Objective: To determine the prevalence, level of severity of potential drug–drug interactions(PDDIs) and the associated factors for PDDIs in hospitalized pediatric patients of Gondar University Hospital.Methods: A re...Objective: To determine the prevalence, level of severity of potential drug–drug interactions(PDDIs) and the associated factors for PDDIs in hospitalized pediatric patients of Gondar University Hospital.Methods: A retrospective cross-sectional study was conducted for a period of 3 months from March to May 2014 in pediatric wards of Gondar University Hospital. Systematic random sampling technique was used to select charts from all pediatric patients' charts with every 7th interval to get sample size of 384. Univariate and multivariate analysis were performed to compute crude odds ratio and adjusted odds ratio respectively. Statistical significance was set at P value < 0.05.Results: A total of 176(45.8%) patients had at least one PDDI. A total of 393 PDDIs,which were comprised of 283 types of interacting combinations, were identified. Of the total of 393 PDDIs, most were of moderate severity [201(51%)] followed by minor [152(39%)] and major severity [40(10%)]. The most common interacting pairs of major severity were gentamicin + furosemide(6), cotrimoxazole + methotrexate(4) and phenytoin + artemether(4). The occurrence of PDDIs was significantly associated with age and polypharmacy.Conclusions: The study showed that most of the interactions had moderate severity followed by minor severity. Age and polypharmacy were found to show statistically significant association with the occurrence of PDDIs. Due to sensitive nature of pediatrics population, close monitoring is recommended for the detection and management of PDDIs to prevent its negative consequences.展开更多
目的:探讨重症监护室(Intensive care unit,ICU)与普通病房患者碳青霉烯类耐药鲍曼不动杆菌(Carbapenem-resistant Acinetobacter baumannii,CRAB)感染特征及耐药性。方法:随机抽取2022年1月至2024年3月我院收治的120例CRAB感染患者,其...目的:探讨重症监护室(Intensive care unit,ICU)与普通病房患者碳青霉烯类耐药鲍曼不动杆菌(Carbapenem-resistant Acinetobacter baumannii,CRAB)感染特征及耐药性。方法:随机抽取2022年1月至2024年3月我院收治的120例CRAB感染患者,其中ICU与普通病房各60例,采用微生物鉴定及药敏分析系统观察两组CRAB感染特点,分析其耐药情况。结果:ICU与普通病房CRAB感染均以呼吸道感染为主,ICU病房、普通病房对于替加环素、米诺环素的耐药率低于其他抗生素类型(P<0.05);ICU病房分离出的CRAB菌株对氨苄西林/舒巴坦、头孢哌酮/舒巴坦、头孢吡肟、阿米卡星的耐药率均高于普通病房(P<0.05);ICU与普通病房AmpC、OXA-23、OXA-24、OXA-51、IMP-1、IMP-2、VIM-1、VIM-2耐药基因阳性率比较(P>0.05)。结论:ICU与普通病房CRAB感染均以呼吸道感染为主,且相较于普通病房,ICU中CRAB菌株耐药率更高。展开更多
基金Supported by University of Gondar(Grant No.Uo G/Re/Core/Pro/138862/2014)
文摘Objective: To determine the prevalence, level of severity of potential drug–drug interactions(PDDIs) and the associated factors for PDDIs in hospitalized pediatric patients of Gondar University Hospital.Methods: A retrospective cross-sectional study was conducted for a period of 3 months from March to May 2014 in pediatric wards of Gondar University Hospital. Systematic random sampling technique was used to select charts from all pediatric patients' charts with every 7th interval to get sample size of 384. Univariate and multivariate analysis were performed to compute crude odds ratio and adjusted odds ratio respectively. Statistical significance was set at P value < 0.05.Results: A total of 176(45.8%) patients had at least one PDDI. A total of 393 PDDIs,which were comprised of 283 types of interacting combinations, were identified. Of the total of 393 PDDIs, most were of moderate severity [201(51%)] followed by minor [152(39%)] and major severity [40(10%)]. The most common interacting pairs of major severity were gentamicin + furosemide(6), cotrimoxazole + methotrexate(4) and phenytoin + artemether(4). The occurrence of PDDIs was significantly associated with age and polypharmacy.Conclusions: The study showed that most of the interactions had moderate severity followed by minor severity. Age and polypharmacy were found to show statistically significant association with the occurrence of PDDIs. Due to sensitive nature of pediatrics population, close monitoring is recommended for the detection and management of PDDIs to prevent its negative consequences.
文摘目的:探讨重症监护室(Intensive care unit,ICU)与普通病房患者碳青霉烯类耐药鲍曼不动杆菌(Carbapenem-resistant Acinetobacter baumannii,CRAB)感染特征及耐药性。方法:随机抽取2022年1月至2024年3月我院收治的120例CRAB感染患者,其中ICU与普通病房各60例,采用微生物鉴定及药敏分析系统观察两组CRAB感染特点,分析其耐药情况。结果:ICU与普通病房CRAB感染均以呼吸道感染为主,ICU病房、普通病房对于替加环素、米诺环素的耐药率低于其他抗生素类型(P<0.05);ICU病房分离出的CRAB菌株对氨苄西林/舒巴坦、头孢哌酮/舒巴坦、头孢吡肟、阿米卡星的耐药率均高于普通病房(P<0.05);ICU与普通病房AmpC、OXA-23、OXA-24、OXA-51、IMP-1、IMP-2、VIM-1、VIM-2耐药基因阳性率比较(P>0.05)。结论:ICU与普通病房CRAB感染均以呼吸道感染为主,且相较于普通病房,ICU中CRAB菌株耐药率更高。
