Effects of the Treatment of Carpal Tunnel Syndrome with Surgery and Injections on the Hospital Anxiety and Depression Scale (HADS)

Background: The prevalence of carpal tunnel syndrome (CTS) and of anxiety and depression in primary care practice are high. Different studies had shown an increased prevalence of anxiety and depression in CTS patients. Nevertheless, few papers had been published studying the anxiety and depression scales in the treatment of CTS, either with corticosteroid injections (I) or with surgical decompression (S). Objective: To assess whether clinical improvement observed after the treatment of CTS either with I or with S correlates with an improvement in the punctuations of the Hospital Anxiety and Depression scales (HADS), at 3, 6 and 12-month follow-up. Methods: Randomized and open-label clinical trial, comparing I and S. Patients with symptoms suggestive of CTS (nocturnal paraesthesias) of at least 3 months duration and neurophysiological confirmation were included. Patients with clinically apparent motor impairment were excluded. The subjective evaluation of symptoms was carried out using the visual-analogue scale of pain (VAS-p). Clinical reviews were performed 3, 6 and 12 months after treatment. Each patient completed the HADS questionnaire and a VAS-p at 0, 3, 6, and 12 months. Statistical significance was established using the Student’s t test and the Mann-Whitney U test when necessary. A linear regression analysis was used to know the effect of the treatment adjusted for the initial score of both scales. Results: 65 patients were included (30 in group I and 35 in group S). There was no statistical difference between both groups in terms of age, gender distribution, disease duration, VAS-p, neurophysiological testing severity of CTS or the 8 subscales of HADS. Both groups improved significantly in relation to the baseline VAS-p values, in the reviews at 3, 6 and 12 months, with no significant differences between I and S. At 6 months, the reduction in the anxiety scale was around 3 points for both treatments (S = 3.6 and I = 3.2), without reaching significant differences. At 12 months, it was somewhat higher for those treated with I, but always around 3 points and without significant differences. The Depression scale score was slightly reduced at 6 months, and in a similar way for both groups (I = 1 and S = 1.19;p = 0.8). After 12 months, group I doubled the previous reduction, with group S experiencing a very slight change (I = 1.96 and S = 1.03;p = 0.3). When analysing the effect of group S on group I, the result was a reduction of 0.25 points for Anxiety (p = 0.7) and of 0.02 points for Depression (p = 0.9). Conclusions: Treatment of CTS with I or S results in a similar and discrete improvement in Anxiety scores on the HADS scale at 6 and 12 months. For both types of treatment, the Depression scores barely changed at 6 months, being somewhat higher in group I after 12-month follow-up. The independent effect of the S on both scales is small and not significant.

Quality of life and emotional change for middle -aged and elderly patients with diabetic retinopathy

AIM:To evaluate the SF-36, Diabetes Specificity Quality of Life Scale (DSQL) and anxiety and depression symptoms and investigate its changes in proliferative diabetic retinopathy (PDR) by vitrectomy interventions. METHODS:The present study included 108 diabetic retinopathy (DR) patients:54 with PDR and 54 with non-proliferative diabetic retinopathy (NPDR). Each healthy control group (n =54) sociodemographically matched to DR groups was established respectively. The quality of life, anxiety and depression symptoms were evaluated and analyzed on preoperative and postoperative month 1 using SF-36, DSQL and Hospital Anxiety and Depression Scale (HADS). · RESULTS:DR patients described impaired HRQL (Health Related Quality of life, SF -36) in 6 out of 8 subscales, including ‘Body Health’, ‘Body RoleFunction’,‘General Health’,‘Society Function’,‘Emotion Role Function’and‘Mental Health’. Compared with controls, DR patients (NPDR and PDR) suffered from statistically significantly impaired HRQL (SF-36 Summary score) (P【 0.05). By surgical intervention, the anxiety and depression score were significantly reduced, while the health and quality of life (SF-36 Summary scores and DSQL scores) was improved in patients with PDR (P 【0.05). CONCLUSION:DR patients were affected in mentation and quality of life. Surgery interventions can improve SF-36, DSQL, anxiety and depression in PDR patients.

