Sociopsychological impact factors of depression patients during the COVID-19 epidemic period

Objective:To investigate the impact factors of the COVID-19 epidemic on the mental health of patients with depression.Methods:The relevant data of 242 residents aged 18-50 years in a certain area were collected,118 patients and 124 healthy people were analyzed by general information questionnaire,the PsychoSocial Index(PSI)questionnaire,Social Support Rating Scale(SSRS)and Symptom Checklist 90(SCL-90).Compare the differences in social and psychological factors between the two groups.Then use logistic regression to evaluate the social and psychological influencing factors of depression patients during the epidemic.Results:Two results of logistic regression analysis showed that marital status,occupational status,abnormal pathological behavior,and utilization of support were still significantly associated with depression.Compared to working,unemployed/unemployed/retired,students are closely related to depression,followed by abnormal pathological behavior and utilization of support.Conclusion:Under the epidemic,depression groups lacking social relationships should actively pay attention to their mental health status and comprehensively enhance their social and psychological support.To avoid the exacerbation of psychological and psychological symptoms caused by the epidemic.

Predictive power of abnormal electroencephalogram for post-cerebral infarction depression

Electroencephalography is a sensitive indicator for measuring brain condition, and can reflect early changes in brain function and severity of cerebral ischemia. However, it is not yet known whether electroencephalography can predict development of post-cerebral infarc- tion depression. A total of 321 patients with ischemic stroke underwent electroencephalography and Hamilton Depression Rating Scale assessment to analyze the relationship between electroencephalography and post-cerebral infarction depression. Our results show that electroencephalograms of ischemic stroke patients with depression exhibit low-amplitude alpha activity and slow theta activity. In con- trast, electroencephalograms of ischemic stroke patients without depression show fast beta activity and slow delta activity. ＂Ihese findings confirm that low-amplitude alpha activity and slow theta activity can be considered as independent predictors for post-cerebral infarction depression.

Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks

AIM: To study the predictive value of the vegetative- depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative- depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi- center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results.

Assessment of Stress Cognitive Control and Executive Function with Stress Control Rating Scale (ECOSTRESS) and Low Resolution Brain Electromagnetic Tomography (LORETA) (In Portuguese People in Situations of Unemployment and Economic Insufficiency)

This article reviews the constructs of stress, appraisal, coping, according to a transactional perspective, and executive function, and presents a stress control rating scale (ECOSTRESS), which design is founded in these constructs. This psychometric tool is useful in the assessment of cognitive control of stress, correlated with the function of dorsolateral prefrontal cortex. It has been validated for its use in the assessment of Portuguese people in situations of stress related to unemployment and economic insufficiency. Also, within the context of the cognitive control of stress, it is highlighted the usefulness of low resolution brain electromagnetic tomography (LORETA).

Development of a Scale to Evaluate the Depressive State among Elderly Patients in General Wards

This study aims to develop a scale to evaluate depressive states among elderly patients in general wards, and verify the reliability and validity of the scale. Based on the results of interviews with nurses, we developed a draft of a scale comprised of 48 questions (NDE48). The Geriatric Depression Scale short version (GDS15), and the Zung Self-rating Depression Scale (SDS) were administered to 54 elderly patients. Two groups of nurses completed the NDE48 on different days. After performing an explanatory factor analysis, the NDE48 was simplified to a 16 question item scale (NDE16), comprising three factors. The correlation coefficient between GDS15 and NDE16 was 0.41 (p = 0.00191), and between SDS and NDE16 was 0.30 (p = 0.02633). Alpha coefficient of the total score of NDE16 was 0.88. For inter-rater reliability, the correlation coefficient was 0.57 (p = 0.00005). The findings suggest that the NDE16 will be highly useful when nurses evaluate depressive states among elderly inpatients.

