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Effect of aging treatment on the precipitation transformation and age hardening of Mg-Gd-Y-Zn-Zr alloy 被引量:2
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作者 Mu Meng Honglei Zhang +2 位作者 Zhi Gao Genxing Lei Jianmin Yu 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2023年第12期4628-4643,共16页
In this study, the precipitation transformation and age hardening of solution-treated Mg-9Gd-4Y-2Zn-0.5Zr(wt.%) alloy were investigated at different aging treatment parameters. The precipitation sequences of the alloy... In this study, the precipitation transformation and age hardening of solution-treated Mg-9Gd-4Y-2Zn-0.5Zr(wt.%) alloy were investigated at different aging treatment parameters. The precipitation sequences of the alloy aged at 200℃, 250℃ and 300℃ are β’’(DO19) → β’(BCO) → β(FCC), β’’(DO19) → β’(BCO) → β_(1)(FCC) → β(FCC) and β(FCC), respectively. The streaks sequences of the alloy aged at 200℃, 250℃ and 300℃ are SF, SF → 14H-LPSO and SF → 14H-LPSO, respectively. For the alloy aged at 200℃ and 250℃, the increase in hardness with increasing aging time is contributed from the increase in precipitate volume fraction and the transformation from β’’ to β’ phase with basal → prismatic and spherical → spindle-like precipitate changes. The decrease in hardness after the peak-aging stage is attributed to the appearance of micro-sized β precipitates. Because of the smaller size of precipitates and the triangular arrangement of β’ precipitate, the hardness of the alloy aged at 200℃ is higher than that aged at 250℃. For the alloy aged at 300℃, the appearance of only micro-sized β precipitate and its coarsening with increasing aging time leads to the lowest hardness and an overall decrease in hardness with the aging time. 展开更多
关键词 Mg-Gd-Y-Zn-Zr alloy aging treatment Precipitation transformation age hardening
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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline
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作者 Lan Zhang Jingge Wei +5 位作者 Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei 《Neural Regeneration Research》 SCIE CAS 2025年第4期990-1008,共19页
With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterati... With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition. 展开更多
关键词 age aging Alzheimer’s disease ASTROCYTES cognitive decline dementia gut microbiota gut–brain axis microbial metabolites NEUROINFLAMMATION Parkinson’s disease
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Relationship between Self-Perceived Age and Social Activity in Older Japanese Adults: The KAGUYA Study
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作者 Katsuhiko Takatori Daisuke Matsumoto +2 位作者 Makoto Miyazaki Naomi Yamasaki Jong-Seong Moon 《Health》 2018年第11期1459-1473,共15页
Youthful feelings were shown to have a positive effect on the mental and physical conditions of the elderly. On the contrary, elderly people whose self-perceived age is older than their chronological age were shown to... Youthful feelings were shown to have a positive effect on the mental and physical conditions of the elderly. On the contrary, elderly people whose self-perceived age is older than their chronological age were shown to experience negative health outcomes. This study investigated whether the self-perceived age (younger or older) relative to chronological age promotes social activity. The baseline data acquired from 3094 older adults as part of the Keeping Active across Generations Uniting the Youth and the Aged study was used in the current study. The participants completed a questionnaire that solicits information pertaining to sociodemographic factors, felt age, self-rated health, physical activity, depression, disease burden, fall history, fear of falling, level of instrumental activities of daily living (IADLs) and social activity. The discrepancy between felt age and chronological age was defined as the self-perceived age. Self-perceived age was calculated by subtracting the participant’s chronological age from the felt age, and the score for the difference was divided by the chronological age. The Japan Science and Technology Agency Index of Competence was used to evaluate social activity. Regression analysis results revealed that a younger self-perceived age was associated with higher social activity after controlling for sociodemographic factors, self-rated health, depression, physical activity, disease burden, level of IADL, fall history and fear of falling. Fall history was significantly associated with higher social activity in young-old participants (65 - 74 years) (p = 0.014) but not in old-old participants (>75 years). This study suggests that a younger self-perceived age in older adults would lead to a high-level living function. This finding may provide useful information for interventions aimed at the promotion of health and/or the prevention of frailty. 展开更多
