Efficacy of Xiaojin Capsules Combined with Selenium Yeast Capsules on 120 Cases of Hashimoto's Thyroiditis with Abnormal Thyroid Function

[Objectives]To explore the efficacy of Xiaojin Capsules combined with Selenium Yeast Capsules in the treatment of Hashimoto's thyroiditis(HT)with abnormal thyroid function.[Methods]A total of 180 HT patients who were treated in the First Affiliated Hospital of Henan University and Henan Provincial People's Hospital from December 2020 to December 2021 were selected as the research subjects and randomly divided into the observation group(n=120)and the control group(n=60)in at a tratio of 2∶1 ratio according to their visiting time.The observation group was treated with Xiaojin Capsules(oral,5 capsules each time,twice a day for 12 weeks)and Selenium Yeast Capsules(oral,1 capsule each time,twice a day for 12 weeks).The control group was treated with only Selenium Yeast Capsules(oral,1 capsule each time,twice a day for 12 weeks).[Results]The difference in the levels of thyroid peroxidase antibody(TPO-Ab),thyroglobulin antibody(TGAb),serum free triiodothyronine(FT_(3)),serum free thyroxine(FT_(4)),and thyroid stimulating hormone(TSH)between the observation group and control group was statistically significant(P<0.05).The diameters of thyroid between the observation group and the control group before,during and after treatment were significantly different(P<0.05).The total effective rate of the observation group was 82.5%(99/120),which was significantly higher than 56.67%(34/60)in the control group,and the difference was statistically significant(P<0.05).The cure rate(22.50%)in the observation group was significantly higher than the control group(3.33%),and the difference was statistically significant(P<0.01).The ineffective rate of the observation group was 17.50%,which was significantly lower than that of the control group(40.00%),and the difference was statistically significant(P<0.01).The markedly effective rate of the observation group was 40.83%,which was significantly higher than that of the control group(31.67%),and the difference was statistically significant(P<0.05).The effective rate in the observation group was 191%,and the effective rate in the control group was 21.67%,and the difference was not statistically significant(P>0.05).[Conclusions]Xiaojin Capsules combined with Selenium Yeast Capsules in the treatment of HT can eliminate or alleviate the clinical symptoms and signs,significantly reduce the levels of TPO-Ab and TGAb in serum,restore thyroid function,improve thyroid shape and structure in the treatment of HT,and the clinical effect is satisfactory.

Milk selenium content and speciation in response to supranutritional selenium yeast supplementation in cows

The effects of selenium(Se)yeast supplementation on performance,blood biochemical and antioxidant parameters,and milk Se content and speciation were evaluated.Thirty-six mid-lactation Holstein dairy cows were randomly assigned to 1 of 3 treatments:1)control(basal diet containing Se at 0.11 mg/kg DM),2)basal diet+0.5 mg supplemental Se/kg DM(SY-0.5),and 3)basal diet+5 mg supplemental Se/kg DM(SY-5).Selenium was supplemented as Se yeast.The trial consisted of a 1-week pretrial period and an 8-week experimental period.Milk somatic cell score decreased with SY-5 supplementation(P<0.05),but other performance parameters were not affected(P>0.05).The serum Se concentration increased with the increasing levels of Se yeast supplementation(P<0.05),however,blood biochemical parameters showed few treatment effects.The antioxidant capacity of dairy cows was improved with Se yeast supplementation reflected in increased serum glutathione peroxidase activity(P<0.05)and total antioxidant capacity(P=0.08),and decreased malondialdehyde concentration(P<0.05).Milk total Se concentration increased with Se dose(P<0.05).Also,the selenomethionine concentration increased with Se dose from 13.0±0.7 pg/kg in control to 33.1±2.1 pg/kg in SY-0.5 and 530.4±17.5 pg/kg in SY-5 cows(P<0.05).Similarly,selenocystine concentration increased from 15.6±0.9μg/kg in control and 18.9±1.1 pg/kg in SY-0.5 to 22.2±1.5 pg/kg in SY-5 cows(P<0.05).In conclusion,Se yeast is a good organic Se source to produce Se-enriched cow milk with increased Se species including selenomethionine and selenocystine.The results can provide useful information on milk Se species when a high dose Se yeast was supplemented in the cow diet.

