Malignant lymphoma originates from the lymphohematopoietic system.It can occur in any lymphoid tissue.Malignant lymphoma of the salivary gland is rare,but its incidence has increased in recent years.Its clinical-prese...Malignant lymphoma originates from the lymphohematopoietic system.It can occur in any lymphoid tissue.Malignant lymphoma of the salivary gland is rare,but its incidence has increased in recent years.Its clinical-presentations are nonspecific,and it is often manifested as a painless mass in a salivary gland,which can be accompanied by multiple swollen cervical lymph nodes.Confirmation of the diagnosis before an invasive procedure is difficult.Clinically,malignant lymphoma of the salivary gland tends to be misdiagnosed,leading to an inappropriate treatment plan and the ultimate delay in the optimal treatment of the disease.This article reviews the pathogenesis,clinical features,imaging findings,diagnosis,treatment and prognosis of malignant lymphoma of the salivary gland.展开更多
The expression of P16 gene were found in all 3 groups. The positive unit (PU) was higher in tumor group and cancer group than that in normal group ( P <0.01). Furthermore, the PU of P16 was stronger in cytopla...The expression of P16 gene were found in all 3 groups. The positive unit (PU) was higher in tumor group and cancer group than that in normal group ( P <0.01). Furthermore, the PU of P16 was stronger in cytoplasm than in nucleus. Malignant tumors and acini surrounding the tumor revealed strong positives and week positives respectively. The PU of P16 gene was higher in deep lobe of recurrent parotid neoplasm with incomplete capsule than that in shallow lobe of primary parotid neoplasm with complete capsule. Our findings suggests that P16 gene plays equally important role in the salivary gland tumors and tumors in other part of the body.展开更多
Objective: To investigate the 30 bp deletion in LMP-1 in lymphoepithelial carcinoma of salivary glands, and to clarify the deletion rate. Methods: 46 cases of LEC were subjected to PCR examination for the 3?terminal r...Objective: To investigate the 30 bp deletion in LMP-1 in lymphoepithelial carcinoma of salivary glands, and to clarify the deletion rate. Methods: 46 cases of LEC were subjected to PCR examination for the 3?terminal region of LMP-1 gene, in order to observe the 30 bp deletion. To reduce the influence of unsuccessful DNA extraction from paraffin-embedded tissue sections, a bactin PCR was performed at the same time. Additionally, DNA sequencing was performed on 1 case without deletion and 1 case with deletion. Results: 4 of 46 specimens were proved to contain no suitable DNA sample by bactin gene amplification. In the remaining 42 cases, LMP-1 DNA was detected in 35/42 (83.3%) LEC cases. Two kinds of PCR products were found in these 35 cases after further DNA sequencing. 31 cases (88.6%) carried 316 bp product and 4 cases (11.4%) carried 286 bp product. Conclusion: Some LECs of salivary glands carry del-LMP-1. In our study, the deletion rate was 11.4% (4/35).展开更多
BACKGROUND Pleomorphic adenoma(PA)is the most common type of salivary gland tumor,and its common sites are parotid gland,sinus,nasal septum and cleft palate.PA is an uncommon benign type of tumor occurring in the brea...BACKGROUND Pleomorphic adenoma(PA)is the most common type of salivary gland tumor,and its common sites are parotid gland,sinus,nasal septum and cleft palate.PA is an uncommon benign type of tumor occurring in the breast,and there are few reports of cases in Asia.CASE SUMMARY An 84-year-old woman found a mass in the upper outer quadrant of the right breast>1 year ago.The patient underwent a right breast lumpectomy and sentinel lymph node biopsy.The pathological diagnosis was PA in the upper outer quadrant of the right breast,and the malignant component was malignant adenomyoepithelioma.The postoperative course was uneventful,and no chemotherapy was administered.At 18 mo of follow-up,the patient is alive and well,with no evidence of recurrent disease.CONCLUSION Patients with breast PA should first undergo extended excision of breast masses followed by pathological examination.If malignancy is confirmed or the surgical margin is positive,modified radical mastectomy should be performed.展开更多