One-year outcomes of resveratrol supplement with aflibercept versus aflibercept monotherapy in wet agerelated macular degeneration

AIM:To determine the one-year outcomes of resveratrol oral supplement in patients suffering from wet age-related macular degeneration(AMD).METHODS:Fifty naïve and previously untreated patients suffering from wet AMD,were randomly assigned in two subgroups of 25 patients each.All the participants were treated with 3 monthly intravitreal injections of 2.0 mg aflibercept(IAIs)followed by injections“according to need”,while in one group the patients also received daily two tablets of resveratrol oral supplement.Prior to treatment initiation,a complete ophthalmological examination,including best corrected visual acuity(BCVA)and contrast sensitivity evaluation,optical coherence tomography(OCT)scans,fundus autofluorescence(FAF),fluorescein angiography,indocyanine green angiography,and OCT angiography(OCTA),was performed to every participant,while all of them completed the Hospital Anxiety and Depression Scale(HADS)questionnaire,in order to assess their quality of life(QoL)status.The patients were assessed monthly for 1y with FAF,and OCT or OCTA;the main endpoints were the number IAIs,the changes in BCVA,in contrast sensitivity,and in patients’QoL status.RESULTS:No significant differences were present between the groups regarding the baseline demographic and clinical data.Over the 12-month period,a similar number of IAIs was applied in both groups(4.52±1.00 vs 4.28±0.90,P=0.38),while the rest of the clinical data also did not differ significantly after the completion of the study period.However,for HADS Depression(11.88±2.51 vs 8.28±1.54,P<0.001)and HADS Anxiety(11.92±2.52 vs 7.76±1.51,P<0.001)questionnaires values,the score was significantly better in patients who received resveratrol supplements.Moreover,a statistically significant difference was detected in the mean change from baseline values of contrast sensitivity(0.17±0.19 vs 0.35±0.24,P=0.005),HADS Depression(0.08±1.38 vs-3.88±1.48,P<0.001),and HADS Anxiety(0.36±1.98 vs-5.12±2.70,P<0.001)scores,in favour of the patients treated with resveratrol supplements.CONCLUSION:The resveratrol oral supplement is a complementary treatment in cases of wet AMD,highlighting its effectiveness in improving patients’QoL status.

A randomized controlled trial of lifestyle self-monitoring for irritable bowel syndrome in female nursing school students

Background: The aim of this study was to verify the efficacy of lifestyle self-monitoring for the improvement of the IBS and reveal what has been changed due to the intervention. Methods: A total of 111 nursing school students were randomized into three groups, two intervention groups (a two-month intervention group, n = 34, and a four-month intervention group, n = 35) and a control group (n = 34). The intervention groups conducted lifestyle self-monitoring in conjunction with a 15-minutes group work for either two or four months. The primary outcome measure was Rome II criteria for IBS. Other outcome measures were the Hospital Anxiety and Depression Scale (HADS) and the Gastrointestinal Symptom Rating Scale (GSRS). They were assessed at the baseline and the end of both of the intervention periods. Analysis was conducted as intention-to-treat. Results: The prevalence of IBS did not change significantly after the intervention in any of the groups. The HAD-A score, a subscale of the HADS score for anxiety, decreased 1.4 points in the two-month intervention group (p = 0.02) and 2.3 points in the four-month intervention group of (p = 0.01) after intervention. The average GSRS decreased 0.2 points in the control group (p = 0.05) and 0.3 points in the four-month intervention group (p < 0.01). Conclusions: Lifestyle self-monitoring for two or four months did not reduce the prevalence of the IBS significantly, but it did decrease anxiety and improved the QOL related to gastrointestinal symptoms in female nursing school students.

腹针配合左升右降微针调气法治疗抑郁症的临床观察

【目的】观察腹针配合左升右降微针调气法治疗抑郁症的临床疗效。【方法】将60例抑郁症患者随机分为观察组和对照组,每组各30例。观察组给予腹针联合左升右降微针调气法治疗,对照组给予盐酸舍曲林片治疗。共治疗6周。治疗6周后,评价2组临床疗效,观察2组患者治疗前后汉密尔顿抑郁量表(HAMD)评分的变化情况,以及抑郁自评量表(SAS)评分的情况。并评价2组的安全性及不良反应的发生情况。【结果】(1)治疗后,2组患者的HAMD评分明显改善(P<0.05),且观察组在改善HAMD评分方面明显优于对照组,差异有统计学意义(P<0.05)。2组患者HAMD评分治疗前后差值比较,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的SDS评分明显改善,且观察组在改善SDS评分方面明显优于对照组,差异有统计学意义(P<0.05)。2组患者SDS评分治疗前后差值比较,差异有统计学意义(P<0.05)。(3)观察组总有效率为100.00%(30/30),对照组为83.33%(25/30)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(4)观察组与对照组的不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】腹针配合左升右降微针调气法治疗抑郁症,可以明显改善患者的临床症状,疗效显著。