关键词 self-perceived age OLDER ADULTS SOCIAL Activity
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Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer’s disease 被引量:3
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作者 Angie K.Torres Bastián I.Rivera +2 位作者 Catalina M.Polanco Claudia Jara Cheril Tapia-Rojas 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第8期1645-1651,共7页
During normal aging,there is a decline in all physiological functions in the organism.One of the most affected organs is the brain,where neurons lose their proper synaptic function leading to cognitive impairment.Agin... During normal aging,there is a decline in all physiological functions in the organism.One of the most affected organs is the brain,where neurons lose their proper synaptic function leading to cognitive impairment.Aging is one of the main risk factors for the development of neurodegenerative diseases,such as Alzheimer’s disease.One of the main responsible factors for synaptic dysfunction in aging and neurodegenerative diseases is the accumulation of abnormal proteins forming aggregates.The most studied brain aggregates are the senile plaques,formed by Aβpeptide;however,the aggregates formed by phosphorylated tau protein have gained relevance in the last years by their toxicity.It is reported that neurons undergo severe mitochondrial dysfunction with age,with a decrease in adenosine 5′-triphosphate production,loss of the mitochondrial membrane potential,redox imbalance,impaired mitophagy,and loss of calcium buffer capacity.Interestingly,abnormal tau protein interacts with several mitochondrial proteins,suggesting that it could induce mitochondrial dysfunction.Nevertheless,whether tau-mediated mitochondrial dysfunction occurs indirectly or directly is still unknown.A recent study of our laboratory shows that phosphorylated tau at Ser396/404(known as PHF-1),an epitope commonly related to pathology,accumulates inside mitochondria during normal aging.This accumulation occurs preferentially in synaptic mitochondria,which suggests that it may contribute to the synaptic failure and cognitive impairment seen in aged individuals.Here,we review the main tau modifications promoting mitochondrial dysfunction,and the possible mechanism involved.Also,we discuss the evidence that supports the possibility that phosphorylated tau accumulation in synaptic mitochondria promotes synaptic and cognitive impairment in aging.Finally,we show evidence and argue about the presence of phosphorylated tau PHF-1 inside mitochondria in Alzheimer’s disease,which could be considered as an early event in the neurodegenerative process.Thus,phosphorylated tau PHF-1 inside the mitochondria could be considered such a potential therapeutic target to prevent or attenuate age-related cognitive impairment. 展开更多
关键词 age pathology aging Alzheimer’s disease hippocampus memory MITOCHONDRIA PHF-1 phosphorylated tau synaptic mitochondria tau
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Solving an Age Old Problem A new law requires children to visit their aging parents
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作者 Ni Yanshuo 《ChinAfrica》 2013年第8期28-29,共2页
MORE than 10 years ago, the song Come Home As Often As You Can to See Your Parents became popular in China, reminding young people of their obli- gation to set aside their hectic lives and return to their hometowns to... MORE than 10 years ago, the song Come Home As Often As You Can to See Your Parents became popular in China, reminding young people of their obli- gation to set aside their hectic lives and return to their hometowns to visit their aging parents. Today, the idea expressed in this song has been codified in Chinese law. 展开更多
关键词 Solving an age Old Problem A new law requires children to visit their aging parents
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Effects of process parameters on mechanical properties and microstructures of creep aged 2124 aluminum alloy 被引量:7
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作者 湛利华 李炎光 黄明辉 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第7期2232-2238,共7页
A series of tests were carried microstructures of 2124 aluminum alloy in increase of aging time, temperature and low-to-peak-to-low manner. No significant out to investigate the effects of process parameters on mechan... A series of tests were carried microstructures of 2124 aluminum alloy in increase of aging time, temperature and low-to-peak-to-low manner. No significant out to investigate the effects of process parameters on mechanical properties and creep aging process. The results show that creep strain and creep rate increase with the applied stress. The hardness of specimen varies with aging time and stress in a effect of temperature on hardness of material is seen in the range of 185-195 ℃. The optimum mechanical properties are obtained at the conditions of (200 MPa, 185 ℃, 8 h) as the result of the coexistence of strengthening S" and S' phases in the matrix by transmission electron microscopy (TEM). TEM observation shows that applied stress promotes the formation and growth of precioitates and no obvious stress orientation effect is observed in the matrix. 展开更多