Fluvoxamine in Treatment of Depression in Russian Patients: An Open-Label, Uncontrolled and Non-Randomized Multicenter Observational Study

Background: Fluvoxamine, a selective serotonin reuptake inhibitor is widely used in the treatment of depression, one of the most common disorders prevalent in Russia. However, studies demonstrating its efficacy and safety in routine settings in Russia are scarce. Methods: This prospective, uncontrolled, open-label study was conducted at 11 centers in Russia. Total 293 patients (aged ≥ 18 years), meeting DSM-IV criteria for depression and scoring ≥ 17 on 17-item Hamilton Rating Scale of Depression (HAMD-17) received fluvoxamine 50 - 300 mg for 6 weeks. Primary efficacy measures included change from baseline in the HAMD-17 and Clinical Global Impression (CGI) scores. Secondary efficacy measure was evaluation of sleep quality changes on HAMD-17 subscale. Safety was assessed by monitoring of adverse drug reactions (ADRs). Results: Mean age of patients was 42.7 years and the majority of them were women (72%). At the end of treatment (day 42), clinically significant reduction was observed in mean HAMD-17, CGI-severity of illness and HAMD-17 sleep sub-score from 23.1, 4.5 and 3.9 at baseline to day 42;change from baseline (Δ) was: Δ-17.3 [95% CI: -18.0;-16.7]), Δ-2.1 and Δ-3.4 [95% CI: -3.53;-3.20]), respectively. At day 42, 20.8% patients reported as normal (not at all ill) on the CGI-severity scale and 85% patients reported as “much improved” or “very much improved” on the CGI-change in severity and quality of life scores. Nausea (12.6%) and somnolence (5.1%) were the most frequently reported ADRs. No deaths or serious ADRs were reported but eight patients discontinued treatment due to ADRs. Conclusion: Treatment with fluvoxamine under routine settings showed marked improvement in Russian patients with depression as measured by HAMD-17 and CGI ratings and was thus efficacious as well as safe and well-tolerated.

Prevalence of Depression in Pre-Dialytic Chronic Kidney Disease Patients Attending at a Tertiary Care Hospital in Bangladesh

Background: Depression is a common and serious medical illness around the world. It occurs more frequently in patients with chronic illness than in the general population. It is a common psychiatric problem in patients with chronic kidney disease (CKD). Objective: To assess the level of depression in pre-dialytic CKD patients attending at a tertiary care hospital in Bangladesh. Methodology: This cross sectional study was conducted at Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from January 2020 to June 2020. A total of 100 pre-dialytic CKD patients were selected by convenience sampling technique and their level of depression was assessed by Zung Self-Rating Depression Scale (ZSDS). Data were collected by existing questionnaire with face to face interview and analyzed by statistical test. Results: The mean age of the participants was 49.70 ± 11.80 years. Among them 64% were male, 95% were muslim, 98% were married, 65% were completed secondary/above higher secondary level education, 65% were unemployed and 55% were lived in urban area. It was observed that 65% participants were economically dependent to their family, only 6% were engaged in regular exercise, 14% had family history of depression, 8% were smoker and 12% were alcohol/drug abuser. According to the Zung Self-Rating Depression Scale (ZSDS) we found 29% participants were mildly depressed, 39% participants were moderately depressed and 18% participants were severely depressed. Prevalence of depression was 86% in pre-dialytic CKD patients. Of them, 7% was in CKD stage-I, 17.4% was in CKD stage-II, 19.8% was in CKD stage-III, 22.1% was in CKD stage-IV and 33.7% was in CKD stage-V. Conclusion: Depression is highly prevalent in pre-dialytic CKD patients and more frequent in the advanced stages of CKD.