脚踝针结合择时耳穴压丸用于胸外科术后镇痛效果的研究

目的探讨脚踝针结合择时耳穴压丸用于胸外科术后镇痛效果。方法前瞻性选取2020年1月—2022年12月收治的胸外科术后患者130例,采用随机数字表法分为3组,A组44例采取脚踝针结合择时耳穴压丸,B组43例采取脚踝针,C组43例采取择时耳穴压丸。比较3组视觉模拟评分法(VAS)评分、静脉自控镇痛(PCIA)给药次数、疼痛介质[5-羟色胺(5-HT)、前列腺素E_(2)(PGE_(2))、β-内啡肽(β-EP)]、呼吸功能指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、氧合指数(OI)]、匹兹堡睡眠质量指数(PSQI)评分、医院焦虑抑郁量表(HAD)评分、不良事件发生率及舒适度。结果术后3、7 d,A组静息和活动状态VAS评分、PaCO_(2)及血清5-HT、PGE_(2)水平低于B组、C组,PaO_(2)、OI、β-EP高于B组、C组(P<0.05)。术后7 d,A组PSQI、HAD评分均低于B组、C组(P<0.05)。A组舒适度优于B组、C组,PCIA给药次数少于B组、C组(P<0.05)。B组与C组舒适度和PCIA给药次数比较差异均无统计学意义(P>0.05)。3组不良事件发生率比较差异无统计学意义(P>0.05)。结论脚踝针结合择时耳穴压丸用于胸外科术后镇痛效果确切,可减轻负面情绪,提高舒适度,改善睡眠及呼吸功能,可能与调节疼痛介质有关。

心理沟通与睡眠护理对改善肝癌手术患者睡眠质量的效果观察

目的:浅析对肝癌手术患者采用心理沟通与睡眠干预安抚患者的焦虑情绪,改善患者睡眠质量的效果。方法:选取2023年1—12月厦门大学附属第一医院肿瘤内科收治的肝癌手术患者60例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组30例。对照组采用基础护理,观察组采用心理沟通与睡眠干预,比较2组睡眠质量、焦虑、抑郁情绪及健康行为能力。结果:干预后,观察组匹兹堡睡眠质量量表评分、医院焦虑抑郁量表评分低于对照组(P<0.05);观察组健康行为能力量表(SRAHP)评分高于对照组(P<0.05)。结论:针对肝癌手术患者实施心理沟通与睡眠干预的效果显著,有助于改善患者睡眠质量,缓解其医院焦虑和抑郁情绪,值得推广应用。

Association between gastrointestinal symptoms and affectivity in patients with bipolar disorder

AIM To study if anxiety, depression and experience of stress are associated with gastrointestinal(GI) symptoms in patients with bipolar disorder.METHODS A total of 136 patients with bipolar disorder(mean age 49.9 years; 61% women) and 136 controls from the general population(mean age 51.0 years; 60% women) were included in the study. GI symptoms were assessed with The Gastrointestinal Symptom Rating Scale-irritable bowel syndrome(GSRS-IBS), level of anxiety and depression with The Hospital Anxiety and Depression Scale(HADS) and stress-proneness with Perceived Stress Questionnaire. Over a ten year period, all visits in primary care were retrospectively recorded in order to identify functional GI disorders.RESULTS In subjects with low total HADS-score, there were no significant differences in GI-symptoms between patients and controls(GSRS-IBS 7.0 vs 6.5, P = 0.513). In the patients with bipolar disorder there were significant correlations between all GSRS and HADS subscores for all symptom clusters except for "constipation" and "reflux". Factors associated to GI symptoms in the patient group were female sex(adjusted OR = 2.37, 95%CI: 1.07-5.24) and high HADS-Depression score(adjusted OR = 3.64, 95%CI: 1.07-12.4). These patients had also significantly more visits for IBS than patients with low HADS-Depression scores(29% vs 8%, P = 0.008). However, there was no significant differences in consulting behaviour for functional GI disorders between patients and controls(25% vs 17%, P = 0.108).CONCLUSION Female patients and patients with high HADS depression score reported significantly more GI symptoms, whereas patients with low HADS scores did not differ from control subjects.

