Ecteinascidin 743 from sea squirt is one of the most original anti-tumoral activity compounds, as proven by the Natural Cancer Institute. Ecteinascidin 743 could be obtained with traditional liquid extraction, but it ...Ecteinascidin 743 from sea squirt is one of the most original anti-tumoral activity compounds, as proven by the Natural Cancer Institute. Ecteinascidin 743 could be obtained with traditional liquid extraction, but it should be purified and separated from the extract. A molecularly imprinted solid-phase extraction procedure was developed for the selective separation. Ecteinascidin 743 was used as the template and the polymer was synthesized in a methanol environment. Water and n-hexane as the washing solvents can eliminate most of the interference. Good linearity and low relative standard deviations （less than 4.39%）justify its continuing development.展开更多
Sea squirt,as a highly invasive species and main biofouling source in marine aquaculture,has seriously threatened the biodiversity and aquaculture economy.On the other hand,a conductive biomaterial with excellent bioc...Sea squirt,as a highly invasive species and main biofouling source in marine aquaculture,has seriously threatened the biodiversity and aquaculture economy.On the other hand,a conductive biomaterial with excellent biocompatibility,and appropriate mechanical property from renewable resources is urgently required for tissue engineering patches.To meet these targets,we presented a novel and robust strategy for sustainable development aiming at the marine pollution via recycling and upgrading the waste biomass-sea squirts and serving as a renewable resource for functional bio-scaffold patch in tissue engineering.We firstly demonstrated that the tunic cellulose derived natural self-conductive scaffolds successfully served as functional cardiac patches,which significantly promote the maturation and spontaneous contraction of cardiomyocytes both in vitro and enhance cardiac function of MI rats in vivo.We believe this novel,feasible and“Trash to Treasure”strategy to gain cardiac patches via recycling the waste biomass must be promising and beneficial for marine environmental bio-pollution issue and sustainable development considering the large-scale consumption potential for tissue engineering and other applications.展开更多
文摘Ecteinascidin 743 from sea squirt is one of the most original anti-tumoral activity compounds, as proven by the Natural Cancer Institute. Ecteinascidin 743 could be obtained with traditional liquid extraction, but it should be purified and separated from the extract. A molecularly imprinted solid-phase extraction procedure was developed for the selective separation. Ecteinascidin 743 was used as the template and the polymer was synthesized in a methanol environment. Water and n-hexane as the washing solvents can eliminate most of the interference. Good linearity and low relative standard deviations （less than 4.39%）justify its continuing development.
基金This work was supported by the National Natural Science Foundation of China(32071363,52003113,U1601221)Science and Technology Projects of Guangzhou City(201804020035)+1 种基金Guangdong Province Science and Technology Projects(2016B090913004)Key Research&Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110104002).
文摘Sea squirt,as a highly invasive species and main biofouling source in marine aquaculture,has seriously threatened the biodiversity and aquaculture economy.On the other hand,a conductive biomaterial with excellent biocompatibility,and appropriate mechanical property from renewable resources is urgently required for tissue engineering patches.To meet these targets,we presented a novel and robust strategy for sustainable development aiming at the marine pollution via recycling and upgrading the waste biomass-sea squirts and serving as a renewable resource for functional bio-scaffold patch in tissue engineering.We firstly demonstrated that the tunic cellulose derived natural self-conductive scaffolds successfully served as functional cardiac patches,which significantly promote the maturation and spontaneous contraction of cardiomyocytes both in vitro and enhance cardiac function of MI rats in vivo.We believe this novel,feasible and“Trash to Treasure”strategy to gain cardiac patches via recycling the waste biomass must be promising and beneficial for marine environmental bio-pollution issue and sustainable development considering the large-scale consumption potential for tissue engineering and other applications.