Development of a Scale to Evaluate Depressive States among Elderly Patients in General Wards —Verification of the Contents to Improve the Accuracy of the Scale

Purpose: This study aims to verify the validity of the contents of the Nurse Administered Depression Scale for Elderly Inpatients16 (NDE16) using the Delphi approach in order to further improve the accuracy of the NDE16, a scale for rating potential depressive states in elderly inpatients through the observations reported by nurses. Methods: Participants were nurses working in general wards for longer than 3 years and who expressed consent to the study participation. Data were collected using the Delphi method (3 times). Responses are scored from 1 to 5 (3 - 5 points as positive) using the Likert method. The standard criteria for inclusion in the further evaluation are “mean ≥ 3.0”, “standard deviation < 1.0”, “median ≥ 3.0”, and “IQR ≤ 1.0”. Items that meet all the criteria at the third survey are employed as question items in the final questionnaire. Results: The respondents were 139 females, 10 males, and 1 unknown, aged 25 to 65. The collection rates of the three surveys were 75% to 82%. Based on the results of the first survey, wordings of 9 questions were modified. Since Question 13 “Queries are not really responded to.” did not meet the criteria (IQR = 2) at the third survey, we excluded this question and named the revised scale NDE15. Discussion: The reason why Question 13 did not meet the criteria could be due to the difficulty in distinguishing “Expressing thought suppression” from the state of cognitive decline in dementia. Further studies are needed to determine cutoff points.

认知行为干预对伴焦虑状态突发性聋治疗的疗效分析

目的分析认知行为干预对治疗伴焦虑状态突发性聋的疗效。方法选取2020年6月—2022年6月郑州大学第一附属医院收治的突发性聋患者353例,其中低频型108例,高频型72例,平坦型81例,全聋型92例。入院24 h内独立完成焦虑自评量表(SAS)评分,标准分>50分,汉密尔顿焦虑量表(HAMA)评分,标准分>17分接受认知行为干预为A组192例,未接受认知行为干预为B组161例,依据突发性聋诊断和治疗指南(2015)进行治疗。A组患者额外接受认知行为干预治疗。结果A、B两组中,低频型患者治疗有效率分别为90.38%(47/52)、75.00%(42/56),高频型患者治疗有效率分别为64.81%(35/54)、61.11%(11/18),平坦型患者治疗有效率分别为77.27%(34/44)、48.65%(18/37),全聋型患者治疗有效疗有效率分别为76.19%(32/42)、52.00%(26/50),A组中低频型、平坦型、全聋型治疗有效率高于B组;A组治疗总有效率高于B组,差异有统计学意义(P<0.05)。结论认知行为干预可提高伴焦虑状态的低频下降型、平坦型、全聋型治疗有效率及治疗总有效率。

海南沉香灸治疗轻度抑郁性失眠患者的疗效观察

目的探讨海南沉香灸对轻度抑郁性失眠患者的影响。方法选取2020年11月—2022年1月期间因抑郁性失眠于海南省中医院康复科门诊就诊的85例患者,按随机数字表法分为沉香灸组30例、艾灸组30例、安慰灸组25例。沉香灸组采用针刺、耳穴埋针联合海南沉香灸治疗,艾灸组采用针刺、耳穴埋针联合艾灸治疗,安慰灸组采用针刺、耳穴埋针联合安慰灸治疗。治疗2、4、8周后和随访期间,观察比较两组患者临床疗效及治疗前后汉密尔顿抑郁评分(Hamilton depression score,HAMD)、匹兹堡睡眠质量指数量表评分(Pittsburgh sleep quality index,PSQI)、抑郁自评量表评分(Self-rating depressive scale,SDS)。结果治疗后沉香灸组总有效率93.33%(28/30)、艾灸组总有效率73.33%(22/30)均明显高于安慰灸组44.00%(11/25),差异有统计学意义(P<0.05);且沉香灸组总有效率明显高于艾灸组,差异有统计学意义(P<0.05)。治疗2、4、8周后及随访期间,3组患者HAMD评分均较治疗前降低,差异有统计学意义(P<0.05);沉香灸组和艾灸组HAMD评分均低于安慰灸组,差异有统计学意义(P<0.05);治疗8周后及随访期间,沉香灸组HAMD评分低于艾灸组,差异有统计学意义(P<0.05)。治疗2、4、8周后及随访期间,3组患者PSQI评分均较治疗前降低,差异有统计学意义(P<0.05);沉香灸组和艾灸组PSQI评分均低于安慰灸组,差异有统计学意义(P<0.05);沉香灸组PSQI评分低于艾灸组,差异有统计学意义(P<0.05)。治疗2、4、8周后及随访期间,3组患者SDS评分均较治疗前降低,差异有统计学意义(P<0.05);沉香灸组和艾灸组SDS评分均低于安慰灸组,差异有统计学意义(P<0.05);治疗4、8周后及随访期间,沉香灸组SDS评分均低于艾灸组,差异有统计学意义(P<0.05)。结论沉香灸和艾灸可改善轻度抑郁性失眠患者的抑郁症状和睡眠,沉香灸对抑郁症状和睡眠改善优于艾灸。

