Observation on Curative Effect of Self-made Wubeizi Decoction Combined with rhaFGF in Promoting Postoperative Wound Healing in Patients with Anal Fistula

[Objectives]To explore the curative effect of Self-made Wubeizi Decoction combined with recombinant human acidic fibroblast growth factor(rhaFGF)in promoting postoperative wound healing in patients with anal fistula.[Methods]A total of 82 patients with anal fistula who underwent anal fistula resection+use of setons in Luodian Hospital during January and March of 2020 were randomly divided into observation group and control group with 41 cases in each group.The control group was given rhaFGF external application regimen,and the observation group was treated with Self-made Wubeizi Decoction on the basis of the control group.After 3 weeks of treatment,the differences in curative effects of TCM syndromes were compared between the two groups.Besides,the changes in TCM symptom scores,inflammatory mediators[interleukin-12(IL-12),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],anorectal functions[anal resting pressure(ARP),maximal systolic pressure(MSP)and maximum tolerated volume(MTV)of the anal canal],quality of life[GQOLI-74 scores]were compared.[Results]After 3 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of TCM symptom scores,IL-12,TNF-α,IFN-γ,ARP,MSP,and MTV in both groups were significantly lower than those before treatment,and these levels in the observation group was significantly lower than that in the control group at the same time(P<0.05).The GQOLI-74 scores of both groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group(P<0.05).[Conclusions]The Self-made Wubeizi Decoction combined with rhaFGF therapy has a significant effect in promoting postoperative wound healing in patients with anal fistula.It can effectively inhibit the local inflammation of patients,facilitate the recovery of anorectal function and improve the quality of life,thus has high clinical application value.

Protective Effects of Self-made Compound Taoren Danshen Decoction on Rats with Acute Liver Injury

[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury model was established by intraperitoneal injection of 500 mg/kg of D-galactosamine. The ALT,AST,MDA,SOD and GSH-Px in serum,as well as serum TNF-α,IL-1β and IL-6 levels were measured,and liver tissue lesions were observed under microscope. [Results] CTDD can significantly reduce ALT,AST and MDA levels,increase SOD,GSH-Px activity,and significantly reduce serum TNF-α,IL-1β and IL-6 levels,and improve liver tissue lesions.[Conclusions]CTDD has a protective effect on D-galactosamine-induced acute liver injury in rats,and its mechanism may be related to inhibition of oxidative stress and inflammatory reaction.

自拟益肾固元汤加减联合醋酸泼尼松片治疗肾病综合征临床效果

目的观察自拟益肾固元汤加减联合醋酸泼尼松片治疗肾病综合征的临床效果。方法选取2017年5月-2019年5月海南省昌江黎族自治县人民医院收治的肾病综合征患者107例,按照随机数字表法分为观察组和对照组。对照组53例采用醋酸泼尼松片治疗,观察组54例采用自拟益肾固元汤加减联合醋酸泼尼松片治疗。比较2组临床疗效,治疗前后肾功能指标、炎性因子水平、中医症状积分及不良反应。结果观察组总有效率为92.59%,高于对照组的75.47%(χ^(2)=5.867,P=0.015)。治疗后,2组血肌酐、尿素氮及24 h尿蛋白定量均低于治疗前,血浆白蛋白高于治疗前,且观察组优于对照组(P<0.01)。治疗后,2组患者血清TNF-α、IL-1β及IL-6水平均低于治疗前,且观察组低于对照组(P<0.01)。治疗后,2组中医症状积分均低于治疗前,且观察组低于对照组(P<0.01)。观察组不良反应总发生率为5.56%,低于对照组的18.87%(χ^(2)=4.441,P=0.035)。结论自拟益肾固元汤加减联合醋酸泼尼松片治疗肾病综合征可改善患者的临床症状和肾功能,减轻炎性反应,且安全性高,适合临床推广应用。