Biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke

AIM To investigate the specific biomarkers and potential pathogenesis of colorectal cancer-related ischemic stroke(CRCIS).METHODS A retrospective study was conducted on CRCIS patients(colorectal cancer patients with ischemic stroke without conventional stroke risk factors) registered at seven centers between January 2007 and December 2017. Clinical data and laboratory and imaging findings were compared with age-and sex-matched patients with colorectal cancer(CRC) without ischemic stroke that were admitted to the same hospital during the same period. Univariate and multivariate analyses were performed to analyze the independent risk factors for CRCIS. A receiver operator characteristic curve was configured to calculate the optimal cut-off value of the products of the independent risk factors for CRCIS. RESULTS A total of 114 CRCIS patients and 114 CRC patients were included. Multiple lesions in multiple vascular territories were common in CRCIS patients(71, 62.28%). The levels of plasma D-dimer, carcinoembryonic antigen(CEA), cancer antigen 125, and neutrophil count were significantly higher in CRCIS patients than in CRC patients. Multiple logistic regression analysis revealed that plasma D-dimer levels [odds ratio(OR) = 1.002, 95% confidence interval(CI): 1.001-1.003, P < 0.001], CEA levels(OR = 1.011, 95%CI: 1.006-1.015, P < 0.001), and neutrophil count levels(OR = 1.626, 95%CI: 1.268-2.087, P < 0.001) were independent risk factors for CRCIS. In addition, receiver operator characteristic curve revealed that the area under curve for the products of plasma D-dimer, CEA, and neutrophil count was 0.889 ± 0.022(95%CI: 0.847-0.932, P < 0.001), and the optimal cut-off value for the product was 252.06, which was called the CRCIS Index, with a sensitivity of 86.0% and specificity of 79.8%.CONCLUSION Hypercoagulability induced by elevated CEA and neutrophils may be an important cause of CRCIS. The CRCIS index, which serves as a biomarker of CRCIS, needs further study.

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke.As a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from researchers.This article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling pathway.The key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic stroke.Future investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

TCM diagnosis and treatment theory of chronic complete occlusion of coronary artery based on etiology and pathogenesis

Chronic total occlusive disease of the coronary artery belongs to the category of"chest palsy"and"true heart pain"in traditional Chinese medicine.Its etiology has two aspects:deficiency of blood,blood stasis,qi stagnation,and phlegm.Failure can be caused by deficiency or disease.The pathogenesis of this disease is caused by obstruction of the heart pulse,and its pathogenesis can be transformed into each other.The theory of traditional Chinese medicine believes that the general rule is not painful.Therefore,the treatment of coronary CTO lesions should be based on the combination of Tong and Tong tonic.The chronic complete occlusive disease of the coronary artery can be treated through Xuanbi Tongyang,Huoxue Tongluo,and Aroma Wentong.Based on the Chinese medicine's understanding of the etiology and pathogenesis of coronary CTO lesions,it provides a basis for the diagnosis and treatment of traditional Chinese medicine,solves the problems of interventional medicine in western medicine,and gives play to the unique advantages of traditional Chinese medicine for clinical diagnosis and treatment.

Mechanism of sex hormone level in biological clock disorder induced acne and analysis of TCM Pathogenesis

Acne vulgaris is a common chronic inflammatory disease of pilosebaceous units. And sex hormone level disorder has became a hot research topic in the pathogenesis of acne. Studies show that the biological clock disorder can result in the disorder of sex hormone levels which causes or aggravates acne. Biological clock disorder coincides naturally with "sleep rhythm disorder" in Traditional Chinese Medicine(TCM). In this paper, we will discuss the modern medical mechanism of the biological clock disorder resulting in acne from the angle of sex hormones, and analyze the TCM pathogenesis of the disease caused by the disorder of the biological clock.

