Supraclavicular artery island flap for reconstruction of hypopharynx and upper esophagus defects:A case report and literature review

We report a case of a 74-year-old female with hypopharyngeal cancer who developed a pharyngoesophageal fistula and neck skin defect after total laryngectomy.To reconstruct the hypopharynx,upper esophagus,and neck skin defect,we used a supraclavicular artery island flap(SCAIF)for one-stage reconstruction.SCAIF offered reliable blood supply,minimal donor site morbidity,and excellent cosmetic outcomes.Although a small portion of the flap developed necrosis,it healed without surgical intervention.We also conducted a literature review of previously published articles on SCAIF for head and neck reconstruction.Our review highlights the advantages and limitations of SCAIF as a promising option for one-stage reconstruction of complex hypopharyngeal and upper esophageal defects with neck skin defects in selected patients.This case report provides valuable insights into the use of SCAIF in complex head and neck reconstructions,which can help improve patient outcomes and quality of life.

Misdiagnosis of left supraclavicular lymph node metastasis of hepatocellular carcinoma:A case report

Left supraclavicular lymph node metastasis is a rare presentation of hepatocellular carcinoma (HCC).This phenomenon is easily neglected in the clinic.A 56-yearold man presented with HCC.On examination,a 1cm long left supraclavicular lymph node was palpated.Auxiliary examination indicated a lesion located in the right lobe of the liver.Fine needle aspiration cytology (FNAC) of the enlarged lymph node was performed;however,only necrosis was found.Hepatectomy was performed and HCC was confirmed by Hematoxylin-Eosin staining.However,14 d after surgery,significantly enlarged left supraclavicular lymph nodes,a new intrahepatic lesion,and pulmonary and mediastinal metastasis appeared.An excisional biopsy of the left supraclavicular lymph node was performed,and its findings confirmed metastatic HCC.The patient's HCC rapidly progressed and he died one month later.It is possible for HCC tometastasize to the left supraclavicular lymph node.Surgeons should always consider an overall physical examination.When left supraclavicular lymphadenopathy of unknown origin is encountered,FNAC should be performed initially.If the results are negative,an excisional biopsy and subsequent Positron emission tomography computed tomography scanning should be performed.These are very important for making the correct diagnosis and for selecting reasonable therapies.

Effect of Nalbuphine as Adjuvant to Bupivacaine for Ultrasound-Guided Supraclavicular Brachial Plexus Block

Background: Nalbuphine is a derivative of 14-hydroxymorphine which is a strong analgesic with mixed k agonist and μ antagonist. Nalbuphine was studied several times as adjuvant to local anesthetics in spinal, epidural and local intravenous block. The aim of this study was to evaluate the effect of nalbuphine as an adjuvant to local anesthetics in supraclavicular brachial plexus block. Patients and Methods: Fifty-six patients undergoing elective forearm and hand surgery under supraclavicular brachial plexus block were allocated randomly into one of two groups of 28 patients each to receive either 25 ml (0.5%) bupivacaine with 1 ml of NS or 25 ml (0.5%) bupivacaine with 1 ml (20 mg) nalbuphine. Onset time and duration of both sensory and motor block, and post-operative analgesia were observed. Result: Nalbuphine group showed significant increase in the duration of motor block (412.59 ± 18.63), when compared to control group (353.70 ± 29.019) p-value < 0.001, also, there was significant increase in sensory duration in nalbuphine group (718.14 ± 21.04) when compared to control group (610.18 ± 26.33) p-value < 0.001, without affecting the onset time of the blockade. And also, there was a significant increase in the duration of analgesic effect in nalbuphine group (835.18 ± 42.45) when compared to control group (708.14 ± 54.57) p-value < 0.001. Conclusion: The present study demonstrates that addition of 20 mg nalbuphine to bupivacaine in supraclavicular brachial plexus block is associated with significant increase in the duration of both sensory and motor block and also prolong the duration of analgesia.

