quantitative data analyzing software SPSS version 20 and were visually presented using descriptive statistics such as frequency distribution of tables, and figures. Result: The findings of the study showed that majority of the respondents (cancer patients) 105 (60.0%) were experiencing psychological distress among the cancer patients. The cancer patients who are divorced and widow them experience anxiety (p-value 0.01) significant. Those who were low in education were significantly affected with (p-value 0.03) anxiety and (p-value 0.01) depression. The variable in economic;the less satisfaction were significantly (p-value 0.01) were experience adjustment disorder. Conclusion and Recommendation: The study recommends that it is important to involve psychologists in the treatment team among the cancer patients to address psychological distresses they experience. Also Oncology Department should develop interest of doing research on psychological distress management because study showed 60% cancer patients suffer with psychological distress. . 展开更多
关键词 CANCER psychological Distress
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Research on the Intervention of Internet+ Health Education Model on Hemodialysis Patients with Psychological Distress
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作者 Youlan Gong Xi Chen +6 位作者 Lei Ran Hang Chen Li Guo Yanmei Liu Jianmin Zhang Dan Liu Jing Li 《Journal of Clinical and Nursing Research》 2023年第4期105-109,共5页
Objective:To observe the status quo of patients’psychological distress,and to explore the effect of Internet+health education model(IHEM)on patients who experienced psychological distress during their first hemodialy... Objective:To observe the status quo of patients’psychological distress,and to explore the effect of Internet+health education model(IHEM)on patients who experienced psychological distress during their first hemodialysis treatment,with the goal of reducing their psychological distress and improving their quality of life.Methods:IHEM was conducted on 120 first-time hemodialysis patients for 3 months while a distress thermometer and a list of questionnaires were used to screen patients and provide corresponding psychological intervention.The incidence rate of psychological distress was analyzed statistically to explore the difference in psychological distress at various periods.Results:The incidence rate(score≥4)of psychological distress in first-time hemodialysis patients was 46.67%,and their distress was mainly rooted in physical,emotional,practical problems(economy,time,and energy),etc.Through IHEM,the psychological distress scores of the patients decreased to 3.29±1.02 at one month after their discharge,and the incidence rate was 32.14%;the psychological distress scores of the patients were 2.29±1.02 at 3 months after their discharge,and the incidence rate was 21.14%.The difference before and after the intervention was statistically significant(P<0.05).Conclusion:A psychological distress thermometer can timely detect the degree and causes of psychological distress among first-time hemodialysis patients,and the use of IHEM may significantly alleviate the psychological distress among hemodialysis patients. 展开更多
关键词 Internet+health education model psychological distress thermometer HEMODIALYSIS
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Resolving Specific Psychological Stressors Can Instantly Reduce or Relieve Chronic Neck Pain and Upper Back Pain: Case Reports
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作者 Brandy Gillmore Gaetan Chevalier Stefan Kasian 《Health》 2023年第10期1116-1149,共34页
Introduction: The goal of this study was to use a novel approach to pain relief which includes a participant using their mind to reduce or relieve their neck pain in a matter of minutes and taking continuous thermal m... Introduction: The goal of this study was to use a novel approach to pain relief which includes a participant using their mind to reduce or relieve their neck pain in a matter of minutes and taking continuous thermal medical imaging scans during the process to capture any concurrent temperature changes at the location of the self-reported pain. Previous studies using multidisciplinary approaches have shown that it is possible for a person to achieve a moderate reduction in pain over a period of time (typically two or more months). However, in this innovative study, the goal was to demonstrate rapid pain relief (in a matter of minutes) using only the mind. Case report: For this study, six subjects were selected, all of whom were experiencing long-term chronic neck pain. The subjects consisted of five adult females and one adult male. Several of the subjects also had pain that radiated into their upper back region. Each subject participated in one talk therapy session during which the subject’s neck was actively scanned by a thermal imaging (TI) camera that was programmed to take a new thermal image every thirty (30) seconds. The goal of the talk therapy session was to create a strong emotional shift by encouraging the subject to let go of negative emotions and replace buried painful feelings with feelings of positive expectation and optimism. Then, as the subject created this emotional shift, the goal was to observe if this change affected the subject’s self-reported physical pain, as well as noting any visible effects in thermal images. Results: All six subjects reported that they were able to relieve some or all of their pain by the end of the talk therapy session. As they did, there was simultaneously a significant decrease in temperature recorded on the TI images in the corresponding location in their neck and upper back region. This suggested that