清瘿散改善桥本甲状腺炎合并亚临床甲减患者抑郁焦虑状态及抗体紊乱的随机对照研究

[目的]观察清瘿散对于肝郁脾虚型桥本甲状腺炎合并亚临床甲减患者的抑郁焦虑状态的改善作用,及其对血清抗甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体的影响。[方法]采用前瞻性设计,将2021年7月至2022年6月在上海市中医医院甲状腺病专科门诊明确诊断为肝郁脾虚型桥本甲状腺炎(HT)合并亚临床甲减(SCH)患者154例。根据不同治疗方案,用随机数字表法分为两组,试验组以清瘿散联用优甲乐治疗(77例),对照组以单药优甲乐治疗(77例),治疗周期12周。观察治疗前后两组患者抑郁及焦虑自评量表(SDS、SAS)计分、甲状腺疾病生活质量(SF-36)计分和血清抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体浓度(TgAb)、促甲状腺素(TSH)浓度变化。[结果]治疗12周后,试验组SDS、SAS评分较治疗前下降显著多于对照组(P<0.01)、试验组SF-36评分较治疗前提升,显著高于对照组(P<0.05);试验组血清TPOAb、TgAb较治疗前显著下降(P<0.01),对照组治疗前后均未见显著变化;两组治疗后血清TSH均较前显著下降(P<0.01)。试验组总有效率为86.4%,显著高于对照组42.6%,两组间有显著差异(P<0.01)。[结论]清瘿散加小剂量优甲乐治疗12周可显著改善肝郁脾虚型HT合并SCH患者抑郁及焦虑状态、提高患者生活质量,降低血清TSH、TPOAb、TgAb水平,临床疗效优于单药小剂量优甲乐治疗方案。

抑郁症患者血清短链脂肪酸水平与症状及生化指标的相关性

目的 探索抑郁症患者血清短链脂肪酸与生化指标及症状的相关性。方法 本研究共纳入50例住院的抑郁症患者为病例组,并同期海报招募了42名健康志愿者为对照组。采用气相色质谱法检测所有被试者血清中5种短链脂肪酸含量,包括乙酸、丁酸、戊酸、异戊酸和己酸。采用ELISA法检测血脂、血糖、胆汁酸、肌酐、尿素、尿酸、甲状腺素等生化指标。采用流式细胞法检测血液中的免疫指标(白细胞、中性粒细胞、淋巴细胞、单核细胞、中性粒细胞百分比、淋巴细胞百分比、单核细胞百分比)。采用HAMD-17、HAMA-14他评量表以及PHQ-9、GAD-7、PSQI、SDS等自评量表评估抑郁症的临床症状。使用Spearman相关分析计算短链脂肪酸与血液免疫细胞、血糖血脂、甲状腺素等生化指标和临床症状量表的相关性。结果 病例组血清短链脂肪酸中乙酸、戊酸、异戊酸含量显著高于对照组(P<0.05)。相关性分析表明,在抑郁症患者中升高的乙酸与单核细胞百分比呈显著正相关(r=0.39,P<0.01);戊酸与尿酸呈负相关(r=-0.33,P<0.05),与葡萄糖(r=0.31,P<0.05)和GAD7(r=0.31,P<0.05)呈正相关;异戊酸与肌酐(r=0.29,P<0.05)、尿素(r=0.30,P<0.05)、HAMA中的精神焦虑因子(r=0.28,P<0.05)均呈正相关;丁酸与TSH呈正相关(r=0.34,P<0.05),与淋巴细胞数量呈负相关(r=-0.39,P<0.01);己酸与甘油三酯(r=0.36,P<0.05)、总胆固醇(r=0.42,P<0.01)、低密度脂蛋白(r=0.42,P<0.01)、HAMD中睡眠因子(r=0.30,P<0.05)均呈正相关。结论 抑郁症患者血清短链脂肪酸中乙酸、戊酸、异戊酸水平升高,可能与血糖、血脂、血常规、甲状腺功能相互作用,共同对抑郁症的发生产生影响。