Zhang Xijian, a famous Chinese medicine practitioner in China, discusses the pathogenesis characteristics of adolescent central obesity based on "qi change theory"

Obesity[1]is a group of common and ancient metabolic diseases.Central obesity is common in clinical practice.Due to the simple constitution of adolescents,their pathogenesis is simple and changeable,or there is a mixture of cold and heat,or a mixture of cold and heat,or the same disease on the surface,and the pathogenesis of traditional Chinese medicine is complex and changeable.The pathogenesis of TCM pathogenesis of adolescent central obesity is analyzed with examples to provide new theoretical ideas for the treatment of obesity by Chinese medicine.

代谢综合征与缺血性脑卒中

脑卒中是全球第二大致死病因和致残的主要原因,其中缺血性脑卒中是最常见的脑卒中类型。随着人口老龄化程度不断加深以及生活方式的影响,缺血性脑卒中的发病率逐年上升。缺血性脑卒中是多种病因及危险因素综合作用的结果,近年来,越来越多的研究表明代谢综合征与缺血性脑卒中有相关性。本文就代谢综合征与缺血性脑卒中的关系作一综述。

调气舒脉指导建立全生命周期、中风全流程防治护康体系构想

对全生命周期、中风全流程病机进行理论阐述,在此基础上提出以调气舒脉为总原则,建立针对个体、立足全生命周期、中风全流程的预防、治疗、护理、康复技术体系构思。脏腑损伤,气机失调,营卫失常,血脉病变,损脑伤神构成中风发病的基本病机环节,其关键是气病损脉,脉损及脑,脑脉俱损,髓毁神伤。由此构成中风发病前、中、后三个不同阶段病机焦点,而气机失调、血脉病变贯穿中风全流程。提出以调气舒脉为总原则,针对病前、病中、病后病机链不同阶段,分别实施调气护脉保健康、防中风,调气通脉救脑髓、护神机,调气复脉益神机、促康复、防复发。基于全生命周期与中风全流程的防控理念,将调气护脉、调气通脉、调气复脉理念与技术融合,构成“调气舒脉”的总原则与技术体系。

联合指标对缺血性卒中中医辨证分型的诊断价值评价

目的探究联合指标对缺血性卒中不同证型的诊断价值,为西医及基层医生对于缺血性卒中中医辨证分型提供客观依据。方法以2021年8月至2022年4月收集到的589名缺血性卒中患者为研究对象,参照相关标准将其分为风痰上扰证、肝阳暴亢证、气虚血瘀证、阴虚风动证、痰热内闭清窍证、痰湿蒙塞清窍证6种证型,利用工作者特征(ROC)曲线分析疾病史、血清指标等对不同证型诊断的价值。结果UA、高血压、饮酒联合诊断风痰上扰诊断价值较高,AUC为0.865(95%CI:0.800~0.929),灵敏度100%,特异度66.6%;UA、心率、PLT、失眠、高血压联合诊断肝阳暴亢诊断价值较高,AUC为0.734(95%CI:0.674~0.774),灵敏度81.7%,特异度58.3%;UA、PLT、(离)退休联合诊断痰热内闭清窍诊断价值较高,AUC为0.587(95%CI:0.529~0.645),灵敏度94.1%,特异度22.6%;心率、RBC、(离)退休、高血压联合诊断气虚血瘀诊断价值较高,AUC为0.700(95%CI:0.656~0.745),灵敏度57.2%,特异度75.9%;UA、PLT、高血压、失眠、饮酒、颈内动脉斑块、糖尿病联合诊断阴虚风动诊断价值较高,AUC为0.893(95%CI:0.853~0.933),灵敏度89.3%,特异度80.0%;UA、高血压联合诊断痰湿蒙塞清窍诊断价值较高,AUC为0.622(95%CI:0.538~0.705),灵敏度71.7%,特异度51.2%。结论UA、高血压贯穿疾病始终,联合指标对缺血性卒中不同证型诊断价值不同,可作为辨证分型的参考。

中医药调节炎症反应治疗缺血性脑卒中研究进展

中医治疗缺血性脑卒中疗效显著、成本低廉、方便简洁、方式多样,然其成分、作用靶点、作用机制复杂,较多研究者对中医药调节炎症反应治疗缺血性脑卒中展开研究。本文通过文献梳理,分别从临床研究和实验研究2个方面综述中医调节炎症反应相关机制治疗缺血性脑卒中的研究进展,为该病的临床诊疗提供参考。

