为研究环丙沙星(CPFX)对肿瘤生长的抑制作用,该实验将34只小鼠分成3组,用小鼠S_(180)实体瘤接种。对照组给以NS ip 0.2 ml,治疗组分别给以CPFX ip 0.2 ml(按100 mg·kg^(-1)即相当于1/4LD_(50))和CPFX ip 0.4 ml(按200 mg·kg^(...为研究环丙沙星(CPFX)对肿瘤生长的抑制作用,该实验将34只小鼠分成3组,用小鼠S_(180)实体瘤接种。对照组给以NS ip 0.2 ml,治疗组分别给以CPFX ip 0.2 ml(按100 mg·kg^(-1)即相当于1/4LD_(50))和CPFX ip 0.4 ml(按200 mg·kg^(-1)即相当于1/2 LD_(50))。结果显示给以CPFX ip 0.2 ml治疗组在第1疗程停药后d1,d3对小鼠S_(180)的抑制率分别为67.8％(P<0.05)、76.8％(P<0.01),第2疗程治疗后对小鼠S_(180)的抑制率为31.95％(P<0.05)。因此,该实验表明CPFX对小鼠S_(180)有抑制作用。展开更多
Kunming female mice were used and S180 sarcoma cells were transplanted subeutaneously into right anterior armpit or the mice. The mice were divided into three groups randomly, and orally administered with water, galli...Kunming female mice were used and S180 sarcoma cells were transplanted subeutaneously into right anterior armpit or the mice. The mice were divided into three groups randomly, and orally administered with water, gallium chloride and GaCl3+ Na2SeO3 respectively for 2 weeks. After that,the tumors and foreleg bones were taken out for study. The experimental results showed that oral administration with gallium chloride-could inhibit the growth or S180 sarcoma in mice and the tumor morphology was changed. Selenium could accelerate the gallium entering into bone. This fact might supply a new clue to further clinical application of gallium and selenium.展开更多
文摘为研究环丙沙星(CPFX)对肿瘤生长的抑制作用,该实验将34只小鼠分成3组,用小鼠S_(180)实体瘤接种。对照组给以NS ip 0.2 ml,治疗组分别给以CPFX ip 0.2 ml(按100 mg·kg^(-1)即相当于1/4LD_(50))和CPFX ip 0.4 ml(按200 mg·kg^(-1)即相当于1/2 LD_(50))。结果显示给以CPFX ip 0.2 ml治疗组在第1疗程停药后d1,d3对小鼠S_(180)的抑制率分别为67.8％(P<0.05)、76.8％(P<0.01),第2疗程治疗后对小鼠S_(180)的抑制率为31.95％(P<0.05)。因此,该实验表明CPFX对小鼠S_(180)有抑制作用。
文摘Kunming female mice were used and S180 sarcoma cells were transplanted subeutaneously into right anterior armpit or the mice. The mice were divided into three groups randomly, and orally administered with water, gallium chloride and GaCl3+ Na2SeO3 respectively for 2 weeks. After that,the tumors and foreleg bones were taken out for study. The experimental results showed that oral administration with gallium chloride-could inhibit the growth or S180 sarcoma in mice and the tumor morphology was changed. Selenium could accelerate the gallium entering into bone. This fact might supply a new clue to further clinical application of gallium and selenium.