关键词 aluminum alloy creep aging behavior age hardening mechanical property MICROSTRUCTURE process parameter
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Advanced paternal age and reproductive outcome 被引量:13
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作者 Zofnat Wiener-Megnazi Ron Auslender Martha Dirnfeld 《Asian Journal of Andrology》 SCIE CAS CSCD 2012年第1期69-76,176,共9页
Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and imp... Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspectsare clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome. 展开更多
关键词 ART outcomes FERTILITY male aging paternal age reproductive outcome
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The effects of advanced paternal age on fertility 被引量:13
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作者 Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz 《Asian Journal of Andrology》 SCIE CAS CSCD 2013年第6期723-728,I0005,共7页
Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thir... Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life. 展开更多
关键词 aging male fertility outcomes male infertility paternal age
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Personality factors and self-perceived health in Chi-lean elderly population 被引量:2
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作者 Pedro Olivares-Tirado Gonzalo Leyton Eduardo Salazar 《Health》 2013年第12期86-96,共11页
Empirical evidence suggests that the stability of personality itself contributes to successful ageing and is associated with longer life. The aim of this study was to investigate the association between personality tr... Empirical evidence suggests that the stability of personality itself contributes to successful ageing and is associated with longer life. The aim of this study was to investigate the association between personality traits and the self-perceived health status, stratified by medical conditions in a representative sample of non-institutionalized elderly people in Chile. The data used for this study come from the fourth waves (2009) of the Chilean Social Protection Survey (SPS-2009). Included were a total of 2655 subjects aged 65 and over. The results showed that higher scores of all five personality factors were associated with good health. Those with the perception of poor health were more likely to be female, with lower education level and older than those with good health. With the exception of agreeableness, strong and significant associations with self-perceived health were demonstrated for extraversion, conscientiousness, emotional stability and openness, among elderly with medical conditions. Among elderly without medical problems, significant associations with self-perceived health were demonstrated only for extraversion, agreeableness and emotional stability. This study has shown that there is a consistent association between personality factors and self-perceived health throughout the older population. Our results suggest that extraversion and openness traits could be acting as “protector” factors and agreeableness and conscientiousness traits as “resilient” factors, facing to the health problems among elderly people. 展开更多
关键词 SEROUS PERSONALITY self-perceived Health ageing TIPI QUESTIONNAIRE
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Age-related changes in resting-state functional connectivity in older adults 被引量:2
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作者 Laia Farras-Permanyer Nuria Mancho-Fora +4 位作者 Marc Montala-Flaquer David Bartres-Faz Lidia Vaque-Alcazar Maribel Pero-Cebollero Joan Guardia-Olmos 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第9期1544-1555,共12页
Age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years,with some differences in the obtained results.Most of these studies showed decreases in general functional... Age-related changes in the brain connectivity of healthy older adults have been widely studied in recent years,with some differences in the obtained results.Most of these studies showed decreases in general functional connectivity,but they also found increases in some particular regions and areas.Frequently,these studies compared young individuals with older subjects,but few studies compared different age groups only in older populations.The purpose of this study is to analyze whole-brain functional connectivity in healthy older adult groups and its network characteristics through functional segregation.A