Comparative Nursing Study of Patients Undergoing Coronary Intervention Therapy in Different Ways

Purpose: To compare the surgical indicators, perioperative complications and postoperative psychological status of patients with coronary interventional therapy (CIT) by radical artery and femoral artery puncture approaches. Methods: 120 patients with CIT were divided into femoral artery group (FAG) and radial artery group (RAG) according to the operation ways. The interventional operation was performed by the same surgeon team and methods. Data of surgical indicators and perioperative complications were recorded and collected. The psychological questionare survey was made within 48 hours the after surgery by the hospital anxiety and depression scale (HAD), and the results were scored by the psychiatrist. Results: The age, sex, ethnicity, education level, disease type, and combined diseases of the two groups had homogeneity without statistical difference. There was no obvious difference in X-ray exposure time, contrast agent usage and operation time in two ways (P > 0.05). The success rate of one-time catheterization was higher in FAG than in RAG (P Conclusion: CIT via radial artery can reduce the incidence of postoperative complications, postoperative physical discomfort and psychological problems such as anxiety and depression of patients.

人工流产术前患者焦虑抑郁现状及影响因素调查

目的应用医院用焦虑抑郁量表(HADS)探讨人工流产术前患者焦虑抑郁的发生风险。方法采用便利抽样法选取2022年1—9月在北京大学第一医院行人工流产术的患者871例,应用医院用焦虑抑郁量表(HADS)进行筛查焦虑抑郁的发生情况,采用卡方检验和二元逻辑回归分析焦虑抑郁发生的影响因素。结果871例人工流产术前患者中有866例完成了HADS量表测定,其中161例考虑为焦虑抑郁,占18.59%。随着每周锻炼频率、月收入、本人和伴侣文化程度、生活幸福程度、性生活积极性的提高,焦虑抑郁比例逐渐降低。不同职业间体力劳动为主者的焦虑抑郁比例最高,已婚人群的焦虑抑郁比例显著低于未婚人群和离异人群(P<0.05),不同居住状况间独居者的焦虑抑郁所占比例最大,妊娠、人工流产次数分析中,人工流产次数大于3次和妊娠4次的患者焦虑抑郁比例较高,其中妊娠2次的患者焦虑抑郁比例最低。二元Logistic回归分析显示,每周锻炼次数、居住状况、本人文化程度、生活幸福程度和妊娠次数是人工流产术前患者焦虑抑郁发生的影响因素。结论人工流产手术患者产生抑郁、焦虑负面情绪的比例较高,不同特征的人工流产手术患者发生焦虑抑郁的情况具有显著差异。在妇产专科护理工作中应重点关注更易产生焦虑和抑郁情绪的群体,针对性的采取心理护理干预措施,术前做好个性化健康宣教和心理疏导。

五行音乐疗法对跨文化压力探索性试点研究

目的探讨五行音乐疗法(FEMT)对不同文化背景下压力的有效性,并比较五行音乐疗法(FEMT)与西方艺术音乐疗法(WAMT)在缓解压力的差异。方法采用探索性随机对照试点研究,共纳入37名受试者,中方脱落2例,最终纳入35例,其中23名来自加拿大、12名来自中国。知情同意后,所有受试者被随机分配在家中听中医五行音乐或西方艺术音乐30 min,每周2次,持续4周。参与者被要求使用耳机,每次会议前后均测量脉搏率,并填写5份问卷,包括背景和人口统计调查(报告年龄、性别、教育、文化背景、聆听经验)。压力自我评估(每次干预前后),综合医院焦虑/抑郁量表(HADS,第2次干预后每周1次),压力感知调查(PSS,第2次干预后每周1次),音乐治疗干预调查(MTIS,每次干预前后)。结果①与WAMT组相比,FEMT第2次治疗后自我评估的压力评分显著下降(t=-2.057,P=0.046)。②在两组中,每组治疗前的压力评分均显著降低(WAMT:t=5.026;FEMT:T=7.645,P=0.000)。③两组干预后HADS评分差异无统计学意义(P>0.05);在中国样本中,FEMT和WAMT组第八次治疗后HADS评分存在显著差异(t=-3.862,P=0.003),FEMT干预前后HADS的差异有统计学意义(t=5.117,P=0.004)。WAMT组的MTIS治疗前后有显著差异(t=-2.572,P=0.023),但FEMT组没有(t=1.331,P=0.207)。结论该试点研究探索了一种安全可行的自我管理方法-音乐疗法干预两个不同文化群体的压力,并首次提供了FEMT和WAMT在缓解压力和焦虑方面的有效性的初步比较和证据。需要对更大的随机样本进行进一步调查,以阐明不同类型的音乐和文化群体对压力和焦虑水平的影响。

