Objective To observe eflect uf fascial flaps of supraclavicular artery on treatment of neck scar contracture. Methods The supraclavicular flaps were designed according to direction of supraclavicular arteries and tran...Objective To observe eflect uf fascial flaps of supraclavicular artery on treatment of neck scar contracture. Methods The supraclavicular flaps were designed according to direction of supraclavicular arteries and transferred into detective areas caused by scar releasing.展开更多
目的探讨两种较为公认但序列不同的Wiskott-Aldrich综合征蛋白和富含脯氨酸同源物(Wiskott-Aldrich syndrome protein and SCAR homolog,WASH)的差异。方法使用免疫荧光、免疫共沉淀和激光微辐射等实验分析两种WASH在定位模式、与FAM21...目的探讨两种较为公认但序列不同的Wiskott-Aldrich综合征蛋白和富含脯氨酸同源物(Wiskott-Aldrich syndrome protein and SCAR homolog,WASH)的差异。方法使用免疫荧光、免疫共沉淀和激光微辐射等实验分析两种WASH在定位模式、与FAM21或Ku蛋白的相互作用、向DNA损伤位点募集速率和蛋白质稳定性方面的差异;比较多种生物中的WASH蛋白质序列和检测多种在生物和医学研究中常用的细胞中的WASH编码序列,分析两种人WASH序列的普遍性和保守性。结果两种WASH展现出类似的内体(endosome)定位模式。WASH468表现出与FAM21更强的相互作用,并且WASH468展现出更强的稳定性。WASH465表现出与Ku蛋白更强的相互作用,并且WASH465展现出向DNA损伤位点更强的募集。多种生物中的WASH序列与人WASH468序列的一致性明显高于WASH465,并且多种在生物和医学研究中常用的细胞中的WASH氨基酸序列均与WASH468一致。结论WASH468和WASH465的生物学特性存在差异,WASH468序列的普遍性和保守性明显高于WASH465,因此WASH468是更保守的人WASH序列。展开更多
Schwann cells are glial cells of peripheral nervous system, responsible for axonal myelination and ensheathing, as well as tissue repair following a peripheral nervous system injury. They are one of several cell types...Schwann cells are glial cells of peripheral nervous system, responsible for axonal myelination and ensheathing, as well as tissue repair following a peripheral nervous system injury. They are one of several cell types that are widely studied and most commonly used for cell transplantation to treat spinal cord injury, due to their intrinsic characteristics including the ability to secrete a variety of neurotrophic factors. This mini review summarizes the recent findings of endogenous Schwann cells after spinal cord injury and discusses their role in tissue repair and axonal regeneration. After spinal cord injury, numerous endogenous Schwann cells migrate into the lesion site from the nerve roots, involving in the construction of newly formed repaired tissue and axonal myelination. These invading Schwann cells also can move a long distance away from the injury site both rostrally and caudally. In addition, Schwann cells can be induced to migrate by minimal insults （such as scar ablation） within the spinal cord and integrate with astrocytes under certain circumstances. More importantly, the host Schwann cells can be induced to migrate into spinal cord by transplantation of different cell types, such as exogenous Schwann cells, olfactory ensheathing cells, and bone marrow-derived stromal stem cells. Migration of endogenous Schwann cells following spinal cord injury is a common natural phenomenon found both in animal and human, and the myelination by Schwann cells has been examined effective in signal conduction electrophysiologically. Therefore, if the inherent properties of endogenous Schwann cells could be developed and utilized, it would offer a new avenue for the restoration of injured spinal cord.展开更多
目的:探讨流体悬浮床配合细节护理对严重烧伤患者创面外观及身体功能恢复的影响。方法:回顾性分析2018年1月-2022年1月进行治疗的98例严重烧伤患者临床资料,根据其护理方式与治疗床的不同分为两组,对照组(n=50,常规护理+传统翻身床),观...目的:探讨流体悬浮床配合细节护理对严重烧伤患者创面外观及身体功能恢复的影响。方法:回顾性分析2018年1月-2022年1月进行治疗的98例严重烧伤患者临床资料,根据其护理方式与治疗床的不同分为两组,对照组(n=50,常规护理+传统翻身床),观察组(n=48,细节护理+流体悬浮床)。比较两组患者创面恢复相关指标、创面外观、功能恢复、创伤后成长水平及并发症。结果:干预后,观察组创面愈合时间、抗生素使用时间短于对照组(P<0.05),体温低于对照组(P<0.05);干预后6个月,观察组创面外观优良率高于对照组(P<0.05),观察组健康调查简表(36-item short form,SF-36)各维度评分均高于对照组(P<0.05),观察组创伤后成长评定量表(Chinese-posttraumatic growth inventory,C-PTGI)各维度评分均高于对照组(P<0.05);住院期间,观察组总并发症发生率低于对照组(P<0.05)。结论:流体悬浮床配合细节护理可以促进严重烧伤患者早日康复,且能改善患者创面外观,促进患者功能恢复,提高患者创伤后成长水平。展开更多
文摘Objective To observe eflect uf fascial flaps of supraclavicular artery on treatment of neck scar contracture. Methods The supraclavicular flaps were designed according to direction of supraclavicular arteries and transferred into detective areas caused by scar releasing.