Different Volumes of Local Anesthetics in Ultrasound-Guided Combined Interscalene-Supraclavicular Block for Traumatic Humeral Fracture

Background: Procedures that require anesthesia of entire length of the arm should have combined Interscalene block (ISB) and Supraclavicular block (SCB) to ensure adequate block. However, dual block requires high dose of local anesthetic (LA). We examined if Ultrasound (U/S) guided block helps to decrease the required volume of LA by visualizing trunks, so we only need injection of LA toward cervical nerve roots C5 and C6 aiming to block branches escaped from supraclavicular block. Patients and methods: Ninety-three patients were randomly allocated into one of three equal groups, each included 31 patients. All patients received SCB 20 ml (10 ml Bupivacaine 0.5% plus 10 ml lidocaine 2%) and ISB with different volumes of LA according to the group as follow: group A: 20 ml, group B: 15 ml, and group C: 10 ml. Result: No significant difference in onset of block (sensory and motor) and duration of block (motor only) between the three groups (P value > 0.05). The duration of sensory block was significantly longer in group A (760.65 ± 30.87 minutes) than in either group B (740.48 ± 21.15 minutes, P value P value P value P value P value P value < 0.001). Conclusion: A reduced volume of LA can be used in ultra sound guided ISB in combined with SCB to give satisfactory level of anesthesia to entire length of the arm, but the sensory block duration and duration of post-operative analgesia will be decreased significantly with decreasing the volume.

Metastatic Cervical and Supraclavicular Lymphadenopathy from Prostate Mimicking Lymphoma: A Case Series

Prostate cancer is the second most common cancer in men worldwide and the commonest cause of mortality in men. It is the commonest diagnosed cancer in African men. The earliest and common sites of metastasis are the axial skeleton and regional lymph nodes. Initial presentation of the metastatic disease with cervical or supraclavicular lymphadenopathy is rarely reported. We report 3 cases of metastatic cancer of the prostate presenting initially to physicians with huge cervical and supraclavicular lymph nodes enlargement which on biopsy revealed metastatic adenocarcinoma. On further evaluation, there were non-bothersome storage symptoms, elevated prostate specific antigen and abnormal digital rectal examination. Transrectal ultrasound (TRUS)-guided biopsy of hypoechoic nodules revealed high-grade adenocarcinoma of the prostate on histopathological examination. The cervical and supraclavicular lymphadenopathy resolved after commencement of androgen deprivation therapy. We advocate for prostate cancer screening in African men above 50 years of age presenting with cervical or supraclavicular lymphadenopthy to primary care physicians even in the absence of lower urinary tract symptoms.

Comparing the Efficacy of Dexmedetomidine When Used as an Adjuvant to Bupivacaine in Supraclavicular Brachial Plexus Blocks under Ultrasound-Guided

Background: Ultrasound-guided for regional anesthesia offers many potential benefits in the emergency setting. Analgesia can be explicitly targeted to the region of pain and provide relief for many hours and decrease needing to the large volume of local anesthetic. The aim of the work: Comparing the efficacy of dexmedetomidine when used as an adjuvant to bupivacaine in supraclavicular brachial plexus blocks on the onset of sensory, motor blockade and postoperative analgesia. Patients and methods: This prospective, randomized, single-blind clinical study conducted on 60 patients underwent upper limb surgery done by ultrasound-guided supraclavicular brachial plexus block;these patients allocated into two equal groups: Group I (control) received 20 ccs (19 cc bupivacaine 0.5% + 1 cc saline), Group II received 20 cc (19 cc bupivacaine 0.5% + 1 cc volume of Dexmedetomidine 1 ug/kg). Results: Demographic data and surgical characteristics were comparable in both groups. The onset times for sensory and motor blocks were significantly shorter in Group II than Group I (P Conclusion: We recommend adding Dexmedetomidine to local anesthetics in peripheral nerve blocks to take advantage of the prolonged time of both sensory and motor blocks and prolonged postoperative analgesia.