基于HADS评价疏肝和胃方对非糜烂性反流病患者的心理干预作用

目的:探讨疏肝和胃方对非糜烂性反流病(non-erosive reflux disease,NERD)患者焦虑抑郁状态的影响。方法:将90例NERD患者随机分为中药组(予疏肝和胃方颗粒剂)和西药组(予雷贝拉唑钠肠溶片)各45例,疗程8周,治疗前后应用医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)评价两组患者焦虑抑郁状态。结果:HADS-A、HADS-D积分中药组治疗前后组内及两组治疗后组间比较差异均有统计学意义(P<0.05)。结论:疏肝和胃方可改善NERD患者焦虑抑郁状态。

双心护理在冠状动脉粥样硬化性心脏病合并室性心律失常患者的应用及对抑郁自评量表及焦虑自评量表评分的影响

目的探究双心护理在冠状动脉粥样硬化性心脏病(冠心病)合并室性心律失常患者的应用及对抑郁自评量表(SDS)及焦虑自评量表(SAS)评分的影响。方法选取2018年5月至2019年10月本院收治的200例冠心病合并室性心律失常患者作为研究对象,根据护理方式不同分为两组,每组100例。观察组实施双心护理,对照组实施常规护理,比较两组生命质量评分、SDS评分、SAS评分、血脂指标[低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)]及患者满意度情况。结果观察组身体功能、心理功能、社会功能、物质生活评分均高于对照组,差异有统计学意义(P<0.05)。护理前,两组SDS、SAS评分比较差异无统计学意义;护理后,两组SDS、SAS评分均低于护理前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组LDL-C、TG、TC水平均低于对照组,差异有统计学意义(P<0.05)。观察组护理满意度为94.00%,高于对照组的79.00%,差异有统计学意义(P<0.05)。结论双心护理在冠心病合并室性心律失常患者的应用效果显著,可明显改善患者抑郁、焦虑症状,提高其生命质量,患者满意度较高,值得临床推广应用。

皮内针疗法缓解鼻腔鼻窦内镜术后疼痛的随机对照研究

目的:探讨皮内针疗法在鼻腔鼻窦内镜术后疼痛管理中的应用价值。方法:采用前瞻性队列研究,将50例鼻内镜术后的患者随机分为观察组和对照组,观察组给予皮内针治疗,对照组不做皮内针治疗。收集患者的基线资料,分别于术后6h、24h、48h、72h用疼痛视觉评分量表(VAS)评估患者的鼻部及头面部疼痛症状,并记录术后止疼药的使用情况。结果:2组患者的性别、年龄、手术方式、疼痛灾难化量表评分、医院焦虑抑郁量表评分及纳吸棉填充数量的差异均无统计学意义(P>0.05)。2组患者的疼痛VAS评分在术后6h、24h、48h、72h均逐渐下降。与对照组相比,观察组术后48h的疼痛VAS评分低于对照组,差异有统计学意义(P<0.05)。观察组患者均无皮内针治疗相关不良反应。结论:皮内针疗法能一定程度上缓解患者鼻腔鼻窦内镜术后疼痛,治疗后无不良反应。

