A Preliminary Investigation on Anti-inflammatory and Antibacterial Effect of Compound Sarcandra Aerosol

[Objective] This study aimed to reveal the therapeutic mechanism of compound sarcandra aerosol, which was exclusively owned by the Second Affiliated Hospital of Guiyang College of Traditional Chinese Medicine. [Method] An inflammation model was established by xylene-induced inflammation test and carrageenan- induced inflammation test to analyze the anti-inflammatory effect of compound sarcandra aerosol. By bacteriostasis test in vitro, the antibacterial effect of compound sarcandra aerosol against five common pathogens of pharyngitis was investigated. Blood samples were collected from Wistar rats in different compound sarcandra aerosol groups and control group to compare blood routine indicators and interleukin-1 （IL-1） levels. [Result] Three different concentrations of compound sarcandra aerosol could reduce degrees of xylene-induced ear edema in mice and carrageenan- induced paw edema in rats, but the anti-inflammatory effect of compound sarcandra aerosol was reduced as the concentration declined. In bacteriostasis test in vitro, the minimum inhibitory concentration of compound sarcandra aerosol against Streptococcus pneumoniae, Streptococcus hemolytis, Corynebacterium diphtheriae, Staphylococcus aureus and Salmonella typhimurium was 76, 105 38, 65 and 30 mg/ml, respectively. Compound sarcandra aerosol reduced white blood cell count, neutrophil count and lymphocyte percentage in pharyngitis model rats. Moreover, interleukin-1 level in watermelon frost lozenge group and different compound sarcandra aerosol groups was lower compared with control group. [Conclusion] Compound sarcandra aerosol can effectively treat pharyngitis by exerting anti-inflammatory and antibacterial effect and reducing interleukin-1 level. This study laid a solid foundation for clinical application of compound sarcandra aerosol.

Clinical observation on prevention and treatment of radiation-induced parotid-gland injury in patients with nasopharyngeal carcinoma by Compound Sarcandra Glabra

Objective:To investigate the protective effect of the Compound Sarcandra Glabra on radiation injury of parotid glands in patients with nasopharyngeal carcinoma.Methods:Sixty patients with primary nasopharyngeal carcinoma in the First Affiliated Hospital of Guangxi Medical University from June 2018 to January 2019 were collected,which were divided into treatment group and control group using a random number table.All patients were treated by a combination of 9-field intense-modulated radiotherapy and chemotherapy.The treatment group was given the Compound Sarcandra Glabra orally every day from 3 days before radiotherapy to the end.The degree of xerostomia(dry mouth)of patients was compared between the two groups at the end of radiotherapy and 3 months after radiotherapy by the chi-square test.The maximal adsorption and secretion rates of the parotid glands were compared between groups before radiotherapy,at the end of radiotherapy and 3 months after radiotherapy by the independent sample t-test.Results:The symptoms of dry mouth were alleviated in the treatment group,and the degree of dry mouth significantly differed between groups at the end of radiotherapy and 3 months after radiotherapy(χ2=6.696 and 10.977,P<0.05).There were no significant differences in the maximal adsorption and secretion rates of the parotid glands between groups before radiotherapy(t=0.974 and4.646,P>0.05);however,both variables were significantly higher in the treatment group at the end of radiotherapy and 3 months after radiotherapy(t=2.920 and 5.037;t=2.820 and 2.213,P<0.05).Patients presented no liver and kidney injury after radiotherapy.Conclusions:Oral administration of the Compound Sarcandra Glabra can effectively prevent radiation injury of the parotid glands in patients with nasopharyngeal carcinoma,thereby alleviating the degree of dry mouth after radiotherapy.