Risk of Radiation Induced Carotid Artery Stenosis in Supraclavicular Lymph Node Irradiation in Breast Cancer Patients

Background: The risk of carotid vessel stenosis is high after radiotherapy (RT) to neck;however, carotid vessels are unavoidable during supraclavicular (SC-RT) in adjuvant treatment of breast cancer (BC). However, carotid vessels RT dose is less well-understood. We aimed to determine the carotid vessels doses received by different techniques for SC-RT. Materials and Methods: Thirty consecutive BC patients were planned to receive SC-RT and breast after breast conserving surgery (BCS) after taking 5 mm image slices on computed tomography (CT) simulation. Organs at risk (OAR) including carotid vessels, lungs, spinal cord alongwith clinical target volume (CTV) for primary tumor and lymph nodes were delineated. Comparative analysis was done between two treatment plans;three-field conformal radiation therapy (3F-CRT) and four field conformal RT (4F-CRT) for CTV and carotid vessels doses. Results: The 4F-CRT was found better than 3F-3DCRT regarding coverage and homogeneity of the CTV volume. The 98% of the CTV was covered by 84% dose in 3F-CRT and 95% in 4F-CRT (p 0.001). The carotid vessels maximum dose in the in 3F-CRT was 54.5 ± 1.3 Gy compared to 51.6 ± 1.3 Gy in 4F-CRT (p 0.014), however the mean dose did not differ significantly (p value 0.8). The ipsilateral lung dose did not differ between the two techniques (p Value 0.9). Conclusion: The 4F-CRT plan was found better than 3F-CRT in CTV coverage with minimal dose to the carotid vessel and without significant higher dose to the ipsilateral lung.

Ultrasound Guided Supraclavicular Brachial Plexus Block with 0.5% Bupivacaine and Additives: Case Series at Teaching Hospital Anuradhapura

Introduction: Supraclavicular block (SCB) is associated with excellent postoperative patient outcomes for upper limb surgeries. Bupivacainei is a longacting regional anaesthetic, efficacy of which is altered with the co-administration of additives. Aim: Aim of the study was to assess the efficacy of supraclavicular block with 0.5% bupivacaine compared to co-administration of additives and the associated complications. Method: Following ethical clearance and informed written consent, over 5 months from July 2020, 152 adult patients at Teaching Hospital Anuradhapura Sri Lanka undergoing upper limb surgeries were divided into 4 groups & prospectively followed-up. All groups received 0.5% of Bupivacaine while additives 2% Lidocaine, 8.4% sodium bicarbonate & 8 mg Dexamethasone were added to the other 3 groups. Sensory and Motor block onset time, duration of post-block analgesia, acute and late complications and patient satisfaction were noted. Data was analysed using descriptive statistics & ANOVA, using SPSS V.25. Results: Successful surgical anesthesia was achieved in all patients with 0 cases of long-term neurological complications with 94% patient satisfaction. The motor & sensory block onset time & post block analgesia duration respectively for Lidocaine (9.74 min, 9.74 min & 7.07 h), Bicarbonate (12.89 min, 16.32 min & 12.09 h), dexamethasone (19.34 min, 17.24 min & 20.87 h) & Bupivacaine were (20.39 min, 18.42 min & 13.15 h). Conclusion: The differences between bupivacaine and lidocaine groups for sensory & motor block onset times & between Bupivacaine & dexamethasone groups for post-block analgesia duration were statistically significant (p < 0.001). Supraclavicular block has minimal associated complications & additives Lidocaine shortens the onset of anaesthesia and the duration of analgesia while dexamethasone prolongs the duration of analgesia significantly.

Supraclavicular Neck Mass as Sole Presenting Symptom for Seminoma in an Elderly Male

We report an unusual case of genitourinary malignancy in an otherwise asymptomatic elderly male, which was discovered via workup of a supraclavicular neck mass. We present his clinical workup as well as the pathological workup and how it influenced our decision-making. A review of the literature is also discussed and demonstrates how uncommon it is for seminomas to present in this manner.