文摘目的探讨两种较为公认但序列不同的Wiskott-Aldrich综合征蛋白和富含脯氨酸同源物(Wiskott-Aldrich syndrome protein and SCAR homolog,WASH)的差异。方法使用免疫荧光、免疫共沉淀和激光微辐射等实验分析两种WASH在定位模式、与FAM21或Ku蛋白的相互作用、向DNA损伤位点募集速率和蛋白质稳定性方面的差异;比较多种生物中的WASH蛋白质序列和检测多种在生物和医学研究中常用的细胞中的WASH编码序列,分析两种人WASH序列的普遍性和保守性。结果两种WASH展现出类似的内体(endosome)定位模式。WASH468表现出与FAM21更强的相互作用,并且WASH468展现出更强的稳定性。WASH465表现出与Ku蛋白更强的相互作用,并且WASH465展现出向DNA损伤位点更强的募集。多种生物中的WASH序列与人WASH468序列的一致性明显高于WASH465,并且多种在生物和医学研究中常用的细胞中的WASH氨基酸序列均与WASH468一致。结论WASH468和WASH465的生物学特性存在差异,WASH468序列的普遍性和保守性明显高于WASH465,因此WASH468是更保守的人WASH序列。
文摘Schwann cells are glial cells of peripheral nervous system, responsible for axonal myelination and ensheathing, as well as tissue repair following a peripheral nervous system injury. They are one of several cell types that are widely studied and most commonly used for cell transplantation to treat spinal cord injury, due to their intrinsic characteristics including the ability to secrete a variety of neurotrophic factors. This mini review summarizes the recent findings of endogenous Schwann cells after spinal cord injury and discusses their role in tissue repair and axonal regeneration. After spinal cord injury, numerous endogenous Schwann cells migrate into the lesion site from the nerve roots, involving in the construction of newly formed repaired tissue and axonal myelination. These invading Schwann cells also can move a long distance away from the injury site both rostrally and caudally. In addition, Schwann cells can be induced to migrate by minimal insults （such as scar ablation） within the spinal cord and integrate with astrocytes under certain circumstances. More importantly, the host Schwann cells can be induced to migrate into spinal cord by transplantation of different cell types, such as exogenous Schwann cells, olfactory ensheathing cells, and bone marrow-derived stromal stem cells. Migration of endogenous Schwann cells following spinal cord injury is a common natural phenomenon found both in animal and human, and the myelination by Schwann cells has been examined effective in signal conduction electrophysiologically. Therefore, if the inherent properties of endogenous Schwann cells could be developed and utilized, it would offer a new avenue for the restoration of injured spinal cord.
文摘目的:探讨流体悬浮床配合细节护理对严重烧伤患者创面外观及身体功能恢复的影响。方法:回顾性分析2018年1月-2022年1月进行治疗的98例严重烧伤患者临床资料,根据其护理方式与治疗床的不同分为两组,对照组(n=50,常规护理+传统翻身床),观察组(n=48,细节护理+流体悬浮床)。比较两组患者创面恢复相关指标、创面外观、功能恢复、创伤后成长水平及并发症。结果:干预后,观察组创面愈合时间、抗生素使用时间短于对照组(P<0.05),体温低于对照组(P<0.05);干预后6个月,观察组创面外观优良率高于对照组(P<0.05),观察组健康调查简表(36-item short form,SF-36)各维度评分均高于对照组(P<0.05),观察组创伤后成长评定量表(Chinese-posttraumatic growth inventory,C-PTGI)各维度评分均高于对照组(P<0.05);住院期间,观察组总并发症发生率低于对照组(P<0.05)。结论:流体悬浮床配合细节护理可以促进严重烧伤患者早日康复,且能改善患者创面外观,促进患者功能恢复,提高患者创伤后成长水平。