腹针配合左升右降微针调气法治疗抑郁症的临床观察

【目的】观察腹针配合左升右降微针调气法治疗抑郁症的临床疗效。【方法】将60例抑郁症患者随机分为观察组和对照组,每组各30例。观察组给予腹针联合左升右降微针调气法治疗,对照组给予盐酸舍曲林片治疗。共治疗6周。治疗6周后,评价2组临床疗效,观察2组患者治疗前后汉密尔顿抑郁量表(HAMD)评分的变化情况,以及抑郁自评量表(SAS)评分的情况。并评价2组的安全性及不良反应的发生情况。【结果】(1)治疗后,2组患者的HAMD评分明显改善(P<0.05),且观察组在改善HAMD评分方面明显优于对照组,差异有统计学意义(P<0.05)。2组患者HAMD评分治疗前后差值比较,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的SDS评分明显改善,且观察组在改善SDS评分方面明显优于对照组,差异有统计学意义(P<0.05)。2组患者SDS评分治疗前后差值比较,差异有统计学意义(P<0.05)。(3)观察组总有效率为100.00%(30/30),对照组为83.33%(25/30)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(4)观察组与对照组的不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】腹针配合左升右降微针调气法治疗抑郁症,可以明显改善患者的临床症状,疗效显著。

“通督治郁”针刺法对卒中后抑郁患者汉密尔顿抑郁量表各项评分的影响

目的探讨“通督治郁”针刺法治疗卒中后抑郁(PSD)患者的临床疗效以及对患者17项版汉密尔顿抑郁量表(HAMD-17)中各因子和项目评分的影响。方法回顾性收集2022年1月—2023年1月安徽中医药大学第二附属医院脑病六科住院或门诊诊断为PSD患者的资料,应用“通督治郁”针刺法进行治疗,比较治疗前后患者HAMD-17总分及项目评分、因子评分变化情况。结果本研究共纳入122例患者,治疗后疗效确切,无不良反应发生。治疗后,患者兴趣与工作、胃肠道症状、性症状和体质量减轻与治疗前比较,差异无统计学意义(P>0.05),其他HAMD-17项目评分与治疗前比较,差异有统计学意义(P<0.05)。治疗后,除因子2(体质量因子)外,患者HAMD-17各因子评分均较治疗前降低,差异有统计学意义(P<0.05)。结论“通督治郁”针刺法可明显改善PSD患者焦虑/躯体化症候群、睡眠障碍症候群、认知障碍症候群和阻滞症候群症状,是一种安全、有效的治疗方法。

分析行为转变理论健康指导护理对淋巴瘤患者心理负担及睡眠质量的影响

目的:分析行为转变理论健康指导护理对淋巴瘤患者心理负担及睡眠质量的影响。方法:选取2022年6月至2023年6月厦门大学附属第一医院收治的经病理学检查确诊的淋巴瘤患者80例作为研究对象,按照随机数字表法分为对照组和观察组,每组40例。2组均给予综合治疗,对照组实施常规健康宣教及护理干预,观察组则实施行为转变理论健康指导护理干预。在护理前、护理1周后,采用匹兹堡睡眠质量指数(PSQI)比较2组患者睡眠质量的差异,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)比较2组患者焦虑、抑郁症状改善情况,并监测2组患者的睡眠情况。结果:干预后,观察组SAS评分、SDS评分、PSQI评分均显著低于对照组,观察组护理后的睡眠时长、睡眠效率显著高于对照组,观察组觉醒时间显著短于对照组,差异均有统计学意义(均P<0.05)。结论:在淋巴瘤患者临床治疗中开展行为转变理论健康指导护理,能有效减轻患者的心理负担,缓解负性情绪,并改善睡眠质量,值得临床推广应用。