Atypical Presentation of Prostatic Cancer with Left Axillary and Supraclavicular Lymphadenopathy

Introduction: The burden of prostatic cancer is rising in Sudan. Usually, they present late in their disease with urinary tract obstruction, hematuria, bony pain, or cachexia because there is no screening program. Here we present a patient with prostatic cancer who presented with left axillary mass as his main concern. Case Description: 82-year-old Sudanese male presented with a left axillary and left supraclavicular lymphadenopathy of a few months’ duration. He underwent a decisional biopsy which showed metastatic adenocarcinoma. Upper and lower GI endoscopy were performed but the latter was complicated by a sigmoid perforation with peritonitis. During laparatomy, multiple enlarged pelvic lymphnodes were encountered and a biopsy result suggested a metastatic prostatic neoplasm. Later, prostatic biopsy confirmed the diagnosis. The patient was treated with bilateral orchidectomy. Clinical discussion: Lymphatic metastasis to axillary lymph nodes is a very rare manifestation of prostate cancer and only a few cases have been reported in the literature. It can cause diagnostic difficulty since prostate cancer typically metastasis to the pelvic lymph node and very rarely involves he supradiaphragmatic lymph node. Conclusion: Metastatic prostatic carcinoma should be considered among the causes of supra-diaphragmatic lymph adenopathy. Careful physical and imaging examinations combined with PSA and pathological analysis are essential in the diagnosis of advanced prostate cancer with unusual presentation.

Application of fascial flaps of supraclavicular artery in repair of neck scar contracture

Objective To observe eflect uf fascial flaps of supraclavicular artery on treatment of neck scar contracture. Methods The supraclavicular flaps were designed according to direction of supraclavicular arteries and transferred into detective areas caused by scar releasing.

Effect of bilateral supraclavicular postoperative radiotherapy in middle and lower thoracic esophageal carcinoma

AIM:To evaluate whether postoperative radiotherapy is an alternative to neck lymph node surgery and if it provides a survival benefit for those receiving twofield,chest and abdomen,lymphadenectomy.METHODS:A total of 530 cases with middle and lower thoracic esophageal carcinoma in our hospital from January 2008 to April 2009 were selected and analyzed,of which 219 cases received right chest,upper abdominal incision Ivor-Lewis surgery and simultaneously underwent mediastinal and abdominal two-field lymphadenectomy.If regional lymph node metastasis occurred within the recurrent laryngeal nerve,the patients would receive bilateral supraclavicular radiotherapy(DT=5000c Gy)to be adopted at postoperative 4-5 wk(Group A)or cervical lymphadenectomy at postoperative 3-4 wk(Group B).If there were no regional lymph node metastases within the recurrent laryngeal nerve,the patients only underwent two-field,chest and abdomen,lymphadenectomy(Group C).RESULTS:In 219 cases who underwent two-field lymphadenectomy,91 cases were diagnosed with regional lymph node metastasis within the recurrent laryngeal nerve.Of them,48 cases received cervical radiotherapy,and 43 cases underwent staging lymphadenectomy;128patients were not given the follow-up treatment of cervical radiotherapy because there was no regional lymph node metastasis within the recurrent laryngeal nerve.Five-year survival rates in group A and B were 47%and50%,respectively,with no statistical difference between them,and the rate in group C was 58%.CONCLUSION:For patients with middle and lower thoracic esophageal carcinoma combined with lymph node metastasis within the recurrent laryngeal nerve,cervical radiotherapy can be a substitute for surgery and provide benefit.

Bilateral chylothorax following left supraclavicular lymph node dissection for breast cancer: one case report and literature review

Chylothorax is a rare complication of neck dissection, and bilateral chylothorax is even rarer. However, both are potentially serious and sometimes life-threatening, especially those that are associated with left neck dissection for head and neck neoplasms. We report one case of bilateral chylothorax following left supraclavicular dissection for breast cancer. This case was treated successfully with a new conservative management approach.