中医康复护理在脑卒中病人中的应用研究进展

综述中医康复护理在我国脑卒中病人中的应用现状,包括国内外研究现况、病因病机、中医护理论治理念、适宜技术应用、情志饮食,以期为脑卒中病人的康复护理提供参考依据。指出为满足脑卒中病人对康复护理的需求,促进中医康复护理在脑卒中病人治疗和预后康复领域的应用,需要不断加强中医康复护理人员的专业化素养培育及核心中医适宜护理技术掌握等。

阴阳平衡针法联合血府逐瘀汤加减治疗卒中后痉挛性偏瘫患者的效果

目的:观察阴阳平衡针法联合血府逐瘀汤加减治疗卒中后痉挛性偏瘫患者的效果。方法:选取2021—2023年该院收治的100例卒中后痉挛性偏瘫患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各50例。对照组给予血府逐瘀汤加减治疗,研究组在对照组基础上联合阴阳平衡针法治疗。比较两组临床疗效,治疗前后中医证候积分、肢体功能[Fugl-Meyer评测法(FMA)]评分和日常生活能力[日常生活能力量表(ADL)]评分,以及不良反应发生率。结果:研究组治疗总有效率为98.00%(49/50),高于对照组的84.00%(42/50),差异有统计学意义(P<0.05);治疗后,两组中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组上肢功能、下肢功能等各项FMA和ADL评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阴阳平衡针法联合血府逐瘀汤加减治疗卒中后痉挛性偏瘫患者可提高临床疗效,降低中医证候积分,提高肢体功能和日常生活能力,效果优于单纯血府逐瘀汤加减治疗。

Poststroke DNA immunization against neurite growth inhibitors is beneficial to the recovery from local cerebral ischemia in rats

BACKGROUND： Inhibitory signals, i.e. neurite growth inhibitors （NGIs）, presenting on central nervous system （CNS） myelin have been shown to play a crucial role in inhibiting lesioned axonal sprouting and leading to less functional recovery. Vaccines targeting NGIs may provide multifactorial protection against brain insults by overcoming the inhibitory effects of these NGIs and boosting the body＇s immune repair mechanisms. OBJECTIVE： To evaluate the effect of poststroke DNA immunization against NGIs on the rehabilitation for sensorimotor function of rat models of local cerebral ischemia. DESIGN： Completely randomized grouping design, and controlled experiment. SETTING： Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore. MATERIALS： Sixty adult male Sprague-Dawley rats ranging in age from 45 to 120 days and in weight from 180 to 250 grams were provided by Animal Center of Department of Anatomy, Faculty of Medicine, National University of Singapore. pcDNA3.1（＋）-neurite growth inhibitors （pcDNA-NGIs） a gift was provided by Dr. Xiao from Department of Clinical Research, Singapore General Hospital, Singapore. METHODS： The experiment was carried out at Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore from August 2003 to April 2005. （1）The involved rats were randomized into 3 groups： pcDNA-NGIs group （group A）, pcDNA3.1 （＋） group （group B） and model group （group C）, with 20 rats in each group. Left focal cerebral ischemia （FCI） was permanently induced through middle cerebral artery occlusion （MCAO） with the assistance of an operating microscope. Successful MCAO was determined by a 20% decrease to baseline in the ipsilateral cerebral blood flow. 100 μg of pcDNA-NGIs eluted in phosphate-buffered saline （PBS） was intramuscularly injected into the tibial muscle once a week after MCAO for 6 weeks in group A. As control, pcDNA3.1 （＋） was also administrated in the same way in group B and nothing was administrated in group C. （2） The modified neurological severity score （mNSS）, a composite of motor, sensory, reflex and balance tests, was used to test the sensorimotor deficit. The mNSS was graded on a scale of 0 - 18, i.e. normal score was 0, maximal deficit score was 18, and 1 point was warded for the inability to perform the tasks or the lack of a tested reflex. （3） The newly generated axons of corticorubral projection were traced by stereotaxic guided injection of 100 g/L biotinylated dextran amine. Rats were sacrificed two weeks after tracing, and cryostat coronal sections of midbrains （30μm） were reacted to BDA according to the manufacturer＇s instruction by the free-floating method. Images were captured on a DM RXA2 LEICA Microscope with a Spot Digital Camera system （Germany）, and the numbers of labeled axons on the denervated side in four standard coronal sections including the red nucleus were manually quantified. MAIN OUTCOME MEASURES： （1） The number of newly generated axons of corticorubral projection. （2）The improvement in sensorimotor deficit. RESULTS： All the involved 60 rats entered the stage of final analysis. （1） The number of newly generated axons of corticorubral projection of rats： Only ipsilateral axons of CRP were noted with little evidence of fibers crossing to the contralateral red nucleus in rats of groups B and C. More BDA-positive fibers crossing the midline and terminating in the contralateral red nucleus in appropriate target areas mirroring the non-differentiated red nucleus were found in rats of group A. Quantitative analysis showed that BDA-labeled axons in the denervated side of rats in group A were more than those in group B （P 〈 0.05）. （2） Improvement in sensorimotor deficit of rats： At 2 weeks after immunization, significant improvement in sensorimotor deficit was found in rats of group A. There were significant differences of improvement in sensorimotor deficit of rats between group A and group B or group C at 12 and 14 weeks after immunization （P 〈 0.05）. CONCLUSION： （1） Poststroke DNA immunization against NGIs leads to increased sensorimotor recovery following FCI and compensatory newly growth of axons from corticorubral projection.

