The present study established a mouse model of Alzheimer＇s disease, and investigated the effects of treatment with flavone extract from artificially cultivated saussurea. A positive control group was treated with est...The present study established a mouse model of Alzheimer＇s disease, and investigated the effects of treatment with flavone extract from artificially cultivated saussurea. A positive control group was treated with estradiol benzoate, and learning and memory ability were examined in the 8-arm radial maze. The learning and recognition ability of mice with Alzheimer＇s disease treated with flavone extract was significantly improved and the number of hippocampal neurons was significantly increased in the flavone-treated and positive control groups compared with the model group. The results indicate that flavone extract from artificially cultivated saussurea can improve learning and memory deficits in mice with Alzheimer＇s disease, exerting effects similar to those of estradiol benzoate.展开更多
基金the National Natural Science Foundation of China, No. 30901980the Foundation for Distinguished Young Talents in Higher Education of Guangdong, China, No. 51343003+1 种基金a grant from Traditional Chinese Medicine City of South China at Zhongshan, Guangdong Province, No. 2009H016the Medical Scientific Research Foundation Program of Guangdong Province, No. A20100285
文摘The present study established a mouse model of Alzheimer＇s disease, and investigated the effects of treatment with flavone extract from artificially cultivated saussurea. A positive control group was treated with estradiol benzoate, and learning and memory ability were examined in the 8-arm radial maze. The learning and recognition ability of mice with Alzheimer＇s disease treated with flavone extract was significantly improved and the number of hippocampal neurons was significantly increased in the flavone-treated and positive control groups compared with the model group. The results indicate that flavone extract from artificially cultivated saussurea can improve learning and memory deficits in mice with Alzheimer＇s disease, exerting effects similar to those of estradiol benzoate.