从SAS、SDS量表评分推测甲状腺结节中医证型的研究

目的:依据焦虑自评量表(SAS)、抑郁自评量表(SDS)评分推测甲状腺结节可能的中医证型,为甲状腺结节的辨证从新的途径提供部分新数据。方法:收集120例甲状腺结节患者的资料,将SAS、SDS量表评分与中医证型进行相关性分析,进一步采用决策树探讨其中医证型与SAS、SDS量表评分之间的对应性关系。结果:通过决策树得出:SAS<48且SDS≥46为气郁痰阻;SAS<48且SDS<46为痰结血瘀;SAS≥48且SDS<46为肝火旺盛;SAS≥48且SDS≥61为气郁痰阻;SAS≥48且46≤SDS<61为气阴两虚。结论:甲状腺结节患者中气郁痰阻证、肝火旺盛证的轻重程度分别与抑郁、焦虑程度关系最密切。采用基于决策树的算法可以筛选出甲状腺结节患者各中医证型对应的焦虑、抑郁量表的具体得分,并建立根据SAS、SDS量表评分推测相应中医证型的模式。

Effects of Biologics on Mental Health and Health-Related Quality of Life in Patients With Psoriasis:A Repeated Cross-Sectional Survey in Chinese Population

Objective:Psoriasis is a chronic inflammatory systemic disease that severely impacts patients’ quality of life (QoL) and psychological health.While biologics have been shown to be effective in treating psoriatic lesions,thus improving QoL,real-life data regarding such effects remain scant.We administered a repeated cross-sectional survey to assess the effects of 8 weeks of biologics treatment on the QoL and mental health status of patients with moderate-to-severe plaque psoriasis.Methods:From March to May 2022,patients with moderate-to-severe plaque psoriasis were enrolled and treated with biologics in the outpatient clinic at the Dermatology Hospital of Southern Medical University.Assessments were performed before treatment and after 4 and 8 weeks of treatment with biologics.Psoriasis severity,QoL,and mental health status were evaluated using the Psoriasis Area and Severity Index (PASI),Dermatology Life Quality Index (DLQI),36-Item Short-form Health Survey (SF-36),and Hospital Anxiety and Depression Scale (HADS).A multivariate generalized estimating equations (GEE) analysis was used to account for repeated measures and to determine the effects of treatment duration and type of biological agent on relevant indicators.Results:Among the 78 enrolled patients,the ranges of pretreatment scores were 4.6 to 46.8 for the PASI,1 to 30 for the DLQI,31.5 to 100.0 for the physical component score (PCS) of the SF-36,16.6 to 100.0 for the mental component score (MCS) of the SF-36,0 to 15 for the HADS-A,and 0 to 17 for the HADS-D.After 8 weeks of biologics treatment,98.7% (77/78) of patients had obtained PASI 75.All assessed scores changed over time (GEE,P < 0.001).Moreover,there were group-by-time interaction effects for the DLQI score (GEE,P = 0.023) and PCS (GEE,P = 0.029).The HADS-A and HADS-D scores were both decreased at week 8 compared with pretreatment values.Correlation analyses revealed that higher DLQI scores were associated with lower levels of QoL and higher levels of anxiety or depression.Conclusion:Biologics are not only effective in the treatment of skin lesions but also exert beneficial effects upon the QoL and mental health of patients with psoriasis as determined in the short-term assessments conducted in this study.

中国囊性纤维化患者单中心焦虑抑郁状况调查

目的研究中国囊性纤维化(CF)患者合并焦虑抑郁情况。方法收集并分析北京协和医院CF注册登记队列研究中28例患者的临床资料,使用综合医院焦虑/抑郁情绪测定表评估CF合并焦虑抑郁患病状况。结果男性患者占42.9%(12/28),平均年龄(23±4.8)岁。检出焦虑或抑郁14例(50%),其中,中重度焦虑或抑郁8例(28.6%),中重度焦虑5例(17.9%),中重度抑郁7例(25.0%),严重焦虑1例(3.6%),无严重抑郁患者,4例患者(14.3%)同时存在中重度焦虑和中重度抑郁。与单纯CF患者相比,CF合并焦虑患者的肺通气功能更差,表现为FVC%pred(合并焦虑54.5%±18.8%,单纯CF 80.0%±14.6%,P<0.05)显著下降。CF合并抑郁患者的肺通气功能同样更差,表现为FEV 1%pred(合并抑郁41.6%±21.6%,单纯CF 64.2%±20.9%,P<0.05)及FVC%pred(合并抑郁53.9%±21.0%,单纯CF 80.0%±14.6%,P<0.01)显著下降。结论半数CF患者合并焦虑或抑郁,焦虑与抑郁共病率较高,严重焦虑或抑郁患病率低。与单纯CF患者相比,合并焦虑或抑郁的CF患者肺通气功能更差。