total of 114 individuals,48 to 89 years old,were scanned using resting-state functional magnetic resonance imaging in a resting state paradigm and were divided into six different age groups(<60,60–64,65–69,70–74,75–79,≥80 years old).A partial correlation analysis,a pooled correlation analysis and a study of 3-cycle regions with prominent connectivity were conducted.Our results showed progressive diminution in the functional connectivity among different age groups and this was particularly pronounced between 75 and 79 years old.The oldest group(≥80 years old)showed a slight increase in functional connectivity compared to the other groups.This occurred possibly because of compensatory mechanism in brain functioning.This study provides information on the brain functional characteristics of every age group,with more specific information on the functional progressive decline,and supplies methodological tools to study functional connectivity characteristics.Approval for the study was obtained from the ethics committee of the Comision de Bioetica de la Universidad de Barcelona(approval No.PSI2012-38257)on June 5,2012,and from the ethics committee of the Barcelona’s Hospital Clinic(approval No.2009-5306 and 2011-6604)on October 22,2009 and April 7,2011 respectively. 展开更多
关键词 brain connectivity resting state default mode network aging HEALTHY functional connectivity resting state network age groups
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Analysis of transcriptome sequencing of sciatic nerves in Sprague-Dawley rats of different ages 被引量:1
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作者 Jiang-Hui Liu Qing Tang +5 位作者 Xiang-Xia Liu Jian Qi Rui-Xi Zeng Zhao-Wei Zhu Bo He Yang-Bin Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第12期2182-2190,共9页
An aging-induced decrease in Schwann cell viability can affect regeneration following peripheral nerve injury in mammals. It is therefore necessary to investigate possible age-related changes in gene expression that m... An aging-induced decrease in Schwann cell viability can affect regeneration following peripheral nerve injury in mammals. It is therefore necessary to investigate possible age-related changes in gene expression that may affect the biological function of peripheral nerves. Ten 1-week-old and ten 12-month-old healthy male Sprague-Dawley rats were divided into young(1 week old) and adult(12 months old) groups according to their ages. mRNA expression in the sciatic nerve was compared between young and adult rats using next-generation sequencing(NGS) and bioinformatics(n = 4/group). The 18 groups of differentially expressed mRNA(DEmRNAs) were also tested by quantitative reverse transcription polymerase chain reaction(n = 6/group). Results revealed that(1) compared with young rats, adult rats had 3608 groups of DEmRNAs. Of these, 2684 were groups of upregulated genes, and 924 were groups of downregulated genes. Their functions mainly involved cell viability, proliferation, differentiation, regeneration, and myelination.(2) The gene with the most obvious increase of all DEmRNAs in adult rats was Thrsp(log2 FC = 9.01, P 〈 0.05), and the gene with the most obvious reduction was Col2 a1(log2 FC = -8.89, P 〈 0.05).(3) Gene Ontology analysis showed that DEmRNAs were mainly concentrated in oligosaccharide binding, nucleotide-binding oligomerization domain containing one signaling pathway, and peptide-transporting ATPase activity.(4) Analysis using the Kyoto Encyclopedia of Genes and Genomes showed that, with increased age, DEmRNAs were mainly enriched in steroid biosynthesis, Staphylococcus aureus infection, and graft-versus-host disease.(5) Spearman's correlation coefficient method for evaluating NGS accuracy showed that the NGS results and quantitative reverse transcription polymerase chain reaction results were positively correlated(rs = 0.74, P 〈 0.05). These findings confirm a difference in sciatic nerve gene expression between adult and young rats, suggesting that, in peripheral nerves, cells and the microenvironment change with age, thus influencing the function and repair of peripheral nerves. 展开更多
关键词 peripheral nerve injury aging Sprague-Dawley rat TRANSCRIPTOME SEQUENCING MRNA rat age Schwann cells neural regeneration
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Why Does China's Labor Income Share Tend to Decline?- From the Perspective of Population Age Structure Change 被引量:2
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作者 魏下海 董志强 赵秋运 《China Economist》 2013年第3期52-63,共12页