Benign tumorous condition can be encountered at very unusual location in oral cavity and pharyngeal region, which leads diagnostic difficulty. Here we describe a very unusual presentation of polypoid hamartoma on the ...Benign tumorous condition can be encountered at very unusual location in oral cavity and pharyngeal region, which leads diagnostic difficulty. Here we describe a very unusual presentation of polypoid hamartoma on the root of the tongue. A 59-year-old woman presented with a polypoid tumor mass on the dorsal root of the tongue. Microscopically, it was hamartoma showing normal salivary glands of mucinous and serous types, lymphoid hyperplasia, and skeletal muscle bundles. Major differential diagnoses include accessory tongue, adenomatoid hyperplasia, and idiopathic hyperplasia of sublingual glands. To our knowledge, this is the first report of hamartoma arising in the root of the tongue presenting as polypoid mass. Correct diagnosis based on pathologic examination is essential for proper treatment.展开更多
Pleomorphic adenoma is the most common benign parotid gland tumor. Although its local recurrence rate is known to be high, the recurrence extending to the cervical region is rare. Here we report a case of a young fema...Pleomorphic adenoma is the most common benign parotid gland tumor. Although its local recurrence rate is known to be high, the recurrence extending to the cervical region is rare. Here we report a case of a young female (25 years old) with pleomorphic adenoma of the parotid gland which showed multiple recurrences through facial to cervical regions over a span of eight years. We also discuss how this benign tumor with a high recurrence rate has been treated in other cases, and how it should be treated.展开更多
AIM:To report the clinical impact of adrenal endoscopic ultrasound fine-needle aspiration(EUS-FNA)in the evaluation of patients with adrenal gland enlargement or mass.METHODS:In a retrospective single-center caseserie...AIM:To report the clinical impact of adrenal endoscopic ultrasound fine-needle aspiration(EUS-FNA)in the evaluation of patients with adrenal gland enlargement or mass.METHODS:In a retrospective single-center caseseries,patients undergoing EUS-FNA of either adrenal gland from 1997-2011 in our tertiary care center were included.Medical records were reviewed and results of EUS,cytology,adrenal size change on follow-up imaging≥6 mo after EUS and any repeat EUS or surgery were abstracted.A lesion was considered benign if:(1)EUS-FNA cytology was benign and the lesion remained<1 cm from its original size on follow-up computed tomography(CT),magnetic resonance imaging or repeat EUS≥6 mo after EUS-FNA;or(2)subsequent adrenalectomy and surgical pathology was benign.RESULTS:Ninety-four patients had left(n=90)and/or right(n=5)adrenal EUS-FNA without adverse events.EUS indications included:cancer staging or sus-pected recurrence(n=31),pancreatic(n=20),mediastinal(n=10),adrenal(n=7),lung(n=7)mass or other indication(n=19).Diagnoses after adrenal EUSFNA included metastatic lung(n=10),esophageal(n=5),colon(n=2),or other cancer(n=8);benign primary adrenal mass or benign tissue(n=60);or was non-diagnostic(n=9).Available follow-up confirmed a benign lesion in 5/9 non-diagnostic aspirates and 32/60benign aspirates.Four of the 60 benign aspirates were later confirmed as malignant by repeat biopsy,followup CT,or adrenalectomy.Adrenal EUS-FNA diagnosed metastatic cancer in 24,and ruled out metastasis in 10patients.For the diagnosis of malignancy,EUS-FNA of either adrenal had sensitivity,specificity,positive predictive value and negative predictive value of 86%,97%,96%and 89%,respectively.CONCLUSION:Adrenal gland EUS-FNA is safe,minimally invasive and a sensitive technique with significant impact in the management of adrenal gland mass or enlargement.展开更多