Research on knowledge reasoning of TCM based on knowledge graphs

With the widespread use of Internet,the amount of data in the field of traditional Chinese medicine(TCM)is growing exponentially.Consequently,there is much attention on the collection of useful knowledge as well as its effective organization and expression.Knowledge graphs have thus emerged,and knowledge reasoning based on this tool has become one of the hot spots of research.This paper first presents a brief introduction to the development of knowledge graphs and knowledge reasoning,and explores the significance of knowledge reasoning.Secondly,the mainstream knowledge reasoning methods,including knowledge reasoning based on traditional rules,knowledge reasoning based on distributed feature representation,and knowledge reasoning based on neural networks are introduced.Then,using stroke as an example,the knowledge reasoning methods are expounded,the principles and characteristics of commonly used knowledge reasoning methods are summarized,and the research and applications of knowledge reasoning techniques in TCM in recent years are sorted out.Finally,we summarize the problems faced in the development of knowledge reasoning in TCM,and put forward the importance of constructing a knowledge reasoning model suitable for the field of TCM.

Rules and Characteristics of TCM Treatment Prescriptions for Patients with Decreased Ovarian Reserve

[Objectives]To analyze the characteristics and rules of traditional Chinese medicine(TCM)in the treatment of decreased ovarian reserve(DOR)in Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine.[Methods]A total of 107 patients with DOR in Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine were selected for sorting,and the usage,classification,nature,taste and meridian homing of the used drugs were statistically analyzed.[Results]A total of 107 patients were included in this stud and a total of 189 flavors of TCM are used.The total frequency of drugs was 4345 times,and a total of 535 prescriptions were issued.The top five frequency of drug use were 2261 times(50.04%)of Paeoniae Radix Alba(Cynanchum otophyllum Schneid.),2037 times(46.88%)of Corni Fructus(Cornus officinalis Sieb.et Zucc.),1818 times(41.84%)of Rehmanniae Radix Praeparata[Rehmannia glutinosa(Gaertn.)Libosch EX Fisch.et Mey.],1610 times(37.05%)of Guiban[Chinemys reevesii(Gray)],and 1303 times(29.99%)of Uncariae Ramulus Cum Uncis(Uncariar hynchophylla Miq.ex Havil.).Kidney deficiency syndrome accounted for the largest proportion at 51.40%,and the use frequency of tonic drugs accounted for the highest at 50.64%;heat-clearing drugs and qi and blood-boosting drugs separately accounted for 19.24%and 17.39%;the top 3 medicinal tastes are sweet(52.02%),pungent(20.71%)and bitter(20.32%);medicinal properties are ranked as warm(60.54%),cold(24.16%),hot(8.72%)and cool(6.49%);the main meridians are spleen,lung,liver,stomach and kidney.[Conclusions]The basic pathogenesis of DOR is deficiency of qi and blood,mainly due to dysfunction of the spleen,lung,liver,liver,stomach and other organs,and kidney deficiency and spleen deficiency are more common.