Microbiome and ileum transcriptome revealed the boosting effects of selenium yeast on egg production in aged laying hens

The declines in laying performance during the late productionperiod have adverse effects on the length of theproduction cycle. Improving the nutrition of laying hens is a crucialmeasure to reverse this declination. Thisstudy investigatedthe effect of seleniumyeast (SY)on egg production, ileal gene expressionandmicrobiota, aswell as elucidating their associations in aged laying hens. A total of 375 Jinghong laying hens at 76weeks oldwere randomly assigned into 5 dietary treatments, which included a selenium-deficient basal diet based oncorn-soybean meal, and dietary supplementation of SY at 0.15, 0.30 and 0.45 mg/kg, and sodium selenite at0.45mg/kg.The results showed that SYamelioratedthe depressionin aged layingperformance inthe 0.30mg/kg group (P < 0.01). Selenium yeast significantly increased ileum selenium concentration (P < 0.05), and SYgroups had higher seleniumdeposition efficiency than the sodiumselenite group. Functional enrichment andShort Time-series Expression Miner (STEM) analysis indicated that SY activated metabolic progress (e.g.,glycerolipidmetabolism, glycerophospholipidmetabolism, andfattyacidmetabolism),immune responseandoxidative stress response. Four hub genes including thioredoxin reductase 1 (TXNRD1), dihydrolipoamidedehydrogenase (DLD), integrin linked kinase (ILK) and leucine zipper tumor suppressor 2 (LZTS2) wereinvolved in intestinal metabolismwhich was closely associated with selenium deposition/status. Moreover,the relative abundance of Veillonella, Turicibacter and Lactobacillus was significantly increased, but the relativeabundance of Stenotrophomonas was significantly decreased by SY supplementation. Multi-omics dataintegration and Canonical correspondence analysis (CCA) showed that both the ileumselenium content andthe laying rate were highly correlated with pathways and bacteria enriched in metabolism and immuneresponse. Meanwhile, the “switched on” gene prostate stem cell antigen (PSCA) had a positive relationshipwith Veillonella and a negative relationship with the opportunistic pathogens Stenotrophomonas. Overall, ourstudy offered insight for the further exploration of the role of SY on boosting egg production and balancingileum intestinal flora in aged laying hens.

Effects of feeding yeast(Saccharomyces cerevisiae), organic selenium and chromium mixed on growth performance and carcass traits of hair lambs

Yeasts and organic minerals are used in diets to improve health, productive performance and some carcass characteristics of ruminants and non-ruminants. Thirty-two lambs（Pelibuey×Katahdin; BW=（30.55±1.67） kg; n=8） were used in a 56-d feeding experiment to study the effects of different levels of live yeast（Saccharomyces cerevisiae; yeast）, selenium（Se） and chromium（Cr） mixed（Se-Cr）, and a mixture of yeast-Se-Cr on growth performance and carcass traits. Animals were stratified by body weight（BW） and randomly assigned to one of four treatments： 1） control group（0.0 g kg–1 yeast）; 2） yeast（1.50 g kg–1 dry matter intake（DMI） d–1）; 3） Se-Cr premix（1.5 mg kg–1 DMI d–1 for each mineral）; and 4） yeast-Se-Cr mixture. There were no treatment effects on final BW; whereas lambs fed Se-Cr or yeast-Se-Cr had higher（P〈0.05） DMI than animals supplemented with only yeast. Average daily gain（ADG）, gain：feed ratio, chop area, dorsal fat and carcass yield were similar（P〉0.05） among treatment groups. In conclusion, supplementation with yeast, Se-Cr mixed or yeast-Se-Cr did not improve ADG, final BW, back fat content and carcass yield of growing of Pelibuey×Katahdin lambs. Supplementation with Se-Cr and yeast-Se-Cr increased DMI, and approximately 250 g ADG animal–1 d–1 was produced with no negative effects on growth and health of the animals.