目的探讨Pan-TRK免疫组化在涎腺分泌性癌(secretory carcinoma of salivary glands,SCSG)诊断及鉴别诊断中的价值。方法收集14例SCSG临床资料,采用免疫组化、FISH对SCSG进行检测。另选取经典的腺泡细胞癌、黏液表皮样癌、腺样囊性癌各1...目的探讨Pan-TRK免疫组化在涎腺分泌性癌(secretory carcinoma of salivary glands,SCSG)诊断及鉴别诊断中的价值。方法收集14例SCSG临床资料,采用免疫组化、FISH对SCSG进行检测。另选取经典的腺泡细胞癌、黏液表皮样癌、腺样囊性癌各10例作为对照。结果14例SCSG患者男女比为4∶3,年龄15~79岁,10例发生于腮腺,2例发生于颊部,1例发生于腭部,1例发生于颈部;11例生存状态良好,1例复发生存,2例失访。14例SCSG,多呈浸润性生长,呈微囊状、乳头-囊状、管状、实性排列或几者混合,腔内伴丰富分泌物,1例见神经侵犯,1例伴淋巴结转移。免疫表型:14例SCSG中CK7、S-100、Mammaglobin均阳性,11例SOX-10阳性,10例GATA-3阳性,14例DOG1均阴性,Ki-67增殖指数为1%~15%。FISH检测:12例SCSG成功检测到FISH信号,10例发现ETV6-NTRK3基因融合阳性。14例SCSG均行Pan-TRK免疫组化检测,10例细胞核阳性,1例细胞质阳性。10例腺泡细胞癌、10例黏液表皮样癌、10例腺样囊性癌中分别有2、4、7例Pan-TRK阳性,定位于细胞膜/细胞质。结论Pan-TRK免疫组化阳性可提示伴ETV6-NTRK3融合的SCSG,尤其以细胞核着色模式为阳性标准时,在SCSG诊断及鉴别诊断中表现为较高的敏感性和高度特异性,并对未来TRK基因靶向治疗提供依据。展开更多
Salivary gland tumors are a group of the most common tumors in the oral and maxillofacial region. They have features with complicated histopathologic classification and wide distribution. There is little knowledge on ...Salivary gland tumors are a group of the most common tumors in the oral and maxillofacial region. They have features with complicated histopathologic classification and wide distribution. There is little knowledge on the clinicopathologic characterics and clinical behaviors of salivary gland tumors of various locations and subtype. The management of salivary gland tumors is also contraversial. Biopsy is not suggested because of seeding of tumor cells. Therefore adjunctive methods are important for preoperative diagnosis. Since 1985, our research group has performed a series of basic and clinical researches on salivary gland tumors including clinicopathologic characteristis and behavior, preoperative adjunctive diagnosis, mechanism, prevention and treatment of distant metastasis of salivary adenoid cystic carcinoma, and histogenesis of salivary gland tumor. These studies have improved our knowledge on the clinical, histopathological, cytological, imaging features, and biobehavior of different types of slivary gland tumors. We have also suggested related principles of management, modified the operative methods of benign tumor of parotid gland. Our efforts have raised the standards of diagnosis and treatment of salivary gland tumors.展开更多
基金Supported by the 345 Talent Project of Shengjing Hospitalthe Natural Science Foundation of Liaoning Province,No.20170541042.
文摘Malignant lymphoma originates from the lymphohematopoietic system.It can occur in any lymphoid tissue.Malignant lymphoma of the salivary gland is rare,but its incidence has increased in recent years.Its clinical-presentations are nonspecific,and it is often manifested as a painless mass in a salivary gland,which can be accompanied by multiple swollen cervical lymph nodes.Confirmation of the diagnosis before an invasive procedure is difficult.Clinically,malignant lymphoma of the salivary gland tends to be misdiagnosed,leading to an inappropriate treatment plan and the ultimate delay in the optimal treatment of the disease.This article reviews the pathogenesis,clinical features,imaging findings,diagnosis,treatment and prognosis of malignant lymphoma of the salivary gland.
文摘The expression of P16 gene were found in all 3 groups. The positive unit (PU) was higher in tumor group and cancer group than that in normal group ( P <0.01). Furthermore, the PU of P16 was stronger in cytoplasm than in nucleus. Malignant tumors and acini surrounding the tumor revealed strong positives and week positives respectively. The PU of P16 gene was higher in deep lobe of recurrent parotid neoplasm with incomplete capsule than that in shallow lobe of primary parotid neoplasm with complete capsule. Our findings suggests that P16 gene plays equally important role in the salivary gland tumors and tumors in other part of the body.
