The knowledge of subnuclear localization in eukaryotic cells is indispensable for under-standing the biological function of nucleus, genome regulation and drug discovery. In this study, a new feature representation wa...The knowledge of subnuclear localization in eukaryotic cells is indispensable for under-standing the biological function of nucleus, genome regulation and drug discovery. In this study, a new feature representation was pro-posed by combining position specific scoring matrix (PSSM) and auto covariance (AC). The AC variables describe the neighboring effect between two amino acids, so that they incorpo-rate the sequence-order information;PSSM de-scribes the information of biological evolution of proteins. Based on this new descriptor, a support vector machine (SVM) classifier was built to predict subnuclear localization. To evaluate the power of our predictor, the benchmark dataset that contains 714 proteins localized in nine subnuclear compartments was utilized. The total jackknife cross validation ac-curacy of our method is 76.5%, that is higher than those of the Nuc-PLoc (67.4%), the OET- KNN (55.6%), AAC based SVM (48.9%) and ProtLoc (36.6%). The prediction software used in this article and the details of the SVM parameters are freely available at http://chemlab.scu.edu.cn/ predict_SubNL/index.htm and the dataset used in our study is from Shen and Chou’s work by downloading at http://chou.med.harvard.edu/ bioinf/Nuc-PLoc/Data.htm.展开更多
The paper describes the development results on one-dimensional (1D) asymptotic model of the formation kinetics for the objects (clusters) of subnuclear (quark) and subatomic (nuclear) matters. A concept of the objects...The paper describes the development results on one-dimensional (1D) asymptotic model of the formation kinetics for the objects (clusters) of subnuclear (quark) and subatomic (nuclear) matters. A concept of the objects distribution density wave φ(a, t) in space of sizes a lies in the basis for analytical description of the processes under consideration. The proposed formalism makes it possible to describe in an adequate way the final outcomes of the well-known catastrophic phenomena in the world of elementary particles. Mass characteristics of different processes of approach to equilibrium in nuclear reactions are calculated.展开更多
文摘The knowledge of subnuclear localization in eukaryotic cells is indispensable for under-standing the biological function of nucleus, genome regulation and drug discovery. In this study, a new feature representation was pro-posed by combining position specific scoring matrix (PSSM) and auto covariance (AC). The AC variables describe the neighboring effect between two amino acids, so that they incorpo-rate the sequence-order information;PSSM de-scribes the information of biological evolution of proteins. Based on this new descriptor, a support vector machine (SVM) classifier was built to predict subnuclear localization. To evaluate the power of our predictor, the benchmark dataset that contains 714 proteins localized in nine subnuclear compartments was utilized. The total jackknife cross validation ac-curacy of our method is 76.5%, that is higher than those of the Nuc-PLoc (67.4%), the OET- KNN (55.6%), AAC based SVM (48.9%) and ProtLoc (36.6%). The prediction software used in this article and the details of the SVM parameters are freely available at http://chemlab.scu.edu.cn/ predict_SubNL/index.htm and the dataset used in our study is from Shen and Chou’s work by downloading at http://chou.med.harvard.edu/ bioinf/Nuc-PLoc/Data.htm.
文摘The paper describes the development results on one-dimensional (1D) asymptotic model of the formation kinetics for the objects (clusters) of subnuclear (quark) and subatomic (nuclear) matters. A concept of the objects distribution density wave φ(a, t) in space of sizes a lies in the basis for analytical description of the processes under consideration. The proposed formalism makes it possible to describe in an adequate way the final outcomes of the well-known catastrophic phenomena in the world of elementary particles. Mass characteristics of different processes of approach to equilibrium in nuclear reactions are calculated.
