This article provides a brief overview of various approaches that may be utilized for the analysis of human semen test results. Reference intervals are the most widely used tool for the interpretation of clinical labo...This article provides a brief overview of various approaches that may be utilized for the analysis of human semen test results. Reference intervals are the most widely used tool for the interpretation of clinical laboratory results. Reference interval development has classically relied on concepts elaborated by the International Federation of Clinical Chemistry Expert Panel on Reference Values during the 1980s. These guidelines involve obtaining and classifying samples from a healthy population of at least 120 individuals and then identifying the outermost 5% of observations to use in defining limits for two-sided or one-sided reference intervals. More recently, decision limits based on epidemiological outcome analysis have also been introduced to aid in test interpretation. The reference population must be carefully defined on the basis of the intended clinical use of the underlying test. To determine appropriate reference intervals for use in male fertility assessment, a reference population of men with documented time to pregnancy of 〈 12 months would be most suitable. However, for epidemiological assessment of semen testing results, a reference population made up ofunselected healthy men would be preferred. Although reference and decision limits derived for individual semen analysis test results will undoubtedly be the interpretational tools of choice in the near future, in the long term, multivariate methods for the interpretation of semen analysis alone or in combination with information from the female partner seem to represent better means for assessing the likelihood of achieving a successful pregnancy in a subfertile couple.展开更多
Adolescents and young adults(AYA)with a cancer diagnosis or those at risk for cancer due to hereditary cancer syndromes may benefit from genetic counseling and testing not only to manage personal risk but also to addr...Adolescents and young adults(AYA)with a cancer diagnosis or those at risk for cancer due to hereditary cancer syndromes may benefit from genetic counseling and testing not only to manage personal risk but also to address reproductive concerns,especially fertility.The opportunity for genetic counselors to provide important risk information is relevant to both the newly diagnosed as well as to unaffected carriers and survivors.However,genetic counselors may need additional training in reproductive options related to AYA cancer to provide this valuable counsel.This commentary uses hereditary breast and ovarian cancer syndrome as a model to highlight important considerations when discussing preimplanatation genetic diagnosis and prenatal diagnosis,particularly in the context of expanded testing for hereditary cancer risk including multigene panels or whole exome or whole genome sequencing.Other hereditary cancers are also addressed;however,less is known about the psychosocial and fertility concerns in these AYA populations.Additionally,we provide an overview of the concept of"oncofertility"-the linkage between cancer care and reproductive medicine that aims to expand the reproductive opportunities of cancer patients-and offer support for the expansion of guidelines to include genetic counselors in AYA cancer patients’treatment planning related to reproductive health and fertility.展开更多
Agricultural chemical use has caused a public concern over environmental issue while decisions about applying chemicals are made by individual farmers. The critical decision-making role of farmers relative to agricult...Agricultural chemical use has caused a public concern over environmental issue while decisions about applying chemicals are made by individual farmers. The critical decision-making role of farmers relative to agricultural chemical use creates a need for accurate information on their perceptions of various chemical-related hazards and the factors that may influence such judgments. Based on data collected from 177 land operators at Xinxiang County in Henan Province of China, an empirical analysis is conducted to examine the relationship between farmers＇ character and the behavior of fertilizer application. Study findings reveal that： the characteristics of household head and household, and the nature of farming management positively affect the amount of fertilizers applied; information on fertilizers and the knowledge about environmental impact of fertilizer application have negative impacts by contrast. To formulate effective pollution control policies at the farm level, it is imperative for policy-makers to convey information to producers by demonstration projects, technical assistance, and education programs. Under a changed political environment, some combination of education and economic incentives could be lower cost and more effective tools for achieving desired environmental conservative goals.展开更多
By analyzing and extracting the research progress on nitrogen fertilization in wheat, a dynamic knowledge model for management decision-making on total nitrogen rate, ratios of organic to inorganic and of basal to dre...By analyzing and extracting the research progress on nitrogen fertilization in wheat, a dynamic knowledge model for management decision-making on total nitrogen rate, ratios of organic to inorganic and of basal to dressing nitrogen under different environments and cultivars in wheat was developed with principle of nutrient balance and by integrating the quantitative effects of grain yield and quality targets, soil characters, variety traits and water management levels. Case studies on the nitrogen fertilization model with the data sets of different eco-sites, cultivars, soil fertility levels, grain yield and quality targets and water management levels indicate a good performance of the model system in decision-making and wide applicability.展开更多
The 13 th Five-Year Plan(2016─2020), with the balanced development of population being the core element, is crucial for China. The superimposed effect of an aging population and low birthrate leading to a reduction i...The 13 th Five-Year Plan(2016─2020), with the balanced development of population being the core element, is crucial for China. The superimposed effect of an aging population and low birthrate leading to a reduction in the labor supply would have a fundamental influence on the long term balanced development of China's population, implying that China's population policy must be adjusted. This paper argues that a gradual relaxation of the family-planning policy adjustments accords with the original intention of the population policy design and development direction. The universal second-child policy is the logical results of the adjustment and improvement of China's family-planning policy, and is designed to bring about positive effects on future demographic and economic development, particularly in sustaining the long term balanced development of China's population, easing the marriage squeeze, extending the demographic dividend, and delaying the population aging process. China needs to develop and improve support and governance systems for fully implementing the universal second-child policy, realizing the policy transition from rewarding one-child families to population security and the modern transition of governance systems and capacity to a universal second-child policy.展开更多
文摘This article provides a brief overview of various approaches that may be utilized for the analysis of human semen test results. Reference intervals are the most widely used tool for the interpretation of clinical laboratory results. Reference interval development has classically relied on concepts elaborated by the International Federation of Clinical Chemistry Expert Panel on Reference Values during the 1980s. These guidelines involve obtaining and classifying samples from a healthy population of at least 120 individuals and then identifying the outermost 5% of observations to use in defining limits for two-sided or one-sided reference intervals. More recently, decision limits based on epidemiological outcome analysis have also been introduced to aid in test interpretation. The reference population must be carefully defined on the basis of the intended clinical use of the underlying test. To determine appropriate reference intervals for use in male fertility assessment, a reference population of men with documented time to pregnancy of 〈 12 months would be most suitable. However, for epidemiological assessment of semen testing results, a reference population made up ofunselected healthy men would be preferred. Although reference and decision limits derived for individual semen analysis test results will undoubtedly be the interpretational tools of choice in the near future, in the long term, multivariate methods for the interpretation of semen analysis alone or in combination with information from the female partner seem to represent better means for assessing the likelihood of achieving a successful pregnancy in a subfertile couple.