血小板相关指标与急性缺血性卒中后抑郁的相关性研究

目的分析血小板相关指标与急性缺血性卒中后抑郁(post-stroke depression,PSD)的关系。方法选取2021年9月至2022年5月在华北理工大学附属唐山市工人医院治疗的急性缺血性卒中病人235例,记录其一般临床资料,根据17项汉密顿抑郁量表(Hamilton depression rating scale,17 item,HAMD-17)评分将病人分为PSD组和非PSD组;测定各组病人血小板相关指标(血小板计数、血小板平均体积、血小板比容、血小板分布宽度);使用美国国立卫生院卒中量表(national institute of health stroke scale,NIHSS)、日常生活活动能力量表(activity of daily living,ADL)分别评估病人神经功能缺损情况和日常生活能力;采用多因素二元logistic回归模型分析与PSD相关的独立危险因素。结果研究共纳入缺血性脑卒中病人235例,PSD组病人85例,非PSD组病人150例。PSD组身体质量指数、NIHSS评分高于非PSD组,PSD组ADL评分低于非PSD组(P<0.05)。两组血小板计数和平均血小板体积分级分布上均差异有统计学差意义(P<0.05);PSD组血小板计数≤183×10^(9)/L、(>183~<257)×10^(9)/L、≥257×10^(9)/L分别有11例(12.9%)、47例(55.3%)、27例(31.8%),非PSD组分别有47例(31.3%)、72例(48.0%)、31例(20.7%)。多因素二元logistic回归分析结果显示,较高水平血小板计数、身体质量指数及NIHSS评分是PSD的独立危险因素(P<0.05)。结论较高水平的血小板计数是PSD发生的独立危险因素。

舍曲林联合生物反馈治疗伴非自杀性自伤的青少年抑郁症患者效果研究

目的探讨舍曲林联合生物反馈治疗伴非自杀性自伤(NSSI)青少年抑郁症患者的效果。方法选取2021年3月—2023年2月门诊和住院治疗的98例伴NSSI青少年抑郁症患者,采用随机数字表法分为观察组及对照组各49例。观察组给予舍曲林联合生物反馈治疗,对照组给予舍曲林治疗,均治疗8周。比较2组临床疗效,治疗前后汉密尔顿抑郁量表(HAMD)评分、抑郁自评量表(SDS)评分、NSSI行为和功能量表(ANSSIQ)评分,治疗前后血清多巴胺(DA)、5-羟色胺(5-HT)和同型半胱氨酸(Hcy)水平,以及治疗期间不良反应及副反应量表(TESS)评分。结果观察组总有效率(93.88%,46/49)高于对照组(77.55%,38/49)(P<0.05)。治疗2周、治疗4周和治疗8周后,2组HAMD评分、SDS评分与治疗前比较逐步降低,且观察组治疗4周和治疗8周后HAMD评分、SDS评分较对照组更低(P<0.05)。治疗后2组血清DA、5-HT均高于治疗前,且观察组比对照组更高(P<0.05,P<0.01);治疗后2组Hcy、ANSSIQ各评分低于治疗前,且观察组比对照组更低(P<0.05,P<0.01)。2组不良反应及TESS评分比较无差异(P>0.05)。结论舍曲林联合生物反馈治疗效果较好,可较好改善伴NSSI青少年抑郁症患者抑郁症状、NSSI行为。

