Salbutamol sulfate was coordinated with Cu2+ when pH was 10, and the characteristic absorption peak of the complex was generated at 334 nm. The absorption intensity of the complex was in linear relation with the conce...Salbutamol sulfate was coordinated with Cu2+ when pH was 10, and the characteristic absorption peak of the complex was generated at 334 nm. The absorption intensity of the complex was in linear relation with the concentration of salbutamol sulfate. The regression equation was A=0.011 ρsalbutamol sulfate-0.123 0, correlation coefficient r=0.999 5, and the detection limit was 4.6 μg/ml. It was used for the determination of salbutamol sulfate samples successfully. The recovery rate was 100.5%-103.0%, and the RSD was 1.5%.展开更多
目的探究沙丁胺醇联合异丙托溴铵治疗慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)效果。方法选取2019年10月至2021年12月浙江医疗健康集团衢州医院收治的AECOPD患者168例,采用随...目的探究沙丁胺醇联合异丙托溴铵治疗慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)效果。方法选取2019年10月至2021年12月浙江医疗健康集团衢州医院收治的AECOPD患者168例,采用随机数字表法分为对照组(n=84)和研究组(n=84)。对照组给予硫酸沙丁胺醇气雾剂吸入治疗,研究组在对照组的基础上加用异丙托溴铵雾化吸入治疗。比较两组临床症状、肺功能、血气分析及不良反应。结果研究组患者的胸闷缓解时间、气急缓解时间、哮鸣音缓解时间、咳嗽缓解时间均显著低于对照组(P<0.05);治疗后研究组第1秒用力呼气容积(forced expiratory volume in first second,FEV1)、第1秒用力呼气容积占预计值的百分比(FEV1 predicted,FEV1%)、FEV1/用力肺活量(forced vital capacity,FVC)显著高于对照组(P<0.05);治疗后,两组的动脉血氧分压(partial pressure of oxygen,PaO_(2))水平升高,动脉血二氧化碳分压(partial pressure of carbon dioxide,PaCO_(2))水平降低,差异均有统计学意义(P<0.05);研究组PaO_(2)显著高于对照组(P<0.05),PaCO_(2)显著低于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论异丙托溴铵联合沙丁胺醇对AECOPD的治疗效果显著优于异丙托溴铵单独治疗,可较好改善临床症状,提高肺功能,临床应用安全,值得临床普及应用。展开更多
基金Supported by School-level Project of Guangxi University of Chinese Medicine(YB140004)The 2017 Basic Ability Improving Project of Young and Middleaged Teachers by the Education Department of Guangxi(2017KY0284)
文摘Salbutamol sulfate was coordinated with Cu2+ when pH was 10, and the characteristic absorption peak of the complex was generated at 334 nm. The absorption intensity of the complex was in linear relation with the concentration of salbutamol sulfate. The regression equation was A=0.011 ρsalbutamol sulfate-0.123 0, correlation coefficient r=0.999 5, and the detection limit was 4.6 μg/ml. It was used for the determination of salbutamol sulfate samples successfully. The recovery rate was 100.5%-103.0%, and the RSD was 1.5%.
文摘目的探究沙丁胺醇联合异丙托溴铵治疗慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)效果。方法选取2019年10月至2021年12月浙江医疗健康集团衢州医院收治的AECOPD患者168例,采用随机数字表法分为对照组(n=84)和研究组(n=84)。对照组给予硫酸沙丁胺醇气雾剂吸入治疗,研究组在对照组的基础上加用异丙托溴铵雾化吸入治疗。比较两组临床症状、肺功能、血气分析及不良反应。结果研究组患者的胸闷缓解时间、气急缓解时间、哮鸣音缓解时间、咳嗽缓解时间均显著低于对照组(P<0.05);治疗后研究组第1秒用力呼气容积(forced expiratory volume in first second,FEV1)、第1秒用力呼气容积占预计值的百分比(FEV1 predicted,FEV1%)、FEV1/用力肺活量(forced vital capacity,FVC)显著高于对照组(P<0.05);治疗后,两组的动脉血氧分压(partial pressure of oxygen,PaO_(2))水平升高,动脉血二氧化碳分压(partial pressure of carbon dioxide,PaCO_(2))水平降低,差异均有统计学意义(P<0.05);研究组PaO_(2)显著高于对照组(P<0.05),PaCO_(2)显著低于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论异丙托溴铵联合沙丁胺醇对AECOPD的治疗效果显著优于异丙托溴铵单独治疗,可较好改善临床症状,提高肺功能,临床应用安全,值得临床普及应用。