酵母硒对肉鸡生长性能、屠宰性能、肉品质和抗氧化性能的影响

旨在探讨酵母硒对肉鸡生长性能、屠宰性能、肉品质和抗氧化性能的影响。选取150只1日龄白羽公肉鸡,随机分成5组,每组6个重复,每个重复5只,对照组以玉米-豆粕为基础饲料,各试验组Ⅰ、Ⅱ、Ⅲ、Ⅳ分别添加0.1、0.2、0.3和0.4 mg/kg的酵母硒,预试期7 d,正式试验期42 d。结果显示:添加酵母硒的各试验组对生长性能和屠宰性能均无显著影响(P>0.05)。在肉品质方面,试验Ⅲ组和试验Ⅳ组的红度(a∗)值和宰后45 min的pH值均显著高于对照组(P<0.05);试验Ⅱ组、试验Ⅲ组、试验Ⅳ组宰后24 h的pH值与对照组相比有显著提高(P<0.05)。在抗氧化性能方面,试验Ⅳ组的超氧化物歧化酶(SOD)活性极显著高于其他各组(P<0.01),试验Ⅱ组和试验Ⅲ组的过氧化氢酶(CAT)活性显著高于对照组(P<0.05),试验Ⅲ组谷胱甘肽过氧化物酶(GSH-Px)活性极显著高于其他各组(P<0.01)。提示:肉鸡日粮添加酵母硒的最适宜添加量为0.3 mg/kg。

酵母硒联合枯草芽孢杆菌对肉羊生长性能、瘤胃发酵及屠宰性能的影响

本文旨在研究酵母硒(Yeast Selenium,YS)联合枯草芽孢杆菌(Bacillus Subtilis,BS)对肉羊生长性能、瘤胃发酵及屠宰性能的影响。试验将60只日龄和体重相近的杜寒杂交羊随机分为4组,每组3个重复,每个重复5只。其中,CON组肉羊饲喂基础日粮,YS组肉羊饲喂基础日粮+100 mg/kg酵母硒,BS组肉羊饲喂基础日粮+30 mg/kg枯草芽孢杆菌,YS+BS组肉羊饲喂基础日粮+100 mg/kg酵母硒+30 mg/kg枯草芽孢杆菌。试验为期72 d,预饲期7 d,正试期65 d。结果显示:(1)与CON组相比,YS+BS组肉羊的末重显著提高5.25%(P<0.05),平均日增重显著提高15.93%(P<0.05)。与CON组相比,YS组、BS组、YS+BS组肉羊的料重比分别显著下降7.18%、6.20%、12.72%(P<0.05)。(2)与CON组、YS组相比,BS组、YS+BS组肉羊瘤胃pH值显著降低(P<0.05),乙酸含量和乙丙比显著提高(P<0.05)。与CON组相比,BS组、YS+BS组肉羊瘤胃氨态氮浓度显著提高(P<0.05)。(3)与CON组相比,YS+BS组肉羊的宰前活重、胴体重、眼肌面积显著提高5.38%、7.49%、17.37%(P<0.05)。由此可见,酵母硒联合枯草芽孢杆菌能提高肉羊生长性能,改善瘤胃发酵及屠宰性能。

软坚消瘿颗粒联合硒酵母胶囊治疗桥本甲状腺炎的效果及对甲状腺相关抗体水平的影响

目的探讨软坚消瘿颗粒联合硒酵母胶囊治疗桥本甲状腺炎的效果及对甲状腺相关抗体水平的影响。方法选取2019年3月至2022年3月我科收治的150例桥本甲状腺炎患者作为研究对象,随机将其分为对照组和观察组,各75例。对照组采用硒酵母胶囊治疗,观察组采用软坚消瘿颗粒联合硒酵母胶囊治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的白细胞介素-10(IL-10)水平高于对照组,白细胞介素-17(IL-17)、白细胞介素-23(IL-23)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的丙二醛(MDA)水平低于对照组,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平高于对照组,差异具有统计学意义(P<0.05)。结论软坚消瘿颗粒联合硒酵母胶囊可提高桥本甲状腺炎患者的临床疗效,降低甲状腺相关抗体水平,也能减轻炎症、氧化应激反应,值得推广。