文摘Objective: To investigate the 30 bp deletion in LMP-1 in lymphoepithelial carcinoma of salivary glands, and to clarify the deletion rate. Methods: 46 cases of LEC were subjected to PCR examination for the 3?terminal region of LMP-1 gene, in order to observe the 30 bp deletion. To reduce the influence of unsuccessful DNA extraction from paraffin-embedded tissue sections, a bactin PCR was performed at the same time. Additionally, DNA sequencing was performed on 1 case without deletion and 1 case with deletion. Results: 4 of 46 specimens were proved to contain no suitable DNA sample by bactin gene amplification. In the remaining 42 cases, LMP-1 DNA was detected in 35/42 (83.3%) LEC cases. Two kinds of PCR products were found in these 35 cases after further DNA sequencing. 31 cases (88.6%) carried 316 bp product and 4 cases (11.4%) carried 286 bp product. Conclusion: Some LECs of salivary glands carry del-LMP-1. In our study, the deletion rate was 11.4% (4/35).
基金Supported by National Natural Science Foundation of China,No.81874063Natural Science Foundation of Anhui Province,No.2008085QH408.
文摘BACKGROUND Pleomorphic adenoma(PA)is the most common type of salivary gland tumor,and its common sites are parotid gland,sinus,nasal septum and cleft palate.PA is an uncommon benign type of tumor occurring in the breast,and there are few reports of cases in Asia.CASE SUMMARY An 84-year-old woman found a mass in the upper outer quadrant of the right breast>1 year ago.The patient underwent a right breast lumpectomy and sentinel lymph node biopsy.The pathological diagnosis was PA in the upper outer quadrant of the right breast,and the malignant component was malignant adenomyoepithelioma.The postoperative course was uneventful,and no chemotherapy was administered.At 18 mo of follow-up,the patient is alive and well,with no evidence of recurrent disease.CONCLUSION Patients with breast PA should first undergo extended excision of breast masses followed by pathological examination.If malignancy is confirmed or the surgical margin is positive,modified radical mastectomy should be performed.
文摘Benign tumorous condition can be encountered at very unusual location in oral cavity and pharyngeal region, which leads diagnostic difficulty. Here we describe a very unusual presentation of polypoid hamartoma on the root of the tongue. A 59-year-old woman presented with a polypoid tumor mass on the dorsal root of the tongue. Microscopically, it was hamartoma showing normal salivary glands of mucinous and serous types, lymphoid hyperplasia, and skeletal muscle bundles. Major differential diagnoses include accessory tongue, adenomatoid hyperplasia, and idiopathic hyperplasia of sublingual glands. To our knowledge, this is the first report of hamartoma arising in the root of the tongue presenting as polypoid mass. Correct diagnosis based on pathologic examination is essential for proper treatment.
文摘Pleomorphic adenoma is the most common benign parotid gland tumor. Although its local recurrence rate is known to be high, the recurrence extending to the cervical region is rare. Here we report a case of a young female (25 years old) with pleomorphic adenoma of the parotid gland which showed multiple recurrences through facial to cervical regions over a span of eight years. We also discuss how this benign tumor with a high recurrence rate has been treated in other cases, and how it should be treated.
