To investigate the correlation between hair selenium （Se） level and gastric cancer. Methods： Atomic fluorescence spectrophotometer（AFS） was used to detect the Se level in hair. Results： The Se concentration in p...To investigate the correlation between hair selenium （Se） level and gastric cancer. Methods： Atomic fluorescence spectrophotometer（AFS） was used to detect the Se level in hair. Results： The Se concentration in patients with gastric cancer ranged from 0.25 to 2.33 μg/g（0.825 ± 0.51 μg/g）, and that of health individuals ranged from 4.23 to 9.21 μg/g（6.29± 1.68 μg/g）. The results showed that the Se concentration in the patients＇ hair was significantly lower than that in controls （P 〈 0.01）. Conclusion： There is a correlation between hair concentration and gastric cancer.展开更多
Serum levers of retinol, α-tocopherol, β-carotene and elements(Zn, Cu, Mn, Ca, Mg, Cr, Co, Cd, Mo, Se)were detemined in 45 gastric cancer and 41 gastric dysplasia patients, and 48 normal subjects. The results showe...Serum levers of retinol, α-tocopherol, β-carotene and elements(Zn, Cu, Mn, Ca, Mg, Cr, Co, Cd, Mo, Se)were detemined in 45 gastric cancer and 41 gastric dysplasia patients, and 48 normal subjects. The results showed that βcarotene and Se, Co were lower in gastric cancer patients than that in gastric dysplasia patients or in normal subjects ,Ni and Cr levels were lower and Mn , Ca and Cd were higherin gastric cancer than in dysplasia patients. Zn , Fe , Cr . Cdwere lower and Mn, Ca, Mg. Mo levels were higher in gastric cancer patients than in normal. The differences mentioned are statistically significant. The stepwise discriminant analysis of 10 variables( Mn, Fe, Ca, Cr,Mo, Co, Cd, Se, α-tocophrol, β-carotene) were used in identifying gastric cancer . with 100% of the positive rate.The potential protective effect of β-carotene and Se against gastric cancer is an interesting postulate. We suggest that optimum supplement of β- carotene and Se might will be beneficial to gastric dysplasia patients in preventing the development of gastric cancer.展开更多
Background People have more and more concerned about allitridum as studies have shown that taking more raw garlic associated with a lower risk for cancers of the alimentary system In the present study, we tried to...Background People have more and more concerned about allitridum as studies have shown that taking more raw garlic associated with a lower risk for cancers of the alimentary system In the present study, we tried to examine whether a large dose of allitridum and a microdose of selenium prevent gastric cancer Methods A double-blind intervention study was performed on the participants aged (35-74) years, who had matched at least one of the following criteria: (1) a medical history of stomach disorder, (2) a family history of tumour, or (3) smoking and/or alcohol consumption A total of 2526 and 2507 persons were randomly enrolled into intervention group and control group respectively from 288 natural villages of seven communities in Qixia County, Shandong Province, China Each person of the intervention group orally took 200 mg synthetic allitridum every day and 100 μg selenium every other day for one month of each year during November 1989 to December 1991. At the same time, people in control group were given 2 placebo capsules containing corn oid with the identical appearance to that in the intervention group Results For all subjects the large dose of allitridum was accepted and no harmful side effects were found during the study In the first follow-up five years (1992-1997) after stopping the intervention, the morbidity rates of malignant tumours in the intervention group declined by 22%, in contrast to the control group, declined by 47 3% After adjusting for age, gender, and other potential confounders, relative risks (RRs) for all tumours and gastric cancer of the whole population were 0 67 (95%CL: 0 43-1 03) and 0 48 (95%CL: 0 21-1 06), respectively, and for male group they were 0 51 (95%CL: 0 30-0 85) and 0 36 (95%CL: 0 14-0 92), respectively. No signigicantly protective effect was found for the female subgroup DConclusion The present study proves that large doses of allitridum and microdorse of selenium may effectively prevent gastric cancer ,especially in men.展开更多
