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Protective Effects of Self-made Compound Taoren Danshen Decoction on Rats with Acute Liver Injury
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作者 Yuman GUAN Kefeng ZHANG +2 位作者 Ya GAO Jiani LI Lin ZHANG 《Medicinal Plant》 CAS 2018年第5期107-110,共4页
[Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury ... [Objectives] To study the protective effects of self-made Compound Taoren Danshen Decoction( CTDD) on acute liver injury induced by D-galactosamine in rats,and to explore its mechanism. [Methods]An acute liver injury model was established by intraperitoneal injection of 500 mg/kg of D-galactosamine. The ALT,AST,MDA,SOD and GSH-Px in serum,as well as serum TNF-α,IL-1β and IL-6 levels were measured,and liver tissue lesions were observed under microscope. [Results] CTDD can significantly reduce ALT,AST and MDA levels,increase SOD,GSH-Px activity,and significantly reduce serum TNF-α,IL-1β and IL-6 levels,and improve liver tissue lesions.[Conclusions]CTDD has a protective effect on D-galactosamine-induced acute liver injury in rats,and its mechanism may be related to inhibition of oxidative stress and inflammatory reaction. 展开更多
关键词 self-made COMPOUND Taoren DANSHEN decoction(CTDD) D-GALACTOSAMINE Acute liver injury Oxidative stress INFLAMMATORY reaction
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Observation on Curative Effect of Self-made Wubeizi Decoction Combined with rhaFGF in Promoting Postoperative Wound Healing in Patients with Anal Fistula
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作者 Yingnan YANG Dan GAN +2 位作者 Zhiqiang YUAN Dongqin WANG Yu CHEN 《Medicinal Plant》 CAS 2023年第3期74-77,81,共5页
[Objectives]To explore the curative effect of Self-made Wubeizi Decoction combined with recombinant human acidic fibroblast growth factor(rhaFGF)in promoting postoperative wound healing in patients with anal fistula.[... [Objectives]To explore the curative effect of Self-made Wubeizi Decoction combined with recombinant human acidic fibroblast growth factor(rhaFGF)in promoting postoperative wound healing in patients with anal fistula.[Methods]A total of 82 patients with anal fistula who underwent anal fistula resection+use of setons in Luodian Hospital during January and March of 2020 were randomly divided into observation group and control group with 41 cases in each group.The control group was given rhaFGF external application regimen,and the observation group was treated with Self-made Wubeizi Decoction on the basis of the control group.After 3 weeks of treatment,the differences in curative effects of TCM syndromes were compared between the two groups.Besides,the changes in TCM symptom scores,inflammatory mediators[interleukin-12(IL-12),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ)],anorectal functions[anal resting pressure(ARP),maximal systolic pressure(MSP)and maximum tolerated volume(MTV)of the anal canal],quality of life[GQOLI-74 scores]were compared.[Results]After 3 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of TCM symptom scores,IL-12,TNF-α,IFN-γ,ARP,MSP,and MTV in both groups were significantly lower than those before treatment,and these levels in the observation group was significantly lower than that in the control group at the same time(P<0.05).The GQOLI-74 scores of both groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group(P<0.05).[Conclusions]The Self-made Wubeizi Decoction combined with rhaFGF therapy has a significant effect in promoting postoperative wound healing in patients with anal fistula.It can effectively inhibit the local inflammation of patients,facilitate the recovery of anorectal function and improve the quality of life,thus has high clinical application value. 展开更多
关键词 self-made Wubeizi decoction Recombinant human acidic fibroblast growth factor(rhaFGF) Anal fistula Anal fistula resection Wound healing Inflammatory mediators Anorectal function Quality of life
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自拟滋胃汤治疗胃阴亏虚型胃溃疡临床观察 被引量:5
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作者 方得祚 张晓丽 《光明中医》 2018年第10期1406-1407,共2页
目的观察自拟滋胃汤治疗胃阴亏虚型胃溃疡患者的临床疗效。方法本研究收入120例胃阴亏虚型胃溃疡患者,随机对照分为2组,对照组60例泮托拉唑钠肠溶片治疗,治疗组60例在对照组基础上自拟滋胃汤治疗。连续治疗14d为一个疗程,观察临床症状... 目的观察自拟滋胃汤治疗胃阴亏虚型胃溃疡患者的临床疗效。方法本研究收入120例胃阴亏虚型胃溃疡患者,随机对照分为2组,对照组60例泮托拉唑钠肠溶片治疗,治疗组60例在对照组基础上自拟滋胃汤治疗。连续治疗14d为一个疗程,观察临床症状、不良反应及胃镜下局部溃疡愈合状况,判定疗效。结果治疗组显效46例,有效12例,无效2例,总有效率为96.67%;对照组显效31例,有效15例,无效14例,总有效率为76.67%;治疗组疗效优于对照组(P<0.05)。结论自拟滋胃汤联合西医常规用药治疗胃阴亏虚型胃溃疡效果确切,值得推广。 展开更多
关键词 胃溃疡 胃阴亏虚 自拟滋胃汤 中医药疗法
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