Using a theoretical model, this article concludes that age structures influence people's propensity to save and thereby influence their capital intensity. In the context that capital and labor are in a substitutional... Using a theoretical model, this article concludes that age structures influence people's propensity to save and thereby influence their capital intensity. In the context that capital and labor are in a substitutional relation, increased capital intensity may lead to a drop of labor income share. We perform empirical research with provincial-level data from 1990 to 2007 and have proved that the rising of the old dependency ratio and the decrease of the children dependency rate both contribute to the fall of labor income share. This assumption still holds true after the authors control the influences of other potential factors that may influence labor income share 展开更多
关键词 population age structure labor income share aging
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Comparative Study on Population Ageing Between China and Other Asian Countries 被引量:1
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作者 Hui Yang Peng Du 《Sociology Study》 2011年第2期96-100,共5页
Compared with developed countries, the main characteristics of population ageing in China have been regarded as a rapid ageing society. However, China and other Asian countries have been experiencing the demographic t... Compared with developed countries, the main characteristics of population ageing in China have been regarded as a rapid ageing society. However, China and other Asian countries have been experiencing the demographic transition simultaneously, it is better to understand the characteristics of population ageing in China when compared with other Asian countries. Using the latest UN data, this paper compares the percentage of elderly population, the speed of ageing and the size of aged population among China and other Asian countries. The result indicates that China has a relatively high percentage of aged population, relatively rapid ageing population and will keep the largest size of aged population of the world in the next 60 years. 展开更多
关键词 Population ageing speed of ageing size of aged population
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Unhealthy aging? Featuring older people in television food commercials in China
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作者 Wen Jiao Angela Wen-Yu Chang 《International Journal of Nursing Sciences》 CSCD 2020年第S01期67-73,共7页
Objectives:Advertising messages can affect the public as a risk or protective factor for socially disadvantaged groups,and they may reflect how characters reflect perceptions are perceived in a society.This study aime... Objectives:Advertising messages can affect the public as a risk or protective factor for socially disadvantaged groups,and they may reflect how characters reflect perceptions are perceived in a society.This study aimed to investigate how older people are portrayed in televised food commercials from the approach of a healthy aging perspective in contemporary Chinese society.Methods:All televised advertising in the Ad Topic archive were screened against inclusion and exclusion criteria,and a total of 164 commercials from the years of 2016-2019 that portrayed Chinese older people were sampled.The association between the main older characters with the product categories,healthy vs.unhealthy foods,use of health claims,sex,type of spokesperson,companions,and tones and manners were included in the analysis.Results:Older people more frequently appeared in unhealthy food products than in healthy food products.Health claims involving older adults were portrayed adequately,whereas nursing professions as companions of older adults were overlooked.Positive advertising that delivered happy,caring,or warm tones was overwhelmingly represented.Thus,the advertising messages circulated in China represent a binary stereotype model of images of older adults'characteristics that reflect ageist and the so-called agelessism,referring to the new application of the look from the approach of social psychology and marketing field.Conclusions:This study examined aging discrimination reflected in advertisements.Studies exploring the impact of a crisis remain limited.Research is needed to improve the accuracy of advertised healthy older adults and normal aging. 展开更多
关键词 ADVERTISING aged ageISM China FOOD Healthy aging Marketing STEREOTYPES
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Correlation of Depression with the Functional Profile of Elderly People Living in Homes for the Aged
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作者 Alexandre Gomes Sancho Ataiane de Lima Silva +9 位作者 Leonela Ribeiro de Paula Joã o da Silva Rosa Á lvaro Camilo de Faria Simone Neves Daniel Heitti Zidde Marcus Vinicius de Mello Pinto Aline Ronis Sampaio Miriam Viviane Baron 《Advances in Aging Research》 2021年第3期59-70,共12页
