Selenoprotein-p and insulin resistance in children and adolescents with obesity

BACKGROUND Insulin resistance and obesity present significant challenges in pediatric populations.Selenoprotein P1(SEPP1)serves as a biomarker for assessing selenium levels in the body.While its association with metabolic syndrome is established in adults,its relevance in children remains underexplored.AIM To ascertain SEPP1 blood levels in children and adolescents diagnosed with obesity and to assess its correlation with insulin resistance and adiposity indices.METHODS 170 children participated in this study,including 85 diagnosed with obesity and an equal number of healthy counterparts matched for age and sex.Each participant underwent a comprehensive medical evaluation,encompassing a detailed medical history,clinical examination,and anthropometric measurements like waist circumference and waist-to-height ratio.Furthermore,routine blood tests were conducted,including serum SEPP1,visceral adiposity index(VAI),and Homeostatic Model Assessment of Insulin Resistance(HOMA-IR)level.RESULTS Our findings revealed significantly lower serum SEPP1 levels in children with obesity compared to their healthy peers.Moreover,notable negative correlations were observed between serum SEPP1 levels and body mass index,VAI,and HOMA-IR.CONCLUSION The study suggests that SEPP1 could serve as a valuable predictor for insulin resistance among children and adolescents diagnosed with obesity.This highlights the potential utility of SEPP1 in pediatric metabolic health assessment and warrants further investigation.

大鼠硒耗竭过程中不同组织硒蛋白利用硒的优先性

以低硒酵母配制的低硒基础饲料（含硒量为０．０１ｍｇ／ｋｇ）和在此基础上加亚硒酸钠配成硒水平为０．５０ｍｇ／ｋｇ的足硒饲料来喂养雄性Ｗｉｓｔａｒ断乳大鼠。于０、１、２、４、６、８、１２、１５、１７、１９、２０和２４周时处死大鼠取其组织，分别对各种组织中的硒、细胞内谷胱甘肽过氧化物酶（ｃＧＰＸ）、细胞外谷胱甘肽过氧化物酶（ｅＧＰＸ）、磷脂氢谷胱甘肽过氧化物酶（ＰＨＧＰＸ）、Ⅰ型脱碘酶（ＩＤⅠ）和Ⅱ型脱碘酶（ＩＤⅡ）活性进行动态观察。结果发现睾丸中的硒和脑垂体中的ｃＧＰＸ在耗竭过程中降低速度较其它组织慢，且降低幅度较小；而硒蛋白中ＩＤⅠ和ＰＨＧＰＸ对硒的利用优先于ｃＧＰＸ和ｅＧＰＸ，ＰＨＧＰＸ和ＩＤⅠ的功能可能比ｃＧＰＸ和ｅＧＰＸ更重要。