SNAPC3 gene rs12093 polymorphism is significantly associated with ischemic stroke wind syndrome

Objective:To investigate whether The small nuclear RNA activating complex polypeptide 3(SNAPC3)gene rs12093 polymorphism is associated with ischemic stroke(IS)and Traditional Chinese Medicine(TCM)syndromes of IS.Methods:This study enrolled 774 patients with ischemic stroke(IS)and 793 normal controls.Massarray technology was used for genotyping.And genetic association analysis was estimated by PLINK program.Results:①SNAPC3 gene rs12093 polymorphism was significantly associated with the risk of ischemic stroke wind syndrome of IS[OR=0.76,95%CI(0.58-0.99),P=0.047 in dominant model)].②After adjusting age and gender,SNAPC3 gene rs12093 polymorphism and the score of ischemic stroke wind syndrome(Padj=0.037 in additive model;Padj=0.009 in recessive model),the correlation is statistically significant.③After adjusting age and gender,platelet(PLT)(Padj=0.024 in addiction model;Padj=0.039 in dominant model)and thrombin time(TT)(Padj=0.042 in dominant model)were significantly associated with rs12093 polymorphism in patients with ischemic stroke wind syndrome.Conclusion:SNAPC3 gene rs12093 polymorphism may affect the occurrence of ischemic stroke wind syndrome.

脑卒中后睡眠障碍的发病机制及康复治疗

脑卒中后睡眠障碍分为睡眠呼吸障碍(SDB)、失眠、日间嗜睡(EDS)与不宁腿综合征(RLS),对脑卒中患者认知、运动等功能预后及生活质量影响较大,应尽早针对脑卒中患者的睡眠障碍开展康复治疗。本研究对脑卒中后睡眠障碍的发病机制与康复治疗研究现状进行综述,其中脑卒中后睡眠障碍发病机制研究主要包括脑卒中后SDB[阻塞性睡眠呼吸暂停综合征(OSAS)、中枢性睡眠呼吸暂停综合征(CSAS)与混合型睡眠呼吸暂停综合征(MSAS)]发病机制;脑卒中后失眠发病机制;脑卒中后EDS发病机制;脑卒中后RLS发病机制。脑卒中后睡眠障碍康复治疗主要包括脑卒中后SDB康复治疗[持续气道正压通气(CPAP)、体位治疗、口咽肌训练];脑卒中后失眠康复治疗[认知行为疗法(CBT)、针刺疗法、无创性经颅神经调控技术(低频重复经颅磁刺激和经颅直流电刺激)和光照疗法];脑卒中后EDS康复治疗(CPAP和光照疗法);脑卒中后RLS康复治疗(针刺)。但脑卒中后睡眠障碍的发病机制尚未完全明确,其基础研究仍处于表型确定阶段;康复治疗仍存在治疗依从性、安全性、精准度等方面的问题,且脑卒中后EDS和RLS的康复研究较少。下一步研究需要探索适合脑卒中后睡眠障碍研究的实验动物模型,为开展基础性研究提供支撑;同时,开展更多高质量、大样本、多中心的临床随机对照试验,为脑卒中后睡眠障碍的康复治疗提供参考。

Pharmaceutical Rules of Traditional Chinese Medicine For Stroke Based on Dictionary of Prescriptions and Complex Network Analysis

