The key intermediate, 2-isopropyl-2-(3-methyl-1-benzoxyl-5-phenylsulfonyl-3E-pentenyl)-1, 3-dithiocycllohexane(Ⅲ), for the total synthesis of Sarcophytol-A (1)was prepared through 7 steps from acetone. The key steps ...The key intermediate, 2-isopropyl-2-(3-methyl-1-benzoxyl-5-phenylsulfonyl-3E-pentenyl)-1, 3-dithiocycllohexane(Ⅲ), for the total synthesis of Sarcophytol-A (1)was prepared through 7 steps from acetone. The key steps are nucleophilic addition of 2-1ithio-2-isopropyl-1,3-dithiocyclohexane to aldehyde 5 and double bond migration reaction of allylic alcohol 9 and 10.展开更多
The title compound,sarcophytol-A benzyl ether has been synthesized through 13 steps by employing acetone and geraniol as starting materials.The key steps in the synthesis were double bond migration reaction of allylic...The title compound,sarcophytol-A benzyl ether has been synthesized through 13 steps by employing acetone and geraniol as starting materials.The key steps in the synthesis were double bond migration reaction of allylic alcohols 5 and 6,phase transfer catalytic coupling (PTC)reaction of Ⅱ with 7 and the cyclization reaction of dicarbonyl acyclic precursor induced by TiCl_3-AlCl_3(3:1)/Zn-Cu system.展开更多
基金Supported by the National Natural Science Foundation of China State Educational Commission Foundation of China
文摘The key intermediate, 2-isopropyl-2-(3-methyl-1-benzoxyl-5-phenylsulfonyl-3E-pentenyl)-1, 3-dithiocycllohexane(Ⅲ), for the total synthesis of Sarcophytol-A (1)was prepared through 7 steps from acetone. The key steps are nucleophilic addition of 2-1ithio-2-isopropyl-1,3-dithiocyclohexane to aldehyde 5 and double bond migration reaction of allylic alcohol 9 and 10.
基金This project was supported by the National Natural Science Foundation of China Special Research Grant for Doctoral Sites in Universities.
文摘The title compound,sarcophytol-A benzyl ether has been synthesized through 13 steps by employing acetone and geraniol as starting materials.The key steps in the synthesis were double bond migration reaction of allylic alcohols 5 and 6,phase transfer catalytic coupling (PTC)reaction of Ⅱ with 7 and the cyclization reaction of dicarbonyl acyclic precursor induced by TiCl_3-AlCl_3(3:1)/Zn-Cu system.
