The aim of this study was to fabricate composite gel beads based on natural polysaccharides. Hyaluronic acid（HA） and Chitosan（CS） were successfully admixed with Ca^2＋/alginate（SA） gel system to produce SA/HA/CS...The aim of this study was to fabricate composite gel beads based on natural polysaccharides. Hyaluronic acid（HA） and Chitosan（CS） were successfully admixed with Ca^2＋/alginate（SA） gel system to produce SA/HA/CS gel beads by dual crosslinking： the ionic gelation and the polyelectrolyte complexation. The preparation procedure was that the weight ratio of SA（2%, m/v） to HA（2%, m/v） was kept at 2：1, then the mixture was dripped into the Ca^2＋ solution for ion-crosslinking, and finally polyelectrolyte crosslinked with 2% low molecular weight CS（LMW-CS） for 1.5 hours. The optimal formulation was achieved by adjusting the concentration and the weight ratio of SA, HA and LMW-CS. Due to the incorporation of HA and LMWCS, the swelling ratio of the beads at pH 7.4 was increased up to 120, and the time for the maximum swelling degree was prolonged to 7.5 h. The swelling behavior was obviously improved compared to the pure SA/Ca^2＋ system. The preliminary results clearly suggest that the SA/HA/CS gel beads may be a potential candidate for biomedical delivery vehicles.展开更多
目的比较两种中度宫腔粘连治疗方案的疗效。方法将120例中度宫腔粘连患者随机分为两组,研究组：60例,采用治疗方案A：宫腔粘连分离术后立即宫腔内留置Foley导管并注入2 mL透明质酸钠凝胶（HA）,术后第3天再次于宫腔内注入2 mL HA,术后第...目的比较两种中度宫腔粘连治疗方案的疗效。方法将120例中度宫腔粘连患者随机分为两组,研究组：60例,采用治疗方案A：宫腔粘连分离术后立即宫腔内留置Foley导管并注入2 mL透明质酸钠凝胶（HA）,术后第3天再次于宫腔内注入2 mL HA,术后第4天取出Foley导管并上宫型环,同时予雌孕激素人工周期治疗3个月;对照组60例,采用治疗方案B：除术后第3天宫腔内未注入HA外,其余治疗方法均同研究组。所有患者均于术后第3次月经干净3~7 d内复查宫腔镜,观察两组的宫腔粘连复发情况及月经改善情况,以初步评价两种治疗方案的疗效。结果研究组粘连复发率15%,月经改善率90%;对照组粘连复发率31.67%,月经改善率71.67%,两组比较差异具有显著性（P值均〈0.05）。结论对于中度宫腔粘连的患者,治疗方案A的疗效明显优于治疗方案B,值得进一步探讨其临床推广应用价值。展开更多
基金Funded by the National Natural Science Foundation of China(No.81401510)
文摘The aim of this study was to fabricate composite gel beads based on natural polysaccharides. Hyaluronic acid（HA） and Chitosan（CS） were successfully admixed with Ca^2＋/alginate（SA） gel system to produce SA/HA/CS gel beads by dual crosslinking： the ionic gelation and the polyelectrolyte complexation. The preparation procedure was that the weight ratio of SA（2%, m/v） to HA（2%, m/v） was kept at 2：1, then the mixture was dripped into the Ca^2＋ solution for ion-crosslinking, and finally polyelectrolyte crosslinked with 2% low molecular weight CS（LMW-CS） for 1.5 hours. The optimal formulation was achieved by adjusting the concentration and the weight ratio of SA, HA and LMW-CS. Due to the incorporation of HA and LMWCS, the swelling ratio of the beads at pH 7.4 was increased up to 120, and the time for the maximum swelling degree was prolonged to 7.5 h. The swelling behavior was obviously improved compared to the pure SA/Ca^2＋ system. The preliminary results clearly suggest that the SA/HA/CS gel beads may be a potential candidate for biomedical delivery vehicles.
文摘目的比较两种中度宫腔粘连治疗方案的疗效。方法将120例中度宫腔粘连患者随机分为两组,研究组：60例,采用治疗方案A：宫腔粘连分离术后立即宫腔内留置Foley导管并注入2 mL透明质酸钠凝胶（HA）,术后第3天再次于宫腔内注入2 mL HA,术后第4天取出Foley导管并上宫型环,同时予雌孕激素人工周期治疗3个月;对照组60例,采用治疗方案B：除术后第3天宫腔内未注入HA外,其余治疗方法均同研究组。所有患者均于术后第3次月经干净3~7 d内复查宫腔镜,观察两组的宫腔粘连复发情况及月经改善情况,以初步评价两种治疗方案的疗效。结果研究组粘连复发率15%,月经改善率90%;对照组粘连复发率31.67%,月经改善率71.67%,两组比较差异具有显著性（P值均〈0.05）。结论对于中度宫腔粘连的患者,治疗方案A的疗效明显优于治疗方案B,值得进一步探讨其临床推广应用价值。