芪贞归脾汤辅助治疗对食管癌伴锁骨上淋巴结转移患者细胞E-cadherin表达的影响

目的探讨芪贞归脾汤辅助治疗对食管癌伴锁骨上淋巴结转移患者细胞钙黏素(E-cadherin)表达的影响。方法选取2016年1月—2021年1月食管癌伴锁骨上淋巴结转移病例96例,随机编号方法分两组,各48例,对照组采用常规放疗;在此基础上,观察组采用芪贞归脾汤辅助治疗,持续治疗8周。治疗前后评价中医证候积分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)、免疫功能、细胞角蛋白19片段(cytokeratin 19 fragment,CYFRA21-1)、癌胚抗原(carcinoembryonic antigen,CEA)、癌抗原(cancer antigen 125,CA125)、E-cadherin和不良反应情况。结果观察组治疗后咽下困难、胸闷不舒、形体消瘦、气短乏力等积分低于对照组,差异有统计学意义(均P<0.05)。观察组治疗后睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间功能障碍等评分低于对照组,差异有统计学意义(均P<0.05)。观察组治疗后CD^(+)_(3)、CD^(+)_(4)、CD^(+)_(4)/CD^(+)_(8)高于对照组,CD^(+)_(8)低于对照组,差异有统计学意义(均P<0.05)。观察组治疗后血清CYFRA21-1、CEA、CA125低于对照组,差异有统计学意义(均P<0.05)。观察组治疗后E-cadherin阳性率72.92%高于对照组54.17%,差异有统计学意义(P<0.05)。两组放射性皮炎、恶心呕吐、白细胞减少、肝功能异常、神经毒性等不良反应比较,差异无统计学意义(均P>0.05)。结论芪贞归脾汤辅助治疗可以提高食管癌伴锁骨上淋巴结转移患者的免疫功能和睡眠质量,降低肿瘤标志物及E-cadherin的表达,安全性高。

保留与不保留锁骨上神经对锁骨切口周围皮肤感觉的影响

目的探讨锁骨骨折切开复位内固定术中保留与不保留锁骨上神经对锁骨切口周围皮肤感觉的影响。方法选择2016年3月至2023年2月采用切开复位钢板内固定治疗锁骨骨折患者60例,男20例、女40例,年龄20~73(40.70±14.57)岁,根据是否保留锁骨上神经分为试验组(保留锁骨上神经)和对照组(不保留锁骨上神经)各30例。试验组术中游离保护锁骨上神经,对照组则不保留此神经。术后1周测定两组患者手术切口周围皮肤触觉、痛觉减退区域的面积,用SPSS 26.0软件统计分析。结果60例患者均获得随访。试验组30例患者中,25例患者的触觉、痛觉完全正常,5例患者有较小范围的感觉障碍;对照组30例患者中,3例患者有较小范围的感觉障碍,其余27例均有大面积的触觉、痛觉缺失。两组触觉及痛觉障碍区域的面积比较差异有统计学意义(P<0.001)。结论锁骨骨折切开复位内固定术中游离保护锁骨上神经可明显降低手术切口周围皮肤感觉障碍,有利于患者术后患侧肩部功能恢复。