酵母硒复合制剂对蛋鸡生产性能及蛋品质的影响

为分析酵母硒复合制剂对蛋鸡生产性能及蛋品质的影响。试验选取300羽28周龄的海兰褐蛋鸡,随机分为4组,每组5个重复,每个重复15羽。对照组根据《海兰褐壳蛋鸡商品代饲养管理技术规程》(DB34/T1650~2012)配制基础日粮,试验组分别在基础日粮中添加100、200、300mg/kg酵母硒复合制剂。预饲期7d,正试期60d。结果表明:(1)1~30d阶段,随着基础日粮中酵母硒复合制剂添加水平的提高,产蛋率有增加趋势(P <0.10)。31~60d阶段,与对照组相比,基础日粮添加200、300mg/kg酵母硒复合制剂可显著提高蛋鸡的产蛋率、平均日产蛋重(P <0.05),且显著降低了蛋鸡的料蛋比(P <0.05)。(2)试验第30天,与对照组相比,基础日粮添加200、300mg/kg酵母硒复合制剂可显著提高蛋黄颜色(P <0.05)。试验第60天,与对照组相比,基础日粮添加200、300mg/kg酵母硒复合制剂可显著提高鸡蛋重量、蛋白高度(P <0.05),基础日粮添加100、200、300mg/kg酵母硒复合制剂可显著提高了蛋黄颜色(P <0.05)。由此可见,基础日粮中添加200、300mg/kg酵母硒复合制剂均能提高蛋鸡生产性能,有效改善蛋品质。

富硒啤酒酵母的选育及有机硒含量的测定

为了进一步研究微生物富硒的能力,得到富硒能力较强的啤酒酵母,以啤酒酵母WX-01为出发菌,通过高浓度亚硒酸钠初筛,再经过常压室温等离子体(atmospheric and room temperature plasma,ARTP)诱变处理以及亚硒酸钠抗性平板筛选,观察菌株的生长状况结合对其生物量与硒含量的测定,选育出一株富硒优势啤酒酵母。通过培养条件为添加质量浓度35 mg/L,加硒时间8 h,培养时间36 h,得到的酵母WX-1的生物量提高到(5192±36)mg/L,较原始菌株WX-01提高了201%,硒含量达到(1475±33)μg/g,较原始菌株提高了330%,其有机硒产量和转化率分别为7658μg/L和97.1%。扫描电镜分析酵母菌富集后表面有少量单质硒析出。另外红外光谱在特定区域出现不同强度的吸收峰表明酵母细胞参与了硒蛋白的合成。

一种抗氧化膳食补充剂的增强免疫作用和毒理学评价

研究以雨生红球藻为主要原料复配富硒酵母、蜂花粉提取物和维生素E组成的抗氧化膳食补充剂的免疫作用和安全性。采用低、中、高三个剂量(0.1、0.2、0.4 g/kg bw)每天一次灌胃,连续30 d,观察对小鼠脾脏、胸腺指数、脾淋巴细胞转化活性、迟发型变态反应、抗体生成细胞水平、半数溶血值(HC_(50))、碳粒廓清速率、巨噬细胞的吞噬作用和自然杀伤细胞活性等指标的影响;通过Ames试验、骨髓细胞微核试验和小鼠精子畸形试验分别评估受试物的致癌潜力,以及对细胞和生殖系统的遗传毒性情况;通过30 d喂养试验考察受试物亚急性毒性。结果发现,与对照组相比,中、高剂量组OD差值分别提高了10.32%(P<0.05)和14.29%(P<0.01),说明该膳食补充剂可以促进小鼠的脾淋巴细胞增殖转化能力;高剂量组左右耳肿胀度差增加了8.02%(P<0.05),抗体积数增加了22.12%(P<0.05),说明该膳食补充剂可以显著提升迟发型变态反应能力和抗体生成细胞能力;无急性毒性、遗传毒性和亚急性毒性。实验证明,雨生红球藻、富硒酵母、蜂花粉提取物和维生素E复配的抗氧化膳食补充剂食用安全,具有增强免疫力的功能。

