Two new secoiridoid glycosides from the roots of Picrorhiza scrophulariiflora

From the roots ofPicrorhiza scrophulariiflora, two new secoifidoid glycosides, named picrosecosides Ⅰ and Ⅱ （1, 2） have been isolated. Their structures were elucidated on the basis of chemical and spectropic evidences.

Three new secoiridoid glycosides from the flower buds of Lonicera japonica

Three new secoiridoid glycosides,named lonijapoglycol A(1),aldosecolohanin C(2)and aldosecolohanin B(3),together with three known ones(4–6),have been isolated from the flower the buds of Lonicera japonica.All the structures were identified by spectroscopic analyses.Lonijapoglycol A(1)expressed significant anti-inflammatory activity to inhibit the release ofβ-glucuronidase induced by platelet-activating factor in rat polymorphonuclear leukocytes with an IC50 value of 3.76μmol·L^-1.

Pharmacokinetic and Relative Bioavailability of Three Secoiridoid Glycosides in Beagle Dog Plasma After Oral Administration of Conventional and Enteric-Coated Capsules of Gentianella acuta Extract

Objective:To simultaneously investigate the pharmacokinetics of gentiopicroside,sweroside,and swertiamarin,which are constituents of Gentianella acuta,by developing and validating a simple,sensitive,and fast ultra-high-performance liquid chromatography–tandem mass spectrometry method.Materials and Methods:Blood samples were collected from the forward limb veins of six beagle dogs following oral gavage with G.acuta,the whole plant extract(39.90 mg/kg).Plasma samples were processed using liquid–liquid extraction.The analytes and paeoniflorin(internal standard[IS])were separated using an Acquity?UPLC ethylene bridged hybrid amide column(2.1 mm×100 mm,1.7μm)with isocratic elution using a mobile phase consisting of acetonitrile and 0.1%formic acid in water(80:20,v/v)at a flow rate of 0.4 mL/min.Quantification was performed using multiple reaction monitoring of the fragmentation transitions at m/z 401.1→179.0,403.1→195.0,419.1→179.0,and 525.2→449.1 for gentiopicroside,sweroside,swertiamarin,and the IS,respectively.Results:The linearity of the analytical response was good and the calibration curves were linear over concentration ranges of 1.20–192.0,0.40–159.0,and 0.20–209.3 ng/mL for gentiopicroside,sweroside,and swertiamarin,respectively.The extraction recovery was in the range of 84.72%–91.34%,84.58%–93.43%,and 82.75%–91.37%for gentiopicroside,sweroside,and swertiamarin,respectively.Conclusions:The method was successfully used to evaluate the pharmacokinetic parameters of gentiopicroside,sweroside,and swertiamarin in beagle dogs.

Five new sucrose esters from the whole plants of Phyllanthus cochinchinensis

Chemical investigation of the whole plants of Phyllanthus cochinchinensis(Euphorbiaceae)led to the isolation of five new sucrose benzoyl esters,3,6'-di-O-benzoylsucrose(1),3,6'-di-O-benzoyl-2'-O-acetylsucrose(2),3,6'-di-O-benzoyl-4'-O-acetylsucrose(3),3,6'-di-O-benzoyl-3'-O-acetylsucrose(4)and 3-O-benzoyl-6'-O-(E)-cinnamoylsucrose(5),together with two known secoiridoid glycosides,jasminoside(6)and jaslanceoside B(7).Their structures were established on the basis of detailed spectroscopic analysis and chemical method.

A New Secoiridoid Glycoside from Roots of Picrorhiza scrophulariiflora

Objective To study the chemical constituents in the roots of Picrorhiza scrophulariiflora.Methods The chemical constituents in the roots of P.scrophulariiflora were separated and purified with chromatographic methods.The structures were elucidated by spectroscopic methods and chemical analyses.Results A new secoiridoid glycoside,picrogentioside II(1) was successfully isolated from the roots of P.scrophulariiflora.Conclusion Compound 1 is a new secoiridoid glycoside.

A New Secoiridoid Glycoside from Swertia cincta

Objective To study the chemical constituents of Swertia cincta. Methods Preparative liquid chromatography was employed. The structures of the compounds were elucidated by spectroscopic analysis. isolated from S. cincta and identified as Results Three secoiridoid glycosides were 8-methoxyl-eustomorusside （1）, secoiridoids eustomorusside （2）, and eustomoside （3）. Conclusion Compound 1 is a new secoiridoid glycoside. Compounds 2 and 3 are isolated from this plant for the first time.