文摘AIM:To report the clinical impact of adrenal endoscopic ultrasound fine-needle aspiration(EUS-FNA)in the evaluation of patients with adrenal gland enlargement or mass.METHODS:In a retrospective single-center caseseries,patients undergoing EUS-FNA of either adrenal gland from 1997-2011 in our tertiary care center were included.Medical records were reviewed and results of EUS,cytology,adrenal size change on follow-up imaging≥6 mo after EUS and any repeat EUS or surgery were abstracted.A lesion was considered benign if:(1)EUS-FNA cytology was benign and the lesion remained<1 cm from its original size on follow-up computed tomography(CT),magnetic resonance imaging or repeat EUS≥6 mo after EUS-FNA;or(2)subsequent adrenalectomy and surgical pathology was benign.RESULTS:Ninety-four patients had left(n=90)and/or right(n=5)adrenal EUS-FNA without adverse events.EUS indications included:cancer staging or sus-pected recurrence(n=31),pancreatic(n=20),mediastinal(n=10),adrenal(n=7),lung(n=7)mass or other indication(n=19).Diagnoses after adrenal EUSFNA included metastatic lung(n=10),esophageal(n=5),colon(n=2),or other cancer(n=8);benign primary adrenal mass or benign tissue(n=60);or was non-diagnostic(n=9).Available follow-up confirmed a benign lesion in 5/9 non-diagnostic aspirates and 32/60benign aspirates.Four of the 60 benign aspirates were later confirmed as malignant by repeat biopsy,followup CT,or adrenalectomy.Adrenal EUS-FNA diagnosed metastatic cancer in 24,and ruled out metastasis in 10patients.For the diagnosis of malignancy,EUS-FNA of either adrenal had sensitivity,specificity,positive predictive value and negative predictive value of 86%,97%,96%and 89%,respectively.CONCLUSION:Adrenal gland EUS-FNA is safe,minimally invasive and a sensitive technique with significant impact in the management of adrenal gland mass or enlargement.
文摘目的探讨Pan-TRK免疫组化在涎腺分泌性癌(secretory carcinoma of salivary glands,SCSG)诊断及鉴别诊断中的价值。方法收集14例SCSG临床资料,采用免疫组化、FISH对SCSG进行检测。另选取经典的腺泡细胞癌、黏液表皮样癌、腺样囊性癌各10例作为对照。结果14例SCSG患者男女比为4∶3,年龄15~79岁,10例发生于腮腺,2例发生于颊部,1例发生于腭部,1例发生于颈部;11例生存状态良好,1例复发生存,2例失访。14例SCSG,多呈浸润性生长,呈微囊状、乳头-囊状、管状、实性排列或几者混合,腔内伴丰富分泌物,1例见神经侵犯,1例伴淋巴结转移。免疫表型:14例SCSG中CK7、S-100、Mammaglobin均阳性,11例SOX-10阳性,10例GATA-3阳性,14例DOG1均阴性,Ki-67增殖指数为1%~15%。FISH检测:12例SCSG成功检测到FISH信号,10例发现ETV6-NTRK3基因融合阳性。14例SCSG均行Pan-TRK免疫组化检测,10例细胞核阳性,1例细胞质阳性。10例腺泡细胞癌、10例黏液表皮样癌、10例腺样囊性癌中分别有2、4、7例Pan-TRK阳性,定位于细胞膜/细胞质。结论Pan-TRK免疫组化阳性可提示伴ETV6-NTRK3融合的SCSG,尤其以细胞核着色模式为阳性标准时,在SCSG诊断及鉴别诊断中表现为较高的敏感性和高度特异性,并对未来TRK基因靶向治疗提供依据。
文摘Salivary gland tumors are a group of the most common tumors in the oral and maxillofacial region. They have features with complicated histopathologic classification and wide distribution. There is little knowledge on the clinicopathologic characterics and clinical behaviors of salivary gland tumors of various locations and subtype. The management of salivary gland tumors is also contraversial. Biopsy is not suggested because of seeding of tumor cells. Therefore adjunctive methods are important for preoperative diagnosis. Since 1985, our research group has performed a series of basic and clinical researches on salivary gland tumors including clinicopathologic characteristis and behavior, preoperative adjunctive diagnosis, mechanism, prevention and treatment of distant metastasis of salivary adenoid cystic carcinoma, and histogenesis of salivary gland tumor. These studies have improved our knowledge on the clinical, histopathological, cytological, imaging features, and biobehavior of different types of slivary gland tumors. We have also suggested related principles of management, modified the operative methods of benign tumor of parotid gland. Our efforts have raised the standards of diagnosis and treatment of salivary gland tumors.