饲粮中添加酵母硒和二羟基丙酮对山羊生长性能、营养物质表观消化率、屠宰性能、肉品质及血清生化、抗氧化指标的影响

本试验旨在研究饲粮中添加酵母硒和二羟基丙酮对山羊生长性能、营养物质表观消化率、屠宰性能、肉品质及血清生化、抗氧化指标的影响。选取6月龄健康、雄性川中黑山羊96只,平均体重(24.83±1.50)kg,随机分为4组,每组4个重复,每个重复6只羊。对照组(CON组)饲喂基础饲粮,试验组分别在基础饲粮中添加0.3 mg/kg的酵母硒(SY组)、25 mg/kg的二羟基丙酮(DHA组)及0.3 mg/kg的酵母硒+25 mg/kg的二羟基丙酮(SY-DHA组)。预试期10 d,正试期60 d。结果表明:1)与CON组相比,SY组和SY-DHA组的平均日增重(ADG)和平均日采食量(ADFI)显著提高(P<0.05),料重比(F/G)显著降低(P<0.05)。2)与CON组相比,SY组和SY-DHA组的干物质、粗蛋白质和中性洗涤纤维表观消化率显著提高(P<0.05)。3)各组之间屠宰性能和器官指数均无显著差异(P>0.05)。4)与CON组相比,SY组和SY-DHA组的背最长肌和股二头肌红度值、pH 45 min显著提高(P<0.05),且SY-DHA组的股二头肌红度值显著高于SY组(P<0.05)。与CON组相比,SY组、DHA组和SY-DHA组的背最长肌滴水损失和股二头肌pH 24h显著降低(P<0.05)。5)与CON相比,SY组、DHA组和SY-DHA组的血清总蛋白(TP)含量显著提高(P<0.05),血清碱性磷酸酶(ALP)活性显著降低(P<0.05);DHA组和SY-DHA组的血清球蛋白(GLB)、高密度脂蛋白(HDL)含量显著提高(P<0.05),SY-DHA组的血清白蛋白(ALB)、总胆固醇(TC)含量显著提高(P<0.05)。6)与CON相比,SY组、DHA组和SY-DHA组的血清总抗氧化能力(T-AOC)显著提高(P<0.05),血清丙二醛(MDA)含量显著降低(P<0.05);SY组和SY-DHA组的血清谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活性显著提高(P<0.05)。综上所述,饲粮中添加酵母硒可以提高山羊生长性能和营养物质表观消化率;饲粮中添加酵母硒或二羟基丙酮均可以改善山羊肉品质,提高血清TP含量,改善脂质代谢,提高抗氧化能力,酵母硒和二羟基丙酮联合添加效果更优。

酵母硒对肠道健康的调节机理及其应用于猪生产的研究进展

酵母硒是一种有机硒补充剂,具有抗氧化、增强免疫、抗癌、保护肝脏等多种生物学功能。近年来研究表明,酵母硒作为饲料添加剂能够提高动物肠道抗氧化能力、维持肠道屏障完整性,调节免疫和微生物菌群。文章总结了酵母硒调节动物肠道健康的功能及作用机理,并对其在猪生产中的应用进行综述,以期为酵母硒在改善动物肠道健康方面的基础研究和富硒猪肉的生产应用提供参考依据。

