We present numerical modeling of SH-wave propagation for the recently proposed whole Moon model and try to improve our understanding of lunar seismic wave propagation. We use a hybrid PSM/FDM method on staggered grids...We present numerical modeling of SH-wave propagation for the recently proposed whole Moon model and try to improve our understanding of lunar seismic wave propagation. We use a hybrid PSM/FDM method on staggered grids to solve the wave equations and implement the calculation on a parallel PC cluster to improve the computing efficiency. Features of global SH-wave propagation are firstly discussed for a 100-km shallow and900-km deep moonquakes, respectively. Effects of frequency range and lateral variation of crust thickness are then investigated with various models. Our synthetic waveforms are finally compared with observed Apollo data to show the features of wave propagation that were produced by our model and those not reproduced by our models. Our numerical modeling show that the low-velocity upper crust plays significant role in the development of reverberating wave trains. Increasing frequency enhances the strength and duration of the reverberations.Surface multiples dominate wavefields for shallow event.Core–mantle reflections can be clearly identified for deep event at low frequency. The layered whole Moon model and the low-velocity upper crust produce the reverberating wave trains following each phases consistent with observation. However, more realistic Moon model should be considered in order to explain the strong and slow decay scattering between various phases shown on observation data.展开更多
We present a parallel hybrid algorithm based on pseudospectral method （PSM） and finite difference method （FDM） for two-dimensional （2-D） global SH- wavefield simulation. The whole-Earth model is taken as a cross...We present a parallel hybrid algorithm based on pseudospectral method （PSM） and finite difference method （FDM） for two-dimensional （2-D） global SH- wavefield simulation. The whole-Earth model is taken as a cross section of spherical Earth, and corresponding wave equations are defined in 2-D cylindrical coordinates. Spatial derivatives in the wave equations are approximated with efficient and high accuracy PSM in the lateral and high-order FDM in the radial direction on staggered grids. This algorithm allows us to divide the whole-Earth into sub-domains in radial direction and implement efficient parallel computing on PC cluster, while retains high accuracy and efficiency of PSM in lateral direction. A transformation of moment tensor between 3-D spherical Earth and our 2-D model was proposed to give corre- sponding moment tensor components used in 2-D modeling. Comparison of modeling results with those obtained by direct solution method shows very good accuracy of our algorithm. We also demonstrate its feasibility with a lateral heterogeneous whole-Earth model with localized velocity perturbation.展开更多
目的探讨氯化钴(Co Cl2)诱导SH-SY5Y细胞缺氧损伤的作用及相关机制。方法用四甲基偶氮唑蓝比色法(MTT)观察不同浓度Co Cl2对SH-SY5Y细胞生长情况影响;ELISA法检测细胞内相关凋亡蛋白Bcl-2、Bax、Caspase-3及缺氧相关蛋白HIF-1α的表达...目的探讨氯化钴(Co Cl2)诱导SH-SY5Y细胞缺氧损伤的作用及相关机制。方法用四甲基偶氮唑蓝比色法(MTT)观察不同浓度Co Cl2对SH-SY5Y细胞生长情况影响;ELISA法检测细胞内相关凋亡蛋白Bcl-2、Bax、Caspase-3及缺氧相关蛋白HIF-1α的表达情况。结果 Co Cl2可以诱导SH-SY5Y细胞损伤,并呈现浓度和时间依赖性;Co Cl2作用于SH-Y5Y细胞导致HIF-1α、Caspace-3和Bax的表达增多(P<0.05),Bcl-2表达减少(P<0.01)。结论 Co Cl2诱导SH-SY5Y细胞缺氧损伤与上调HIF-1α表达、促进细胞凋亡有关。展开更多
In this paper, antiplane response of an isosceles triangular hill to incident SH waves is studied based on the method of complex function and by using moving coordinate system. The standing wave function, which can sa...In this paper, antiplane response of an isosceles triangular hill to incident SH waves is studied based on the method of complex function and by using moving coordinate system. The standing wave function, which can satisfy the governing equation and boundary condition, is provided. Furthermore, numerical examples are presented; the influences of wave number and angle of the incident waves and the angle of the hill’s peak on ground motion are discussed.展开更多
