Electrical stimulation has recently received attention as noninvasive treatment in skin wound healing with its outstanding biological property for clinical setting.However,the complexity of equipment for applying appr...Electrical stimulation has recently received attention as noninvasive treatment in skin wound healing with its outstanding biological property for clinical setting.However,the complexity of equipment for applying appropriate electrical stimulation remains an ongoing challenge.Here,we proposed a strategy for skin scar inhibition by providing electrical stimulation via a multilayer stacked electret(MS-electret),which can generate direct current(DC)electric field(EF)without any power supply equipment.In addition,the MS-electret can easily control the intensity of EFs by simply stacking electret layers and maintain stable EF with the surface potential of 3400 V over 5 days owing to the injected charges on the electret surface.We confirmed inhibition of type 1 collagen andα-SMA expression of human dermal fibroblasts(hDFs)by 90%and 44%in vitro,indicating that the transition of hDFs to myofibroblasts was restricted by applying stable electrical stimulation.We further revealed a 20%significant decrease in the ratio of myofibroblasts caused by the MS-electret in vivo.These findings present that the MS-electret is an outstanding candidate for effective skin scar inhibition with a battery-free,physiological electrical microenvironment,and noninvasive treatment that allows it to prevent external infection.展开更多
The black hole model of the Universe evolution, accompanied by matter creation, already successfully accounting for many features of the past is discussed and further justified. It is once more stressed that even a ve...The black hole model of the Universe evolution, accompanied by matter creation, already successfully accounting for many features of the past is discussed and further justified. It is once more stressed that even a very large object but with a big mass is in its own right a black hole. As a consequence, the extrapolation of the past predicts for the future no big crunch, nor big bounce but a steady expansion with smaller matter density.展开更多
Comparison of the Hubble parameter with cosmological quantities strongly supports the black hole model for the description of the Universe evolution. Such evolution requires matter creation and has implications for wh...Comparison of the Hubble parameter with cosmological quantities strongly supports the black hole model for the description of the Universe evolution. Such evolution requires matter creation and has implications for what is currently referred to as “dark energy” and the “cosmological constant”.展开更多
基金National Research Foundation of Korea(NRF),Grant/Award Numbers:2021R1A4A1032782,2022R1C1C1008831Korean Fund for Regenerative Medicine(KFRM),Grant/Award Number:21A0102L1-12Postdoctoral Research Program of Sungkyunkwan University。
文摘Electrical stimulation has recently received attention as noninvasive treatment in skin wound healing with its outstanding biological property for clinical setting.However,the complexity of equipment for applying appropriate electrical stimulation remains an ongoing challenge.Here,we proposed a strategy for skin scar inhibition by providing electrical stimulation via a multilayer stacked electret(MS-electret),which can generate direct current(DC)electric field(EF)without any power supply equipment.In addition,the MS-electret can easily control the intensity of EFs by simply stacking electret layers and maintain stable EF with the surface potential of 3400 V over 5 days owing to the injected charges on the electret surface.We confirmed inhibition of type 1 collagen andα-SMA expression of human dermal fibroblasts(hDFs)by 90%and 44%in vitro,indicating that the transition of hDFs to myofibroblasts was restricted by applying stable electrical stimulation.We further revealed a 20%significant decrease in the ratio of myofibroblasts caused by the MS-electret in vivo.These findings present that the MS-electret is an outstanding candidate for effective skin scar inhibition with a battery-free,physiological electrical microenvironment,and noninvasive treatment that allows it to prevent external infection.
文摘The black hole model of the Universe evolution, accompanied by matter creation, already successfully accounting for many features of the past is discussed and further justified. It is once more stressed that even a very large object but with a big mass is in its own right a black hole. As a consequence, the extrapolation of the past predicts for the future no big crunch, nor big bounce but a steady expansion with smaller matter density.
文摘Comparison of the Hubble parameter with cosmological quantities strongly supports the black hole model for the description of the Universe evolution. Such evolution requires matter creation and has implications for what is currently referred to as “dark energy” and the “cosmological constant”.