中药熏洗联合蛋黄油治疗肺癌靶向药物相关性皮疹临床效果及对血液指标、复发率影响

目的 探讨中药熏洗联合蛋黄油治疗肺癌靶向药物相关性皮疹的临床效果及对血液指标、复发率的影响。方法 选取2019年3月—2021年3月收治的肺癌口服靶向药物并出现相关性皮疹80例,根据治疗方法不同将其分为观察组和对照组2组各40例。观察组给予中药熏洗联合蛋黄油治疗,对照组给予糠酸莫米松乳膏治疗。观察比较2组治疗后皮疹分级改善情况、临床效果,治疗前后焦虑和抑郁量表评分、生活质量(QOL)评分、血液安全性指标,以及停药4周后皮疹复发情况。结果 治疗前后2组皮疹分级和治疗后2组临床效果经等级资料秩和检验显示差异均具有统计学意义(P<0.05)。治疗后,2组汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分均低于治疗前,QOL评分高于治疗前;观察组HAMA和HAMD评分低于对照组,QOL评分高于对照组(P<0.01)。治疗前后,2组血清丙氨酸转氨酶、天冬氨酸转氨酶和肌酐比较差异无统计学意义(P>0.05)。停药4周后,观察组皮疹复发率40.0%(16/40)低于对照组72.5%(29/40)(P<0.05)。结论 中药熏洗联合蛋黄油治疗肺癌靶向药物相关性皮疹效果确切,有助于防止皮疹复发。

结直肠肿瘤经自然腔道取标本手术在临床中的推广及应用

目的 分析结直肠肿瘤患者通过自然腔道取标本手术在临床中的推广及临床应用效果。方法 将2020年1月至2023年3月于本院治疗的56例结直肠肿瘤患者纳入研究对象,依据随机数表法,分为观察组与对照组各28例。观察组行经自然腔道取标本手术,对照组行常规腹腔镜结直肠肿瘤手术。出院时,比较两组术中出血量、手术时间、淋巴结清扫数、术后进食与排气时间、下床活动时间、住院时间、住院费用、视觉模拟评分(VAS)、术后心理状况[焦虑自评量表(SAS)、抑郁自评量表(SDS)]及并发症情况。结果 两组患者术中出血量、淋巴结清扫枚数相比,差异无统计学意义(P>0.05);观察组手术时间明显长于对照组,术后进食时间、术后排气时间、下床活动时间、住院时间及住院费用均明显短/低于对照组,差异有统计学意义(P<0.05);观察组患者术后1 d、3 d、5 d、7 d的VAS评分明显低于对照组,差异有统计学意义(P<0.05);观察组患者的SAS、SDS评分明显低于对照组,差异有统计学意义(P<0.05);两组并发症发生率相比,差异无统计学意义(P>0.05)。结论 结直肠肿瘤经自然腔道取标本手术在医院应用可降低住院费用,对胃肠功能影响小,且术后痛感轻、心理状态好,值得推广应用。

骨科创伤患者院前急救常见失误及应对分析措施分析

目的 分析创伤骨科患者在院前急救过程中经常发生的失误性操作及相关的处理措施。方法 选择本院2021年9月-2022年10月纳入的60例创伤骨科患者作为观察对象,以随机数字法分组,对照组、观察组患者各有30例。依次采取常规急救、针对性急救,对比患者急救效果及患者的情绪状态。结果 观察组患者满意度比对照组高,差异有统计学意义(P<0.05)。观察组并发症发生率比对照组低,差异有统计学意义(P<0.05)。2组患者急救前的SAS及SDS评分相比,差异无统计学意义(P>0.05);急救后,观察组SAS及SDS评分比对照组低,差异有统计学意义(P<0.05)。结论 创伤骨科患者在入院前急救发生失误时,采取针对性急救措施,可提升急救质量,使患者得以安全入院治疗,并改善负面情绪。