Advances and Challenges in Screening Traditional Chinese Anti-Aging Materia Medica

To provide a better service for senior health care, we summarized screening studies of traditional Chinese anti-aging materia medica （TCAM）. We collected and analyzed literature of TCAM screening studies using the lifespan test and animal models of aging from 1984 to 2012. We found 26 screening methods for TCAM, and 153 single herbs or active ingredients of TCAM that have been screened out during the past 28 years. The cell lifespan test, the fruit fly lifespan test, and D-galactose aging model were the most widely used and intensively studied screening methods. However, the method for establishing the D-galactose aging model needs to be standardized, and the D-galactose aging model cannot completely be a substitute for the normal aging mouse model. Great success has been achieved in screening studies in TCAM. To further improve screening studies in TCAM, we suggest that the D-galactose aging model be incorporated into the lifespan test in the New Drugs of Traditional Chinese Medicine Research Guide.

Parametric sensitivity analysis of precipitation and temperature based on multi-uncertainty quantification methods in the Weather Research and Forecasting model

Sensitivity analysis(SA) has been widely used to screen out a small number of sensitive parameters for model outputs from all adjustable parameters in weather and climate models, helping to improve model predictions by tuning the parameters. However, most parametric SA studies have focused on a single SA method and a single model output evaluation function, which makes the screened sensitive parameters less comprehensive. In addition, qualitative SA methods are often used because simulations using complex weather and climate models are time-consuming. Unlike previous SA studies, this research has systematically evaluated the sensitivity of parameters that affect precipitation and temperature simulations in the Weather Research and Forecasting(WRF) model using both qualitative and quantitative global SA methods. In the SA studies, multiple model output evaluation functions were used to conduct various SA experiments for precipitation and temperature. The results showed that five parameters(P3, P5, P7, P10, and P16) had the greatest effect on precipitation simulation results and that two parameters(P7 and P10) had the greatest effect for temperature. Using quantitative SA, the two-way interactive effect between P7 and P10 was also found to be important, especially for precipitation. The microphysics scheme had more sensitive parameters for precipitation, and P10(the multiplier for saturated soil water content) was the most sensitive parameter for both precipitation and temperature. From the ensemble simulations, preliminary results indicated that the precipitation and temperature simulation accuracies could be improved by tuning the respective sensitive parameter values, especially for simulations of moderate and heavy rain.