目的研究食管癌、胃癌及结直肠癌肿瘤组织、癌旁组织中硒元素(selenium,Se)含量及硒结合蛋白1(selenium binding protein 1,SBP1)的表达。方法收集山西医科大学第一医院经手术切除的食管癌、胃癌、结直肠癌组织及相应的癌旁组织各30例,...目的研究食管癌、胃癌及结直肠癌肿瘤组织、癌旁组织中硒元素(selenium,Se)含量及硒结合蛋白1(selenium binding protein 1,SBP1)的表达。方法收集山西医科大学第一医院经手术切除的食管癌、胃癌、结直肠癌组织及相应的癌旁组织各30例,采用原子吸收光谱法检测各组织中Se元素的含量,Western blot检测SBP1蛋白的表达。分析SBP1的表达量与患者临床病理特征之间的关系。结果与癌旁组织相比,食管癌、胃癌及结直肠癌癌组织中Se元素含量明显降低,SBP1的表达量显著下调,差异有统计学意义(P<0.05);食管癌中SBP1蛋白的表达在不同性别、年龄、分化程度、TNM分期及淋巴结转移的患者中无显著差异(P>0.05),胃癌及结直肠癌中SBP1在TNM分期Ⅲ+Ⅳ及淋巴结转移组织中的表达显著低于TNM分期Ⅰ+Ⅱ及淋巴结无转移的患者,差异有统计学意义(P<0.05),SBP1蛋白的表达在不同性别、年龄、分化程度的胃癌及结直肠癌患者中无显著差异(P>0.05)。结论 Se元素及SBP1在食管癌、胃癌及结直肠癌组织中下调,SBP1的低表达可能与胃癌、结直肠癌的进展及预后相关。展开更多
文摘To investigate the correlation between hair selenium （Se） level and gastric cancer. Methods： Atomic fluorescence spectrophotometer（AFS） was used to detect the Se level in hair. Results： The Se concentration in patients with gastric cancer ranged from 0.25 to 2.33 μg/g（0.825 ± 0.51 μg/g）, and that of health individuals ranged from 4.23 to 9.21 μg/g（6.29± 1.68 μg/g）. The results showed that the Se concentration in the patients＇ hair was significantly lower than that in controls （P 〈 0.01）. Conclusion： There is a correlation between hair concentration and gastric cancer.
文摘Serum levers of retinol, α-tocopherol, β-carotene and elements(Zn, Cu, Mn, Ca, Mg, Cr, Co, Cd, Mo, Se)were detemined in 45 gastric cancer and 41 gastric dysplasia patients, and 48 normal subjects. The results showed that βcarotene and Se, Co were lower in gastric cancer patients than that in gastric dysplasia patients or in normal subjects ,Ni and Cr levels were lower and Mn , Ca and Cd were higherin gastric cancer than in dysplasia patients. Zn , Fe , Cr . Cdwere lower and Mn, Ca, Mg. Mo levels were higher in gastric cancer patients than in normal. The differences mentioned are statistically significant. The stepwise discriminant analysis of 10 variables( Mn, Fe, Ca, Cr,Mo, Co, Cd, Se, α-tocophrol, β-carotene) were used in identifying gastric cancer . with 100% of the positive rate.The potential protective effect of β-carotene and Se against gastric cancer is an interesting postulate. We suggest that optimum supplement of β- carotene and Se might will be beneficial to gastric dysplasia patients in preventing the development of gastric cancer.
文摘Background People have more and more concerned about allitridum as studies have shown that taking more raw garlic associated with a lower risk for cancers of the alimentary system In the present study, we tried to examine whether a large dose of allitridum and a microdose of selenium prevent gastric cancer Methods A double-blind intervention study was performed on the participants aged (35-74) years, who had matched at least one of the following criteria: (1) a medical history of stomach disorder, (2) a family history of tumour, or (3) smoking and/or alcohol consumption A total of 2526 and 2507 persons were randomly enrolled into intervention group and control group respectively from 288 natural villages of seven communities in Qixia County, Shandong Province, China Each person of the intervention group orally took 200 mg synthetic allitridum every day and 100 μg selenium every other day for one month of each year during November 1989 to December 1991. At the same time, people in control group were given 2 placebo capsules containing corn oid with the identical appearance to that in the intervention group Results For all subjects the large dose of allitridum was accepted and no harmful side effects were found during the study In the first follow-up five years (1992-1997) after stopping the intervention, the morbidity rates of malignant tumours in the intervention group declined by 22%, in contrast to the control group, declined by 47 3% After adjusting for age, gender, and other potential confounders, relative risks (RRs) for all tumours and gastric cancer of the whole population were 0 67 (95%CL: 0 43-1 03) and 0 48 (95%CL: 0 21-1 06), respectively, and for male group they were 0 51 (95%CL: 0 30-0 85) and 0 36 (95%CL: 0 14-0 92), respectively. No signigicantly protective effect was found for the female subgroup DConclusion The present study proves that large doses of allitridum and microdorse of selenium may effectively prevent gastric cancer ,especially in men.
