Two new ent-kaurane diterpenoids, sculponeatins L (1) and M (2), were isolated from the EtOAc extract of Isodon sculponeata. Their structures were elucidated by spectroscopic evidences. The cytotoxicities of 1 and 2...Two new ent-kaurane diterpenoids, sculponeatins L (1) and M (2), were isolated from the EtOAc extract of Isodon sculponeata. Their structures were elucidated by spectroscopic evidences. The cytotoxicities of 1 and 2 against human tumor cells K562 and T24 were tested.展开更多
b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isod...b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isodon sculponeatus afforded two new ent kaurane diterpenoids, sculponeatins J and K . Their structures were elucidated on the basis of their spectral properties, as well as X ray crystallographic analysis. The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested, and sculponeatin J showed significant inhibitory effects with IC 50 values less than 1.0 μg/mL.展开更多
文摘Two new ent-kaurane diterpenoids, sculponeatins L (1) and M (2), were isolated from the EtOAc extract of Isodon sculponeata. Their structures were elucidated by spectroscopic evidences. The cytotoxicities of 1 and 2 against human tumor cells K562 and T24 were tested.
文摘b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isodon sculponeatus afforded two new ent kaurane diterpenoids, sculponeatins J and K . Their structures were elucidated on the basis of their spectral properties, as well as X ray crystallographic analysis. The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested, and sculponeatin J showed significant inhibitory effects with IC 50 values less than 1.0 μg/mL.