the pain relief the subjects reported was not merely “mind over matter”, since there were marked physiological changes taking place. Discussion and Conclusion: It’s worth noting that three of the subjects had moments during their talk therapy session where they thought about a specific painful memory that increased their negative emotions. At that moment, their self-reported pain also increased, and simultaneously, the infrared camera detected an increase in temperature in the corresponding location where the subjects reported increased pain. Subsequently, when the subjects were able to change the painful memory and once again move towards feelings of optimism, they reported pain relief, and simultaneously, the TI camera reported a decrease in temperature. Neither this potential outcome nor any other potential outcome was discussed with the subjects before or during the session. This research shows that talk therapy may be used as a new therapeutic option for people not only with neck pain, but possibly other types of pain, and that under certain circumstances, the results can be rapid. 展开更多
关键词 Neck Pain stress Chronic Pain Cervicalgia THERMOGRAPHY Thermal Imaging Infrared Imaging
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Evaluation of Postoperative Psychological Distress and Its Driving Factors in Patients with Oral and Maxillofacial Malignant Tumors
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作者 Yanqing Feng Fengqiao Lin Mengjun Huang 《Proceedings of Anticancer Research》 2023年第6期78-83,共6页
Objective:To explore and analyze the evaluation and driving factors of postoperative psychological pain inpatients with oral and maxillofacial malignant tumors.Methods:Relevant data were collected from 80 patients wit... Objective:To explore and analyze the evaluation and driving factors of postoperative psychological pain inpatients with oral and maxillofacial malignant tumors.Methods:Relevant data were collected from 80 patients with oral and maxillofacial malignant tumors who attended the outpatient clinic for follow-up consultations between May 2021 to May 2023.The patients used the psychological distress thermometer(DT)to circle words that best described their experiences in the past week,assigning a numerical value(0-10)to indicate their pain level on each day.The scoring results were employed to assess the psychological pain in these patients.A self-developed patient basic information questionnaire was utilized to record demographic details.Logistic regression analysis was employed to evaluate patients two weeks after surgery,focusing on the assessment of psychological distress and the identification and location of driving factors.Results:Following evaluation,the results revealed that the average postoperative DT score for the 80 patients with oral and maxillofacial malignant tumors was 4.53±1.98 points.Scores<4 points indicated no psychological pain(Group N)in 48 cases,while scores≥4 points indicated psychological pain(Group Y)in 32 cases.The differences in postoperative DT scores among patients with varying educational levels,fears and worries about disease progression,economic problems,sleep problems,level of hope,and oral pain were statistically significant(P<0.05).Multiple linear regression analysis results indicated that education level,fear and worry about disease progression,economic problems,sleep problems,level of hope,and oral pain are driving factors of postoperative psychological pain in patients with oral and maxillofacial malignant tumors(P<0.05).Conclusion:The postoperative psychological pain level in patients with oral and maxillofacial malignant tumors is at a moderate level.Educational level,fear and worry about disease progression,economic problems,sleep problems,level of hope,and oral pain were identified as driving factors for postoperative psychological pain in these patients. 展开更多
关键词 Oral and maxillofacial malignant tumors psychological pain Driving factors Regression analysis
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Psychological Stress and Nursing Intervention of Sick Children
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作者 Yiying Chen Feiyan Li 《International Journal of Clinical Medicine》 2021年第5期202-210,共9页
Holistic nursing is guided by modern nursing concept and framed by nursing procedures, providing high quality nursing according to patients’ psychological, physiological, social and cultural needs. To develop holisti... Holistic nursing is guided by modern nursing concept and framed by nursing procedures, providing high quality nursing according to patients’ psychological, physiological, social and cultural needs. To develop holistic nursing in pediatrics is to develop nursing services for the purpose of satisfying the various clinical needs and psychological nursing of children. It is of great significance to establish holistic nursing concept, provide high quality nursing service for hospitalized children, and take targeted psychological intervention to alleviate their adverse psychological stress, which can improve treatment compliance and clinical efficacy, and shorten the length of hospital stay. In this paper, scientific and effective psychological nursing stress intervention means are used to improve the psychological anti-stress level of hospitalized children, and nursing intervention means are put forward, contribute to the maintenance of children’s mental health and the development of children’s mental health work and also to provide a theoretical basis for the intervention and treatment of children with psychological stress. 展开更多
关键词 Sick Children psychological stress NURSING psychological Intervention
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