角袋注射技术对锁骨上臂丛神经阻滞后膈肌麻痹的影响

目的分析角袋注射技术的临床疗效及对锁骨上臂丛神经阻滞后膈肌麻痹的影响。方法选择2020年1月至2021年12月于沧州市人民医院诊治的需在臂丛神经阻滞麻醉下行手术患者80例,其中男性52例,女性28例;年龄20~40岁,平均年龄30.46岁;身体质量指数(BMI)17.42~28.01 kg/m^(2),平均BMI 22.51 kg/m^(2);美国麻醉医师协会(ASA)分级Ⅰ级24例,Ⅱ级40例,Ⅲ级16例;手术部位,肘部24例,前臂21例,手腕27例,手8例。随机分为试验组(n=40例)及对照组(n=40例)。对照组予传统神经丛周围阻滞麻醉,试验组则采用超声引导角袋注射技术进行麻醉。对两组患者麻醉前和麻醉后30 min平静呼吸膈肌移动度及肺功能指标进行比较。比较两组患者膈肌麻痹发生率及并发症;以患者阻滞后30 min是否出现膈肌麻痹为终点,对两组患者阻滞后30 min用力呼吸膈肌移动度与膈肌麻痹发生风险进行比较。结果试验组麻醉效果为优良率的患者明显高于对照组[92.5%(37/40)vs 70%(28/40)。P<0.05]。感觉及运动阻滞起效时间显著低于对照组[(5.41±1.09)min vs(6.84±1.65)min、(9.06±1.27)min vs(11.98±2.71)min],而持续时间显著高于对照组[(404.96±89.73)min vs(11.98±2.71)min、(417.93±91.78)min vs(300.86±51.92)min](均P<0.05);阻滞后试验组患者的膈肌移动度及肺功能指标均显著高于对照组(P<0.05)。试验组患者膈肌麻痹发生率及并发症发生率明显低于对照组[(12.5%(5/40)vs 37.5%(15/40),7.5%(3/40)vs 25%(10/40)。均P<0.05]。以出现膈肌麻痹为终点,试验组膈肌活动度大于对照组,膈肌麻痹发生风险延后对照组(P<0.05)。结论角袋注射技术麻醉效果优于传统神经丛周围阻滞麻醉,且对膈肌麻痹的影响较小,术后不良反应少。

Usefulness of supraclavicular flap in reconstruction following resection of oral cancer

Objective: To evaluate the usefulness of supraclavicular artery flap in reconstruc-tion of defects following resection of buccal mucosa cancer. Methods: Twenty-five patients who presented to R.L Jalappa Hospital and Research centre and diagnosed as squamous cell carcinoma of buccal mucosa staged T2 and above were included in our study. All patients underwent wide excision of tumour and neck dissection. Six patients un-derwent hemi-mandibulectomy while 4 patients underwent marginal mandibulectomy depend-ing on extent of the tumour along with neck dissection. The defect following surgery was reconstructed using the supraclavicular artery flap and were followed up for minimum 6 months during which they were assessed for the functional and aesthetic outcome using a scoring system. The details of the scoring system comprised of 7 attributes. Each attribute was given a score of 10 if the patients experienced that attribute, while a score of 0 was given if the patient did not experience that particular attribute. Results: Seven (28％) patients had complete necrosis of the flap. One patient had a local recur-rence 2 months following surgery and was lost to follow up. The remaining 17 patients were followed up for a minimum of 6 months and a scoring system was adopted to evaluate the func-tional and aesthetic outcome of the supraclavicular flap. We observed that 14 patients had an excellent outcome score (58％), 3 patients had a good outcome score (13％), while 7 patients (28％) had flap necrosis.Conclusions: We find the supraclavicular flap to be safe, technically simple, sensate, thin, pliable and reliable regional fasciocutaneous flap in reconstructing intra oral defects. Preser-ving the external jugular vein and sacrificing supraclavicular nerves give good outcome.

经皮项链弧形切口锁定板内固定治疗锁骨中段骨折

目的探讨经皮项链弧形切口锁定板内固定治疗锁骨中段骨折的疗效。方法根据随机数字表法将62例锁骨中段骨折患者分为观察组(采用经皮项链弧形切口锁定板内固定治疗,31例)与对照组(采用切开复位锁定板内固定治疗,31例)。记录两组手术情况、骨折愈合时间、胸前上区皮肤感觉麻木发生情况,采用Constant-Murley评分评价肩关节功能。结果患者均获得随访,时间5~9个月。手术时间观察组长于对照组(P<0.05),切口长度、术后24 h疼痛VAS评分、骨折愈合时间观察组均优于对照组(P<0.05)。术后1个月胸前上区皮肤感觉麻木发生率观察组低于对照组(P<0.05)。末次随访时Constant-Murley评分观察组高于对照组(P<0.05)。结论经皮项链弧形切口锁定板内固定治疗锁骨中段骨折手术切口短、术后疼痛轻、锁骨上神经损伤少、肩关节功能恢复更好,但手术时间比切开复位内固定稍长。

