Objective: To investigate the effects of safflower yellow pigment combined with cerebellin on neurological function in patients with ischemic stroke and analyze its possible mechanism. Methods: A total of 130 patients...Objective: To investigate the effects of safflower yellow pigment combined with cerebellin on neurological function in patients with ischemic stroke and analyze its possible mechanism. Methods: A total of 130 patients with ischemic stroke admitted to my hospital from May 2017 to August 2018 were enrolled. The patients were divided into the control group and the study group according to the random number table method, 65 cases in each group. The control group was treated with cerebroside carnosine. And the study group was treated with safflower yellow pigment on the basis of the control group. The changes of neurological function index, oxidative stress index, vascular endothelial function index and inflammatory factor were compared before and after treatment. Results: There were no significant differences in preoperative neurological parameters, oxidative stress, vascular endothelial function and inflammatory factors between the two groups (P>0.05). After treatment, the neurological function indexes S-100β and NSE were significantly lower in both groups, and NGF levels were significantly increased. The S-100β and NSE levels in the study group were (0.91±0.10) ng/L and (12.91±1.33) ng/L, respectively, which were significantly lower than control group. While the NGF level of the study group was (79.52±8.07) μg/L significantly higher than that of the control group (both P<0.05). The levels of Ox-LDL were significantly reduced and GSH-Px levels were significantly elevated in both groups after treatment. The level of oxidative stress index Ox-LDL was (563.51±57.10) μg/dL, which was significantly lower than that of the control group, and the GSH-Px level was (154.55±16.07) U/L, which was significantly higher than the control group (both P<0.05). The levels of vascular endothelial function NT-proBNP, TXB2 and ET-1 were significantly lower in the two groups after treatment. The NT-proBNP, TXB2 and ET-1 in the study group were (95.91±9.77) pg/mL, (245.69±25.06) pg/mL and (64.26±6.65) ng/L, respectively, which were significantly lower than the control group (both P<0.05). The levels of inflammatory factors MMP-9 and TNF-α were significantly lower in the two groups after treatment. The levels of MMP-9 and TNF-α in the study group were (60.64±6.12) ng/mL and (0.33±0.04) ng/mL, respectively, which were significantly lower than those in the control group (both P<0.05). Conclusion: Safflor yellow combined with cerebellin in the treatment of ischemic stroke has higher clinical efficacy and can significantly improve the neurological function of patients. The possible mechanism is related to the improvement of vascular endothelial function and stress response.展开更多
文摘Objective: To investigate the effects of safflower yellow pigment combined with cerebellin on neurological function in patients with ischemic stroke and analyze its possible mechanism. Methods: A total of 130 patients with ischemic stroke admitted to my hospital from May 2017 to August 2018 were enrolled. The patients were divided into the control group and the study group according to the random number table method, 65 cases in each group. The control group was treated with cerebroside carnosine. And the study group was treated with safflower yellow pigment on the basis of the control group. The changes of neurological function index, oxidative stress index, vascular endothelial function index and inflammatory factor were compared before and after treatment. Results: There were no significant differences in preoperative neurological parameters, oxidative stress, vascular endothelial function and inflammatory factors between the two groups (P>0.05). After treatment, the neurological function indexes S-100β and NSE were significantly lower in both groups, and NGF levels were significantly increased. The S-100β and NSE levels in the study group were (0.91±0.10) ng/L and (12.91±1.33) ng/L, respectively, which were significantly lower than control group. While the NGF level of the study group was (79.52±8.07) μg/L significantly higher than that of the control group (both P<0.05). The levels of Ox-LDL were significantly reduced and GSH-Px levels were significantly elevated in both groups after treatment. The level of oxidative stress index Ox-LDL was (563.51±57.10) μg/dL, which was significantly lower than that of the control group, and the GSH-Px level was (154.55±16.07) U/L, which was significantly higher than the control group (both P<0.05). The levels of vascular endothelial function NT-proBNP, TXB2 and ET-1 were significantly lower in the two groups after treatment. The NT-proBNP, TXB2 and ET-1 in the study group were (95.91±9.77) pg/mL, (245.69±25.06) pg/mL and (64.26±6.65) ng/L, respectively, which were significantly lower than the control group (both P<0.05). The levels of inflammatory factors MMP-9 and TNF-α were significantly lower in the two groups after treatment. The levels of MMP-9 and TNF-α in the study group were (60.64±6.12) ng/mL and (0.33±0.04) ng/mL, respectively, which were significantly lower than those in the control group (both P<0.05). Conclusion: Safflor yellow combined with cerebellin in the treatment of ischemic stroke has higher clinical efficacy and can significantly improve the neurological function of patients. The possible mechanism is related to the improvement of vascular endothelial function and stress response.