蚯蚓处理添加不同硒源牛粪的比较研究

根据蚯蚓的生长繁殖和蚓体富硒情况,选出两种不同的硒源按不同的浓度混入牛粪中,利用蚯蚓处理牛粪,实现养殖业粪污的资源化利用。试验利用亚硒酸钠(Sodium selenite,SS)与富硒酵母(Selenium enriched yeast,SY)易富硒、价格低廉优势,选取亚硒酸钠和富硒酵母作为硒源添加剂,促进蚯蚓对硒富集,生产优质富硒肥料。探索有机硒与无机硒对蚯蚓生长繁殖的影响,以期实现蚯蚓养殖处理粪污的同时生产富硒肥料,提高特种养殖经济效益。试验通过在牛粪基料中添加2种硒源(亚硒酸钠SS、富硒酵母SY)、3个水平(5、10、15 mg·kg^(-1)),以硒元素计,选择出两种硒源的最适富硒量。结果表明,随着牛粪中硒添加量升高,蚯蚓的生长繁殖逐渐被抑制,硒浓度越高,蚯蚓的生长繁殖被抑制程度越高,当SY的硒添加量为15 mg·kg^(-1)时,蚯蚓有明显的中毒现象;硒浓度越高,蚯蚓体硒含量越高,二者成正比;牛粪中添加同一水平的SS与SY,SY组蚯蚓的硒含量明显高于SS组。

姜黄素联合富硒酵母对小鼠急性酒精性肝损伤的保护作用

目的:探讨姜黄素联合富硒酵母对急性酒精性肝损伤的保护作用。方法:将60只C57B6L/J小鼠随机分为空白组、模型组、姜黄素组(33.33 mg·kg^(-1) bw)、富硒酵母组(7.50 mg·kg^(-1) bw)和联合组(姜黄素33.33 mg·kg^(-1) bw+富硒酵母7.50 mg·kg^(-1) bw),每组12只;干预30 d后,一次性灌胃50%乙醇溶液(12 mL·kg^(-1) bw)建立急性酒精性肝损伤模型;观察小鼠体重、摄食、行为变化;检测小鼠肝脏指数与丙二醛(Malondialdehyde,MDA)、还原型谷胱甘肽(Glutathione,GSH)和甘油三酯(Triglyceride,TG)水平;油红染色观察小鼠肝脏组织病理学变化。结果:与空白组比较,模型组小鼠表现出肝脏肿大、肝细胞中脂滴大量堆积病理损伤,肝脏组织MDA和TG水平显著升高(P<0.05);姜黄素联合富硒酵母能显著降低小鼠肝脏中MDA和TG表达,提高GSH水平(P<0.05),减轻小鼠肝脏脂肪沉积。结论:姜黄素联合富硒酵母能够改善急性酒精灌胃诱导的肝脏脂质异常堆积,减轻氧化应激水平,对急性酒精性肝损伤具有良好的保护作用。

基于油凝胶的富硒绞股蓝戚风蛋糕制备

以绞股蓝超微粉部分替代小麦粉,以油凝胶部分替代黄油,制备了一款富硒绞股蓝戚风蛋糕。考查了绞股蓝超微粉、富硒酵母、油凝胶等添加量对蛋糕感官评分的影响,并对产品质构特性进行了评价。结果表明,最佳原料配方中各组分用量依次为低筋面粉90 g,绞股蓝超微粉10 g,全蛋液100 g,牛奶50 g,白砂糖40 g,黄油25 g,油凝胶25 g,富硒酵母0.2 mg/kg。该蛋糕产品外形蓬松,色泽呈浅绿色,甘甜不腻。与传统戚风蛋糕相比,强化了硒含量,降低了饱和脂肪含量,可为绞股蓝焙烤食品的开发提供理论依据和实践参考。