Identifying the main factors on spatial diff erences in net growth rate of Yesso scallop(Patinopecten yessoensis)in culture system is the key to eff ective aquaculture management and development.Coupling a 3D ecosyste...Identifying the main factors on spatial diff erences in net growth rate of Yesso scallop(Patinopecten yessoensis)in culture system is the key to eff ective aquaculture management and development.Coupling a 3D ecosystem model(ROMS-CoSiNE)with a dynamic energy budget model for scallops,a Yesso scallop culture ecosystem(YeSCE)model was established with which scallop growth was simulated with real seeding density and juvenile size from local aquaculture experiments from December 1,2012 to November 30,2013.Results show that the YeSCE model has reasonably simulated the environmental variation and scallop net growth rate in the Changhai sea area.The growth of scallops was slow in winter and midsummer and was limited mainly by temperature.Food availability was a key factor that contributed to the fast growth of the scallops during spring to early summer and in autumn.Generally,the scallops cultured in the north part of the Changhai sea area grew faster than those in the south;and the net growth rate for scallops cultured near the island was signifi cantly higher compare to the others,which is probably correlated to the spatial distribution of food availability.Based on the correlation analysis,the spatial diff erences of the net growth rate were largely aff ected by the length of the match timing of temperatures and food availability.The results of this study provide a scientifi c support for optimizing bottom culture planning and adjusting bottom culture methods.展开更多
在二维椭圆各向异性介质条件下,各向异性波动方程可以分解为一个独立的 SH 波波动方程和一个 P-SV 波波动方程组。本文用褶积求微分的有限差分方法实现了二维椭圆各向异性介质中 SH 波的共炮点记录的模拟。模拟结果的成败在于求解 SH ...在二维椭圆各向异性介质条件下,各向异性波动方程可以分解为一个独立的 SH 波波动方程和一个 P-SV 波波动方程组。本文用褶积求微分的有限差分方法实现了二维椭圆各向异性介质中 SH 波的共炮点记录的模拟。模拟结果的成败在于求解 SH 波波动方程时对边界条件的处理,文中分别给出内边界及边界端点的吸收公式;同时给出多种各向同性和椭圆各向异性介质中的共炮点记录和波场切片图(Snapshot),展示了椭圆各向异性 SH 波波场的特性。从中可以看出:①反射 SH 波的时距曲线并非双曲线;②各向异性波在界面上的反射和透射仍满足Snell 定律;③各向异性介质中的 SH 波和各向同性介质中的波型是完全对应的,只是两种介质中的同一类型的波在传播时间、传播速度和同相轴的形态及能量分布有所不同。展开更多
Previous studies have shown that PRDX5 and Nrf2 are antioxidant proteins related to abnormal reactive oxidative species(ROS).PRDX5 and Nrf2 play a critical role in the progression of inflammations and tumors.The combin...Previous studies have shown that PRDX5 and Nrf2 are antioxidant proteins related to abnormal reactive oxidative species(ROS).PRDX5 and Nrf2 play a critical role in the progression of inflammations and tumors.The combination of PRDX5 and Nrf2 was examined by Co-immunoprecipitation,western blotting and Immunohistochemistry.H2O2 was applied to affect the production of ROS and induced multi-resistant protein 1(MRP1)expression in NSCLC cells.The zebrafish models mainly investigated the synergistic effects of PRDX5 and Nrf2 on lung cancer drug resistance under oxidative stress.We showed that PRDX5 and Nrf2 form a complex and significantly increase the NSCLC tissues compared to adjacent tissues.The oxidative stress improved the combination of PRDX5 and Nrf2.We demonstrated that the synergy between PRDX5 and Nrf2 is positively related to the proliferation and drug resistance of NSCLC cells in the zebrafish models.In conclusion,our data indicated that PRDX5 could bind to Nrf2 and has a synergistic effect with Nrf2.Meanwhile,in the zebrafish models,PRDX5 and Nrf2 have significant regulatory impacts on lung cancer progression and drug resistance activities under oxidative stress.展开更多