锁骨上臂丛神经阻滞麻醉用于小儿上肢手术的效果研究

目的探讨小儿上肢手术中锁骨上臂丛神经阻滞麻醉的应用价值。方法56例行小儿上肢手术的患儿,用随机数字表法分为观察组和对照组,各28例。对照组行气管插管全身麻醉(全麻),观察组行锁骨上臂丛神经阻滞麻醉。比较两组患儿术前、切皮时、术中、手术结束时的生命体征指标及麻醉效果、麻醉不良反应发生率、麻醉起效时间、入睡时间、苏醒时间。结果观察组患儿在切皮时、术中、手术结束后的收缩压(SBP)、舒张压(DBP)、心率(HR)与对照组相比更加平稳,且手术结束时观察组患儿血氧饱和度(SpO2)(98.96±4.05)%明显高于对照组的(93.62±4.15)%,差异显著(P<0.05)。观察组患儿麻醉优良率96.43%高于对照组的78.57%,差异显著(P<0.05)。观察组麻醉不良反应发生率7.14%低于对照组的28.57%,差异显著(P<0.05)。观察组患儿的苏醒时间(7.25±1.38)min短于对照组的(31.14±4.16)min,差异显著(P<0.05)。结论小儿上肢手术中运用锁骨上臂丛神经阻滞麻醉可提高麻醉优良率,缩短患儿的苏醒时间,且麻醉安全性较高,因此,具备临床借鉴与推广的价值。

Development and validation of a nomogram for predicting survival of breast cancer patients with ipsilateral supraclavicular lymph node metastasis

Background:Breast cancer patients with ipsilateral supraclavicular lymph node metastasis(ISLNM)but without distant metastasis are considered to have a poor prognosis.This study aimed to develop a nomogram to predict the overall survival(OS)of breast cancer patients with ISLNM but without distant metastasis.Methods:Medical records of breast cancer patients who received surgical treatment at the Affiliated Cancer Hospital of Zhengzhou University,Jiyuan People’s Hospital and Huaxian People’s Hospital between December 21,2012 and June 30,2020 were reviewed retrospectively.Overall,345 patients with pathologically confirmed ISLNM and without evidence of distant metastasis were identified.They were further randomized 2:1 and divided into training(n=231)and validation(n=114)cohorts.A nomogram to predict the probability of OS was constructed based on clinicopathologic variables identified by the univariable and multivariable analyses.The predictive accuracy and discriminative ability were measured by calibration plots,concordance index(C-index),and risk group stratification.Results:Univariable analysis showed that estrogen receptor-positive(ER+),progesterone receptor-positive(PR+),human epidermal growth factor receptor 2-positive(HER2+)with Herceptin treatment,and a low axillary lymph node ratio(ALNR)were prognostic factors for better OS.PR+,HER2+with Herceptin treatment,and a low ALNR remained independent prognostic factors for better OS on multivariable analysis.These variables were incorporated into a nomogram to predict the 1-,3-,and 5-year OS of breast cancer patients with ISLNM.The C-indexes of the nomogram were 0.737(95%confidence interval[CI]:0.660–0.813)and 0.759(95%CI:0.636–0.881)for the training and the validation cohorts,respectively.The calibration plots presented excellent agreement between the nomogram prediction and actual observation for 3 and 5 years,but not 1 year,OS in both the cohorts.The nomogram was also able to stratify patients into different risk groups.Conclusions:In this study,we established and validated a novel nomogram for predicting survival of patients with ISLNM.This nomogram may,to some extent,allow clinicians to more accurately estimate prognosis and to make personalized therapeutic decisions for individual patients with ISLNM.