Protective Effects of Self-made Compound Taoren Danshen Decoction on Rats with Acute Liver Injury

[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury model was established by intraperitoneal injection of 500 mg/kg of D-galactosamine. The ALT,AST,MDA,SOD and GSH-Px in serum,as well as serum TNF-α,IL-1β and IL-6 levels were measured,and liver tissue lesions were observed under microscope. [Results] CTDD can significantly reduce ALT,AST and MDA levels,increase SOD,GSH-Px activity,and significantly reduce serum TNF-α,IL-1β and IL-6 levels,and improve liver tissue lesions.[Conclusions]CTDD has a protective effect on D-galactosamine-induced acute liver injury in rats,and its mechanism may be related to inhibition of oxidative stress and inflammatory reaction.

Observation on Curative Effect of Self-made Wubeizi Decoction Combined with rhaFGF in Promoting Postoperative Wound Healing in Patients with Anal Fistula

[Objectives]To explore the curative effect of Self-made Wubeizi Decoction combined with recombinant human acidic fibroblast growth factor(rhaFGF)in promoting postoperative wound healing in patients with anal fistula.[Methods]A total of 82 patients with anal fistula who underwent anal fistula resection+use of setons in Luodian Hospital during January and March of 2020 were randomly divided into observation group and control group with 41 cases in each group.The control group was given rhaFGF external application regimen,and the observation group was treated with Self-made Wubeizi Decoction on the basis of the control group.After 3 weeks of treatment,the differences in curative effects of TCM syndromes were compared between the two groups.Besides,the changes in TCM symptom scores,inflammatory mediators[interleukin-12(IL-12),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],anorectal functions[anal resting pressure(ARP),maximal systolic pressure(MSP)and maximum tolerated volume(MTV)of the anal canal],quality of life[GQOLI-74 scores]were compared.[Results]After 3 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of TCM symptom scores,IL-12,TNF-α,IFN-γ,ARP,MSP,and MTV in both groups were significantly lower than those before treatment,and these levels in the observation group was significantly lower than that in the control group at the same time(P<0.05).The GQOLI-74 scores of both groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group(P<0.05).[Conclusions]The Self-made Wubeizi Decoction combined with rhaFGF therapy has a significant effect in promoting postoperative wound healing in patients with anal fistula.It can effectively inhibit the local inflammation of patients,facilitate the recovery of anorectal function and improve the quality of life,thus has high clinical application value.

创复汤辨证加减联合西医治疗下肢骨折的效果

目的:分析创复汤辨证加减联合西医治疗下肢骨折的效果。方法:选取2022年5月—2023年5月揭阳市荣成中心医院收治的100例下肢骨折患者为研究对象,随机分为对照组和观察组,各50例。对照组采用常规西医治疗,观察组在对照组基础上联合创复汤辨证加减治疗。对比两组中医证候积分、下肢周径差及炎性指标。结果:治疗后,两组肿胀、疼痛、皮温升高、皮色变化积分降低,观察组低于对照组(P<0.05);治疗后,两组大腿周径差、小腿周径差减小,观察组小于对照组(P<0.05);治疗后,两组白细胞介素-6、超敏C反应蛋白、肿瘤坏死因子-α水平降低,观察组低于对照组(P<0.05)。结论:创复汤辨证加减联合西医治疗可以改善下肢骨折术后患者的临床症状,减轻患者下肢肿胀,降低机体炎性因子水平。

自拟创复汤辨证加减对踝关节骨折脱位骨折固定术后骨愈合进程及预后的影响分析

目的:观察踝关节骨折脱位骨折固定术后口服自拟创复汤辨证加减对骨愈合进程及预后的影响。方法:选取本院2013年4月至2018年8月收治的75例踝关节骨折患者,随机数表法分为观察组(38例)和对照组(37例)。两组患者均接受踝关节骨折脱位骨折固定术治疗,术后对照组给予常规治疗,观察组在对照组基础上给予口服自拟创复汤辨证加减治疗,均治疗8周。比较两组患者X线评分、恢复时间以及术后并发症发生率,并评估患者预后。结果:治疗后观察组X线评分明显高于对照组。观察组骨折愈合时间以及肿痛消失时间明显短于对照组(P<0.05)。治疗后,观察组D-二聚体(D-D)水平以及C反应蛋白(CRP)水平明显低于对照组(P<0.05)。治疗后2周以及8周后观察组视觉模拟评分(VAS)评分明显低于对照组,美国矫形足踝协会(AOFAS)踝与后足评分明显高于对照组(P<0.05)。观察组术后并发症总发生率明显低于对照组(P<0.05)。结论:踝关节骨折脱位患者术后采用口服自拟创复汤辨证加减治疗可缩短骨愈合进程,有利于患者预后。