疏肝解郁胶囊联合阿戈美拉汀对抑郁症患者汉密尔顿抑郁量表评分及孤啡肽、白细胞介素-2的影响

目的探讨疏肝解郁胶囊联合阿戈美拉汀对抑郁症患者汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分及孤啡肽(Orphanin-FQ,OFQ)、白细胞介素-2(Interleukin-2,IL-2)的影响。方法收集诊治为抑郁症的患者90例,随机分为对照组与试验组,每组45例,对照组仅给予阿戈美拉汀口服治疗,试验组采用联合疗法,给予疏肝解郁胶囊联合阿戈美拉汀口服治疗,治疗3个月,观察治疗前后中医证候积分、HAMD评分及血清OFQ及IL-2变化,对治疗疗效进行评定。结果两组治疗前饮食、精神、大小便、夜寐、舌脉积分比较差异无统计学意义(P>0.05),治疗后较治疗前积分下降(对照组t=19.104、33.773、22.839、18.861、17.178,试验组t=43.690、48.830、45.737、39.032、31.847),且试验组下降幅度大于对照组(t=32.593、15.532、20.189、23.032、16.500),差异具有统计学意义(P<0.05)。两组治疗前HAMD评分比较差异无统计学意义(P>0.05),治疗后较治疗前评分下降(对照组t=5.531,试验组t=8.930),且试验组下降幅度大于对照组(t=5.360),差异具有统计学意义(P<0.05)。两组治疗前血清OFQ及IL-2水平比较差异无统计学意义(P>0.05),治疗后较治疗前血清OFQ及IL-2水平下降(对照组t=7.099、4.204,试验组t=13.099、7.411),且试验组下降幅度大于对照组(t=6.677、5.531),差异具有统计学意义(P<0.05)。试验组治疗总有效率为93.33%(42/45),高于对照组77.78%(35/45),差异具有统计学意义(P<0.05)。结论疏肝解郁胶囊联合阿戈美拉汀治疗抑郁症能明显降低HAMD评分及血清OFQ、IL-2水平,治疗疗效优于单用阿戈美拉汀,疗效肯定。

乒乓球运动对抑郁倾向人群的干预效果分析

为了研究乒乓球运动对抑郁倾向的干预效果,使运动者提升自我价值感,同时有效减轻负面影响,在体育运动干预抑郁症领域的有限研究基础上,深入进行乒乓球运动抑郁症领域的探索,通过精心设计的乒乓球运动课程方案,深入研究体育锻炼对自我效能的积极影响。该文采用SDS抑郁自评量表对抑郁倾向的研究对象进行评估。结果显示,乒乓球运动对抑郁症状的干预效果显著,实验组的数据明显优于对照组。在躯体化、抑郁、焦虑和恐惧因子上,实验组与对照组之间表现出显著性差异(P<0.05)。在强迫和精神因子上,实验组与对照组之间没有统计学意义。乒乓球运动是一种适合进行抑郁倾向干预的运动项目,能够达到减轻症状的效果。该文旨在为改善抑郁症状提供一定的参考。

重复经颅磁刺激治疗抑郁症伴睡眠障碍的效果观察

目的:分析重复经颅磁刺激(rTMS)在合并睡眠障碍抑郁症患者治疗中的应用效果。方法:选取2022年4月至2023年12月泉州市第三医院收治的抑郁症合并睡眠障碍患者78例作为研究对象,按照随机数字表法分为对照组和观察组,每组39例。对照组采用药物治疗,观察组采用药物治疗+低频rTMS治疗。比较2组治疗后抑郁症状、睡眠质量与心率变异性。抑郁症状采用汉密顿抑郁量表(HAMD)评价,睡眠质量采用匹兹堡睡眠质量指数(PSQI)评价。结果:观察组在4周、8周后HAMD低于对照组,差异有统计学意义(P<0.05),PSQI与睡眠障碍发生率均显著较低,差异有统计学意义(P<0.05)。观察组4周后正常窦性心搏RR间期的标准差(SDNN)、24 h内每5 min RR间期平均值的标准差(SDANN)、总功率(TP)、高频(HF)、低频(LF)高于对照组,差异有统计学意义(P<0.05)。结论:低频rTMS可改善抑郁症合并睡眠障碍患者自主神经功能,减轻抑郁症状,减少睡眠障碍。