<strong>Introduction:</strong> Due to the growth of the elderly population, there is a notable lack of preparation among family members and society to face the challenges of this new reality, resulting in ... <strong>Introduction:</strong> Due to the growth of the elderly population, there is a notable lack of preparation among family members and society to face the challenges of this new reality, resulting in an increasing demand for homes for the aged (HA). It is necessary to understand how the impairment of physical health, mental health and the level of depression can affect the functional capacity of the institutionalized elderly who live in homes for the aged. <strong>Objective:</strong> To describe the correlation between depression and functionality of elderly people who live in homes for the aged. <strong>Method:</strong> A cross-sectional, descriptive study with 70 elderly people of both sexes, aged 60 years or older, who live in HA in the state of Rio de Janeiro. <strong>Result: </strong>It was verified that the female gender was predominant in the HA consulted. The majority of elderly live in HA voluntarily 48.6% and that 41.43% did not complete elementary school. The majority of the elderly 81.43% had the ability to perform basic activities of daily living and the elderly 52.86% had normal psychological pictures. The worsening of the depressive picture is associated with the worse functioning of elderly who live in HA (p < 0.02). <strong>Conclusion: </strong>Depression is a factor that is associated with the functional capacity of the institutionalized elderly. The worse the functional level of the institutionalized elderly, the greater the chances of presenting a depressive state. 展开更多
关键词 ELDERLY aging DEPRESSION FUNCTIONALITY Homes for the aged
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Research on the problem of delaying retiring age in China
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作者 Ge ZhiYong 《International English Education Research》 2015年第4期45-47,共3页
In recent years, China's aging population continues to accelerate the process, so that our aging population and the pension system is generated between the sustainable development of the serious contradictions, resul... In recent years, China's aging population continues to accelerate the process, so that our aging population and the pension system is generated between the sustainable development of the serious contradictions, resulting in a waste of human resources, increasing the operating pressure pensions, working hours inequity the negative impact on the existing retirement system challenges. Recently, the delay of the retirement age controversy sparked widespread concern in the community, the paper is as a starting point, a comprehensive analysis of the social contradictions of the current status of China's current retirement system, drawing on the successful adjustment of retirement abroad experience from multiple perspectives demonstrates the urgency of delayed retirement age and feasibility. This paper is divided into four chapters. The first chapter proposes the research background and significance of the age of retirement, as well as domestic and foreign scholars on the issue of research in the retirement age. The second chapter describes the status of China's retirement system, the contradiction between the implementation of the background, family problems and the current retirement age and the aging population about three aspects. The third chapter analyzes the feasibility to extend the retirement age. Chapter IV presents a delayed retirement policies and recommendations, with emphasis on "flexible retirement system." 展开更多
关键词 aging population the retirement system delayed retirement age flexible retirement system
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The Practical Application of the Concept about Active Aging: Younger Serve the Elder
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作者 Ping Chen 《International Journal of Technology Management》 2017年第2期32-34,共3页
At present, China has entered the aging society, pension issues are more concerned about today’s social hot issues, is also an important livelihood issues. From the analysis of the physiological and psychological cha... At present, China has entered the aging society, pension issues are more concerned about today’s social hot issues, is also an important livelihood issues. From the analysis of the physiological and psychological characteristics of the elderly, this paper discusses how to strengthen the development of the human resources of the aged and the aged, and give full play to the value of “old age”, to promote the elderly to regain their independent spirit. 展开更多
关键词 An aging Society the low age old person Service Help Each Other
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How to Predict AGEs Accumulation Slowdown Effect of a Cosmetic Ingredient? Two Steps <i>In-Vitro</i>System for Evaluating the Anti-AGE Impact of a New Blend
