Clk/STY is a LAMMER protein kinase capable to phosphorylate serine/arginine-rich (SR) proteins that modulate pre-mRNA splicing. Clk/STY alternative splicing generates transcripts encoding a full-length kinase and a tr...Clk/STY is a LAMMER protein kinase capable to phosphorylate serine/arginine-rich (SR) proteins that modulate pre-mRNA splicing. Clk/STY alternative splicing generates transcripts encoding a full-length kinase and a truncated catalyti-cally inactive protein. Here we showed that clk/STY, as well as other members of the family (e.g. clk2, clk3 and clk4),are up-regulated during HMBA-induced erythroleukemia cell differentiation. mRNAs coding for the full-length and thetruncated forms were responsible for the overall increased expression. In clk/STY, however, a switch was observed forthe ratio of the two alternative spliced products. In undifferentiated cells the full-length transcript was more abundantwhereas the transcript encoding for the truncated form predominated at latter stages of differentiation. Surprisingly,overexpression of clk/STY did not alter the splicing switch upon differentiation in MEL cells. These results suggest thatclk/STY might contribute to control erythroid differentiation by a mechanism that implicates a balance between thesetwo isoforms.展开更多
Envisaged as a sort of‘international house of skewers’,STYX is a charismatic little restau・rant inside Yong Ping Li,a redeveloped complex on Hengshan Lu that's also home to such luminaries as Colca,Crafted and L...Envisaged as a sort of‘international house of skewers’,STYX is a charismatic little restau・rant inside Yong Ping Li,a redeveloped complex on Hengshan Lu that's also home to such luminaries as Colca,Crafted and La Bodeguita del Medio.展开更多
Pure benzeneIn early July 2009, because of the price riseof pure benzene in Asian market, China’s purebenzene prices rose considerably.From mid to late July, the price of pure ben-zene was dull in response to the dec...Pure benzeneIn early July 2009, because of the price riseof pure benzene in Asian market, China’s purebenzene prices rose considerably.From mid to late July, the price of pure ben-zene was dull in response to the decreased de-mand for pure benzene in downstream sectors.As of July 30th, pure benzene was tradingbetween RMB5 600/t and RMB5 800/t ineastern China, a rise of RMB200-300/t over amonth earlier.展开更多
Drastic reduction ofoperating rateBy the end of 2008 the total capacity tomake ABS(acrylonitrile-butadienestyrene)resin reached 2.045 million t/a inChina.With impacts from the global financialcrisis and a slack demand...Drastic reduction ofoperating rateBy the end of 2008 the total capacity tomake ABS(acrylonitrile-butadienestyrene)resin reached 2.045 million t/a inChina.With impacts from the global financialcrisis and a slack demand,the operatingrate of ABS producers was low inthe second half of 2008.The overall operatingrate was around 30%.The output ofABS was around 1.329 million tons展开更多
SBR In October 2008,because of the slack economy globally,the export of SBR (styrene-butadiene rubber) downstream products was apparently affected,and the demand for SBR in downstream sectors fell further.China’s SBR...SBR In October 2008,because of the slack economy globally,the export of SBR (styrene-butadiene rubber) downstream products was apparently affected,and the demand for SBR in downstream sectors fell further.China’s SBR producers consider-ably lowered ex-factory prices,China’s price of SBR therefore was down consider-ably in response to the soft demand展开更多
文摘Clk/STY is a LAMMER protein kinase capable to phosphorylate serine/arginine-rich (SR) proteins that modulate pre-mRNA splicing. Clk/STY alternative splicing generates transcripts encoding a full-length kinase and a truncated catalyti-cally inactive protein. Here we showed that clk/STY, as well as other members of the family (e.g. clk2, clk3 and clk4),are up-regulated during HMBA-induced erythroleukemia cell differentiation. mRNAs coding for the full-length and thetruncated forms were responsible for the overall increased expression. In clk/STY, however, a switch was observed forthe ratio of the two alternative spliced products. In undifferentiated cells the full-length transcript was more abundantwhereas the transcript encoding for the truncated form predominated at latter stages of differentiation. Surprisingly,overexpression of clk/STY did not alter the splicing switch upon differentiation in MEL cells. These results suggest thatclk/STY might contribute to control erythroid differentiation by a mechanism that implicates a balance between thesetwo isoforms.
文摘Envisaged as a sort of‘international house of skewers’,STYX is a charismatic little restau・rant inside Yong Ping Li,a redeveloped complex on Hengshan Lu that's also home to such luminaries as Colca,Crafted and La Bodeguita del Medio.
文摘Pure benzeneIn early July 2009, because of the price riseof pure benzene in Asian market, China’s purebenzene prices rose considerably.From mid to late July, the price of pure ben-zene was dull in response to the decreased de-mand for pure benzene in downstream sectors.As of July 30th, pure benzene was tradingbetween RMB5 600/t and RMB5 800/t ineastern China, a rise of RMB200-300/t over amonth earlier.
文摘Drastic reduction ofoperating rateBy the end of 2008 the total capacity tomake ABS(acrylonitrile-butadienestyrene)resin reached 2.045 million t/a inChina.With impacts from the global financialcrisis and a slack demand,the operatingrate of ABS producers was low inthe second half of 2008.The overall operatingrate was around 30%.The output ofABS was around 1.329 million tons
文摘SBR In October 2008,because of the slack economy globally,the export of SBR (styrene-butadiene rubber) downstream products was apparently affected,and the demand for SBR in downstream sectors fell further.China’s SBR producers consider-ably lowered ex-factory prices,China’s price of SBR therefore was down consider-ably in response to the soft demand