富硒酵母植物甾醇酯软胶囊辅助降血脂功能研究

为研究富硒酵母植物甾醇酯软胶囊辅助降血脂的效果,开展人体试食试验。本研究有效受试者104例,试食组58例,对照组56例。试食组每日服用富硒酵母植物甾醇酯软胶囊,对照组服用安慰剂。连续服用60天,检测相关指标。试食组前后比较,血清总胆固醇、甘油三酯及低密度脂蛋白胆固醇有显著性差异(P<0.05),而高密度脂蛋白胆固醇无显著性差异(P>0.05)。试验后,两组受试者甘油三酯、总胆固醇、低密度脂蛋白胆固醇组间比较,均有显著性差异(P<0.05),而高密度脂蛋白胆固醇组间比较无显善性差异(P>0.05)。试验期间未见与受试品或安慰剂有关的不良反应,并且受试者的安全性检查指标均未见明显变化或异常现象。根据辅助降血脂功能评价方法判定标准,认为富硒酵母植物醇酯软胶囊具有辅助降血脂功能。

海洋源富硒酵母的分离鉴定及其发酵工艺优化

目的:从海洋样品中分离、筛选及鉴定具有富硒功能的酵母菌,并探究发酵工艺对菌株富硒效果的影响。方法:结合耐硒法和红硒法从海南省东寨港红树林中分离纯化筛选出具有高富硒能力的海洋源微生物,通过形态学、生理生化和分子生物学方法对菌株进行鉴定。采用3,3'-二氨基联苯胺盐酸盐法对菌株的硒含量进行定量测定,最后经单因素实验对菌株的发酵工艺进行优化。结果:从海洋源样品中筛选鉴定出一株安全的具有富硒功能的发酵性拉茜斯酵母Lachancea fermentati HN-10,该酵母在接种量为5%、初始pH为6、发酵温度为22℃、发酵转速为180 r/min、发酵时间为48 h、硒添加量为20μg/mL的最优发酵工艺下生物量可达4.52 g/L,富硒量可达1.57 mg/g,对应的硒转化率可达35.43%。结论:海洋源L.fermentati HN-10具有潜在的富硒食品开发应用前景。

苦瓜提取物硒铬酵母组合物辅助降血糖功效研究

为研究苦瓜提取物、硒酵母、铬酵母组合物辅助降血糖效果,开展人体试食试验。本研究受试组52例,对照组53例,共采集到有效试验者105例。试食组每日服用苦瓜硒铬酵母胶囊,对照组服用安慰剂,连续服用60天,检测相关指标。试食组空腹血糖下降率5.52%,有效率48.08%;餐后2 h血糖下降率10.18%,有效率59.62%。试验后,两组空腹血糖有效率差异显著(P<0.05),餐后2 h血糖有效率差异显著(P<0.01);试食组空腹血糖、餐后2h血糖、糖化血红蛋白、血脂四项指标均无明显升高,餐后2 h血糖平均下降幅度≥10%。试验期间未见与受试品或安慰剂有关的不良反应,并且受试者的安全性检查指标均未见明显变化或异常现象,根据评价标准,认为苦瓜提取物、硒、铬组合物具有辅助降血糖功能。

硒酵母片联合左甲状腺素钠片对桥本甲状腺炎伴甲状腺功能减退患者临床研究

目的 分析硒酵母片与左甲状腺素钠片联合使用对桥本甲状腺炎伴甲状腺功能减退患者的临床效果。方法 选择2022年1月至2023年1月被九江市第一人民医院收治的84例桥本甲状腺炎伴甲状腺功能减退患者,采用随机数字表法分为观察组(42例)和对照组(42例)。比较两组临床疗效、甲状腺激素、甲状腺抗体及免疫功能。结果 观察组临床疗效为95.24%,与对照组的78.57%比较,差异有统计学意义(P<0.05)。治疗后,观察组游离三碘甲状腺原氨酸(FT_(3))、血清游离甲状腺素-4(FT_(4))、免疫细胞CD3^(+)、CD8^(+)水平较对照组高;血清促甲状腺激素、甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体、免疫细胞CD4^(+)、CD4^(+)/CD8^(+)水平较对照组低,差异有统计学意义(P<0.05)。结论 硒酵母片联合左甲状腺素钠片治疗疗效更佳,能有效改善甲状腺激素水平,降低免疫反应,安全可靠。