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作者 Dror Cohen Ze’evi Ma’or +4 位作者 Ya’ara Laor-Costa Alexandra Blinderman David Barak Ron Kohen Meital Portugal-Cohen 《Journal of Cosmetics, Dermatological Sciences and Applications》 2021年第4期320-329,共10页
Advanced Glycation End-Products (AGEs), play a crucial part in advancing the process of cellular skin aging and its link to chronological age was re-assessed. AGEs accumulation alters cell structure and function of mo... Advanced Glycation End-Products (AGEs), play a crucial part in advancing the process of cellular skin aging and its link to chronological age was re-assessed. AGEs accumulation alters cell structure and function of most types of skin cells, affecting skin’s mechanical and physiological properties, following the molecular transformations. Slowdown AGEs accumulation rate in skin, although a potent anti-aging strategy, is difficult and tricky. The lack of working methods for <span style="white-space:nowrap;"><i>In-Vitro</i></span> and <span style="white-space:nowrap;"><i>In-Vitro</i></span> measuring AGEs level complicates the evaluation and prediction of active ingredients’ ability to affect cellular AGEs accumulation. A two-step <span style="white-space:nowrap;"><i>In-Vitro</i></span> systematic screening method is proposed and three different cosmetic active ingredients were selected for its demonstration, using BSA-Glucose and Collagen-Glucose predicting models. Candidates’ effects on AGEs accumulation were evaluated as standalone, and when formulated in a blend. Additionally, the potency of non-invasive auto-fluorescence in-vivo measurement to detect AGEs levels among subjects of different ages was demonstrated. The results are presented in this work and the potential contribution of the proposed system to assist the desired inhibition of AGEs accumulation in skin is discussed. 展开更多
关键词 Advanced Glycation End-Products (ages) Cellular Skin aging ANTI-aging ages Accumulation Predicting Models
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Analysis on the industry of tourism for the aged
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作者 YANG Yue 《International English Education Research》 2018年第3期65-67,共3页
The problem of aging, as a severe test in the world, has attracted wide attention all over the world. This article will study the development of the tourism pension industry on the basis of traditional old-age mode, c... The problem of aging, as a severe test in the world, has attracted wide attention all over the world. This article will study the development of the tourism pension industry on the basis of traditional old-age mode, compare the experience of the development of foreign tourism for the aged, and finally put forward some suggestions and thinking for the development of China's special color. 展开更多
关键词 the international experience of aging tourism for the aged
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DNA methylation clocks for estimating biological age in Chinese cohorts 被引量:1
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作者 Zikai Zheng Jiaming Li +24 位作者 Tianzi Liu Yanling Fan Qiao-Cheng Zhai Muzhao Xiong Qiao-Ran Wang Xiaoyan Sun Qi-Wen Zheng Shanshan Che Beier jiang Quan Zheng Cui Wang Lixiao Liu Jiale Ping Si Wang Dan-Dan Gao Jinlin Ye Kuan Yang Yuesheng Zuo Shuai Ma Yun-GuiYang Jig Qu Feng Zhang Peilin Jia Guang-Hui Liu Weiqi Zhang 《Protein & Cell》 SCIE CSCD 2024年第8期575-593,共19页
Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation(DNAm)at specific CpG sites.However,a systematic comparison between DNA methylation data and other omics dat... Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation(DNAm)at specific CpG sites.However,a systematic comparison between DNA methylation data and other omics datasets has not yet been performed.Moreover,available DNAm age predictors are based on datasets with limited ethnic representation.To address these knowledge gaps,we generated and analyzed DNA methylation datasets from two independent Chinese cohorts,revealing age-related DNAm changes.Additionally,a DNA methylation aging clock(iCAS-DNAmAge)and a group of DNAm-based multi-modal clocks for Chinese individuals were developed,with most of them demonstrating strong predictive capabilities for chronological age.The clocks were further employed to predict factors influencing aging rates.The DNAm aging clock,derived from multi-modal aging features(compositeAge-DNAmAge),exhibited a close association with multi-omics changes,lifestyles,and disease status,underscoring its robust potential for precise biological age assessment.Our findings offer novel insights into the regulatory mechanism of age-related DNAm changes and extend the application of the DNAm clock for measuring biological age and aging pace,providing the basis for evaluating aging intervention strategies. 展开更多
关键词 DNA methylation aging clock aging age prediction
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