文摘Adolescents and young adults(AYA)with a cancer diagnosis or those at risk for cancer due to hereditary cancer syndromes may benefit from genetic counseling and testing not only to manage personal risk but also to address reproductive concerns,especially fertility.The opportunity for genetic counselors to provide important risk information is relevant to both the newly diagnosed as well as to unaffected carriers and survivors.However,genetic counselors may need additional training in reproductive options related to AYA cancer to provide this valuable counsel.This commentary uses hereditary breast and ovarian cancer syndrome as a model to highlight important considerations when discussing preimplanatation genetic diagnosis and prenatal diagnosis,particularly in the context of expanded testing for hereditary cancer risk including multigene panels or whole exome or whole genome sequencing.Other hereditary cancers are also addressed;however,less is known about the psychosocial and fertility concerns in these AYA populations.Additionally,we provide an overview of the concept of"oncofertility"-the linkage between cancer care and reproductive medicine that aims to expand the reproductive opportunities of cancer patients-and offer support for the expansion of guidelines to include genetic counselors in AYA cancer patients’treatment planning related to reproductive health and fertility.
基金supported by 2008 Program for New Century Excellent Talents in University of Chinathe National Natural Science Foundation of China(70873108)+1 种基金Zhejiang Provincial Natural Science Foundation, China (Z607126)the Ministry of Education of China (2007JJD630014)
文摘Agricultural chemical use has caused a public concern over environmental issue while decisions about applying chemicals are made by individual farmers. The critical decision-making role of farmers relative to agricultural chemical use creates a need for accurate information on their perceptions of various chemical-related hazards and the factors that may influence such judgments. Based on data collected from 177 land operators at Xinxiang County in Henan Province of China, an empirical analysis is conducted to examine the relationship between farmers＇ character and the behavior of fertilizer application. Study findings reveal that： the characteristics of household head and household, and the nature of farming management positively affect the amount of fertilizers applied; information on fertilizers and the knowledge about environmental impact of fertilizer application have negative impacts by contrast. To formulate effective pollution control policies at the farm level, it is imperative for policy-makers to convey information to producers by demonstration projects, technical assistance, and education programs. Under a changed political environment, some combination of education and economic incentives could be lower cost and more effective tools for achieving desired environmental conservative goals.
基金supported by the National Natural Science Foundation of China(30030090)National High Tech R&D Program(863 Program)of China(2001AA245041,2001AA115420).
文摘By analyzing and extracting the research progress on nitrogen fertilization in wheat, a dynamic knowledge model for management decision-making on total nitrogen rate, ratios of organic to inorganic and of basal to dressing nitrogen under different environments and cultivars in wheat was developed with principle of nutrient balance and by integrating the quantitative effects of grain yield and quality targets, soil characters, variety traits and water management levels. Case studies on the nitrogen fertilization model with the data sets of different eco-sites, cultivars, soil fertility levels, grain yield and quality targets and water management levels indicate a good performance of the model system in decision-making and wide applicability.
文摘The 13 th Five-Year Plan(2016─2020), with the balanced development of population being the core element, is crucial for China. The superimposed effect of an aging population and low birthrate leading to a reduction in the labor supply would have a fundamental influence on the long term balanced development of China's population, implying that China's population policy must be adjusted. This paper argues that a gradual relaxation of the family-planning policy adjustments accords with the original intention of the population policy design and development direction. The universal second-child policy is the logical results of the adjustment and improvement of China's family-planning policy, and is designed to bring about positive effects on future demographic and economic development, particularly in sustaining the long term balanced development of China's population, easing the marriage squeeze, extending the demographic dividend, and delaying the population aging process. China needs to develop and improve support and governance systems for fully implementing the universal second-child policy, realizing the policy transition from rewarding one-child families to population security and the modern transition of governance systems and capacity to a universal second-child policy.