The propagation of shear-horizontal(SH)waves in the periodic layered nanocomposite is investigated by using both the nonlocal integral model and the nonlocal differential model with the interface effect.Based on the t...The propagation of shear-horizontal(SH)waves in the periodic layered nanocomposite is investigated by using both the nonlocal integral model and the nonlocal differential model with the interface effect.Based on the transfer matrix method and the Bloch theory,the band structures for SH waves with both vertical and oblique incidences to the structure are obtained.It is found that by choosing appropriate interface parameters,the dispersion curves predicted by the nonlocal differential model with the interface effect can be tuned to be the same as those based on the nonlocal integral model.Thus,by propagating the SH waves vertically and obliquely to the periodic layered nanostructure,we could invert,respectively,the interface mass density and the interface shear modulus,by matching the dispersion curves.Examples are further shown on how to determine the interface mass density and the interface shear modulus in theory.展开更多
基金supported by the National Natural Science Foundation of China(Grants 41374046 and41174034)
文摘We present numerical modeling of SH-wave propagation for the recently proposed whole Moon model and try to improve our understanding of lunar seismic wave propagation. We use a hybrid PSM/FDM method on staggered grids to solve the wave equations and implement the calculation on a parallel PC cluster to improve the computing efficiency. Features of global SH-wave propagation are firstly discussed for a 100-km shallow and900-km deep moonquakes, respectively. Effects of frequency range and lateral variation of crust thickness are then investigated with various models. Our synthetic waveforms are finally compared with observed Apollo data to show the features of wave propagation that were produced by our model and those not reproduced by our models. Our numerical modeling show that the low-velocity upper crust plays significant role in the development of reverberating wave trains. Increasing frequency enhances the strength and duration of the reverberations.Surface multiples dominate wavefields for shallow event.Core–mantle reflections can be clearly identified for deep event at low frequency. The layered whole Moon model and the low-velocity upper crust produce the reverberating wave trains following each phases consistent with observation. However, more realistic Moon model should be considered in order to explain the strong and slow decay scattering between various phases shown on observation data.
基金supported by the National Natural Science Foundation of China (Granted Nos.41174034 and 40874020)
文摘We present a parallel hybrid algorithm based on pseudospectral method （PSM） and finite difference method （FDM） for two-dimensional （2-D） global SH- wavefield simulation. The whole-Earth model is taken as a cross section of spherical Earth, and corresponding wave equations are defined in 2-D cylindrical coordinates. Spatial derivatives in the wave equations are approximated with efficient and high accuracy PSM in the lateral and high-order FDM in the radial direction on staggered grids. This algorithm allows us to divide the whole-Earth into sub-domains in radial direction and implement efficient parallel computing on PC cluster, while retains high accuracy and efficiency of PSM in lateral direction. A transformation of moment tensor between 3-D spherical Earth and our 2-D model was proposed to give corre- sponding moment tensor components used in 2-D modeling. Comparison of modeling results with those obtained by direct solution method shows very good accuracy of our algorithm. We also demonstrate its feasibility with a lateral heterogeneous whole-Earth model with localized velocity perturbation.
文摘目的探讨氯化钴(Co Cl2)诱导SH-SY5Y细胞缺氧损伤的作用及相关机制。方法用四甲基偶氮唑蓝比色法(MTT)观察不同浓度Co Cl2对SH-SY5Y细胞生长情况影响;ELISA法检测细胞内相关凋亡蛋白Bcl-2、Bax、Caspase-3及缺氧相关蛋白HIF-1α的表达情况。结果 Co Cl2可以诱导SH-SY5Y细胞损伤,并呈现浓度和时间依赖性;Co Cl2作用于SH-Y5Y细胞导致HIF-1α、Caspace-3和Bax的表达增多(P<0.05),Bcl-2表达减少(P<0.01)。结论 Co Cl2诱导SH-SY5Y细胞缺氧损伤与上调HIF-1α表达、促进细胞凋亡有关。
文摘In this paper, antiplane response of an isosceles triangular hill to incident SH waves is studied based on the method of complex function and by using moving coordinate system. The standing wave function, which can satisfy the governing equation and boundary condition, is provided. Furthermore, numerical examples are presented; the influences of wave number and angle of the incident waves and the angle of the hill’s peak on ground motion are discussed.