Objective:Taking the Dictionary of Prescriptions as a clue,we collected effective prescriptions for treating Stroke,and systematically summarized the medication and compatibility rules of the core Chinese medicines for treating Stroke.Methods:A database of prescriptions for stroke based on complex relationship analysis system of traditional Chinese medicine was established.From the point of view of complex network,the hierarchy of drug compatibility rules of compound prescriptions(such as courtiers and envoys)was analyzed,the statistical characteristics of complex networks were analyzed,and an attempt was made to explain the characteristics of complex networks of drugs for stroke.Results:A total of 974 prescriptions were collected,including 1040 Chinese herbs.The core Chinese herbal medicines with nodal degree(>500)for Stroke were divaricate saposhnikovia root,liquorice root,Chinese angelica,tall gastrodia tuber,incised notopterygium rhizome and root.The compatibility relationship of the core Chinese medicines in the treatment of stroke is divaricate saposhnikovia root-liquorice root,ephedra-divaricate saposhnikovia root,divaricate saposhnikovia root-sichuan lovage rhizome,divaricate saposhnikovia root-Chinese angelica in order of frequency.Conclusion:Through the analysis of the common network structure of effective prescriptions for Stroke,the core prescription compatibility structure reflecting the prescription thinking and clinical characteristics was found.

隐性听力损失中医病机及防治研究进展

隐性听力损失是以纯音听阈正常,噪声背景下言语识别能力降低为主要症状的疾病,噪声暴露、药物损伤、年龄老化是主要的致病危险因素,其发病隐匿,容易忽视,危险因素持续暴露可造成不可逆听力损伤,目前临床多无有效的治疗方法,以早期预防为主。根据隐性听力损失的致病因素及发病机制,探讨隐性听力损失的中医病机,认为脾虚湿滞、清窍蒙蔽、肾元不足、邪聚耳窍为致病的内在因素,毒邪犯耳、内毒留滞、毒瘀经络为病理机制,并对近年来隐性听力损失的预防与治疗研究概况做一总结,为中医药治疗隐性听力损失研究提供理论依据和临床经验。

Construction of an Early Warning Model for Ischemic Stroke Recurrence Based on Generalized Estimating Equation

Objective:To explore the appropriate modeling method of the early warning model of ischemic stroke recurrence in TCM.Methods:This was a prospective,multi-center and registered study conducted in 7 clinical subcenters from 8 provinces and 10 cities in China between 3rd November 2016 and 27th April,2019.1,741 patients with first-ever ischemic stroke were recruited.Univariate analysis was carried out using distance correlation coefficient,mutual information entropy,and statistical correlation test.Multivariate analysis adopted multi-factor Cox regression model and combined with expert opinions in the field of stroke to determine modeling variables.The generalized estimating equation of longitudinal data and the Cox proportional hazard regression model of cross-sectional data were used to construct and compare in the early warning model of ischemic stroke recalls.The area under the ROC curve(AUC value)was used to evaluate the early warning capability of the model.Results:The follow-up time was 1-3 years,and the median follow-up time was 1.42 years(95%CI:1.37-1.47).Recurrence events occurred in 175 cases,and the cumulative recurrence rate was 10.05%(95%CI:8.64%-11.47%).The AUC values of the TCM syndrome and TCM constitution model were 0.71809 and 0.72668 based on the generalized estimating equation and the AUC values.Conclusion:The generalized estimating equation may be more suitable for the construction of early warning models of stroke recurrence with TCM characteristics,which provides a certain reference for the evaluation of secondary prevention of ischemic stroke.

国医大师周仲瑛融贯古今创建病机理论新体系学术思想述要

概述了国医大师周仲瑛教授以创建中医病机理论新体系为核心学术思想的探索历程、学术意义,对其理论内涵进行解读。作为中医高等教育教材建设的开拓者,周仲瑛教授创建了中医内科脏腑辨证纲要,坚持不懈开展病机理论创新研究,取得丰硕的学术成果,充实、发展了中医理论学术体系。在对外感热病和内伤急难症临床诊疗过程中,系统创建了瘀热论、癌毒论等病机新理论,据此立法用药能够提高临床疗效,感悟出辨识病机是辨证论治的关键环节。周仲瑛教授晚年以整体观为指引,提出“病机十三条”,构建了中医病机辨证新体系,突出复合病机、病机要素因果链对临床复杂性病证的指导价值,形成以“审证求机,活化辨证”思想为灵魂的理论。该理论突破了从单一病机或固定证型辨证论治的僵化思维,以整体观思想重构了中医理论框架,是现代中医学的一次重大学术创新。