基金Supported by the National Key Research and Development Program of China(Nos.2017YFC1404403,2016YFC1401602)the National Natural Science Foundation of China(No.41806018)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA23050502)。
文摘Identifying the main factors on spatial diff erences in net growth rate of Yesso scallop(Patinopecten yessoensis)in culture system is the key to eff ective aquaculture management and development.Coupling a 3D ecosystem model(ROMS-CoSiNE)with a dynamic energy budget model for scallops,a Yesso scallop culture ecosystem(YeSCE)model was established with which scallop growth was simulated with real seeding density and juvenile size from local aquaculture experiments from December 1,2012 to November 30,2013.Results show that the YeSCE model has reasonably simulated the environmental variation and scallop net growth rate in the Changhai sea area.The growth of scallops was slow in winter and midsummer and was limited mainly by temperature.Food availability was a key factor that contributed to the fast growth of the scallops during spring to early summer and in autumn.Generally,the scallops cultured in the north part of the Changhai sea area grew faster than those in the south;and the net growth rate for scallops cultured near the island was signifi cantly higher compare to the others,which is probably correlated to the spatial distribution of food availability.Based on the correlation analysis,the spatial diff erences of the net growth rate were largely aff ected by the length of the match timing of temperatures and food availability.The results of this study provide a scientifi c support for optimizing bottom culture planning and adjusting bottom culture methods.
文摘在二维椭圆各向异性介质条件下,各向异性波动方程可以分解为一个独立的 SH 波波动方程和一个 P-SV 波波动方程组。本文用褶积求微分的有限差分方法实现了二维椭圆各向异性介质中 SH 波的共炮点记录的模拟。模拟结果的成败在于求解 SH 波波动方程时对边界条件的处理,文中分别给出内边界及边界端点的吸收公式;同时给出多种各向同性和椭圆各向异性介质中的共炮点记录和波场切片图(Snapshot),展示了椭圆各向异性 SH 波波场的特性。从中可以看出:①反射 SH 波的时距曲线并非双曲线;②各向异性波在界面上的反射和透射仍满足Snell 定律;③各向异性介质中的 SH 波和各向同性介质中的波型是完全对应的,只是两种介质中的同一类型的波在传播时间、传播速度和同相轴的形态及能量分布有所不同。
基金supported by grants from National Natural Science Foundation of China(82273162)The Recruitment Program of Overseas High-Level Young Talents,Jiangsu Cancer Hospital Spark Fundamental Research Special Fund(ZJ202103)+1 种基金Jiangsu Province Health Care and Elderly Health Research Key Topics(LKZ2022007)Funding of Postdoctoral Funding of Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University and Xisike Clinical Oncology Research Foundation(Y-HS202102-0177).
文摘Previous studies have shown that PRDX5 and Nrf2 are antioxidant proteins related to abnormal reactive oxidative species(ROS).PRDX5 and Nrf2 play a critical role in the progression of inflammations and tumors.The combination of PRDX5 and Nrf2 was examined by Co-immunoprecipitation,western blotting and Immunohistochemistry.H2O2 was applied to affect the production of ROS and induced multi-resistant protein 1(MRP1)expression in NSCLC cells.The zebrafish models mainly investigated the synergistic effects of PRDX5 and Nrf2 on lung cancer drug resistance under oxidative stress.We showed that PRDX5 and Nrf2 form a complex and significantly increase the NSCLC tissues compared to adjacent tissues.The oxidative stress improved the combination of PRDX5 and Nrf2.We demonstrated that the synergy between PRDX5 and Nrf2 is positively related to the proliferation and drug resistance of NSCLC cells in the zebrafish models.In conclusion,our data indicated that PRDX5 could bind to Nrf2 and has a synergistic effect with Nrf2.Meanwhile,in the zebrafish models,PRDX5 and Nrf2 have significant regulatory impacts on lung cancer progression and drug resistance activities under oxidative stress.
基金Project supported by the National Natural Science Foundation of China(Nos.11472182 and 11272222)the China Scholarship Council(No.201907090051)。
文摘The propagation of shear-horizontal(SH)waves in the periodic layered nanocomposite is investigated by using both the nonlocal integral model and the nonlocal differential model with the interface effect.Based on the transfer matrix method and the Bloch theory,the band structures for SH waves with both vertical and oblique incidences to the structure are obtained.It is found that by choosing appropriate interface parameters,the dispersion curves predicted by the nonlocal differential model with the interface effect can be tuned to be the same as those based on the nonlocal integral model.Thus,by propagating the SH waves vertically and obliquely to the periodic layered nanostructure,we could invert,respectively,the interface mass density and the interface shear modulus,by matching the dispersion curves.Examples are further shown on how to determine the interface mass density and the interface shear modulus in theory.
